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| 1 | Multimodality management of gallbladder cancer can lead to a better outcome:Experience from a tertiary care oncology centre in North India显示文摘BACKGROUND Surgical resection is a treatment of choice for gallbladder cancer(GBC)patients but only 10%of patients have a resectable disease at presentation.Even after surgical resection,overall survival(OS)has been poor due to high rates of recurrence.Combination of surgery and systemic therapy can improve outcomes in this aggressive disease.AIM To summarize our single-center experience with multimodality management of resectable GBC patients.METHODS Data of all patients undergoing surgery for suspected GBC from January 2012 to December 2018 was retrieved from a prospectively maintained electronic database.Information extracted included demographics,operative and perioperative details,histopathology,neoadjuvant/adjuvant therapy,follow-up,and recurrence.To know the factors associated with recurrence and OS,univariate and multivariate analysis was done using log rank test and cox proportional hazard analysis for categorical and continuous variables,respectively.Multivariate analysis was done using multiple regression analysis.RESULTS Of 274 patients with GBC taken up for surgical resection,172(62.7%)were female and the median age was 56 years.On exploration,102 patients were found to have a metastatic or unresectable disease(distant metastasis in 66 and locally unresectable in 34).Of 172 patients who finally underwent surgery,93(54%)underwent wedge resection followed by anatomical segment IVb/V resection in 66(38.4%)and modified extended right hepatectomy in 12(7%)patients.The postoperative mortality at 90 d was 4.6%.During a median follow-up period of 20 mo,71(41.2%)patients developed recurrence.Estimated 1-,3-,and 5-years OS rates were 86.5%,56%,and 43.5%,respectively.Estimated 1-and 3-year disease free survival(DFS)rates were 75%and 49.2%,respectively.On multivariate analysis,inferior OS was seen with pT3/T4 tumor(P=0.0001),perineural invasion(P=0.0096),and R+resection(P=0.0125).However,only pT3/T4 tumors were associated with a poor DFS(P<0.0001).CONCLUSION Multimodality treatment significantly improves the 5-year survival rate of patients with GBC up to 43%.R+resection,higher T stage,and perineural invasion adversely affect the outcome and should be considered for systemic therapy in addition to surgery to optimize the outcomes.Multimodality treatment of GBC has potential to improve the survival of GBC patients. | Shaifali Goel Abhishek Aggarwal Assif Iqbal Vineet Talwar Swarupa Mitra Shivendra Singh | 2021 | World Journal of Gastroenterology2021，27，45： | 5 |
| 2 | New discovery rarely runs smooth: an update on progranulin/TNFR interactions显示文摘Progranulin (PGRN ) 是一个生长因素在各种各样的 pathophysiological 过程含有,包括愈合弯屈,发炎, tumorigenesis,和 neurodegeneration。PGRN 绑在肿瘤坏死因素受体(TNFR ) 并且在煽动性的关节炎有治疗学的效果,这以前被报导(唐等在科学 332:478484, 2011 ) ;然而,陈等。报导了他们的无能在他们的自己的条件下面表明 PGRN-TNFR 相互作用(陈等在 J Neurosci 33:92029213, 2013 ) 。letter-to-editor 然后被原来的组响应陈等出版。讨论了原因让后者无能概括相互作用的纸。另外,这个组出版了进一步增强了并且把的后续研究 PGRN-TNFR 的相互作用。最近,关于 PGRN-TNFR 相互作用的合法性的争论看起来被众多的实验室最后处于各种各样的条件与这些相互作用的独立证实解决。这评论在 PGRN-TNFR 相互作用的故事上介绍按年代先后的更改,加亮在各种各样的疾病和条件的这些相互作用的独立证实。 | Betty C. Wang Helen Liu Ankoor Talwar Jinlong Jian | 2015 | Protein & Cell2015，6，11： | 5 |
| 3 | Post splenectomy related pulmonary hypertension显示文摘Splenectomy predisposes patients to a slew of infectious and non-infectious complications including pulmonary vascular disease. Patients are at increased risk for venous thromboembolic events due to various mechanisms that may lead to chronic thromboembolic pulmonary hypertension(CTEPH). The development of CTEPH and pulmonary vasculopathy after splenectomy involves complex pathophysiologic mechanisms, some of which remain unclear. This review attempts to congregate the current evidence behind our understanding about the etio-pathogenesis of pulmonary vascular disease related to splenectomy and highlight the controversies that surround its management. | Atul V Palkar Abhinav Agrawal Sameer Verma Asma Iftikhar Edmund J Miller Arunabh Talwar | 2015 | World Journal of Respirology2015，5，2： | 3 |
| 4 | A comparison of inflammation-based prognostic scores in patients with cancer. A Glasgow Inflammation Outcome Study显示文摘 | Michael J. Proctor David S. Morrison Dinesh Talwar Steven M. Balmer Colin D. Fletcher Denis St.J. O’Reilly Alan K. Foulis Paul G. Horgan Donald C. McMillan | 2011 | European Journal of Cancer2011，，17： | 2 |
| 5 | Gallbladder cancer with tumor thrombus in the superior vena cava显示文摘BACKGROUND:Gastrointestinal cancers,especially pancreatobiliary cancers,are frequently associated with or are complicated by thromboembolic phenomena due to hypercoagulability and/or altered venous drainage,especially of the abdomen and lower limbs.This report describes an unusual and interesting case of gallbladder carcinoma developing a viable tumor thrombus in the superior vena cava(SVC)with resultant SVC obstruction,while on gefitinibbased anti-epidermal growth factor receptor(EGFR)therapy.METHODS:A 60-year-old woman was incidentally diagnosed to have gallbladder cancer on cholecystectomy.She had disease recurrence and received systemic chemotherapy followed by gefitinib-based anti-EGFR therapy.Subsequently,while on gefitinib-based therapy,she presented with clinical signs and symptoms suggestive of SVC thrombosis.RESULTS:A whole body PET scan revealed a metabolically active tumor thrombus in the SVC,besides other sites of metabolically active disease inclusive of the lung parenchyma, lymph nodes and abdomen.She was treated with antithrombotics and external beam radiotherapy directed to the SVC thrombus leading to symptomatic relief.She continues to survive on the day of writing this report.CONCLUSIONS:This rare complication,though theoretically possible,is unreported because of the short overall survival of advanced gallbladder cancer patients.This highlights that with the availability of better chemotherapeutic/biotherapeutic agents for increasing in the lifespan of cancer patients,we may come across such cases more frequently in the future. | Sandeep Batra Dinesh Chandra Doval Ullas Batra Pandalanghat Suresh Amit Dhiman Vineet Talwar | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，3： | 2 |
| 6 | Combination immunotherapy with Survivin and luteinizing hormone-releasing hormone fusion protein in murine breast cancer model显示文摘AIM To investigate the therapeutic potential of two recombinant proteins, Survivin and luteinizing hormone-releasing hormone (LHRH) fusion protein [LHRH(6 leu)-LTB] for immunotherapy of breast cancer.METHODS Murine 4 T-1 breast cancer model was used to evaluate the efficacy of recombinant proteins in vivo. Twenty four Balb/c mice were divided into 4 groups of 6 mice each. Recombinant Survivin and LHRH fusion protein, alone or in combination, were administered along with immunomodulator Mycobacterium indicus pranii (MIP) in Balb/c mice. Unimmunized or control group mice were administered with phosphate buffer saline. Each group was then challenged with syngeneic 4 T-1 cells to induce the growth of breast tumor. Tumor growth was monitored to evaluate the efficacy of immune-response in preventing the growth of cancer cells.RESULTS Preventive immunization with 20 μg recombinant Survivin and MIP was effective in suppressing growth of 4 T-1 mouse model of breast cancer (P = 0.04) but 50 μg dose was ineffective in suppressing tumor growth. However, combination of Survivin and LHRH fusion protein was more effective in suppressing tumor growth (P = 0.02) as well as metastasis in vivo in comparison to LHRH fusion protein as vaccine antigen alone.CONCLUSION Recombinant Survivin and MIP suppress tumor growth significantly. Combining LHRH fusion protein with Survivin and MIP enhances tumor suppressive effects marginally which provides evidence for recombinant Survivin and LHRH fusion protein as candidates for translating the combination cancer immunotherapy approaches. | Himani Garg Rohit Singh Hada Jagdish C Gupta G P Talwar Shweta Dubey | 2018 | World Journal of Clinical Oncology2018，9，8： | 2 |
| 7 | Response of fuzzy clustering on different threshold determination algorithms in spectral change vector analysis over Western Himalaya, India显示文摘Change detection is a standard tool to extract and analyze the earth's surface features from remotely sensed data. Among the different change detection techniques, change vector analysis(CVA) have an exceptional advantage of discriminating change in terms of change magnitude and vector direction from multispectral bands. The estimation of precise threshold is one of the most crucial task in CVA to separate the change pixels from unchanged pixels because overall assessment of change detection method is highly dependent on selected threshold value. In recent years, integration of fuzzy clustering and remotely sensed data have become appropriate and realistic choice for change detection applications. The novelty of the proposed model lies within use of fuzzy maximum likelihood classification(FMLC) as fuzzy clustering in CVA. The FMLC based CVA is implemented using diverse threshold determination algorithms such as double-window flexible pace search(DFPS), interactive trial and error(T&E), and 3×3-pixel kernel window(PKW). Unlike existing CVA techniques, addition of fuzzy clustering in CVA permits each pixel to have multiple class categories and offers ease in threshold determination process. In present work, the comparative analysis has highlighted the performance of FMLC based CVA overimproved SCVA both in terms of accuracy assessment and operational complexity. Among all the examined threshold searching algorithms, FMLC based CVA using DFPS algorithm is found to be the most efficient method. | SINGH Sartajvir TALWAR Rajneesh | 2017 | Journal of Mountain Science2017，14，7： | 2 |
| 8 | Effects of carrier release kinetics on bone morphogenetic protein-2-induced periodontal regeneration in vivo显示文摘 | Talwar R Di Silvio L Hughes FJ | 2001 | J Clin Periodontol2001，28，4： | 1 |
| 9 | Plasma N terminal probrain natriuretic peptide and cardiotrophin are raised in unstable anginal 显示文摘 | Talwar S Squire IB Downie PF | 2000 | Heart2000，84，4： | 1 |
| 10 | Children's conceptual knowledge of lying and its relation to their actual behaviors:Implications for court competence examination显示文摘 | Lee K Bala N | 2002 | Law and Human Behavior2002，，4： | 1 |
| 11 | Extraction and separation of urinary catecholamines as their diphenyl boronate complexes using C 18 solid-phase extraction sorbent and high-performance liquid chromatography显示文摘 | Talwar D Williamsou C McLaughlin A | 2002 | Chromatogr B2002，769，2： | 1 |
| 12 | Biodegradable delivery system for a birth control vaccine:immunogenicity studies in rats and monkeys显示文摘 | Singh M Singh O Talwar G P | 1995 | Pharm Res1995，12，： | 1 |
| 13 | A fourth-generation MIMO-OFDM broadband wireless systems, design, performance, and field trial results显示文摘 | SAMPATH H TALWAR S TELLADO J | 2002 | IEEE Commun Mag2002，40，9： | 1 |
| 14 | A tight bound on approximating arbitrary metrics by tree metrics显示文摘 | FAKCHAROENPHOL J RAO S TALWAR K | 2004 | Journal of Computer and System Sciences2004，69，3： | 1 |
| 15 | Elevated circulating cardiotro- phin - 1 in heart failure : Relationship with parameters of left ventricular systolic dysfunction显示文摘 | Talwar S Squire IB Downie PF | 2000 | Clin Sci2000，99，1： | 1 |
| 16 | Plasma N - terminal pro - brain natriuretic peptide and cardiotrophin 1 are raised in unstable angina显示文摘 | Talwar S Squire IB Downie PF | 2004 | Heart2004，84，： | 1 |
| 17 | Inflammtion-promoting activity of HMGB-1 on human microvascular endothelial cells显示文摘 | Fiuza C Baustion M Talwar S | 2003 | Blood2003，101，7： | 1 |
| 18 | Necrosis and inhibition of growth of human lung tumor by anti-alpha-human chorionic gonadotropin antibody显示文摘 | Kumar S Talwar GP Biswas DK | 1992 | J Natl Cancer Inst1992，84，1： | 1 |
| 19 | NgLL Plasma N-terminal pro-brain natriure tiepeptide and cardiotrophinl are raise dinun stableangina显示文摘 | Talwar S Squire IB Downie PF | 2000 | Heart2000，84，： | 1 |
| 20 | Identification and management of ventricu-lar tachycardia显示文摘 | Naik N Talwar KK | 2003 | J Indian Med Assoc2003，101，2： | 1 |
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