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| 1 | 初级保健中原发性醛固酮增多症的患病率和临床表现显示文摘原发性醛固酮增多症(primaryaldosteronism,PA)是一种异质性疾病,以高血压和相对自主于肾素血管紧张素系统产生过量醛固酮为特征。与心血管病风险相似的原发性高血压患者相比,PA患者发生心脑血管并发症的风险以及代谢综合征患病率增加,提示正确诊断PA的重要性。 | Monticone S Burrello J Tizzani D Bertello C Viola A Buffolo F Gabetti L Mengozzi G Williams TA Rabbia F Veglio F Mulatero P 练桂丽 叶鹏 | 2017 | 中华高血压杂志2017，25，5： | 58 |
| 2 | Intestinal alkaline phosphatase in the colonic mucosa of children with inflammatory bowel disease显示文摘AIM:To investigate intestinal alkaline phosphatase(iAP) in the intestinal mucosa of children with inflammatory bowel disease(IBD).METHODS:Colonic biopsy samples were taken from 15 newly diagnosed IBD patients and from 10 healthy controls.In IBD patients,specimens were obtainedboth from inflamed and non-inflamed areas.The iAP mRNA and protein expression was determined by reverse transcription-polymerase chain reaction and Western blotting analysis,respectively.Tissue localization of iAP and Toll-like receptor(TLR) 4 was investigated by immunofluorescent staining.RESULTS:The iAP protein level in the inflamed mucosa of children with Crohn's disease(CD) and ulcerative colitis(UC) was significantly decreased when compared with controls(both P < 0.05).Similarly,we found a significantly decreased level of iAP protein in the inflamed mucosa in CD compared with non-inflamed mucosa in CD(P < 0.05).In addition,the iAP protein level in inflamed colonic mucosa in patients with UC was decreased compared with non-inflamed mucosa in patients with CD(P < 0.05).iAP protein levels in the non-inflamed mucosa of patients with CD were similar to controls.iAP mRNA expression in inflamed colonic mucosa of children with CD and UC was not significantly different from that in non-inflamed colonic mucosa with CD.Expression of iAP mRNA in patients with noninflamed mucosa and in controls were similar.Co-localization of iAP with TLR4 showed intense staining with a dotted-like pattern.iAP was present in the inflamed and non-inflamed mucosa of patients with CD,UC,and in control biopsy specimens,irrespective of whether it was present in the terminal ileum or in the colon.However,the fluorescent signal of TLR4 was more pronounced in the colon compared with the terminal ileum in all groups studied.CONCLUSION:Lower than normal iAP protein levels in inflamed mucosa of IBD patients may indicate a role for iAP in inflammatory lesions in IBD.Based on our results,administration of exogenous iAP enzyme to patients with the active form of IBD may be a therapeutic option. | Kriszta Molnár dám Vannay Beáta Szebeni Nóra Fanni Bánki Erna Sziksz ron Cseh Hajnalka Gyrffy Péter László Lakatos Mária Papp András Arató Gábor Veres | 2012 | World Journal of Gastroenterology2012，18，25： | 5 |
| 3 | Relationship between skin fold thickness and insulin resistance in the essential hypertensive patients in Vietnam显示文摘Previous studies reported a close relationship between obesity and insulin resistance in the essential hypertensive patients. Objective In this study, we examined the relationship between the skin fold thickness and insulin resistance then developed a formula to estimate the insulin resistance index according to the skin fold thickness in the essential hypertensive patients. Subjects and Methods Medical records of 80 patients (37 males, 43 females) were reviewed and the data were tabulated. Anthropometric indexes (including height, weight, waist circumference, hip circumference, and skins fold thickness at 5 fatty difference points on the Erdheim diagram), fasting plasma glucose and insulin concentration were recorded. The mean age was 57.0±9.2 years. The insulin resistance index was calculated following the Homeostasis Model Assessment (HOMA) formula. Results Compared with the group with BMI<23kg/m2, the group with BMI≥23 kg/m2 had higher fasting insulin concentration (8.85 ± 4.97 pmol/L vs 15.60 ± 8.70 pmol/L, P<0.001 ) and higher insulin resistance index in (2.15±1,24 vs 3.76±2.22, P<0.001). No significant difference in fasting plasma insulin concentration,insulin resistance index between male and female was observed (P>0.05). There was a positive correlation between skin fold thickness and the fasting insulin concentration and insulin resistance index. The skin fold thickness at point A8 had the best coefficient correlated with fasting plasma insulin(r=0.79, P<0.001) and insulin resistance index (r= 0.79, P < 0.001). A formula to estimate the insulin resistance index by skin fold thickness at point A8 as: Insulin resistance index = 0.12 × [skin fold thickness at A8 point (mm)] - 1.Conclusion: In the essential hypertensive patients, the formula to estimate insulin resistance index as 0.12 × [skin fold thickness at A8 point (mm)]-1 may predict accurately the level of insulin resistance. | Toan C Nguyen Khoa TA Pham Quyen TL Do Cuong T Nguyen Diep D Nguyen Vinh G Le Cong D Nguyen | 2005 | Journal of Geriatric Cardiology2005，2，4： | 4 |
| 4 | Stable femtosecond X-rays with tunable polarization from a laser-driven accelerator显示文摘Technology based on high-peak-power lasers has the potential to provide compact and intense radiation sources for a wide range of innovative applications.In particular,electrons that are accelerated in the wakefield of an intense laser pulse oscillate around the propagation axis and emit X-rays.This betatron source,which essentially reproduces the principle of a synchrotron at the millimeter scale,provides bright radiation with femtosecond duration and high spatial coherence.However,despite its unique features,the usability of the betatron source has been constrained by its poor control and stability.In this article,we demonstrate the reliable production of X-ray beams with tunable polarization.Using ionization-induced injection in a gas mixture,the orbits of the relativistic electrons emitting the radiation are reproducible and controlled.We observe that both the signal and beam profile fluctuations are significantly reduced and that the beam pointing varies by less than a tenth of the beam divergence.The polarization ratio reaches 80%,and the polarization axis can easily be rotated.We anticipate a broad impact of the source,as its unprecedented performance opens the way for new applications. | Andreas Döpp Benoit Mahieu Agustin Lifschitz Cedric Thaury Antoine Doche Emilien Guillaume Gabriele Grittani Olle Lundh Martin Hansson Julien Gautier Michaela Kozlova Jean Philippe Goddet Pascal Rousseau Amar Tafzi Victor Malka Antoine Rousse Sebastien Corde Kim Ta Phuoc | 2017 | Light(Science & Applications)2017，6，1： | 2 |
| 5 | Differential function of intestinal intraepithelial lymphocyte subsets 显示文摘 | Barrett TA Gajewskj D Danielpour EB | 1992 | J Immunol1992，149，4： | 2 |
| 6 | Skin fold thickness at abdomen:a simple anthropometric measurement may compliment metabolic syndrome definition in patients with normal waist circumference显示文摘Backgroud and Objectives Previous studies have reported that skin fold thickness (SF) strongly correlated with insulin resistance in the metabolic syndrome (MetS). In this study, we developed a MetS definition by SF at A8 point (SFA8) on Erdheim diagram(MetSSFA8) in essential hypertensive patients. Subjects and Methods Medical records of 268 essential hypertensive patients (126males and 122 females) were analyzed, including 210 non-diabetic patients (NDM group) and 58 patients with diabetes (DM group).The mean age was 61.4 ± 9.9 and 59.0 ± 11.0 years, respectively. The control group consisted of 90 non-diabetic, non-hypertensive patients with a mean age of 58.0 ± 11.3 years. The proposed MetSSFA8 definition included SFA8 specific values ( ≥30 mm in female and ≥27 mm in male) and at least two of the following: raised triglyceride levels ( ≥1.7 mmol/L), or specific treatment for this lipid abnormality; raised blood pressure (SBP≥130 mmHg and/or DBP≥85 mmHg), or treatment of previously diagnosed hypertension;reduced HDL-cholesterol (< 1.03 mmol/L in men, <1.29 mmol/L in women), or specific treatment for this lipid abnormality; raised fasting plasma glucose (≥5.6 mmol/l), or previously diagnosed DM. Metabolic Syndrome by the National Cholesterol Education Program and International Diabetes Federation definitions were determined with abdominal obesity defined by Asia-Pacific criteria for waist circumference (NCEPA and IDFA). Results The percentage of MetS as defined by NCEPA, IDFA and MetSSFA8 in NDM group was lower than that of NCEPA, IDFA and MetSSFA8 in DM group [OR=7.7 (95%CI, 2.9-20.2) and 2.5 (95%CI, 1.4-4.8) and 2.7(95%CI, 1.3-5.6), respectively] and higher than that of the control group [OR=53.3 (95%CI, 16.7-170.6), 5.8 (95%CI, 2.6-13.2) and18.8 (95%CI, 7.3-48.7), respectively]. The percentage of MetS by NCEPA, IDFA and MetSSFA8 in males in NDM group was lower than the percentage of MetS by NCEPA, IDFA and MetSSFA8 in females in NDM group (50.8% and 77.9%, P< 0.001; 15,9% and 67.2%, P< 0.001; 60.3% and 73.8%, P <0.05, respectively). In subjects with normal WC or both normal WC and BMI, the percentage of MetS by SFAS was higher than that the percentage of MetS by NCEPA (36.9% and 50.8%, P< 0.05 and 36.0% and 51.0%, P< 0.05).The sensitivity, specificity, false positive rate, positive predictive value, negative predictive value of MetSSFA8 assessed with NCEPA definitions were 0.87, 0.73, 0.27, 0.79 and 0.82, respectively. There was a close agreement between MetSSFA8 and NCEPA (The coefficient of Kapa was 0.60, P< 0.001). Conclusions The MetSSFA8 definition was developed which may be useful in order to define and manage MetS in patients with normal WC or normal weight. | Toan C Nguyen Thai Q Ngo Son V Nguyen Hieu T Luong Khoa TA Pham Cong D Nguyen | 2006 | Journal of Geriatric Cardiology2006，3，2： | 2 |
| 7 | Involvement of serum retinoids and Leiden mutation in patients with esophageal, gastric, liver, pancreatic, and colorectal cancers in Hungary显示文摘AIM: To analyze the serum levels of retinoids and Leiden mutation in patients with esophageal, gastric, liver,pancreatic, and colorectal cancers.METHODS: The changes in serum levels of retinoids (vitamin A, α- and β-carotene, α- and β-cryptoxanthin,zeaxanthin, lutein) and Leiden mutation were measured by high liquid performance chromatography (HPLC)and polymerase chain reaction (PCR) in 107 patients (70 males/37 females) with esophageal (0/8), gastric (16/5), liver (8/7), pancreatic (6/4), and colorectal (30/21including 9 patients suffering from in situ colon cancer)cancer. Fifty-seven healthy subjects (in matched groups)for controls of serum retinoids and 600 healthy blood donors for Leiden mutation were used.RESULTS: The serum levels of vitamin A and zeaxanthin were decreased significantly in all groups of patients with gastrointestinal (GI) tumors except for vitamin A in patients with pancreatic cancer. No changes were obtained in the serum levels of α- and β-carotene,α- and β-cryptoxanthin, zeaxanthin, lutein in patients with GI cancer. The prevalence of Leiden mutation significantly increased in all groups of patients with GI cancer.CONCLUSION: Retinoids (as environmental factors)are decreased significantly with increased prevalence of Leiden mutation (as a genetic factor) in patients before the clinical manifestation of histologically different (planocellular and hepatocellular carcinoma, and adenocarcinoma) GI cancer. | Gyula Mózsik Gy(o|¨)rgy Rumi András D(o|¨)m(o|¨)t(o|¨)r Mária Figler Beáta Gasztonyi El(?)d Papp Alajos Pár Gabriella Pár József Belágyi Zoltán Matus Béla Melegh | 2005 | World Journal of Gastroenterology2005，11，48： | 2 |
| 8 | Combined angiotensin II receptor antagonism and angiotensin-converting enzyme inhibition further attenuates postinf arction left ventricular remodeling显示文摘 | Mankad S d'Amato TA Reichek N | 2001 | Circulation2001，103，23： | 2 |
| 9 | 创伤性急性硬膜下血肿的手术与保守治疗:一项前瞻性、多中心、观察性的比较效果研究显示文摘尽管急诊手术已被证实为创伤性急性硬膜下血肿患者的有效治疗方式之一,但其证据等级尚且较低。该研究旨在比较对于急性硬膜下血肿患者而言,行急诊血肿清除术与一期行保守治疗的治疗策略在疗效上是否存在差异。 | van Essen TA Lingsma HF PisicǎD 闫思宇(译) | 2022 | 中华医学杂志2022，102，29： | 2 |
| 10 | Advanced three dimensional evaluation of acetabular trauma:Volumetric image processing显示文摘 | Magid D Drebin TA | 1989 | J Trauma1989，29，2： | 1 |
| 11 | Co-regulation of Salmonella enterica genes required for virulence and resistance to antimicrobial peptides by SlyA and PhoP/PhoQ显示文摘 | Navarre WW Halsey TA Walthers D | 2005 | Mol Microbiol2005，56，2： | 1 |
| 12 | Survival following hepatic resection of colorectal cancer metastases: a national experience 显示文摘 | Robertson D J Stukel TA Gottlieb D J | 2009 | Cancer2009，115，4： | 1 |
| 13 | Human Cardiotro- phin-1 : protein and gene structure, biological and binding ac- tivities, and chromosomal localization显示文摘 | Pennica D Swanson TA Shaw KJ | 1996 | Cytokine1996，8，3： | 1 |
| 14 | Videouioracoscopic mediastinal lymphadenectomy显示文摘 | D'Amico TA | 2010 | Thorac Surgery Clin2010，20，2： | 1 |
| 15 | Expression of the integrin alphaSbetal during pulmonary and hepatic fibrosis 显示文摘 | Levine D Rockey DC Milner TA | 2000 | Am J Pathol2000，156，6： | 1 |
| 16 | Impaired liver regeneration in Nrf2 kno- ckout mice: role of ROS-mediated insulin/IGF-1 resistance 显示文摘 | Beyer TA Xu W Teupser D | 2008 | The EMBO Journal2008，15，27： | 1 |
| 17 | Cerebral dysautoregulation and the risk of ischemic events in occlusive carotid artery disease 显示文摘 | Reinhard M Gerds TA Grabiak D | 2008 | Journal of Neurology2008，255，8： | 1 |
| 18 | Temporal expression of the transforming growth factor-Beta pathway in the rabbit ear model of wound healing and scarring显示文摘 | Kryger ZB Sisco M Roy NK Lu L Rosenberg D Mustoe TA | | 0，，01： | 1 |
| 19 | Effect of snesthesia on the cytokine responses to abdominal surgery显示文摘 | Crozier TA Muller JE Quttkat D | | 0，，03： | 1 |
| 20 | Efficient patient identification strategies for women with osteoporosis显示文摘 | Abbott TA 3rd Mucha L Manfredonia D | | 0，，03： | 1 |
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