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| 1 | Optimization of fused deposition modeling process parameters:a review of current research and future prospects显示文摘Fused deposition modeling(FDM) is one of the most popular additive manufacturing technologies for various engineering applications.FDM process has been introduced commercially in early 1990 s by Stratasys Inc.,USA.The quality of FDM processed parts mainly depends on careful selection of process variables.Thus,identification of the FDM process parameters that significantly affect the quality of FDM processed parts is important.In recent years,researchers have explored a number of ways to improve the mechanical properties and part quality using various experimental design techniques and concepts.This article aims to review the research carried out so far in determining and optimizing the process parameters of the FDM process.Several statistical designs of experiments and optimization techniques used for the determination of optimum process parameters have been examined.The trends for future FDM research in this area are described. | Omar A.Mohamed Syed H.Masood Jahar L.Bhowmik | 2015 | Advances in Manufacturing2015，3，1： | 38 |
| 2 | A scientometric review of biochar research in the past 20 years(1998-2018)显示文摘Biochar is the carbon-rich product obtained from the thermochemical conversion of biomass under oxygen-limited conditions.Biochar has attained extensive attention due to its agronomical and environmental benefits in agro-ecosystems.This work adopts the scientometric analysis method to assess the development trends of biochar research based on the literature data retrieved from the Web of Science over the period of 1998-2018.By analysing the basic characteristics of 6934 publications,we found that the number of publications grew rapidly since 2010.Based on a keyword analysis,it is concluded that scholars have had a fundamental recognition of biochar and preliminarily found that biochar application had agronomic and environmental benefits during the period of 1998-2010.The clustering results of keywords in documents published during 2011-2015 showed that the main research hotspots were“biochar production”,“biochar and global climate change”,“soil quality and plant growth”,“organic pollutants removal”,and“heavy metals immobilization”.While in 2016-2018,beside these five main research hotspots,“biochar and composting”topic had also received greater attention,indicating that biochar utilization in organic solid waste composting is the current research hotspot.Moreover,updated reactors(e.g.,microwave reactor,fixed-bed reactor,screw-feeding reactor,bubbling fluidized bed reactor,etc.)or technologies(e.g.,solar pyrolysis,Thermo-Catalytic Reforming process,liquefaction technology,etc.)applied for efficient energy production and modified biochar for environmental remediation have been extensively studied recently.The findings may help the new researchers to seize the research frontier in the biochar field. | Ping Wu Syed Tahir Ata-Ul-Karim Bhupinder Pal Singh Hailong Wang Tongliang Wu Cun Liu Guodong Fang Dongmei Zhou Yujun Wang Wenfu Chen | 2019 | Biochar2019，1，1： | 36 |
| 3 | Vasculogenic mimicry is a prognostic factor for postoperative survival in patients with glioblastoma显示文摘A previous report has confirmed the existence and clinical significance of vasculogenic mimicry(VM)in glioma.However,its conclusions about the negative clinical significance of VM in glioblastoma are based on a small group of patients and,thus,might be unconvincing.The aim of the present study was to reevaluate the clinical significance of VM in glioblastoma.Patients were classified as VM-positive or | Wang SY Ke YQ Lu GH Song ZH Yu L Xiao S Sun XL Jiang XD Yang ZL Hu CC | 2013 | 中国神经肿瘤杂志2013，11，3： | 22 |
| 4 | Biodegradation of nonylphenol in soil显示文摘 | Chang BV Chiang BW Yuan SY | 2007 | 中国生物学文摘2007，21，6： | 21 |
| 5 | Association of genetic variants with diabetic nephropathy显示文摘Diabetic nephropathy accounts for the most serious microvascular complication of diabetes mellitus. It is suggested that the prevalence of diabetic nephropathy will continue to increase in future posing a major challenge to the healthcare system resulting in increased morbidity and mortality. It occurs as a result of interaction between both genetic and environmental factors in individuals with both type 1 and type 2 diabetes. Genetic susceptibility has been proposed as an important factor for the development and progression of diabetic nephropathy, and various research efforts are being executed worldwide to identify the susceptibility gene for diabetic nephropathy. Numerous single nucleotide polymorphisms have been found in various genes giving rise to various gene variants which have been found to play a major role in genetic susceptibility to diabetic nephropathy. The risk of developing diabetic nephropathy is increased several times by inheriting risk alleles at susceptibility loci of various genes like ACE, IL, TNF-α, COL4A1, e NOS, SOD2, APOE, GLUT, etc. The identification of these genetic variants at a biomarker level could thus, allow the detection of those individuals at high risk for diabetic nephropathy which could thus help in the treatment, diagnosis and early prevention of the disease. The present review discusses about the various gene variants found till date to be associated with diabetic nephropathy. | Saliha Rizvi Syed Tasleem Raza Farzana Mahdi | 2014 | World Journal of Diabetes2014，5，6： | 20 |
| 6 | 阔叶猕猴桃叶片离体器官发生和植株再生(英文)显示文摘以阔叶猕猴桃(A ctinidia latifolia M err.)叶片为外植体,通过器官发生途径诱导形成不定芽,探讨了不同激素组合、暗培养时间以及不同浓度的蔗糖对叶片器官发生和植株再生的影响。结果表明,BW +0.1μm ol/L N AA +5μm ol/L Zeatin 附加20g/L 蔗糖,先进行21d 暗培养然后转到光下培养效果最好,6周后不定芽再生频率达91.67%,平均每个外植体再生芽数6.87个。再生芽生根良好,生根率可达100%。首次报道了阔叶猕猴桃的器官发生和植株再生,建立了叶片的高效再生体系,为今后的遗传转化研究奠定了基础。 | 毕静华 刘永立 Syed Asghar | 2005 | 果树学报2005，22，4： | 20 |
| 7 | 电催化析氧反应过渡金属磷化物和硫化物催化剂研究进展(英文)显示文摘对化石能源的依赖所造成的环境污染和能源危机在全球引起了广泛的关注.氢能由于其高能量密度、低分子质量以及清洁无污染的优点,被认为是人类根本性解决能源与环境等全球性问题的理想替代能源.电解水是生产高纯度氢的重要方法,是现代清洁能源技术的重要组成部分.水电解由阴极析氢(HER)和阳极析氧(OER)两个半反应构成.对于HER反应,其反应是基于二电子转移过程,反应过程相对容易进行.相比于HER反应,OER反应涉及四电子转移及氧-氧键形成,其反应动力学缓慢,是影响水电解效率的主要原因.因此,为了提高电解水制氢的能量转化效率,发展OER电催化剂成为水电解制氢技术的关键.在过去的十余年间,硫化物、硒化物、磷化物、硼化物等非贵金属基OER电催化剂被大量地研究及报道并取得了长足发展.在这些催化剂中,金属磷化物和硫化物不仅具有成本优势,而且在析氧过电位、耐久性方面正趋接近甚至超越RuO_2和IrO_2等贵金属催化剂,颇具应用潜力.本文总结磷化物和硫化物作为OER电催化剂的研究进展,重点介绍了磷化物和硫化物性能提升策略及其在OER过程中催化反应活性位的变化.本文首先介绍了电解水析氧反应在不同电解质中的反应机理,讨论了析氧反应在动力学和热力学过程的主要障碍.通过对大量文献的归纳,本文分别综述了磷化物和硫化物的化学性质、合成方法和催化性能,介绍了近年来磷化物和硫化物的重要研究进展.通过分析催化剂导电性、质子传输、活性面积、界面化学等因素对催化析氧反应的影响,总结了磷化物和硫化物电催化OER性能提升的策略.由于磷化物和硫化物在OER强氧化条件下,电催化剂表面的成分、物相及结构均会发生显著变化,进而催化反应活性位也会发生相应改变.本文综述了磷化物和硫化物在OER反应过程前后表面组分的变化,探讨了磷化物和硫化物作为OER电催化剂的活性组分,为进一步提高磷化物和硫化物的电催化析氧反应性能提供了崭新的思路. | 彭立山 Syed Shoaib Ahmad Shah 魏子栋 | 2018 | Chinese Journal of Catalysis2018，39，10： | 20 |
| 8 | Nutritional support in chronic liver disease and cirrhotics显示文摘The liver is a major organ and an essential componentin maintaining an appropriate nutritional status in healthy individuals through metabolism of protein, carbohydrates, and fat. In individuals with chronic liver disease(CLD), along with a number of other essen-tial functions that the liver serves, its role in nutrition maintenance is severely impaired. Common causes of CLD include hepatitis C, alcoholic liver disease, and non-alcoholic liver disease. Amongst this population, the most common manifestation of impaired nutritional maintenance is protein-calorie malnutrition. Aside from inherent abnormalities in metabolism, such as malab-sorption and maldigestion, CLD can be associated with anorexia as well as increased metabolic requirements, all of which contribute to a state of malnutrition. Given the systemic implications and impact on prognosis of malnutrition, proper nutritional assessment is essential and can be achieved through a thorough history and physical, as well as biochemical investigations and anthropometry as needed. Following an appropriate assessment of a patient's nutritional status, an approach to management can be decided upon and is based on the extent of malnutrition which directly reflects the severity of disease. Management options can be grossly separated into enteral and parenteral nutrition. The former is usually sufficient in the form of oral supplements in less severe cases of malnutrition, but as the CLD worsens, parenteral nutrition becomes necessary. With appropriate assessment and early intervention, many of the complications of CLD can be avoided, and ultimately better outcomes can be achieved. | Ravi Shergill Wajahat Syed Syed Ali Rizvi Ikjot Singh | 2018 | World Journal of Hepatology2018，10，10： | 17 |
| 9 | Effect of Salicylic Acid on Salinity-induced Changes in Brassica juncea显示文摘Seeds of Indian mustard (Brassica juncea (L.) Czern. et Coss.) were exposed to 0, 50, 100 and 150 mmol/L NaCl for 8 h and seeds were sown in an earthen pot. These stressed seedlings were subsequently sprayed with 10 μmol/L salicylic acid (SA) at 30 d and were sampled at 60 d to assess the changes in growth, photosynthesis and antioxidant enzymes. The seedlings raised from the seeds treated with NaCl had significantly reduced growth and the activities of carbonic anhydrase, nitrate reductase and photosynthesis, and the decrease was proportional to the increase in NaCl concentration. However, the antioxidant enzymes (catalase, peroxidase and superoxide dismutase) and proline content was enhanced in response to NaCl and/or SA treatment, where their interaction had an additive effect. Moreover, the toxic effects generated by the lower concentration of NaCl (50 mmol/L) were completely overcome by the application of SA. It was, therefore, concluded that SA ameliorated the stress generated by NaCl through the alleviated antioxidant system. | Mohammad Yusuf Syed Aiman Hasan Barket Ali Shamsul Hayat Qazi Fariduddin Aqil Ahmad | 2008 | Journal of Integrative Plant Biology2008，50，9： | 16 |
| 10 | Waste heat recovery from heavy-duty diesel engine exhaust gases by medium temperature ORC system显示文摘A medium-temperature waste-heat recovery system based on the organic Rankine cycle (ORC) is designed to recover the exhaust energy from a heavy-duty diesel engine. Analysis of the 1st law of thermodynamics for an ORC system is performed. This analysis contains two parts. The first part is an analysis with undefined heat exchangers to gain an understanding of the ORC and find out suitable organic fluid parameters for a better ORC efficiency. The second part of the analysis uses combined engine test results and two designs of heat exchangers. By comparing the two designs, an improved system of heat exchangers is described. This analysis also quantifies the effect of engine parameters on ORC system. The study concludes that the supercritical Rankine cycle is a better approach towards waste heat recovery. The ORC system is found to perform better under part-load conditions if the medium-high power condition rather than rated working point of the engine is used as the design parameter. The ORC system achieves the highest waste-heat recovery efficiency of up to 10-15% for the optimised heat ex-changer design. | WEI MingShan FANG JinLi MA ChaoChen DANISH Syed Noman | 2011 | Science China(Technological Sciences)2011，54，10： | 16 |
| 11 | Appraisal of active tectonics in Hindu Kush:Insights from DEM derived geomorphic indices and drainage analysis显示文摘在构造地活跃的印度人 Kush (NW 巴基斯坦和 NE 阿富汗) 的风景源于垂直、水平的外壳的块运动以及侵蚀和免职过程的效果的复杂集成。在这个区域的活跃 tectonics 极大地影响了排水系统和似地球形状的表情。学习区域是三条重要山脉(印度人 Kush-Karakorum-Himalayas ) 的一个连接并且因此是一个理想的自然实验室调查源于印度欧亚大陆碰撞的相对构造活动。我们用 DEM 评估活跃 tectonics 导出的排水网络和似地球形状的索引 hypsometric 积分(嗨),溪流长度坡度( SL ),分数维的尺寸( FD ),盆不对称现象因素( AF ),盆形状索引( B ),山谷地板宽度到山谷高度比率( Vf )和山脉前面蜿蜒( Smf )。从这些索引获得的结果被联合用 GIS 产出相对活跃 tectonics (IRAT ) 的一个索引。七个测量似地球形状的索引的一般水准被用来在学习区域评估相对构造活动的分发。我们定义四个班定义相对构造活动的度:班 1__very 高度(1.0 IRAT < 1.3 ) ;班 2__high (1.3 IRAT < 1.5 ) ;班 3moderate (1.5 IRAT < 1.8 ) ;并且班 4low (1.8 IRAT ) 。鉴于结果,我们断定这条联合途径允许与活跃 tectonics 有关的高度使变形的区域的鉴定。Landsat 形象和领域观察也基于偏斜的溪流,使变形的地形,活跃的山前面和三角形的方面证实活跃 tectonics 的存在。IRAT 的指示的价值与已知的亲戚的区域一致高举率,地形和地质学。 | Syed Amer Mahmood Richard Gloaguen | 2012 | Geoscience Frontiers2012，3，4： | 15 |
| 12 | Approach to pseudomyxoma peritonei显示文摘Pseudomyxoma peritonei(PMP) is a mucinous tumour of the appendix that spreads into the peritoneal cavity in the form of gelatinous deposits. The incidence of PMP is believed to be approximately 1-3 out of a million per year. Nonetheless, due to its indolent nature, it is usually discovered at an advanced stage and severely impacts quality of life. Curative treatment for PMP is complete cytoreductive surgery(CRS) with hyperthermic intraperitoneal chemotherapy(HIPEC). An extensive literature review was conducted searching EMBASE, MEDLINE, Pub Med, and Google Scholar databases for PMP in aims to delineate a clinical approach to diagnosis and treatment. Literature was limited to the years 2007-2018. We found the 5-year overall survival with CRS and HIPEC estimated to be between 23%-82% and rates of major complications as high as 24%. Therefore, it is important to appropriately stage and select patients that should undergo CRS with HIPEC. Modalities like MDCT radiological scores have been shown to have sensitivity and specificity of 94% and 81%, respectively, in being able to predict resectability and survival. Despite treatment, the disease often recurs. Tumor markers have significant potential for establishing prognosis preoperatively, and this paper will review the most recent evidence in support of them. | Syed Ali Rizvi Wajahat Syed Ravi Shergill | 2018 | World Journal of Gastrointestinal Surgery2018，10，5： | 15 |
| 13 | Bioactive hydrogels for bone regeneration显示文摘Bone self-healing is limited and generally requires external intervention to augment bone repair and regeneration.While traditional methods for repairing bone defects such as autografts,allografts,and xenografts have been widely used,they all have corresponding disadvantages,thus limiting their clinical use.Despite the development of a variety of biomaterials,including metal implants,calcium phosphate cements(CPC),hydroxyapatite,etc.,the desired therapeutic effect is not fully achieved.Currently,polymeric scaffolds,particularly hydrogels,are of interest and their unique configurations and tunable physicochemical properties have been extensively studied.This review will focus on the applications of various cutting-edge bioactive hydrogels systems in bone regeneration,as well as their advantages and limitations.We will examine the composition and defects of the bone,discuss the current biomaterials for bone regeneration,and classify recently developed polymeric materials for hydrogel synthesis.We will also elaborate on the properties of desirable hydrogels as well as the fabrication techniques and different delivery strategies.Finally,the existing challenges,considerations,and the future prospective of hydrogels in bone regeneration will be outlined. | Xin Bai Mingzhu Gao Sahla Syed Jerry Zhuang Xiaoyang Xu Xue-Qing Zhang | 2018 | Bioactive Materials2018，3，4： | 15 |
| 14 | Antibiotic resistance and cagA gene correlation:A looming crisis of Helicobacter pylori显示文摘AIM:To determine antibiotic resistance of Helicobacter pylori(H.pylori) in Pakistan and its correlation with host and pathogen associated factors.METHODS:A total of 178 strains of H.pylori were isolated from gastric biopsies of dyspeptic patients.Susceptibility patterns against first and second-line antibiotics were determined and trends of resistance were analyzed in relation to the sampling period,gastric conditions and cagA gene carriage.The effect of cagA gene on the acquisition of resistance was investigated by mutant selection assay.RESULTS:The observations showed that monoresistant strains were prevalent with rates of 89% for metronidazole,36% for clarithromycin,37% for amoxicillin,18.5% for ofloxacin and 12% for tetracycline.Furthermore,clarithromycin resistance was on the rise from 2005 to 2008(32% vs 38%,P = 0.004) and it is significantly observed in non ulcerative dyspeptic patients compared to gastritis,gastric ulcer and duodenal ulcer cases(53% vs 20%,18% and 19%,P = 0.000).On the contrary,metronidazole and ofloxacin resistance were more common in gastritis and gastric ulcer cases.Distribution analysis and frequencies of resistant mutants in vitro correlated with the absence of cagA gene with metronidazole and ofloxacin resistance.CONCLUSION:The study confirms the alarming levels of antibiotic resistance associated with the degree of gastric inflammation and cagA gene carriage in H.pylori strains. | Adnan Khan Amber Farooqui Hamid Manzoor Syed Shakeel Akhtar Muhammad Saeed Quraishy Shahana Urooj Kazmi | 2012 | World Journal of Gastroenterology2012，18，18： | 15 |
| 15 | 中国在2100年前消除子宫颈癌的预算优化策略研究显示文摘2018年,世界卫生组织总干事公布了全球消除子宫颈癌的目标,即发病率降至4/10万以下。中国目前人群人乳头瘤病毒(HPV)疫苗接种率和宫颈癌筛查覆盖率均较低,子宫颈癌发病率以年均10.2%的速度增长。本研究开发了一种适应中国人群并经校准的杂交模型,在预测老龄化、城市化和性行为可能改变的趋势下,估计2015—2100年城市和农村每年的子宫颈癌发病率,并确定在不同预算投入下实现消除子宫颈癌目标的最优防控策略。研究结果显示,若不增加子宫颈癌防控预算,到2100年,子宫颈癌发病率预计将达到2015年的3倍;若2020年开始采用优化的防控策略,即95%的12岁女孩接种HPV疫苗,扩大45岁女性终生一次宫颈癌筛查的覆盖率,使城市女性覆盖率达90%、农村女性覆盖率达33%,则预计2072(95%CI:2070—2074)年在城市、2074(95%CI:2072—2076)年在农村可实现消除子宫颈癌的目标;若预算不受限制,最早在2057年(2053—2060年)和2060年(2057—2063年)将分别在城市、农村消除子宫颈癌。中国可通过优化宫颈癌综合防控策略,尽早在适龄人群中引入HPV疫苗来实现消除宫颈癌的目标;并可通过增加预算来加速消除进程,大幅减少罹患子宫颈癌的人数。 | 赵宇倩 乔良(编译) Xia CF Hu SY Xu Xq | 2019 | 中华预防医学杂志2019，53，11： | 15 |
| 16 | A novel (G'/G)-expansion method and its application to the Boussinesq equation显示文摘In this article,a novel(G/G)-expansion method is proposed to search for the traveling wave solutions of nonlinear evolution equations.We construct abundant traveling wave solutions involving parameters to the Boussinesq equation by means of the suggested method.The performance of the method is reliable and useful,and gives more general exact solutions than the existing methods.The new(G/G)-expansion method provides not only more general forms of solutions but also cuspon,peakon,soliton,and periodic waves. | Md.Nur Alam Md.Ali Akbar Syed Tauseef Mohyud-Din | 2014 | Chinese Physics B2014，23，2： | 14 |
| 17 | Effect of cholecystokinin and secretin on contractile activity of isolated gastric muscle strips in guinea pigs显示文摘AIM To study the effect of cholecystokinin-octapeptide(CCK-8)and secretin on contractileactivity of isolated gastric muscle strips inguinea pigs.METHODS Each isolated gastric muscle stripwas suspended in a tissue chamber containing5 mL Krebs solution constantly warmed by waterjacked at 37℃ and supplied with a mixed gas of95% O2 and 5% CO2 After incubating for lhunder 1 g tension,varied concentrations of CCK-8 and secretin were added respectively in thetissue chamber and the contractile response wasmeasured isometrically on ink-writing recorders.RESULTS CCK-8 could increase①all regionalcircular and longitudinal muscular tension at rest(fundus LM 19.7%±2.1%,P<0.01;fundus CM16.7%±2.2%,P<0.01;gastric body LM 16.8%±2.3%,P<0.01;body CM 12.7%±2.6%,P<0.01;antrum LM 12.3%±1.3%,P<0.01;antrum CM 16.7%±4.5%,P<0.01;pylous CM12.7%±5.0%,P<0.05);②contractilefrequencies of body LM,both LM and CM ofantrum and pylorus CM(5.1/min±0.2/min to5.6/min±0.2/min,5.9/min±0.2/min to 6.6/min±0.l/min,5.4/min±0.3/min to 6.3/min±0.4/rain,1.3/min±0.2/min to 2.3/min±0.3/min,respectively,P<0.05);③the mean contractileamplitude of antral circular muscle(58.6%±18.4%,P<0.05)and ④the motility index ofpylorus CM(145.0%±23.8%,P<0.01),butdecrease the mean contractile amplitude ofgastric body and antral LM(-10.3%±3.3%,-10.5%±4.6%,respectively,P<0.05).All the CCK-8 effects were not blocked by atropine orindomethacin.Secretin had no effect on gastricsmooth muscle activity.CONCLUSION CCK-8 possessed bothexcitatory and inhibitory action on contractileactivity of different regions of stomach in guineapigs.Its action was not mediated via cholinergicM receptor and endogenous prostagiandinreceptor, | Li W Zheng TZ Qu SY | 2000 | World Journal of Gastroenterology2000，6，1： | 13 |
| 18 | 橡胶树蒸腾特征及其与环境因子的关系显示文摘于2013年2—11月,应用Granier热消散探针对西双版纳地区橡胶树蒸腾进行了连续观测,并同步测定了环境因子(光合有效辐射(PAR)、气温、相对湿度和土壤含水量),结果表明:橡胶树蒸腾速率为昼高夜低的单峰曲线,晴天平均蒸腾速率、蒸腾量是雨天的4倍之多;雨季蒸腾启动时间较干季提前0.5~1.0 h、峰值时间较干季提前2.0~4.5 h,观测阶段日平均蒸腾量为27.84 kg·d-1;4月蒸腾量最大,其值为54.3 mm,11月蒸腾量最小,其值为29.6 mm。干季环境因子对蒸腾速率影响的大小顺序为:气温>相对湿度>PAR>土壤含水量,雨季为:PAR>相对湿度>气温>土壤含水量。干季橡胶林出现水分亏缺,但橡胶树通过其发达的根系可以获取深层土壤水,因此未对其造成严重的水分胁迫。 | 赵玮 张一平 宋清海 张翔 姬红利 Syed Moazzam Nizami 余雷 | 2014 | 生态学杂志2014，33，7： | 13 |
| 19 | Repellent effect of guava leaf volatiles on settlement of adults of citrus psylla, Diaphorina citri Kuwayama, on citrus显示文摘 | Syed Muhammad Zaka Xin-Nian Zeng Paul Holford George Andrew Charles Beattie | 2010 | Insect Science2010，17，1： | 12 |
| 20 | Relationship between hepatitis C virus infection and type 2 diabetes mellitus:Meta-analysis显示文摘AIM:To investigate the association between hepatitis C infection and type 2 diabetes mellitus.METHODS:Observational studies assessing the relationship between hepatitis C infection and type 2 diabetes mellitus were identified via electronic and hand searches.Studies published between 1988 to March 2011 were screened,according to the inclusion criteria set for the present analysis.Authors performed separate analyses for the comparisons between hepatitis C virus(HCV) infected and not infected,and HCV infected and hepatitis B virus infected.The included studies were further subgrouped according to the study design.Heterogenity was assessed using I2 statistics.The summary odds ratios with their corresponding 95% CIs were calculated based on a random-effects model.The included studies were subgrouped according to the study design.To assess any factor that could potentially affect the outcome,results were further stratified by age group(proportion of ≥ 40 years),gender(proportion of male gender),body mass index(BMI)(pro-portion of BMI ≥ 27),and family history of diabetes(i.e.,self reported).For stability of results,a sensitivity analysis was conducted including only prospective studies.RESULTS:Combining the electronic database and hand searches,a total of 35 observational studies(in 31 articles) were identified for the final analysis.Based on random-effects model,17 studies(n = 286 084) compared hepatitis C-infected patients with those who were uninfected [summary odds ratio(OR):1.68,95% CI:1.15-2.45].Of these 17 studies,7 were both a cross-sectional design(41.2%) and cohort design(41.2%),while 3 were case-control studies(17.6%).Nineteen studies(n = 51 156) compared hepatitis C-infected participants with hepatitis B-infected(summary OR:1.92,95% CI:1.41-2.62).Of these 19 studies,4(21.1%),6(31.6%) and 9(47.4%) were cross-sectional,cohort and case-control studies,respectively.A sensitivity analysis with 3 prospective studies indicated that hepatitis C-infected patients had a higher risk of developing type 2 diabetes compared with uninfected controls(summary odds ratio:1.41,95% CI:1.17-1.7;I2 = 0%).Among hepatitis C-infected patients,male patients(OR:1.26,95% CI:1.03-1.54) with age over 40 years(summary OR:7.39,95% CI:3.82-9.38) had an increased frequency of type 2 diabetes.Some caution must be taken in the interpretation of these results because there may be unmeasured confounding factors which may introduce bias.CONCLUSION:The findings support the association between hepatitis C infection and type 2 diabetes mellitus.The direction of association remains to be determined,however.Prospective studies with adequate sample sizes are recommended. | Cho Naing Joon Wah Mak Syed Imran Ahmed Mala Maung | 2012 | World Journal of Gastroenterology2012，18，14： | 12 |
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