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| 1 | Climate change, water resources and sustainable development in the arid and semi-arid lands of Central Asia in the past 30 years显示文摘The countries of Central Asia are collectively known as the five '-stans': Uzbekistan, Kyrgyzstan, Turkmenistan, Tajikistan and Kazakhstan. In recent times, the Central Asian region has been affected by the shrinkage of the Aral Sea, widespread desertification, soil salinization, biodiversity loss, frequent sand storms, and many other ecological disasters. This paper is a review article based upon the collection, identification and collation of previous studies of environmental changes and regional developments in Central Asia in the past 30 years. Most recent studies have reached a consensus that the temperature rise in Central Asia is occurring faster than the global average. This warming trend will not only result in a higher evaporation in the basin oases, but also to a significant retreat of glaciers in the mountainous areas. Water is the key to sustainable development in the arid and semi-arid regions in Central Asia. The uneven distribution, over consumption, and pollution of water resources in Central Asia have caused severe water supply problems, which have been affecting regional harmony and development for the past 30 years. The widespread and significant land use changes in the 1990 s could be used to improve our understanding of natural variability and human interaction in the region. There has been a positive trend of trans-border cooperation among the Central Asian countries in recent years. International attention has grown and research projects have been initiated to provide water and ecosystem protection in Central Asia. However, the agreements that have been reached might not be able to deliver practical action in time to prevent severe ecological disasters. Water management should be based on hydrographic borders and ministries should be able to make timely decisions without political intervention. Fully integrated management of water resources, land use and industrial development is essential in Central Asia. The ecological crisis should provide sufficient motivation to reach a consensus on unified water management throughout the region. | YU Yang PI Yuanyue YU Xiang TA Zhijie SUN Lingxiao Markus DISSE ZENG Fanjiang LI Yaoming CHEN Xi YU Ruide | 2019 | Journal of Arid Land2019，11，1： | 20 |
| 2 | Novel immunological and nutritional-based prognostic index for gastric cancer显示文摘AIM: To assess the prognostic significance of immunological and nutritional-based indices, including the prognostic nutritional index(PNI), neutrophillymphocyte ratio(NLR), and platelet-lymphocyte ratio in gastric cancer.METHODS: We retrospectively reviewed 632 gastric cancer patients who underwent gastrectomy between1998 and 2008. Areas under the receiver operating characteristic curve were calculated to compare the predictive ability of the indices, together with estimating the sensitivity, specificity and agreement rate.Univariate and multivariate analyses were performed to identify risk factors for overall survival(OS). Propensity score analysis was performed to adjust variables to control for selection bias.RESULTS: Each index could predict OS in gastric cancer patients in univariate analysis, but only PNI had independent prognostic significance in multivariate analysis before and after adjustment with propensity scoring(hazard ratio, 1.668; 95% confidence interval:1.368-2.035). In subgroup analysis, a low PNI predicted a significantly shorter OS in patients with stage Ⅱ-Ⅲ disease(P = 0.019, P < 0.001), T3-T4 tumors(P <0.001), or lymph node metastasis(P < 0.001). Canton score, a combination of PNI, NLR, and platelet, was a better indicator for OS than PNI, with the largest area under the curve for 12-, 36-, 60-mo OS and overall OS(P = 0.022, P = 0.030, P < 0.001, and P = 0.024,respectively). The maximum sensitivity, specificity, and agreement rate of Canton score for predicting prognosis were 84.6%, 34.9%, and 70.1%, respectively.CONCLUSION: PNI is an independent prognostic factor for OS in gastric cancer. Canton score can be a novel preoperative prognostic index in gastric cancer. | Kai-Yu Sun Jian-Bo Xu Shu-Ling Chen Yu-Jie Yuan Hui Wu Jian-Jun Peng Chuang-Qi Chen Pi Guo Yuan-Tao Hao Yu-Long He | 2015 | World Journal of Gastroenterology2015，21，19： | 18 |
| 3 | Aberrant activation of latent transforming growth factor-β initiates the onset of temporomandibular joint osteoarthritis显示文摘There is currently no effective medical treatment for temporomandibular joint osteoarthritis(TMJ-OA) due to a limited understanding of its pathogenesis. This study was undertaken to investigate the key role of transforming growth factor-β(TGF-β)signalling in the cartilage and subchondral bone of the TMJ using a temporomandibular joint disorder(TMD) rat model, an ageing mouse model and a Camurati–Engelmann disease(CED) mouse model. In the three animal models, the subchondral bone phenotypes in the mandibular condyles were evaluated by μCT, and changes in TMJ condyles were examined by TRAP staining and immunohistochemical analysis of Osterix and p-Smad2/3. Condyle degradation was confirmed by Safranin O staining, the Mankin and OARSI scoring systems and type X collagen(Col X), p-Smad2/3 a and Osterix immunohistochemical analyses. We found apparent histological phenotypes of TMJ-OA in the TMD, ageing and CED animal models, with abnormal activation of TGF-βsignalling in the condylar cartilage and subchondral bone. Moreover, inhibition of TGF-β receptor I attenuated TMJ-OA progression in the TMD models. Therefore, aberrant activation of TGF-β signalling could be a key player in TMJ-OA development. | Liwei Zheng Caixia Pi Jun Zhang Yi Fan Chen Cui Yang Zhou Jianxun Sun Quan Yuan Xin Xu Ling Ye Xu Cao Xuedong Zhou | 2018 | Bone Research2018，6，4： | 13 |
| 4 | Degradation potential of ofloxacin and its resulting transformation products during Fenton oxidation process显示文摘The degradation of ofloxacin(OFX)in the aqueous solution by Fenton oxidation process was investigated in the present study.The optimum operating conditions for the degradation of OFX in our system was determined.More importantly,the degradation pathways on a basis of the identification of transformation products during the degradation of OFX were proposed,which revealed that the initial degradation step could be associated with the decarboxylation at the quinolone moiety.Moreover,the detachment of the F element during the Fenton oxidation process has also been detected.Since the carboxylic group within OFX has been considered as an important bridge for binding quinolones with the DNA gyrase target,the decarboxylation process would offer insights into the reduction of antibacterial potentials. | Yunqing Pi Jinglan Feng Mengke Song Jianhui Sun | 2014 | Chinese Science Bulletin2014，59，21： | 10 |
| 5 | No association between low-dose reserpine use and depression in older hypertensive patient: result of a multicenter, cross-sectional study显示文摘Background Reserpine is currently used by millions of Chinese hypertensive patients, in spite of the continued concern of its depressogenic effect, even when used in low dose. This study aimed to investigate the association between low-dose reserpine use and depression in older Chinese hypertensive patient. Methods In this cross-sectional, case-control study, we recruited patient aged 60 years or over who had regularly taken one or two tables of “compound reserpine and triamterene tablets (CRTTs)” for more than one year (reserpine user) from 26 community health centers located in 10 provinces in China. For each patient who took CRTTs, we selected an age (within five years) and sex matched hypertensive patient who had never taken any drugs containing reserpine (non-reserpine user) as control. Depressive symptoms were evaluated using a Chinese depression scale adapted from the Zung Self-Rating Depression Scale. Demographic, clinical data and laboratory examination results within six months were collected. Results From August 2018 to December 2018, 787 reserpine user and 787 non-reserpine user were recruited. The mean age of all study subjects was 70.3 years, with about equal numbers of males and females. The mean depression score was 40.4 in reserpine users and 40.6 in non-reserpine users (P = 0.7). The majority of study subject had a depression score < 53 (87.6% in reserpine users and 88.2% in non-reserpine users, respectively). There were no significant differences in the prevalence of mild, moderate or severe depression in reserpine users and non-reserpine users. Conclusions There is no association between low-dose reserpine use and depression in older hypertensive patient. The role of reserpine in the treatment and control of hypertension should be reconsidered;and further studies, especially randomized, controlled clinical trials to compare efficacy and safety of reserpine and other widely recommended anti-hypertensive agents are needed. | Guo-Hua ZHU Xi-Peng SUN Jing LI Lin PI Hai-Qin TANG Hai-Qing GAO Hong-Liang CONG Peng QU Xin-Zheng LU Xin-Jun ZHANG Luo-Sha ZHAO Yi-Fang GUO Dong-Xia LIU Liang-Qing ZHANG Hua TANG Yi-Xin HU Li FAN Qi HUA | 2019 | Journal of Geriatric Cardiology2019，16，8： | 8 |
| 6 | Multiple constraints QoS multicast routing optimization algorithm in MANET based on GA显示文摘Usually multiple quality of service (QoS) guarantees are required in most multicast applications. This paper presents a multiple con-straints algorithm for multicast traffic engineering in mobile ad hoc networks (MANET). The proposed algorithm is a new version of multiple constraints QoS multicast routing optimization algorithm in MANET based on genetic algorithm (MQMGA). The proposed MQMGA can optimize the maximum link utilization, the cost of the multicast tree, the selection of the long-life path, the average delay and the maximum end-to-end delay. Experimental result shows that the approach is efficient, has promising performance in multicast traffic engineering and for evaluating the route stability in dynamic mobile networks. | Baolin Sun Shangchao Pi Chao Gui Yue Zeng Bing Yan Wenxiang Wang Qianqing Qin | 2008 | Progress in Natural Science:Materials International2008，18，3： | 6 |
| 7 | Radioimmunoimaging of colorectal cancer using ^(99m)Tc-labeled monoclonal antibody显示文摘Radioimmunoimagingofcolorectalcancerusing99mTclabeledmonoclonalantibodyHUJinYue1,SUJiaanZhi2,PIZhiMing3,ZHUJianGao1,ZHO... | HU JinYue1, SU JianZhi2, PI ZhiMing3, ZHU JianGao1, ZHOU GuoHua1 and SUN QuBing1Keywords colorectal neoplasms/radioimmunoimaging antibody, monoclonal isotope labeling technium/diagnostic use | 1998 | World Journal of Gastroenterology1998，4，4： | 4 |
| 8 | A new alkaloid from Lycoris aurea显示文摘新碱从 Lycoris 的灯泡被孤立脲(L’ Herit ) 植物。它的结构包括 2D NMR 通过化学、分光镜的研究作为 3-o-ethyltazettinol 被建立。 | Hui Fang Pi Peng Zhang Han Li Ruan Yong Hui Zhang Han Dong Sun Ji Zhou Wu | 2009 | Chinese Chemical Letters2009，20，11： | 4 |
| 9 | Hepatic progenitor cell activation in liver repair显示文摘The liver possesses an extraordinary ability to regenerate after injury.Hepatocyte-driven liver regeneration is the default pathway in response to mild-to-moderate acute liver damage.When replication of mature hepatocytes is blocked,facultative hepatic progenitor cells(HPCs),also referred to as oval cells(OCs)in rodents,are activated.HPC/OCs have the ability to proliferate clonogenically and differentiate into several lineages including hepatocytes and bile ductal epithelia.This is a conserved liver injury response that has been studied in many species ranging from mammals(rat,mouse,and human)to fish.In addition,improper HPC/OC activation is closely associated with fibrotic responses,characterized by myofibroblast activation and extracellular matrix production,in many chronic liver diseases.Matrix remodeling and metalloprotease activities play an important role in the regulation of HPC/OC proliferation and fibrosis progression.Thus,understanding molecular mechanisms underlying HPC/OC activation has therapeutic implications for rational design of anti-fibrotic therapies. | Adam Bria Jorgensen Marda Junmei Zhou Xiaowei Sun Qi Cao Bryon E.Petersen Liya Pi | 2017 | Liver Research2017，1，2： | 3 |
| 10 | Design and Synthesis of 6α-Corticosteroid Haptens and Their Bovine Serum Albumin (BSA) Conjugates显示文摘The site of attachment of protein carrier to corticosteroids has great influence on the specificity of produced antibody. In order to obtain highly specific and accurate antibodies for bioimmunoassay determination of cortisol, different tether lengths of 6-corticosteroid haptens and their BSA conjugates were designed and synthesized. | Pi SUN*, Norihiro KOBAYASHI, Junichi GOTO Graduate School of Pharmaceurical Sciences, Tohoku University, Aobayama, Aoba-ku, Sendai 980-8578, Japan | 2003 | Chinese Chemical Letters2003，14，3： | 3 |
| 11 | Near-atomic structure of the inner ring of the Saccharomyces cerevisiae nuclear pore complex显示文摘Nuclear pore complexes(NPCs)mediate bidirectional nucleocytoplasmic transport of substances in eukaryotic cells.However,the accurate molecular arrangement of NPCs remains enigmatic owing to their huge size and highly dynamic nature.Here we determined the structure of the asymmetric unit of the inner ring(IR monomer)at 3.73Åresolution by single-particle cryo-electron microscopy,and created an atomic model of the intact IR consisting of 192 molecules of 8 nucleoporins.In each IR monomer,the Z-shaped Nup188–Nup192 complex in the middle layer is sandwiched by two approximately parallel rhomboidal structures in the inner and outer layers,while Nup188,Nup192 and Nic96 link all subunits to constitute a relatively stable IR monomer.In contrast,the intact IR is assembled by loose and instable interactions between IR monomers.These structures,together with previously reported structural information of IR,reveal two distinct interaction modes between IR monomers and extensive flexible connections in IR assembly,providing a structural basis for the stability and malleability of IR. | Zongqiang Li Shuaijiabin Chen Liang Zhao Guoqiang Huang Xiong Pi Shan Sun Peiyi Wang Sen-Fang Sui | 2022 | Cell Research2022，32，5： | 2 |
| 12 | Degradation of the antibiotic sulfamonomethoxine sodium in aqueous solution by photo-Fenton oxidation显示文摘In this study, photo-Fenton oxidation was applied to degradation of sulfamonomethoxine sodium (SMMS) in aqueous solution. The operation parameters of pH, temperature, and concentrations of H2O2, Fe2+ and SMMS were investigated. The optimum conditions for the photo-Fenton process were determined as follows: [SMMS]=4.53 mg/L, pH 4.0, [H2O2]=0.49 mmol/L, [Fe2+]= 19.51 μmol/L and T=25°C. Under these conditions 98.5% of the SMMS degraded. The kinetics were also studied, and degradation of SMMS by the photo-Fenton process could be described by first-order kinetics. The apparent activation energy was calculated as 23.95 kJ/mol. Mineralization of the process was investigated by measuring the chemical oxygen demand (COD), and the COD decreased by 99% after 120 min. This process could be used as a pretreatment method for wastewater containing sulfamonomethoxine sodium. | SUN JianHui FENG JingLan SHI ShaoHui PI YunQing SONG MengKe SHI Yan | 2012 | Chinese Science Bulletin2012，57，5： | 2 |
| 13 | Peptide NGR Modified TiO_(2) Nanofiber Substrate for Circulating Tumor Cells Capture显示文摘The analysis of circulating tumor cells(CTCs)allows a noninvasive method of“real-time liquid biopsy”from the blood samples of cancer patients for the diagnosis of early-stage cancer,prognosis,and monitoring therapeutic response.In this study,we develop a simple,inexpensive,and reliable method that utilizes a small molecule peptide,the asparagine-glycine-arginine(NGR),as a capture probe for the selective enrichment and isolation of circulating tumor cells(CTCs).The multiscale TiO_(2) nanofibers are obtained by electrospinning and calcination.Bovine serum albumin(BSA)is decorated onto TiO_(2) nanofiber surfaces to inhibit non-target cell adhesion,while NGR peptides are conjugated onto the TiO_(2)-BSA surface through the glutaraldehyde(GA)to specifically capture the target cells.The TiO_(2)-BSA-NGR substrate exhibits a high capture sensitivity and efficiency from the mimical blood samples with PC-3 cancer cells as low as 10 cells/mL.The TiO_(2) nanofiber substrate can be a promising strategy for the capture and enumeration of CTCs in cancer progression monitoring. | Changchong Chen Zeen Wu Pi Ding Na Sun Hui Liu Yong Chen Zhili Wang Renjun Pei | 2020 | Advanced Fiber Materials2020，2，4： | 2 |
| 14 | A new cycloartane triterpenoid from the leaves and stems of Fritillaria hupehensis显示文摘A new triterpenoid has been isolated from the leaves and stems of Fritillaria hupehensis Hsiao et K.C.Hsia.Its structure wasestablished as(23Z)-9,19-cycloart-23-ene-3α,25-diol 1 through chemical and spectroscopic studies including 2D NMR.Anotherknown triterpenoid 9,19-cycloart-25-ene-3β,24ξ-diol 2 was also isolated. | Hui Fang Pi Peng Zhang Tian Zhu Han Li Ruan Yong Hui Zhang Han Dong Sun Ji Zhou Wu | 2007 | Chinese Chemical Letters2007，18，4： | 2 |
| 15 | Current research problems of chronic arsenicosisin China显示文摘 | Sun G Li X Pi J | 2006 | J Health Popul Nutr2006，24，： | 1 |
| 16 | Gene deficiency of glutathione S-tran-sferase mu isoform associated with susceptibility to lung cancer in a Chinese population显示文摘 | N Shimojo JB Pi | 1997 | Cancer Lett1997，113，： | 1 |
| 17 | Arsenic-induced malignant transformation of human keratinocytes:involvement of Nrf2显示文摘 | PI J DIWAN B A SUN Y | 2008 | Free Radic Biol Med2008，45，5： | 1 |
| 18 | Aberrant cytokeratin expression during arsenic-induced acquired malignant phenotype in human HaCaT keratinocytes consistent with epidermal carcinogenesis显示文摘 | Sun Y Pi J Wang X | 2009 | Toxicology2009，262，2： | 1 |
| 19 | Haplotype structures and large-scale association testing of the 5'-AMP-activated protein kinase genes PRKAA2,PRKABI,and PRKAB1 with type 2 diabetes 显示文摘 | Sun MW Lee JY de Bakker PI | 2006 | Diabetes2006，55，3： | 1 |
| 20 | Evaluation of DNA damage in patients with arsenic poisoning: urinary 8-hydroxydeoxyguanine显示文摘 | Hiroshi Yamauchi Yoshito Aminaka Katsumi Yoshida Guifan Sun Jingbo Pi Michael P Waalkes | 2004 | Toxicology and Applied Pharmacology2004，，3： | 1 |
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