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| 1 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 2 | Enhancement of the current efficiency for sodium hydroxide production from sodium sulphate in a two-compartment bipolar membrane electrodialysis system显示文摘 | Paleogou M Thibault A Wong P Y | 1997 | Sep Purif Technol1997，11，1： | 1 |
| 3 | A 3D fictitious domain method for incompressible fluid flow problems 显示文摘 | Bertrand F Tanguy P A Thibault F | 1997 | International Journal of Numerical Methods Fluids1997，，25： | 1 |
| 4 | A phase Ⅱstudy of Saza-2:deoxycytidine ( Decitabine ) in hormone independent metastatic (D2) prostate cancer显示文摘 | Thibault A Figg WD Bergan RC | 1998 | Tumori1998，84，1： | 1 |
| 5 | Diffuse axonal in- jury and traumatic coma in the primate 显示文摘 | Gennarelli T A Thibault L E Adams J H | 1982 | Ann Neurol1982，12，6： | 1 |
| 6 | Control and navigation framewoek for quadrotor helicopters显示文摘 | NAGATY A SAEEDI S THIBAULT C | 2013 | J Intel Robot Syst2013，，5： | 1 |
| 7 | A three-di- mensional fictitious domain method for incompressible fluid flow problems 显示文摘 | BERTRAND F TANGUY P A THIBAULT F | 1997 | Int Num Meth Fluids1997，，25： | 1 |
| 8 | 显示文摘 | BUZY A THIBAULT P LAYLOCK M V | 1994 | J Chromatogr: A1994，688，： | 1 |
| 9 | The AME2003 atomic mass evaluation:Ⅱ Tables,graphs and references显示文摘 | AUDI G WAPSTRA A H THIBAULT C | 2003 | Nuclear Phys A2003，729，1： | 1 |
| 10 | A three-dimensional statistical approach to improved image quality for multislice helical CT显示文摘 | Thibault J B Sauer K D Bouman C A | 2007 | Med Phys2007，34，： | 1 |
| 11 | Left ventricular versus simultaneous biventricular pacing in patients with heart failure and a QRS complex≥120 milliseconds显示文摘 | Thibault B Ducharme A Harel F | | 0，，： | 1 |
| 12 | Long-term outcomes after totally robotic sacrocolpopexy for treatment of pelvic organ prolapse显示文摘 | Germain A Thibault F Galifet M | 2013 | Surg Endosc2013，27，2： | 1 |
| 13 | Digital detectors for mammography: the technical challenges显示文摘 | Noel A Thibault F | 2004 | Eur Radiol2004，14，11： | 1 |
| 14 | Direct nu- merical simulation of interphase heat and mass transfer in multicomponent vapour-liquid flows显示文摘 | Haelssig J B Tremblay A Y Thibault J | 2010 | International Jour- nal of Heat and Mass Transfer2010，53，1920： | 1 |
| 15 | Local differentiability of distance functions显示文摘 | POLIQUIN R A ROCKAFELLAR R T THIBAULT L | 2000 | Trans Am Math Soc2000，352，： | 1 |
| 16 | Seasonal estimates of actual evapo-transpiration from Tamarix ramosissima stands using three-dimensional eddy covariance显示文摘 | Cleverly J R Dahm C N Thibault J R Gilroy D J Coonrod J E A | 2002 | Journal of Arid Environments2002，52，： | 1 |
| 17 | On- line prediction of fermentation variables using neural networks 显示文摘 | Thibault J V Breusegem V C Cheruy A | 1990 | Biotechnol Bioeng1990，43，： | 1 |
| 18 | Effects of nitrates on hydrocarbon-air flames and detonations显示文摘 | Zhang F Akbar R Thibault P A | 2001 | Shock Waves2001，，10： | 1 |
| 19 | Explosive dispersal of solid particles显示文摘 | Zhang F Frost D L Thibault P A | 2001 | Shock Waves2001，10，6： | 1 |
| 20 | Inhibition of mitochondrial permeability transition improves functional recovery and reduces mortality following acute myocardial infarction in mice显示文摘 | Gomez L Thibault H Gharib A Dumont JM Vuagniaux G Seal- faro P | 2007 | Am J Physiol Heart Circ Physi- ol2007，293，3： | 1 |
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