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	题名	作者	年代	出处	被引量
1	Melatonin attenuates cisplatin-induced HepG2 cell death via the regulation of mTOR and ERCC1 expressions显示文摘AIM:To elucidate the effects of melatonin on cisplatininduced hepatocellular carcinoma(HepG2) cell death and to identify potential cross-talk pathways.METHODS:Hepatocellular carcinoma HepG2 cells were treated with melatonin and/or cisplatin for 24 to 48 h.Cell viability and the 50% cytotoxic concentration(CC50) were calculated by MTT assays.The effects and intracellular events induced by the selected concentrations of melatonin(1 mmol/L) and cisplatin(20 μmol/L) were investigated.Cell death and survival detection were primarily evaluated using a fluorescence microscope to assess 4',6 diamideno-2-phenylindol DNA staining and acridine orange lysosome staining and then further analyzed with immunocytochemistry using an anti-LC3 antibody.The potential molecularresponses mediated by melatonin against cisplatin after the combined treatment were investigated by reverse transcription-polymerase chains reaction and Western blot analyses of the genes and proteins associated with cell survival and death.A cell cycle analysis was performed using a flow cytometry assay.RESULTS:Melatonin had a concentration-dependent effect on HepG2 cell viability.At 1 mmol/L,melatonin significantly increased the cell viability percentage and decreased reactive oxygen species production due to cisplatin.Melatonin reduced cisplatin-induced cell death,decreasing phosphorylated p53 apoptotic protein,cleaved caspase 3 and Bax levels but increasing anti-apoptotic Bcl-2 gene and protein expression.When combined with cisplatin,melatonin induced S phase(DNA synthesis) cell cycle arrest and promoted autophagic events in HepG2 cells.Melatonin also had a concentration-dependent effect on Beclin-1 and its autophagic regulator mammalian target of rapamycin(mTOR) as well as the DNA excision repair cross complementary 1(ERCC1) protein.The expression levels of these proteins were altered in HepG2 cells during cisplatin or melatonin treatment alone.In the combination treatment,melatonin reversed the effects of cisplatin by suppressing the over-expression of mTOR and ERCC 1 and enhancing the expression levels of Beclin-1 and microtubule-associated protein-light chain3-Ⅱ,leading to intracellular autophagosome progression.CONCLUSION:Melatonin attenuated cisplatin-induced cell death in HepG2 cells via a counter-balance between the roles of apoptotic- and autophagy-related proteins.	Kangsadarn Bennukul Sucha Numkliang Vijittra Leardkamolkarn	2014	World Journal of Hepatology2014，6，4：	2
2	Rare-earth elemental systematics of mixed-layered illite-smectite from sedimentary and hydrothermal environments of the Western Carpathians(Slovakia) 显示文摘	Honty M Clauer N Sucha V	2008	Chemical Geology2008，124，：	1
3	Broad bandwidths from frequency shifting solitons in fibers显示文摘	Islam M N Sucha G Bar-Joseph I	1989	Opt Lett1989，14，：	1
4	Hydrothermal synthesis of ammonium illite显示文摘	SUCHA V ELSASS F EBERL D D	1998	American Mineralogist1998，83，12：	1
5	Profinet IO IRT message scheduling with temporal constraints显示文摘	Hanzalek Z Burget P Sucha P	2010	IEEE Transactions on Industrial Informat- ics2010，6，3：	1
6	Mixed-layer ammonium illite-smectite and ammonium illite from hydrothermal system Hargita Bai, the East Carpathians(Romania) 显示文摘	Bobos I Sucha V Soboleva S	1995	Euroclay 95 Abstracts Volume1995，，：	1
7	Particle properties of hydrothermal am- monium-bearing illite-semctite 显示文摘	Sucha V Uhlik P Madjova J	2007	Clays and Clay Minerals2007，55，1：	1
8	Hydrothermal synthesis of ammonium illite 显示文摘	Sucha V Elsass F Eberld D	1998	American Mineralogist1998，83，12：	1
9	The impact of a new model-based iterative reconstruction algorithm on prosthetic heart valve related artifacts at reduced radiation dose MDCT显示文摘	Sucha D Willemink MJ de Jong PA	2014	Int J Cardiovasc Imaging2014，30，4：	1
10	Hydroxyurea, azacitidine and gemtuzumab ozogamicin therapy in patients with previously untreated non-M3 acute myeloid leukemia and high-risk myelodysplastic syndromes in the elderly: results from a pilot trial 显示文摘	Sucha N John G Scott S	2008	Leuk Lymphoma2008，49，11：	1
11	An ap- proach based on the catenary equation to deal with static analysis of three dimensional cable structures 显示文摘	Sucha M Jimenez-Octavio J Carnicero A	2009	Engi- neering Structures2009，31，9：	1
12	Period doubling and quasi-periodicity in additive-pulse mode-locked lasers显示文摘	Sucha G Bolton S R Weiss S	1995	Optics Letters1995，20，17：	1
13	The impact of a new model-based iterative reconstruction algorithm on prosthetic heart valve related artifacts at reduced radiation dose MDCT显示文摘	Sucha D Willemink M J de Jung P A	2014	]nt J Cardiovasc Imaging2014，30，4：	1
14	Fiber laser for ultrafast optics显示文摘	Fermann M E Galvanauskas A Sucha G	1997	Appl Phys B1997，，65：	1
15	Potassium and ammonium fixation in smec- tites by wetting and drying显示文摘	Sucha V Siranova V	1991	Clays and Clay Minerals1991，39，：	1
16	Ammonium illite from anchimeta- morphic shales associated with anthracite in the zemplinicum of the western Carpathians显示文摘	Sucha V Kraus I Madejova J	1994	Clay Minerals1994，29，：	1
17	T‐DNA insertional mutagenesis for functional genomics in rice显示文摘	Jong‐SeongJeon SichulLee Ki‐HongJung Sung‐HoonJun Dong‐HoonJeong JinwonLee ChanhongKim SeonghoeJang ShinyoungLee KiyoungYang JongminNam KyungsookAn Min‐JungHan Ryo‐JinSung Hyun‐SookChoi Jung‐HwaYu Jung‐HwanChoi Se‐YuCho Sang‐SuCha Shi‐InKim	2001	The Plant Journal2001，，6：	1
18	Profinet IO IRT mes- sage scheduling with temporal constraints 显示文摘	Hanzlek Z Burget P Sucha P	2010	IEEE Transactions on Industrial Informatics2010，6，3：	1
19	Fiber-lasers for ultrafast optics显示文摘	Fermann M E Galvanauskas A Sucha G	1997	Applied Physics1997，65，：	1
20	Larval toxocarosis in childhood from eastern part of Slovak Republic显示文摘	Kincekova J Sucha E Dubinsky P	1997	Immun to parasites1997，56，2：	1

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