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| 1 | Sitagliptin in patients with non-alcoholic steatohepatitis: A randomized, placebo-controlled trial显示文摘AIM To evaluate the effect of sitagliptin vs placebo on histologic and non-histologic parameters of nonalcoholic steatohepatitis(NASH).METHODS Twelve patients with biopsy-proven NASH were randomized to sitagliptin(100 mg daily)(n=6)or placebo(n=6)for 24 wk.The primary outcome was improvement in liver fibrosis after 24 wk.Secondary outcomes included evaluation of changes in NAFLD activity score(NAS),individual components of NAS(hepatocyte ballooning,lobular inflammation,and steatosis),glycemic control and insulin resistance[including measurements of glycated hemoglobin(Hb A1C)and adipocytokines],lipid profile including free fatty acids,adipose distribution measured using magnetic resonance imaging(MRI),and thrombosis markers(platelet aggregation and plasminogen activator inhibitor 1 levels).We also sought to determine the correlation between changes in hepatic fat fraction(%)[as measured using the Iterative Decomposition of water and fat with Echo Asymmetry and Least-squares estimation(IDEAL)MRI technique]and changes in hepatic steatosis on liver biopsy.RESULTS Sitagliptin was not significantly better than placebo at reducing liver fibrosis score as measured on liver biopsy(mean difference between sitagliptin and placebo arms,0.40,P=0.82).There were no significant improvements evident with the use of sitagliptin vs placebo for the secondary histologic outcomes of NAS total score as well as for the individual components of NAS.Compared to baseline,those patients who received sitagliptin demonstrated improved Hb A1C(6.7%±0.4%vs 7.9%±1.0%,P=0.02),and trended towards improved adiponectin levels(4.7±3.5μg/m L vs 3.9±2.7μg/m L,P=0.06)and triglyceride levels(1.26±0.43 mmol/L vs 2.80±1.64 mmol/L,P=0.08).However,when compared with placebo,sitagliptin did not cause a statistically significant improvement in Hb A1C(mean difference,-0.7%,P=0.19)nor triglyceride levels(mean difference-1.10mmol/L,P=0.19)but did trend towards improved adiponectin levels only(mean difference,0.60μg/m L,P=0.095).No significant changes in anthropometrics,liver enzymes,other adipocytokines,lipid profile,thrombosis parameters,or adipose distribution were demonstrated.The MRI IDEAL procedure correlated well with steatosis scores obtained on liver biopsy in both groups at baseline and post-treatment,and the Spearman correlation coefficients ranged from r=0.819(baseline)to r=0.878(post-treatment),P=0.002.CONCLUSION Sitagliptin does not improve fibrosis score or NAS after 24 wk of therapy.The MRI IDEAL technique may be useful for non-invasive measurement of hepatic steatosis. | Tisha R Joy Charles A McKenzie Rommel G Tirona Kelly Summers Shannon Seney Subrata Chakrabarti Neel Malhotra Melanie D Beaton | 2017 | World Journal of Gastroenterology2017，23，1： | 18 |
| 2 | Effects of deletion and overexpression of the Autographa califomica nuclear polyhedrosis vires FP25K gene on synthesis of two occlusionderived virus envelope proteins and their transport into virusinduced intranuclear membranes显示文摘 | Rosas-Acosta G Braunagel S C & Summers M D | 2001 | J Virol2001，75，10： | 1 |
| 3 | Correlation of Particle-induced Displacement Damage in Silicon显示文摘 | | 1987 | IEEE Trans on Nucl Sci1987，34，6： | 1 |
| 4 | Earlyeventsin canine distemper demyelinating encephalomyelitis显示文摘 | SUMMERS B A GREISEN H A APPEL M J G | 1979 | Acta Neuropathologica1979，52，： | 1 |
| 5 | Experimental investigation on the breakage of hard rock by the PDC cutters with combined action modes 显示文摘 | LI Xi -bing Summers D A Rupert G | 2001 | Tunnelling and Underground Space Technology2001，16，： | 1 |
| 6 | Pathogenicity of morbiliviruses for terresttial carnivores显示文摘 | Appel M J G Summer B A | 1995 | Vet Microbiol1995，44，： | 1 |
| 7 | 显示文摘 | Sheng W Oecaussin G Summer S | 2001 | Oncogene2001，20，10： | 1 |
| 8 | Investigation into the penetration and impact resistance of PDC cutters inclined at different attack angles显示文摘 | LI Xi - bing Summers D A Rupert G | 2001 | Transation of Nonferrous Metals Society of China2001，10，2： | 1 |
| 9 | Production of human beta interferon in insect cells infected with a baculovirus expression vector显示文摘 | SMITH G E SUMMERS M D FRASER M J | 1983 | Mol Cell Bio1983，3，12： | 1 |
| 10 | Virus of Pekin ducks with structural and biological relatedness to human hepatitis B virus 显示文摘 | Mason W S Seal G & Summers J | 1980 | J Virol1980，36，3： | 1 |
| 11 | A novelmethod for quantification of canalicular transporterinhibition in primary rat hepatocytes sandwich cul-tures 显示文摘 | Hopwood J Summers C Barrett G | 2006 | Toxicology2006，226，1： | 1 |
| 12 | I Production of human beta interferon in insect cells infected with a baculovirus expression vector显示文摘 | Smith G E Summers M D Fraser M | 1983 | Mol Cell Biol1983，3，： | 1 |
| 13 | Bacterialpathogensof oyster larvae (Crassostrea gigas) in a Tasmanian hatchery显示文摘 | GARLAND CD NASH G V SUMMER C E | 1983 | Aust JMar Freshwater Res1983，34，： | 1 |
| 14 | Cell fusionindependent differentiation of neural stem cells to the endothelial lineage显示文摘 | Wurmser A E Nakashima K Summers R G | | 0，，6997： | 1 |
| 15 | Recombinant protein secretion in Escherichia coli 显示文摘 | Mergulhao F J Summers D K Monteiro G A | 2005 | Biotechnology Advances2005，23，： | 1 |
| 16 | Virus of Peking ducks with structural and biological relatedness to human hepatitis B virus显示文摘 | Mason W S Seal G Summers J | 1980 | J Virol1980，36，2： | 1 |
| 17 | SNR Mismatch and On-line Estimation in Turbo Decoding显示文摘 | SUMMERS T A WILSON S G | 1998 | IEEE Trans on Commun1998，46，4： | 1 |
| 18 | Antioxidant systems in insects 显示文摘 | Felton G W Summers C B | 1995 | Archives of Insect Biochemistry and Physiology1995，29，： | 1 |
| 19 | Dynamics of ubiquitin pools in developing sea urchin embryos显示文摘 | Piekart C M Summers R G Shim H | 1991 | Dev Growth Differ1991，33，6： | 1 |
| 20 | Production of human beta interferon in insect cells infected with baculovirus expression vector显示文摘 | Smith G E Summers M D Fraser M J | 1983 | Mol Cell Biol1983，3，12： | 1 |
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