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| 1 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 2 | Treatment of relapsing autoimmune pancreatitis with immunomodulators and rituximab: the Mayo Clinic experience显示文摘 | Phil A Hart Mark D Topazian Thomas E Witzig Jonathan E Clain Ferga C Gleeson Robin R Klebig Michael J Levy Randall K Pearson Bret T Petersen Thomas C Smyrk Aravind Sugumar Naoki Takahashi Santhi S Vege Suresh T Chari | 2013 | Gut2013，，11： | 2 |
| 3 | Treatment of relapsing autoimmune pancreatitis with immunomodulators and rituximab: the Mayo Clinic experience显示文摘 | Phil A Hart Mark D Topazian Thomas E Witzig Jonathan E Clain Ferga C Gleeson Robin R Klebig Michael J Levy Randall K Pearson Bret T Petersen Thomas C Smyrk Aravind Sugumar Naoki Takahashi Santhi S Vege Suresh T Chari | 2013 | Gut2013，，11： | 2 |
| 4 | Effect of hepatic artery embolization on liver hypertrophy response in a rabbit liver VX2tumor model显示文摘BACKGROUND:Portal vein embolization not only induces hypertrophy of the non-embolized liver,but also enhances tumor growth.The latter could be prevented by embolizing the hepatic arteries supplying the tumor-bearing liver segments.This study aimed to determine the effects of transcatheter arterial embolization(TAE)on tumor volume and liver regeneration in a rabbit VX2 tumor model.METHODS:Twenty-three rabbits underwent subcapsular tumor implantation with a VX2 tumor.Two weeks after implantation,18 rabbits were used for TAE experiments,5were for sham controls.Tumor response and liver regeneration response of the embolized cranial and non-embolized caudal liver lobes were assessed by CT volumetry,liver to body weight index,and the amount of proliferating hepatocytes.RESULTS:All super-selective arterial tumor embolization procedures were performed successfully.Despite embolization,the tumor volume increased after an initial steady state.The tumor volume after embolization was smaller than that of the sham group,but this difference was not significant.Massive necrosis of the tumor,however,was seen after embolization,without damage of the surrounding liver parenchyma.There was a significant atrophy response of the tumor bearing cranial lobe after super-selective arterial embolization of the tumor with a concomitant hypertrophy response of the non-embolized,caudal lobe.This regeneration response was confirmed histologically by a significantly higher number of proliferating hepatocytes on the Ki-67 stained slides.CONCLUSIONS:Super-selective,bland arterial coil embolization causes massive necrosis of the tumor,despite increase of volume on CT scan.Atrophy of the tumor bearing liver lobe is seen after arterial embolization of the tumor with a concomitant hypertrophy response of the non-embolized lobe,despite absence of histological damage of the tumor-surrounding liver parenchyma. | Krijn P van Lienden Lisette T Hoekstra Jessica D van Trigt Joris J Roelofs Otto M van Delden Thomas M van Gulik | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，6： | 2 |
| 5 | Effects of process parameters on melt-spun Ag-Cu显示文摘 | THOMA D J GLASGOW T K TEWARI S N | 1988 | J Mater Sci1988，98，： | 1 |
| 6 | Registration of LD00- 2817P soybean germplasm line with resistance to soybean cyst nematode from PI 437654 显示文摘 | Diets B W Cary T Thomas D | 2010 | Journal of Plant Registrations2010，4，2： | 1 |
| 7 | Post-collisional magmatism in the central East African orogen: The Maevarano suite of north Madagascm显示文摘 | Goodenough K M Thomas R J De Waele B Key R M Schofield D I Bauer W Tucker R D Kafahatelo J M Rabrimanana M Ralison A V Randriamananjma T | 2010 | Lithos2010，116，12： | 1 |
| 8 | Telangiectatic osteosarcoma:radiologic-pathologic comparison显示文摘 | Mark D M Suphanee wan Jaovisidha H Thomas T | 2003 | Radiology2003，229，： | 1 |
| 9 | Improving the nutritive value of full-fat rice bran for broiler chickens using a lipase-basedenzyme preparation显示文摘 | Tan S H Thomas D V Cumden B Je t al | 2000 | Asian Australasian Journal of Animal Sciences2000，13，3： | 1 |
| 10 | Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase 显示文摘 | Thoma R Schulz-Gasch T D'Arcy B | 2004 | Nature2004，432，7013： | 1 |
| 11 | Hydrogenolysis of diethyl oxalate over copper-based catalysts显示文摘 | Thomas D J Wehrli J T Wainwright M S | | 0，，： | 1 |
| 12 | Late paleocene to eocene paleocenography of the equatorial pacific ocean: stable isotopes recorded at ocean drilling program site 865, allison guyot显示文摘 | Zachos J C Thomas E Parrow M Paul C K Kelly D C Silva I P Sliter W V Lohmann K C | 1995 | Paleoceanography1995，10，： | 1 |
| 13 | Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor,dHAND显示文摘 | THOMAS T LIN Q | 1996 | Nat Genet1996，16，： | 1 |
| 14 | Correlations for thermal contact conductance in vacuum 显示文摘 | Thomas T R Probert S D | 1972 | Trans ASME J of Heat Transfer1972，21，8： | 1 |
| 15 | Water hyacinth: a major neglected resource, material science, wind energy 显示文摘 | Thomas T H Eden R D | 1990 | BiomasS Technology1990，3，： | 1 |
| 16 | Dynamics of mitochondrial DNA evolution in animals: amplification and sequencing with conserved primers 显示文摘 | Kocher T D Thomas W K Meyer A | 1989 | Proc Natl Acad Sci USA1989，86，： | 1 |
| 17 | Newborn and 5-week-old calves vocalize in response to milk deprivation 显示文摘 | Thomas T J Weary D M Appleby M C | 2001 | AppliedAnimal Behaviour Science2001，74，3： | 1 |
| 18 | Activity-dependent beta-adrenergic modulation of low frequency stimulation induced LTP in hippocampal CA1 region显示文摘 | Thomas M J Moody T D Makhison M | 1996 | Neuron1996，17，3： | 1 |
| 19 | Neodymium isotopic reconstruction of late Paleocene-early Eocene thennohaline eirculation显示文摘 | Thomas D J Bralower T J Jones C E | 2003 | Earth and Planetary Science Letters2003，209，： | 1 |
| 20 | Chemical sen- sors based on amplifying fluorescent conjugated poly- mers显示文摘 | Thomas m S W Joly G D Swager T M | 2007 | Chem Rev2007，107，4： | 1 |
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