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| 1 | Sitagliptin in patients with non-alcoholic steatohepatitis: A randomized, placebo-controlled trial显示文摘AIM To evaluate the effect of sitagliptin vs placebo on histologic and non-histologic parameters of nonalcoholic steatohepatitis(NASH).METHODS Twelve patients with biopsy-proven NASH were randomized to sitagliptin(100 mg daily)(n=6)or placebo(n=6)for 24 wk.The primary outcome was improvement in liver fibrosis after 24 wk.Secondary outcomes included evaluation of changes in NAFLD activity score(NAS),individual components of NAS(hepatocyte ballooning,lobular inflammation,and steatosis),glycemic control and insulin resistance[including measurements of glycated hemoglobin(Hb A1C)and adipocytokines],lipid profile including free fatty acids,adipose distribution measured using magnetic resonance imaging(MRI),and thrombosis markers(platelet aggregation and plasminogen activator inhibitor 1 levels).We also sought to determine the correlation between changes in hepatic fat fraction(%)[as measured using the Iterative Decomposition of water and fat with Echo Asymmetry and Least-squares estimation(IDEAL)MRI technique]and changes in hepatic steatosis on liver biopsy.RESULTS Sitagliptin was not significantly better than placebo at reducing liver fibrosis score as measured on liver biopsy(mean difference between sitagliptin and placebo arms,0.40,P=0.82).There were no significant improvements evident with the use of sitagliptin vs placebo for the secondary histologic outcomes of NAS total score as well as for the individual components of NAS.Compared to baseline,those patients who received sitagliptin demonstrated improved Hb A1C(6.7%±0.4%vs 7.9%±1.0%,P=0.02),and trended towards improved adiponectin levels(4.7±3.5μg/m L vs 3.9±2.7μg/m L,P=0.06)and triglyceride levels(1.26±0.43 mmol/L vs 2.80±1.64 mmol/L,P=0.08).However,when compared with placebo,sitagliptin did not cause a statistically significant improvement in Hb A1C(mean difference,-0.7%,P=0.19)nor triglyceride levels(mean difference-1.10mmol/L,P=0.19)but did trend towards improved adiponectin levels only(mean difference,0.60μg/m L,P=0.095).No significant changes in anthropometrics,liver enzymes,other adipocytokines,lipid profile,thrombosis parameters,or adipose distribution were demonstrated.The MRI IDEAL procedure correlated well with steatosis scores obtained on liver biopsy in both groups at baseline and post-treatment,and the Spearman correlation coefficients ranged from r=0.819(baseline)to r=0.878(post-treatment),P=0.002.CONCLUSION Sitagliptin does not improve fibrosis score or NAS after 24 wk of therapy.The MRI IDEAL technique may be useful for non-invasive measurement of hepatic steatosis. | Tisha R Joy Charles A McKenzie Rommel G Tirona Kelly Summers Shannon Seney Subrata Chakrabarti Neel Malhotra Melanie D Beaton | 2017 | World Journal of Gastroenterology2017，23，1： | 18 |
| 2 | Mesenchymal progenitor cell research: limitations and recommendations显示文摘 | Summer R Fine A | 2008 | Proc Am Thorac Soc2008，5，6： | 1 |
| 3 | Diagenesis and preservation of porosity in Norphlet Formation (Upper Jurassic), southern Alabama显示文摘 | DIXON S A SUMMERS D M SURDAM R C | 1989 | Am Assoc Pet Geol Bull1989，73，： | 1 |
| 4 | Scale dependence of hypsometric integrals:An analysis of southeast African hasin显示文摘 | Waleott R C Summer? eld M A | 2008 | Geomorphology2008，96，17： | 1 |
| 5 | A Model for Stochastic Acceleration of Electrons During Geomagnetic Storms显示文摘 | Thorne R M Xiao F L | 2000 | Adv Space Res2000，25，12： | 1 |
| 6 | A virus similar to human hepatitis B virus associated with hepatitis and hepatoma in woodchucks显示文摘 | Summers J Smolec J M Snyder R | 1978 | Proc Natl Acad Sci U S A1978，75，： | 1 |
| 7 | Cough,fever and weight loss in a young male显示文摘 | Summer R Zacks J Ieong M | 2002 | Eur Respir J2002，19，6： | 1 |
| 8 | Diagenesis and prservation of porosity in Norphlet Formation( Upper Jurassic) , southern Alabama 显示文摘 | DIXON S A SUMMERS D M SURDAM R C | 1989 | Am Assoc Petrol Geol Bull1989，73，6： | 1 |
| 9 | Diagenesis and prservation of porosity in Norphlet Formation(Upper Jurassic),southern Alabama显示文摘 | Dixon S A Summers D M Surdam R C | 1989 | American Association of Petroleum Geologists Bulletin1989，73，6： | 1 |
| 10 | Assessing DBP yield:Uniform formation conditions显示文摘 | R Scott Summers Stuart M Hooper Hiba M Shukairy | 1996 | American Water Works Association Journal1996，88，6： | 1 |
| 11 | Mobile genetic elements: the agents of open source evolution显示文摘 | Frost L S Leplae R Summers A O | 2005 | Nat Rev Microbiol2005，3，9： | 1 |
| 12 | Side population cells and Bcrplexpression in lung显示文摘 | Summer R Kotton DN Sun X | 2003 | Am J Physiol Lung Cell Mol Physiol2003，285，1： | 1 |
| 13 | The relaxin family peptide receptor 3 activates extracellular signal-regulated kinase 1/2 through a protein kinase C-dependent mechanism 显示文摘 | Westhuizen E T Werry T D Summers R J | 2007 | Mol Pharmacol2007，71，： | 1 |
| 14 | CT vitural bronchoscopy of simulated endobronchinial lesions:effect of scanning,reconstruction,and display settings and potential pitfalls显示文摘 | SUMMERS R M SHAW D J SHELHAMER J H | 1998 | AJR Am J Roentgenol1998，170，4： | 1 |
| 15 | Jaagsiekte sheep ret- rovirus-specific immune responses induced by vaccination : a compar- ison of immunisation strategies 显示文摘 | Summers C Dewar P van der Molen R | 2006 | Vaccine2006，24，11： | 1 |
| 16 | Bauxite residue(Red Mud)increases phosphorus retention in sandy soil catchments in Western Australia显示文摘 | Summers R N | 1993 | Fertilizer Research1993，34，： | 1 |
| 17 | Evaluation of metals in wa-- ster sludge显示文摘 | Stover R C Summer L E Silviem D J | 1976 | Water Pollution Control Fed1976，48，： | 1 |
| 18 | Noise trader risk in financial markets显示文摘 | Delong J B Shleifer A Summers L Waldmann R J | 1990 | Journal of Political Economy1990，98，4： | 1 |
| 19 | Multigoal heuristic model predictive control technique applied to a cascaded H-bridge StatCom显示文摘 | Townsend C D Summers T J Betz R E | 2012 | IEEE Transactions on Power Electronics2012，27，3： | 1 |
| 20 | Dead-time issues in predictive current control显示文摘 | SUMMERS T J BETZ R E | 2004 | Industry Applications IEEE Transactions on2004，40，3： | 1 |
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