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| 1 | 尼泊尔喜马拉雅地区塔玛科什3级水电工程--穿越软弱构造片岩修建隧洞所面临的挑战显示文摘由于尼泊尔喜马拉雅地区岩石强度较低,水平应力较高,因此在该软弱构造片岩带中开挖隧洞具有较大的挑战性。文章主要阐述装机容量为650 kW的塔玛科什3级水电工程17km长大跨度隧洞和大型地下发电厂房(这两项工程计划穿越夹杂有软弱构造片岩带的坚硬眼球状片麻岩区域)所面临的重大技术挑战。穿过片岩带开挖的隧洞长度约占总长的15%,由于此岩层带岩石强度较低,具有剪切特性和渗流现象,且水平应力较高,围岩挤压和隧洞塌方都是可预期的问题,因此该工程地下开挖主要关注的问题是大尺寸隧洞的可施工性和工期。为了解决可预期问题,进行了更进一步的研究,主要集中在隧洞最大可建尺寸、方位、减少围岩挤压的开挖方法,以及地下发电厂房稳定性和合理岩石支护设计上。研究发现,在构造片岩带中可施工的全断面隧洞最大尺寸可达9m,为改进的马蹄形(有弧形仰拱)。通过对隧洞三种不同方位方案(即正交、斜交、平行)的分析发现,与叶理面正交的方案最佳,可减少围岩挤压近50%。 | Subas Chandra Sunuwar Sandip Shah Ashish Subedi Muna Sharma | 2013 | 现代隧道技术2013，50，1： | 3 |
| 2 | Improvement in the dissolution rate and tableting properties of cefuroxime axetil by melt-granulated dispersion and surface adsorption显示文摘A combination of melt-granulated dispersion and surface adsorption techniques was used to enhance the dissolution and tableting properties of cefuroxime axetil(CA).Gelucire 50/13 was used as the melt-dispersion carrier and Sylysia 350 was used to adsorb the melt dispersion.Solubility studies showed an 8-fold increase in solubility at a ratio of 1:1.5 for CA:Gelucire 50/13.The minimum quantity of Sylysia 350 required to achieve the desired flowability and compressibility was 0.5 parts of Sylysia 350 per unit of Gelucire 50/13.Phase solubility studies showed negative ΔG_(tr)^(0) values for Gelucire 50/13 at various concentrations(2-10%,vv/v),indicating the spontaneous nature of solubilization.FT-IR and DSC spectra exhibited drug-excipient compatibility.Molecular modeling by a computational method employing energy minimization revealed entrapment of CA in Gelucire 50/13.The total potential energy of CA(70.562 keal/mol)was reduced to 33.578 keal/mol after solid dispersion with Gelucire 50/13.P-XRD studies indicated that the presence of Sylysia 350 is less likely to promote the reversion of the amorphous CA to a crystalline state.In vitro dissolution studies demonstrated an improved dissolution rate,and drug release at 15 min(Q_(15min))exhibited a 15-fold improvement.The rapidly dissolving CA tablets showed improved dissolution with improved tableting properties. | Jammula Sruti Chinam Niranjan Patra Suryakanta Swain Kanhu Charan Panigrahi Allupati Premananda Patro Sarwar Beg Subas Chandra Dinda Muddana Eswara Bhanoji Rao | 2013 | Acta Pharmaceutica Sinica B2013，3，2： | 2 |
| 3 | Autogenous bone versus β-tricalcium phosphate graft alone for bilateral sinus elevations(2-and 3-dimensional computed tomographic, histologic, and histomo-rphometric evaluations):preliminary result 显示文摘 | Szabo G Suba Z Hrabak k | 2001 | Int J Oral Maxillof-ac Implants2001，16，： | 1 |
| 4 | Development and evaluation of controlled porosity osmotic pump for nifedipine and metoprolol combinatio显示文摘 | Kumaravelrajan R Narayanan N Suba V | 2011 | Lipids Health Dis2011，11，10： | 1 |
| 5 | Antimicrobial and antiproliferative prospective of kosinostatin-a secondary metabolite isolated from Streptomyces sp.显示文摘Cancer is a communal health hazard worldwide. The present investigation attempts to evaluate antimicrobial and anticancer potential of kosinostatin on mammary carcinoma cell line(MCF-7). The anticancer and antiproliferative activities of kosinostatin were analyzed on MCF cell line by MTT assay and cytotoxicity assays like lactate dehydrogenase(LDH) and glutathione(GSH). The secondary metabolite kosinostatin exhibited its apoptotic nature by expressing p53 protein. Collectively, the results acquired from this study promise that kosinostatin shows the potent anticancer activity. | Vinayagam Rambabu Subramaniyan Suba Suburamaniyan Vijayakumar | 2015 | Journal of Pharmaceutical Analysis2015，5，6： | 1 |
| 6 | Correlations of insulin resistance and neoplasms显示文摘 | Suba Z Ujpál M | 2006 | Magy Onkol2006，50，2： | 1 |
| 7 | Triple-negative breast cancer risk in women is defined by the defect of estrogen signaling: preventive and therapeutic implica- tions显示文摘 | Suba Z | 2014 | Onco Targets Ther2014，7，： | 1 |
| 8 | Alterations in rat aortic alpha1-adrenoceptors and alpha1-adrenergic stimulated phosphoinositide hydrolysis in intraperitoneal sepsis显示文摘 | Litten RZ Suba EA | 1988 | Circ Shock1988，26，： | 1 |
| 9 | Surface analysis methods of biomaterials usedin oral surgery:liter ature review显示文摘 | SUBA C VELICH N TURI C | 2005 | J Craniofac Surg2005，16，1： | 1 |
| 10 | Uptake of dyes by a promising locally agricultural solid waste:coir pith显示文摘 | Namasivayam C Radhika R Suba S | 2001 | Waste Management2001，21，： | 1 |
| 11 | Evaluation of the topographical sur-face changes and roughness of zirconia after different sur-face treatments显示文摘 | Suba§iMGjnan 0 | 2012 | Lasers Med Sci2012，27，4： | 1 |
| 12 | Development and evaluation of a rapid flow-through immunofiltration test using recombinant filarial antigen for diagnosis of brugian and bancroftian filariasis 显示文摘 | Baskar LK Srikanth TR Suba S | 2004 | Microbiol Immunol2004，48，7： | 1 |
| 13 | Capillary isoelectric focusing method development and validation for investigation of recombinant therapeutic monoclonal antibody 显示文摘 | Suba D Urbanyi Z Salgo A | 2015 | Journal of Pharmaceutical and Biomedical Analysis2015，114，： | 1 |
| 14 | Lessons learned from successful Papanicolaou cytology cervical cancer prevention in the Socialist Republic of Vietnam显示文摘 | Suba EJ Raab SS | 2012 | Diagn Cytopathol2012，40，4： | 1 |
| 15 | Correlations of insulin resistance and neoplasms 显示文摘 | Suba Z Ujpal M | 2006 | Magy Onkol2006，50，2： | 1 |
| 16 | Cleidocranial dysplasia:Diagnostic criteria and combined treatment显示文摘 | Suba Z Balaton C Gyulai-Gaál S | 2005 | J Craniofac Surg2005，16，6： | 1 |
| 17 | Triple -negative breast cancer risk in women is defined by the defect of estrogen signaling: preventive and therapeutic im- plications 显示文摘 | Suba Z | 2014 | Oneo Targets Ther2014，7，： | 1 |
| 18 | Maxillary sinus floorgrafting with beta 2 tricalcium phos phate in humans:density and microarchite-cture of the newly formed bone显示文摘 | Suba Z Takacs D Matusovits D | 2006 | Clin Oral I mp lants Res2006，17，1： | 1 |
| 19 | Cost-effectiveness of cervical cancer screening in developing countries显示文摘 | Suba E J Raab S S FrableW J | 2006 | N Engl JMed2006，354，： | 1 |
| 20 | Stability of Spin Orbit Coupled Fermi Gases with Population Imbalance显示文摘 | ISKIN M SUBAS A L | 2011 | Phys Rev Lett2011，107，05： | 1 |
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