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| 1 | Alcohol metabolites and lipopolysaccharide: Roles in the development and/or progression of alcoholic liver disease显示文摘The onset of alcoholic liver disease (ALD) is initiated by different cell types in the liver and a number of different factors including: products derived from ethanol-induced inflammation, ethanol metabolites, and the indirect reactions from those metabolites. Ethanol oxidation results in the production of metabolites that have been shown to bind and form protein adducts, and to increase inflammatory, fibrotic and cirrhotic responses. Lipopolysaccharide (LPS) has many deleterious effects and plays a significant role in a number of disease processes by increasing inflammatory cytokine release. In ALD, LPS is thought to be derived from a breakdown in the intestinal wall enabling LPS from resident gut bacterial cell walls to leak into the blood stream. The ability of adducts and LPS to independently stimulate the various cells of the liver provides for a two-hit mechanism by which various biological responses are induced and result in liver injury. Therefore, the purpose of this article is to evaluate the effects of a two-hit combination of ethanol metabolites and LPS on the cells of the liver to increase inflamma-tion and fi brosis, and play a role in the development and/or progression of ALD. | Courtney S Schaffert Michael J Duryee Carlos D Hunter Bartlett C Hamilton 3rd Amy L DeVeney Mary M Huerter Lynell W Klassen Geoffrey M Thiele | 2009 | World Journal of Gastroenterology2009，15，10： | 20 |
| 2 | 采用不同导管和技术的去肾交感神经术治疗单纯收缩期高血压:一项随机试验结果显示文摘目前认为单纯收缩期高血压(isolated systolic hypertension,ISH)患者经去肾交感神经术(renal sympathetic denervation,RDN)后血压降低。此结论绝大多数来自单极射频导管消融的研究。但采用新的RDN的数据有限。研究者采用比较3种不同RDN方法的RADIOSOUND-HTN(采用不同RDN导管与技术治疗顽固性高血压患者的三臂随机试验)数据,探讨ISH与RDN反应的可能交互作用。 | Fengler K Rommel KP Lapusca R Blazek S Besler C Hartung P von Roeder M Kresoja KP Desch S Thiele H Lurz P 赵狄 练桂丽 | 2019 | 中华高血压杂志2019，27，7： | 2 |
| 3 | Intensive insulin therapy exerts anti-inflammatory effects in critically ill patients and counteracts the ad- verse effect of low mannose-binding lectin levels 显示文摘 | Hansen TK Thiel S Wouters PJ | 2003 | J Clin Endocrinol Metal2003，88，3： | 1 |
| 4 | Assays for the functional activity of the mannan-binding lectin pathway of complement activation显示文摘 | M? ller-Kristensen M Jensen L | 2002 | Immunobiology2002，205，45： | 1 |
| 5 | Inhibition of pyruvat-edehydrogenase complex by moniliformin显示文摘 | Gathercole P S Thiel P G Hofmeyr J H S | 1986 | Biochemical Journal1986，233，： | 1 |
| 6 | A second serine protease associated with mannan-binding lectin that activates complement显示文摘 | Thiel S Vorup-Jensen T Stover CM | 1997 | Nature1997，386，6624： | 1 |
| 7 | Association between mannose-binding lectin and vascular complications in Type 1 dia- betes显示文摘 | TK Hansen Tarnow L Thiel S et oZ | 2004 | Scandinavian Journal Of Immunology2004，59，6： | 1 |
| 8 | Imaging of posterior cham- ber phakic intraocular lens by optical coherence tomography 显示文摘 | Beelunann M Ullrich S Thiel M J | 2002 | J Cataract Refract Surg2002，28，2： | 1 |
| 9 | Adsorption of the antibiotic pharmaceutical compound sulfapyridine by a long -term differently fertilized loess chernozem 显示文摘 | Thiele S | 2000 | Journal of Plant Nutrition and Soil Science2000，163，12： | 1 |
| 10 | Thermodynamic equipartition for increased second law efficiency显示文摘 | THIEL G P MCGOVERN P K ZUBAIR S M | 2014 | Applied Energy2014，136，4： | 1 |
| 11 | A positive geno-type-phenotype correlation in a large cohort of patientswith Pseudohypoparathyroidism Type Ia and Pseudo-pseudohypoparathyroidism and 33 newly identified muta-tions in the GNAS gene显示文摘 | Thiele S Werner R Grotzinger J | 2015 | Mol Genet Genomic Med2015，3，2： | 1 |
| 12 | Valproate-induced encepha lopathy: assessment with MR imaging and 1H MR spectros copy显示文摘 | Ziyeh S Thiel T Spreer J eta| | 2002 | Epilepsia2002，43，9： | 1 |
| 13 | Clinical manifesta-tions of mannan-binding lectin deficiency显示文摘 | Thiel S Frederiksen PD Jensenius JC | 2006 | Mol Immunol2006，43，： | 1 |
| 14 | Functionalcharacterization of GNAS mutations found in patientswith pseudohypoparathyroidism type Ic defines a newsubgroup of pseudohypoparathyroidism affecting Gsα-receptor interaction显示文摘 | Thiele S de Sanctis L Werner R | 2011 | Hum Mutat2011，32，6： | 1 |
| 15 | Liquid chromatographic determination of Fumonisins B1,B2, and B3 in foods and feeds显示文摘 | Eric W Sydenham Gordon S Shephard Pieter G Thiel | 1992 | Mycotoxins1992，75，： | 1 |
| 16 | Mannose-binding lee- tin deficiency attenuates renal changes in a streptozotocin-in- duced model of type 1 diabetes in mice显示文摘 | J Ostergaard Thiel S Gadjeva M | 2007 | Diabetologia2007，50，7： | 1 |
| 17 | Discovery of a novel tumour metastasis-promoting gene, NVM-1 显示文摘 | Thiele W Novac N Mink S | 2011 | J Pathol2011，225，： | 1 |
| 18 | Interplay between pro- moter and structural gene variants control basal serum level of man- nan - binding protein 显示文摘 | MADSEN H O GARRED P THIEL S | 1995 | J Immunol1995，155，6： | 1 |
| 19 | Anharmonic force fields from density functional theory 显示文摘 | Dressier S Thiel W | 1997 | Chem Phys Lett1997，273，12： | 1 |
| 20 | Uptake of the anticancer drug cisplatin mediated by the copper transporter Ctr1 in yeast and mammals显示文摘 | ISHIDA S LEE J THIELE D J | 2002 | Proc Natl Acad Sci U S A2002，99，14： | 1 |
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