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| 1 | 北京大气细粒子PM_(2.5)的化学组成显示文摘为了解北京大气细粒子(PM2.5)的污染水平和污染特征,在车公庄和清华园进行了连续1年、每周1次同步采样和全样品分析。2个采样点PM2.5的化学组成相似。含碳组分和水溶性离子是主要的组分,其质量浓度之和超过PM2.5的50%。有机碳、元素碳和细粒子PM2.5的季节变化一致,即冬季质量浓度最高,夏季最低。夏季NO-3的质量浓度最低且在采样过程中从特氟隆滤膜上有近50%的挥发。SO2-4不同于PM2.5的季节变化主要取决于SO2的转化率。地壳元素的质量浓度从冬季到春季大幅度上升,春季沙尘天气频是一个重要原因。 | 杨复沫 贺克斌 马永亮 张强 姚小红 Chak K. Chan Steven Cadle Tai Chan Patricia Mulawa | 2002 | 清华大学学报(自然科学版)2002，42，12： | 116 |
| 2 | 北京大气PM_(2.5)中微量元素的浓度变化特征与来源显示文摘为了解北京大气细粒子中微量元素的污染水平和来源 ,在车公庄和清华园进行了连续 1年、每周 1次的PM2 5采样和全样品分析 .微量元素浓度的周变化大 ,尤以冬季为甚 ,相邻 2周最大相差达 1 6倍 ;但除冬季的平均浓度较高之外 ,其季节变化并不显著 .微量元素的富集因子在春季最低 ,反映了频繁发生的沙尘天气的影响 .Se、Br和Pb的浓度比来自于北京A层土壤中的含量要高出约 1 0 0 0~ 80 0 0倍 ,表明它们主要来自于人为污染 .其中Se的富集度最高 ,反映了北京细粒子来自于燃煤污染的特征 .Pb的年均浓度 (0 31 μg·m- 3 )虽然未超过WHO的年均标准 ,但与洛杉矶和布里斯班相比处于较高的水平 ;与Br、Se的比较分析表明 ,燃煤可能是Pb除机动车排放之外的另一个重要来源 . | 杨复沫 贺克斌 马永亮 陈旭 Steven H.Cadle Tai Chan Patricia A.Mulawa | 2003 | 环境科学2003，24，6： | 82 |
| 3 | 长春市儿童医院1998~2001年婴幼儿杯状病毒腹泻流行病学研究显示文摘人类杯状病毒(humancalicivirus,HuCV)是引起儿童和成人非菌性胃肠炎的主要病原之一。为了掌握HuCV在我国的流行情况,1998年7月至2001年6月,从长春市儿童医院2343例5岁以下腹泻患儿中共收集粪便标本1264份,其中1056份来自2135例住院患儿。对轮状病毒检测为阴性的588份标本,经多价酶免疫试验(EIA)和两组引物反转录-聚合酶链反应(RT-PCR)检测HuCV,202份为阳性,其中住院患儿标本178份,HuCV检出率为16 9%。HuCV腹泻以2岁以下儿童为主(占96%),流行高峰季节为11月至次年3月。选择17株HuCV进行分子鉴定,15株属GⅡ 4群,1株属GⅡ 3群,另1株属GⅠ 2群,表明GⅡ 4群HuCV是我国流行的优势株。根据HuCV住院患儿的监测资料初步估计,HuCV腹泻住院率约为0 5‰~2 4‰。讨论了长春地区HuCV的流行趋势和疾病负担。以上结果为我国HuCV腹泻的预防和控制提供了科学依据。 | 谢华萍 方肇寅 王光 孙利炜 吕红霞 Zhong WM Tai JH 林思恩 童志礼 章青 Glass RI Jiang X | 2002 | 病毒学报2002，18，4： | 75 |
| 4 | Ex vivo liver resection followed by autotransplantation for end-stage hepatic alveolar echinococcosis显示文摘为有结束阶段的病人的背景肝的牙槽的包虫病(AE ) ,因此,在 vivo,肝的深奥部分的切除术通常是很困难的 allogenic 肝移植被显示。然而,我们假设为选择专利,为深奥纸巾和肝自体移植的彻底的消除的前 vivo 肝切除术可以为我们介绍了的临床的 cure.Methods 提供一个机会一个24岁的孩子与 hepatectomy 被对待的有巨大的肝的 AE 损害的女人,深奥织物和肝的自体移植的前 vivo 切除术。耐心的有的中等黄疸和包含了片断的先进肝的 AE 损害,,,,,并且 retrohepatic 晚辈静脉 cava。侧面的片断(并且) 左,肝在它的体积与超过 1000 ml 仍然保持正常。没有 extrahepatic 转移(例如到肺或大脑) 能被发现。作为治疗的第一步, X 光检查指导了经皮的 transhepatic cholangiodrainage (PTCD ) 在片断并且独立为胆汁排水被执行两次直到她的浆液总数 bilirubin 从 236 ~ 88 mol/L 逐渐地减少了。全部的肝切除术然后被执行,由扩大恰好肝的 trisegmentectomy 列在后面,当她的 hemodynamics 参数是稳定的时,全部 retrohepatic 静脉 cava 通过手术在团体被移开。两 veino-veinous 绕过也不暂时的 intracorporeal cavo-caval 或 porto-caval 分流在 5.7 小时的 anhepatic 阶段期间被使用。左肝的仍然是的 AE 免费的侧面的片断在 situ 被重新植入。左肝的静脉直接被吻合对 suprahepatic 晚辈静脉 cava 端对端由于有 AE 全部的渗入的 retrohepatic 晚辈静脉 cava 的缺乏。因为补偿 retroperitoneal porto-caval 担保循环发展了,没有任何 haemodynamics problems.Results ,我们在操作以后在60天的后面起来期间在肾的静脉水平围住仍然是的 infrahepatic 晚辈静脉 cava ,病人作为一个激进分子除了温和地提高的浆液总数 bilirubin.Conclusions 有好恢复途径,在一种情况中的前 vivo 肝切除术和肝自体移植为结束阶段的治疗显示出一个最佳的潜力肝的 AE 。对它的指示的严格的依从,病人的容器的评估 pre-operatively,并且精确外科的技术是钥匙改进病人的预后。 | WEN Hao DONG Jia-hong ZHANG Jin-hui ZHAO Jin-ming SHAO Ying-mei DUAN Wei-dong LIANG Yu-rong JI Xue-wen TAI Qin-wen Tuerganali Aji LI Tao | 2011 | Chinese Medical Journal2011，，18： | 38 |
| 5 | Characterization of the receptor-binding domain(RBD)of 2019 novel coronavirus:implication for development of RBD protein as a viral attachment inhibitor and vaccine显示文摘The outbreak of Coronavirus Disease 2019(COVID-19)has posed a serious threat to global public health,calling for the development of safe and effective prophylactics and therapeutics against infection of its causative agent,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),also known as 2019 novel coronavirus(2019-nCoV).The CoV spike(S)protein plays the most important roles in viral attachment,fusion and entry,and serves as a target for development of antibodies,entry inhibitors and vaccines.Here,we identified the receptor-binding domain(RBD)in SARS-CoV-2 S protein and found that the RBD protein bound strongly to human and bat angiotensin-converting enzyme 2(ACE2)receptors.SARS-CoV-2 RBD exhibited significantly higher binding affinity to ACE2 receptor than SARS-CoV RBD and could block the binding and,hence,attachment of SARS-CoV-2 RBD and SARS-CoV RBD to ACE2-expressing cells,thus inhibiting their infection to host cells.SARS-CoV RBD-specific antibodies could crossreact with SARS-CoV-2 RBD protein,and SARS-CoV RBD-induced antisera could cross-neutralize SARS-CoV-2,suggesting the potential to develop SARS-CoV RBD-based vaccines for prevention of SARS-CoV-2 and SARS-CoV infection. | Wanbo Tai Lei He Xiujuan Zhang Jing Pu Denis Voronin Shibo Jiang Yusen Zhou Lanying Du | 2020 | Cellular & Molecular Immunology2020，17，6： | 35 |
| 6 | Agricultural non-point nitrogen pollution control function of dierent vegetation types in riparian wetlands: A case study in the Yellow River wetland in China显示文摘Riparian wetland is the major transition zone of matter, energy and information transfer between aquatic and terrestrial ecosystems and has important functions of water purification and non-point pollution control. Using the field experiment method and an isotope tracing technique, the agricultural non-point nitrogen pollution control function of dierent vegetation types in riparian wetland was studied in the Kouma Section of the Yellow River. The results showed that the retention of agricultural non-point nitrogen pollution by riparian wetland soil occurs mainly in top 0-10 cm layer. The amount of nitrogen retained by surface soils associated with three types of vegetation are 0.045 mg/g for Phragmites communis Trin Linn, 0.036 mg/g for Scirpus triqueter Linn, and 0.032 mg/g for Typha angustifolia Linn, which account for 59.21%, 56.25%, and 56.14% of the total nitrogen interception, respectively. Exogenous nitrogen in 0-10 cm soil layer changes more quickly than in other layers. One month after adding K15NO3 to the tested vegetation, nitrogen content was 77.78% for P. communis Trin, 68.75% for T. angustifolia, and 8.33% for S. triqueter in the surface soil. After three months, nitrogen content was 93.33% for P. communis Trin, 72.22% for S. triqueter, and 37.50% for T. Angustifolia. There are large dierences among vegetation communities respecting to purification of agricultural non-point nitrogen pollution. The nitrogen uptake amount decreases in the sequence: new shoots of P. communis Trin (9.731 mg/g) > old P. communis Trin (4.939 mg/g) > S. triqueter (0.620 mg/g) > T. angustifolia (0.186 mg/g). Observations indicated that the presence of riparian wetlands as buers on and adjacent to stream banks could be recommended to control agricultural non-point pollution. | ZHAO Tongqian XU Huashan HE Yuxiao TAI Chao MENG Hongqi ZENG Fanfu XING Menglin | 2009 | Journal of Environmental Sciences2009，21，7： | 29 |
| 7 | Effect of sinter layer porosity distribution on flow and temperature fields in a sinter cooler显示文摘When sinters are filled into the sinter cooler from the sintering machine, it is commonly seen that, due to segregation effects, sinters of larger size usually accumulate closer to the inner wall of the sinter cooler, whereas those of smaller size are to the outer wall. This nonuniform distribution of sinters has led to uneven cooling effect throughout the cooler. This causes the sinters leaving the cooler at a large temperature difference. This undesired temperature difference leads to the deformation and even the destruction of the conveyors. The computational fluid dynamics (CFD) technique was used in the present work to investigate the heat and fluid flow phenomena within the sinter cooler corresponding to the different distribution of sinter layer porosity, which was highly dependent on the arrangement and orientation of sinters within the sinter cooler. It is confirmed that a high mass flow rate within the sinter layer causes a low temperature region and vice versa. The flow fields for vertically reducing porosity distribution and random distribution are almost identical indicating the relative insignificance of convective heat transfer mechanism. | Jik-chang Leong Kai-wun Jin Jia-shyan Shiau Tzer-ming Jeng Chang-hsien Tai | 2009 | International Journal of Minerals,Metallurgy and Materials2009，16，3： | 27 |
| 8 | Management of acquired bronchobiliary fistula:A systematic literature review of 68 cases published in 30 years显示文摘AIM:To outline the appropriate diagnostic methods and therapeutic options for acquired bronchobiliary fistula(BBF).METHODS:Literature searches were performed in Medline,EMBASE,PHMC and LWW(January 1980August 2010)using the following keywords:biliobronchial fistula,bronchobiliary fistula,bronchobiliary fistula,biliarybronchial fistula,tracheobiliary fistula,hepatobronchial fistula,bronchopleural fistula,and biliptysis.Further articles were identified through crossreferencing.RESULTS:Sixtyeight cases were collected and reviewed.BBF secondary to tumors(32.3%,22/68),including primary tumors(19.1%,13/68)and hepatic metastases(13.2%,9/68),shared the largest proportion of all cases.Biliptysis was found in all patients,and other symptoms were respiratory symptoms,such as irritating cough,fever(36/68)and jaundice(20/68).Half of the patients were treated by lessinvasive methods such as endoscopic retrograde biliary drainage.Invasive approaches like surgery were used less frequently(41.7%,28/67).The outcome was good at the end of the followup period in 28 cases(range,2 wk to 72 mo),and the recovery rate was 87.7%(57/65).CONCLUSION:The clinical diagnosis of BBF can be established by sputum analysis.Careful assessment of this condition is needed before therapeutic procedure.Invasive approaches should be considered only when noninvasive methods failed. | Guan-Qun Liao Hao Wang Guang-Yong Zhu Kai-Bin Zhu Fu-Xin Lv Sheng Tai | 2011 | World Journal of Gastroenterology2011，17，33： | 28 |
| 9 | Esophagectomy for locally advanced esophageal cancer, followed by chemoradiotherapy and adjuvant chemotherapy显示文摘AIM: To compare the efficacy and toxicity of a three-step combination therapy with post-operative radiation alone for locally advanced esophageal cancer.METHODS: Patients with T3-4 and N0-1 esophageal carcinoma from a number of institutions were non-randomly,prospectively enrolled in the study. All patients underwent single-stage curative en bloc esophagectomy. The patients were then assigned into one of two treatment groups based on treatment consisting of either post-operative concurrent chemoradiotherapy (CCRT) with weekly cisplatin 30 mg/m2 followed by systemic adjuvant chemotherapy (four monthly cycles of cisplatin 20 mg/m2 and 5-fiuorouracil 1 000 mg/m2 for five consecutive days),or, post-operative radiation alone. The radiotherapy dose was 55-60 Gy for all patients. Primary end-point of this study was to assess the per-protocol patients' improvement of overall survival benefit. Secondary end-point was designed to evaluate both the per-protocol and intent-to-treat patients' outcome of survival.RESULTS: A total of 60 patients (n = 30 per group) were enrolled in this study. The two groups were generally comparable for demographic characteristics and hematological and non-hematological toxicities. The CCRT with weekly cisplatin was well tolerated, with significantly better overall survival (30.9 mo vs 20.7 mo; 95% CI,27.5-36.4 vs15.2-26.1) and 3-year survival (70.0% vs 33.7%; P = 0.003). Low histological grade of tumor (P<0.001) was associated with favorable survival in these locally advanced patients.CONCLUSION: For locally advanced esophageal cancer,the combination of esophagectomy, post-operative CCRT with weekly cisplatin and systemic adjuvant chemotherapy is well tolerated and effective. A large-scale, prospective randomized trial of this regimen is in progress. | Hung-Chang Liu Shih-Kai Hung Cham-Jer Huang Chung-Chu Chen Ming-Jen Chen Chun-Chao Chang Cheng-Jeng Tai Chi-Yuan Tzen Li-Hua Lu Yu-Jen Chen | 2005 | World Journal of Gastroenterology2005，11，34： | 25 |
| 10 | Smashing Tissue Extraction and HPLC Determination of Active Saponins from Different Parts of Panax notoginseng显示文摘Objective To optimize the extraction technology used for extracting active saponins from the roots,fibrous roots,basal part of stems,root verrucae,fruits,flowers,stems,and leaves of Panax notoginseng based on the contents of ginsengsides Rg1,Rb1,and notoginsengside R1 as evaluation indexes.Methods Different parts of P.notoginseng were extracted by smashing tissue extraction(STE),ultrasound extraction,and reflux extraction.The contents of ginsengsides Rg1,Rb1,and notoginsengside R1 in 24 kinds of extracts were determined by HPLC-UV.Hypersil C18 column(200 mm × 4.6 mm,5 μm) and acetonitrile-warter(20:80 for 30 min→45:55 for 18 min→70:30 for 2 min→80:20 for 10 min→100:0) were used;UV detector was set at 203 nm;The flow rate was set at 1.0 mL/min.Results STE was the most efficient technology with the highest yield of active saponins among the three tested extraction technologies.Conclusion STE is a fast,effective,and economical method to extract the active saponins from different parts of P.notoginseng.It could significantly shorten the extraction time and simplify the determination of the pre-processing work on identifying P.notoginseng.Such quick and effective extraction provides a powerful tool for analyzing P.notoginseng in the future. | Sheng-ming SHI Yan-ze LIU Wen TAI Chang-qing CHEN Yu-qing ZHAO | 2012 | Chinese Herbal Medicines2012，4，4： | 24 |
| 11 | Transduction of Fas gene or Bcl-2 antisense RNA sensitizes cultured drug resistant gastric cancer cells to chemotherapeutic drugs显示文摘INTRODUCTIONChemotherapyisoneofthemajormethodsintumortreatment,butitoftendoesnotworkduetomultidrugresistance(MDR).Recentstudi... | XIAO Bing, SHI Yong Quan, ZHAO Yan Qiu, YOU Han, WANG Zuo You, LIU Xian Ling, YIN Fang, QIAO Tai Dong and FAN Dai Ming | 1998 | World Journal of Gastroenterology1998，4，5： | 24 |
| 12 | Shear-wave splitting in the crust:Regional compressive stress from polarizations of fast shear-waves显示文摘When propagating through anisotropic rocks in the crust,shear-waves split into faster and slower components with almost orthogonal polarizations.For nearly vertical propagation the polarization of fast shear-wave(PFS)is parallel to both the strike of the cracks and the direction of maximum horizontal stress,therefore it is possible to use PFS to study stress in the crust.This study discusses several examples in which PFS is applied to deduce the compressive stress in North China,Longmenshan fault zone of east edge of Tibetan plateau and Yunnan zone of southeast edge of Tibetan plateau,also discusses temporal variations of PFS orientations of 1999 Xiuyan earthquake sequences of northeastern China.The results are consistent to those of other independent traditional stress measurements.There is a bridge between crustal PFS and the crustal principal compressive stress although there are many unclear disturbance sources.This study suggests the PFS results could be used to deduce regional and in situ principal compressive stress in the crust only if there are enough seismic stations and enough data.At least,PFS is a useful choice in the zone where there are a large number of dense seismic stations. | Yuan Gao Yutao Shi Jing Wu Lingxue Tai | 2012 | Earthquake Science2012，25，1： | 20 |
| 13 | Effect of ginger Effect of ginger on gastric motility and symptoms of functional dyspepsiaon gastric motility and symptoms of functional dyspepsia显示文摘AIM:To evaluate the effects of ginger on gastric motility and emptying,abdominal symptoms,and hormones that influence motility in dyspepsia.METHODS:Eleven patients with functional dyspepsia were studied twice in a randomized double-blind manner.After an 8-h fast,the patients ingested three capsules that contained ginger(total 1.2 g) or placebo,followed after 1 h by 500 mL low-nutrient soup.Antral area,fundus area and diameter,and the frequency of antral contractions were measured using ultrasound at frequent intervals,and the gastric half-emptying time was calculated from the change in antral area.Gastrointestinal sensations and appetite were scored using visual analog questionnaires,and blood was taken for measurement of plasma glucagon-like peptide-1(GLP-1),motilin and ghrelin concentrations,at intervals throughout the study.RESULTS:Gastric emptying was more rapid after ginger than placebo [median(range) half-emptying time 12.3(8.5-17.0) min after ginger,16.1(8.3-22.6) min after placebo,P ≤ 0.05].There was a trend for more antral contractions(P = 0.06),but fundus dimensions and gastrointestinal symptoms did not differ,nor did serum concentrations of GLP-1,motilin and ghrelin.CONCLUSION:Ginger stimulated gastric emptying and antral contractions in patients with functional dyspepsia,but had no impact on gastrointestinal symptoms or gut peptides. | Ming-Luen Hu Christophan K Rayner Keng-Liang Wu Seng-Kee Chuah Wei-Chen Tai Yeh-Pin Chou Yi-Chun Chiu King-Wah Chiu Tsung-Hui Hu | 2011 | World Journal of Gastroenterology2011，17，1： | 19 |
| 14 | 北京市大气PM_(2.5)中矿物成分的污染特征显示文摘为了解北京市大气细粒子中矿物成分的浓度水平和污染特征 ,在清华园和车公庄进行了连续 1a的PM2 5累积周采样和全样品分析 .Al、Si、Ca、Mg和Fe等地壳元素的周变化相似 ,最大周均浓度均出现在春季有强沙尘天气的一周 ;其季节变化显著 ,显示季节性的源排放以及气象条件对矿物成分的含量影响显著 .土壤尘的季节平均浓度从夏季逐步上升 ,至次年春季达到最高 (2 1 1 μg·m-3 ) ,表明春季频繁发生的沙尘天气对土壤尘细粒子有重要贡献 .大量的建筑活动可能大大增加了北京细粒子中Ca的负荷 。 | 杨复沫 贺克斌 马永亮 Steven H.Cadle Tai Chan Patricia A.Mulawa | 2004 | 环境科学2004，25，5： | 18 |
| 15 | FoxM1 overexpression promotes epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma显示文摘AIM: To investigate the expression of forkhead box protein M1(Fox M1) in the process of epithelial mesenchymal transition in hepatocellular carcinoma(HCC) and its role in metastasis.METHODS: Fox M1 and E-cadherin expression in HCC tissue microarray specimens was evaluated by immunohistochemical staining,and statistical methods were applied to analyze the correlation between FoxM 1 and epithelial-mesenchymal transition(EMT).KaplanMeier analysis of the correlation between the Fox M1 expression level and recurrence or overall survival of HCC patients was performed.The expression of FoxM 1,E-cadherin and snail homologue 1(SNAI1) in HCC cell lines was evaluated by real-time reverse transcriptionpolymerase chain reaction and Western blot.Hepatocyte growth factor(HGF) was used to induce EMT and stimulate cell migration in HCC cells.The expression of Fox M1 and SNAI1 was regulated by transfection with plasmids pc DNA3.1 and si RNAs in vitro.The occurrence of EMT was evaluated by Transwell assay,morphologic analysis and detection of the expression of EMT markers(E-cadherin and vimentin).Luciferase and chromatin immunoprecipitation assays were used to evaluate whether SNAI1 is a direct transcriptional target of FoxM 1.RESULTS: FoxM 1 expression was increased significantly in HCC compared with para-carcinoma(10.7 ± 0.9 vs 8.2 ± 0.7,P < 0.05) and normal hepatic(10.7 ± 0.9 vs 2.7 ± 0.4,P < 0.05) tissues.Overexpression of Fox M1 was correlated with HCC tumor size,tumor number,macrovascular invasion and higher TNM stage,but was negatively correlated with E-cadherin expression in microarray specimens and in cell lines.Fox M1 overexpression was correlated significantly with HCC metastasis and EMT.In vitro,we found that FoxM 1 plays a key role in HGF-induced EMT,and overexpression of Fox M1 could suppress E-cadherin expression and induce EMT changes,which were associated with increased HCC cell invasiveness.Next,we confirmed that FOXM1 directly binds to and activates the SNAI1 promoter,and we identified SNAI1 as a direct transcriptional target of FOXM1.Moreover,inhibiting the expression of SNAI1 significantly inhibited FoxM 1-mediated EMT.CONCLUSION: Fox M1 overexpression promotes EMT and metastasis of HCC,and SNAI1 plays a critical role in FoxM 1-mediated EMT. | Fan-Di Meng Ji-Chao Wei Kai Qu Zhi-Xin Wang Qi-Fei Wu Ming-Hui Tai Hao-Chen Liu Rui-Yao Zhang Chang Liu | 2015 | World Journal of Gastroenterology2015，21，1： | 17 |
| 16 | Identification of Hercynian shoshonitic intrusive rocks in central Hainan Island and its geotectonic implications显示文摘An identification has been made of some shoshonitic intrusive rocks in central Hainan Island recently. These rocks are K-rich (K2O=2.9%―5.1%, K2O/Na2O=0.95―2.12), distinctly enriched in LILE and LREE, strongly depleted in Nb, Ta, and moder- ately depleted in Sr and Ti, with (87Sr/86Sr)i = 0.70859―0.71425 and ε Nd(t) = (?2.77―?7.49). They were derived from an EMⅡ-type mantle source. The enrichment process is related to metasomatism of depleted mantle caused by a great amount of fluid-melt released from oceanic crust and terri- genous sediments at great depth (eclogite facies) during the subduction of the South China plate under the Indochina-South China Sea plate in the Carbon- iferous–Early Permian. A SHRIMP U-Pb zircon dating yields a crystallization age of 272±7 Ma for the sho- shonitic intrusions, which is coeval with the strongly peraluminous granites found in central Hainan Island. These two kinds of rocks generally possess syn-intrusion ductile deformation structures. Thus they are considered to have been generated during the early stage (syn-thrust phase) of a post-collisional event. The primary magma of shoshonitic rocks was produced at a depth > 80 km by decompression- dehydration melting of previously enriched litho- spheric mantle wedge, phlogopite-bearing garnet peridotite, which was in turn caused by the break-off of a descendent slab and upwelling of a hot as- thenosphere. The rising of melts was accompaniedby crustal contamination and crystallization fractiona- tion (AFC). Combining with other related data, it is proposed that the southwards subduction and amal- gamation of the South China plate with the Indo- China-South China Sea plate took place at ca. 287- 278 Ma, which was a part of the convergence proc- ess of the Pangea supercontinent. The suture zone was probably located along the line of Song Ma-Beibu Gulf-north margin of the Yunkai Moun- tains-Wuyi Mountains. | XIE Caifu ZHU Jinchu DING Shijiang ZHANG Yeming FU Tai'an LI Zhihong | 2006 | Chinese Science Bulletin2006，51，20： | 17 |
| 17 | Current medical therapy for ulcerative colitis显示文摘NTRODUCTIONInrecentyears,theadvancesintherapyofulcerativecolitis(UC)havebeencharacterizedmainlybythemoreextensiveuseofimmuno... | XU Chang Tai and PAN Bo Rong | 1999 | World Journal of Gastroenterology1999，5，1： | 16 |
| 18 | Transcriptional Repression by Histone Deacetylases in Plants显示文摘在 histone 尾巴的 N 终点的可逆 histone acetylation 和 deacetylation 在 eukaryoticgene 活动的规定起关键作用。核心 histones 的 Acetylation 通常导致开的染色质结构并且与基因激活被联系,而 histone 的 deacetylation 经常与关上的染色质和基因压抑被相关。由 histone deacetylases (HDAC ) 的 Histone deacetylation iscatalyzed。越来越多的研究在植物表明了 histone deacetylation/acetylationon 染色体稳定性, transcriptional 规定,和开发的重要性。而且, HDAC 被显示交往在多重 developmentalprocesses 涉及 transcriptional 压抑的 withvarious 染色质 remolding 因素和抄写因素。在这评论,我们在 transcriptional 压抑上总结了最近的调查结果在 plants.Key 词由 HDAC 调停了: | Xuncheng Liua Songguang Yang Minglei Zhaoa Ming Luo Chun-Wei Yu Chia-Yang Chen Ready Tai Keqiang Wu | 2014 | Molecular Plant2014，7，5： | 16 |
| 19 | Current status in the treatment options for esophageal achalasia显示文摘Recent advances in the treatment of achalasia include the use of high-resolution manometry to predict the outcome of patients and the introduction of peroral endoscopic myotomy(POEM).The first multicenter randomized,controlled,2-year follow-up study conducted by the European Achalasia Trial group indicated that laparoscopic Heller myotomy(LHM)was not superior to pneumatic dilations(PD).Publications on the long-term success of laparoscopic surgery continue to emerge.In addition,laparoscopic single-site surgery is applicable to advanced laparoscopic operations such as LHM and anterior fundoplication.The optimal treatment option is an ongoing matter of debate.In this review,we provide an update of the current progress in the treatment of esophageal achalasia.Unless new conclusive data prove otherwise,LHM is considered the most durable treatment for achalasia at the expense of increased reflux-associated complications.However,PD is the first choice for non-surgical treatment and is more costeffective.Repeated PD according to an'on-demand'strategy based on symptom recurrence can achieve long-term remission.Decision making should be based on clinical evidence that identifies a subcategory of patients who would benefit from specific treatment options.POEM has shown promise but its long-term efficacy and safety need to be assessed further. | Seng-Kee Chuah Chien-Hua Chiu Wei-Chen Tai Jyong-Hong Lee Hung-I Lu Chi-Sin Changchien Ping-Huei Tseng Keng-Liang Wu | 2013 | World Journal of Gastroenterology2013，19，33： | 15 |
| 20 | Current status of gene therapy in gastroenterology显示文摘CurentstatusofgenetherapyingastroenterologyXUChangTai1andPANBoRong2Subjectheadingsgastroenterology;genetherapy;genetransfer... | XU Chang Tai 1 and PAN Bo Rong 2 | 1998 | World Journal of Gastroenterology1998，4，1： | 15 |
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