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| 1 | New cucurbitacin glycosides from kircorhiza kurrooa显示文摘 | STUPPNER H WAGNER H | 1989 | Plantea Med1989，55，： | 1 |
| 2 | Comparative Study of Roots of Angelica sinensis and Related Umbelliferous Drugs by Thin Layer Chromatography, HPLC Chromatography, and LGMS Spectrometry 显示文摘 | Sibylle Zschock Jiang-Hua Liu Hermann Stuppner | 1998 | PHYTOCHEMICAL ANALYSIS1998，9，6： | 1 |
| 3 | Physicochemical properties of oosporein, the major secreted metabolite of the entomopathogenic fungus Beauveria brongniartii显示文摘 | Seger C Erlebach D Stuppner H | 2005 | Helvetica Chimica Acta2005，88，4： | 1 |
| 4 | Minor iridoid and phenol glycosides of Picrorhiza kurrooa 显示文摘 | Stuppner H Wagner H | 1989 | Planta Med1989，55，5： | 1 |
| 5 | Analysis of cucurbitacins in medicinal plants by high-pressure liquid chromatography-mass spectrometry 显示文摘 | Sturm S Stuppner H | 2000 | Phytochem Anal2000，11，2： | 1 |
| 6 | Cycloartane triterpenes from Combretum quadrangulare显示文摘 | Ganzera M Ellmerer-Muller E P Stuppner H | 1998 | Phytochemistry1998，49，3： | 1 |
| 7 | Gewinnung von immunologisch aktiven polysacchariden aus Echinacea-Drogen und-Gewebekulturen 显示文摘 | Wagner H Stuppner H Puhlmann J | 1989 | ZPhytother1989，10，： | 1 |
| 8 | Monitoring the distribution of secondary metabolites produced by the entomogenous fungus Beauveria brongniartii with particular reference to oosporein显示文摘 | Strasser H Abendstein D Stuppner H | 2000 | Mycological Research2000，104，10： | 1 |
| 9 | Antiasthmatic effects of Picrorhiza kurroa : androsin prevents allergen-and PAF-induced bronchial obstruction in guinea pigs 显示文摘 | Dorsch W Stuppner H Wagner H | 1991 | Int Arch Allergy Appl Immunol1991，95，23： | 1 |
| 10 | Minor iridoid and phenol glycosides of Picrorhiza kurrooa显示文摘 | Wagner H | 1989 | Planta Med1989，55，： | 1 |
| 11 | Antiasthmatic effects of Picrorhiza kurroa:androsin prevents allergen and PAFinduced bronchial obstruction in guinea pigs显示文摘 | Dorsch W Stuppner H Wagner H | 1991 | lnt Arch All Appl Immunol1991，95，23： | 1 |
| 12 | Helenalin trig- gers a CD95 death receptor-independent apoptosis that is not af- fected by overexpression of Bcl-x(L) or Bcl-2显示文摘 | Dirsch V M Stuppner H Vollmar A M | 2001 | Cancer Research2001，61，15： | 1 |
| 13 | Mass spectrometry and NMR spec- troscopy: modem high-end detectors for high resolution separation techniques-state of the art in natural product HPLC-MS, HPLC- NMR, and CE-MS hyphenations显示文摘 | Seger C Sturm S Stuppner H | 2013 | Nat Prod Rep2013，30，7： | 1 |
| 14 | From Vietnamese plants to a biflavonoid that relieves inflammation by triggering the lipid mediator class switch to resolution显示文摘Chronic inflammation results from excessive pro-inflammatory signaling and the failure to resolve the inflammatory reaction.Lipid mediators orchestrate both the initiation and resolution of inflammation.Switching from pro-inflammatory to pro-resolving lipid mediator biosynthesis is considered as efficient strategy to relieve chronic inflammation,though drug candidates exhibiting such features are unknown.Starting from a library of Vietnamese medical plant extracts,we identified isomers of the biflavanoid 8-methylsocotrin-4’-ol from Dracaena cambodiana,which limit inflammation by targeting 5-lipoxygenase and switching the lipid mediator profile from leukotrienes to specialized pro-resolving mediators(SPM).Elucidation of the absolute configurations of 8-methylsocotrin-4’-ol revealed the 2 S,γSisomer being most active,and molecular docking studies suggest that the compound binds to an allosteric site between the 5-lipoxygenase subdomains.We identified additional subordinate targets within lipid mediator biosynthesis,including microsomal prostaglandin E2 synthase-1.Leukotriene production is efficiently suppressed in activated human neutrophils,macrophages,and blood,while the induction of SPM biosynthesis is restricted to M2 macrophages.The shift from leukotrienes to SPM was also evident in mouse peritonitis in vivo and accompanied by a substantial decrease in immune cell infiltration.In summary,we disclose a promising drug candidate that combines potent 5-lipoxygenase inhibition with the favorable reprogramming of lipid mediator profiles. | Tran Thi Van Anh Alilou Mostafa Zhigang Rao Simona Pace Stefan Schwaiger Christian Kretzer Veronika Temml Carsten Giesel Paul M.Jordan Rossella Bilancia Christina Weinigel Silke Rummler Birgit Waltenberger Tran Hung Antonietta Rossi Hermann Stuppner Oliver Werz Andreas Koeberle | 2021 | Acta Pharmaceutica Sinica B2021，11，6： | 1 |
| 15 | Cytotoxic sesquiterpene lactones mediate their death-inducing effect in leukemia T cells by triggering apoptosis显示文摘 | Dirsch VM Stuppner H Vollmar AM | 2001 | Planta Med2001，67，6： | 1 |
| 16 | amara alkaloids by ion-pair chromatography显示文摘 | Ganzera M Lamer C Stuppner H Simultaneous determination of Ephedra sinica and Citrus aurantium var | 2005 | Talanta2005，66，4： | 1 |
| 17 | Honokiol: A non-adipogenic PPARγ agonist from nature显示文摘 | Atanas G. Atanasov Jian N. Wang Shi P. Gu Jing Bu Matthias P. Kramer Lisa Baumgartner Nanang Fakhrudin Angela Ladurner Clemens Malainer Anna Vuorinen Stefan M. Noha Stefan Schwaiger Judith M. Rollinger Daniela Schuster Hermann Stuppner Verena M. Dirsch El | 2013 | BBA - General Subjects2013，，10： | 1 |
| 18 | Cytotoxic sesquiterpene lactones mediate their death-inducing effect in leukemia T cells by triggering apoptosis 显示文摘 | Dirsch V M Stuppner H Vollmar A M | 2001 | Planta Med2001，67，6： | 1 |
| 19 | HPLC analysis of the main oxindole alkaloids from Uncaria tomentosa显示文摘 | Stuppner H Stunn S Konwalinka G | 1992 | Chromatographia1992，34，1112： | 1 |
| 20 | Development and vali dation of an HPLC/UV/MS method for simuhaneous deler mination of 18 preservatives in grapefruit seed exlract显示文摘 | Ganzera M Aberham A Stuppner H | 2006 | Food Chem2006，54，11： | 1 |
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