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| 1 | 查看详情显示文摘 | W C Huang H Y Tam P K A Wai X Y Dong H Ming J P Xie | | 中国物理快报(英文版)0，，： | 4 |
| 2 | 神经连接蛋白-3缺乏可阻止高分级神经胶质瘤生长显示文摘在一项新的研究中,来自美国国家卫生研究院、斯坦福大学、达纳法伯癌症研究所和哈佛医学院的研究人员发现某些侵袭性脑瘤的生长能够通过切断它们获取大脑中神经细胞产生的一种信号分子加以阻止.这些研究人员发现当这种被称作神经连接蛋白-3(neuroligin-3,NLGN3)的信号分子缺乏时,或者当利用药物干扰这种信号分子时,人高分级神经胶质瘤不能够在小鼠大脑中扩散. | Venkatesh H S Tam L T Woo P J | 2017 | 临床误诊误治2017，30，11： | 3 |
| 3 | 利钠肽受体2的缺乏促进小鼠二叶主动脉瓣、主动脉瓣疾病、左心室功能不全以及升主动脉扩张显示文摘主动脉瓣疾病是无有效药物治疗的细胞介导的病变过程。C型利钠肽(C-type natriuretic peptide,CNP)抑制瓣膜间质细胞(valve interstitial cells,VIC)的肌纤维形成和成骨过程,并且在出现主动脉瓣狭窄时水平下调。然而,CNP信号是否调节体内主动脉瓣的健康状态尚不清楚。该研究旨在确定小鼠CNP信号通路的缺失是否导致主动脉瓣疾病加速发展。 | 刘青 叶鹏 Blaser MC Wei K Adams RL Zhou YQ Caruso LL Mirzaei Z Lam A Tam RK Zhang H Heximer SP Henkelman M Simmons CA | 2018 | 中华高血压杂志2018，26，1： | 3 |
| 4 | Bulk endocytosis at neuronal synapses显示文摘Neurotransmitter-containing synaptic vesicle(SV)fusion with the nerve terminal plasma membrane initiates neurotransmission in response to neuronal excitation.Under mild stimulation,the fused vesicular membrane is retrieved via kiss-and-run and/or clathrin-mediated endocytosis,which is sufficient to maintain recycling of SVs.When neurons are challenged with very high stimulation,the number of fused SVs can be extremely high,resulting in significant plasma membrane addition.Under such conditions,a higher capacity retrieval pathway,bulk endocytosis,is activated to redress this large membrane imbalance.Despite first being described more than 40 years ago,the molecular mechanisms underpinning this important process have yet to be clearly defined.In this review,we highlight the current evidence for bulk endocytosis and its prevalence in various neuronal models,as well as discuss the underlying molecular components. | NGUYEN Tam H QIU XuFeng SUN JianYuan MEUNIER Frederic A | 2014 | Science China(Life Sciences)2014，57，4： | 3 |
| 5 | 紫外均匀曝光对长周期光纤光栅耦合特性的影响显示文摘写于载氢光纤上的长周期光纤光栅经过高温退火后 ,对其进行紫外均匀曝光能够有效改变其耦合特性。随着曝光量的增加 ,其共振波长向长波方向移动 ,共振峰强度先增大继而减小。并对此给出了理论解释。 | 关柏鸥 Tam H Y HoSL 董孝义 | 2001 | 光学学报2001，21，2： | 3 |
| 6 | Gastroesophageal reflux disease after diagnostic endoscopy in the clinical setting显示文摘AIM: To investigate the outcome of patients with symptoms of gastroesophageal reflux disease (GERD) referred for endoscopy at 2 and 6 mo post endoscopy. METHODS: Consecutive patients referred for upper endoscopy for assessment of GERD symptoms at two large metropolitan hospitals were invited to participate in a 6-mo non-interventional (observational) study.The two institutions are situated in geographically and socially disparate areas. Data collection was by selfcompletion of questionnaires including the patient assessment of upper gastrointestinal disorders symptoms severity and from hospital records. Endoscopic finding using the Los-Angeles classification, symptom severity and it's clinically relevant improvement as change of at least 25%, therapy and socio-demographic factors were assessed. RESULTS: Baseline data were available for 266 patients and 2-mo and 6-mo follow-up data for 128 and 108 patients respectively. At baseline, 128 patients had erosive and 138 non-erosive reflux disease. Allmost all patient had proton pump inhibitor (PPI) therapy in the past. Overall, patients with non-erosive GERD at the index endoscopy had significantly more severe symptoms as compared to patients with erosive or even complicated GERD while there was no difference with regard to medication. After 2 and 6 mo there was a small, but statistically significant improvement in symptom severity (7.02 ± 5.5 vs 5.9 ± 5.4 and 5.5 ± 5.4 respectively); however, the majority of patients continued to have symptoms (i.e. , after 6 mo 81% with GERD symptoms). Advantaged socioeconomic status as well as being unemployed was associated with greater improvement. CONCLUSION: The majority of GORD patients receive PPI therapy before being referred for endoscopy even though many have symptoms that do not sufficiently respond to PPI therapy. | Nora B Zschau Jane M Andrews Richard H Holloway Mark N Schoeman Kylie Lange William CE Tam Gerald J Holtmann | 2013 | World Journal of Gastroenterology2013，19，16： | 2 |
| 7 | Short-term postural reflexes in diabetic patients with autonomic dysfunction 显示文摘 | ZHANG Y CRITCHLEY L A TAM Y H TOMLINSON B | 2004 | Diabetologia2004，47，： | 1 |
| 8 | Non-structural Fuzzy Decision Support System for Evaluation of Construction Safety Management System显示文摘 | Tam C M Tong Thomas K L Chiu Gerald C W Fung Ivan W H | 2002 | International Journal of Project Management2002，，20： | 1 |
| 9 | Robust eigenstructure assignment under regional pole constaints显示文摘 | TAM H K LAM J | 1996 | IEEE1996，，12： | 1 |
| 10 | Deformable Model Retrieval Based on Topological and Geometric Signatures 显示文摘 | Gary K L Tam Rynson W H Lau | 2007 | IEEE Transactions on Visualization and Computer Graphics (S1077-2626)2007，13，3： | 1 |
| 11 | Possible role of the bulge region in the pathogenesis of inflammatory scarring alopecia: lichen planopilaris as the prototype 显示文摘 | Mobini N Tam S Kamino H | 2005 | J Cutan Pathol2005，32，10： | 1 |
| 12 | Microbial population dynamics and enzyme activities during composting 显示文摘 | Tiquia S M Wan J H C Tam N F Y | 2002 | Compost Science and Utilization2002，10，2： | 1 |
| 13 | Multimode project scheduling based on particle swarm optimization显示文摘 | Zhang H Tam C M Li H | | 0，，02： | 1 |
| 14 | Machine fault diagnosis through an effective exact wavelet analysis 显示文摘 | Tse P W Yang W X Tam H Y | 2004 | Journal of Sound and Vibration2004，277，45： | 1 |
| 15 | Cholangitis After Hepatic Portoenterostomy For Biliary Atresia:A Multivariate Analysis Of Risk Factors显示文摘 | Tam H | 2003 | J Pediatr2003，142，： | 1 |
| 16 | Microbial population dynamics and enzyme activities during omposting 显示文摘 | Tiquia S M Wan J H C Tam N F Y | 2002 | Compost Science and Utilization2002，10，2： | 1 |
| 17 | A biological survey of' ballast water in container ships entering Hong Kong显示文摘 | CHU K H TAM P F FUNG C H | 1997 | Hydrobiologia1997，352，1： | 1 |
| 18 | Nitrogen use efficiency characteristics of Andigena and diploid potato selections 显示文摘 | Zebarth B J Tam T R Jong H de | 2008 | American Journal of Potato Research2008，85，： | 1 |
| 19 | Improvement in cavitation erosion resistance of a copper-based propeller alloy by laser surface melting显示文摘 | Tam K F Cheng F T Man H C | 2004 | Surface and Coatings Technology2004，182，2： | 1 |
| 20 | Rheologlcal properties of semidilute hydrophobically modified alkali-soluble emul- sion polymers in sodium dodecyl sulfate and salt solutions 显示文摘 | Tan H Tam K C Jenkins R D | 2000 | Langmuir2000，16，13： | 1 |
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