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| 1 | 非诺贝特治疗与2型糖尿病患者长期心血管病风险的关系显示文摘2型糖尿病患者心血管病风险高,部分原因在于高三酰甘油和低高密度脂蛋白胆固醇血症。而在他汀类药物治疗基础上,加强降低三酰甘油治疗,能否降低这种风险尚不清楚。该研究的目的是在使用他汀类药物治疗的2型糖尿病患者中,确定非诺贝特能否降低心血管病风险。 | 刘莉 叶鹏 Elam MB Ginsberg HN Lovato LC Corson M Largay J Leiter LA Lopez C O'Connor PJ Sweeney ME Weiss D Friedewald WT Buse JB Gerstein HC Probstfield J Grimm R Ismail-Beigi F Goff DC Jr Fleg JL Rosenberg Y Byington RP ACCORDION study investigators | 2017 | 中华高血压杂志2017，25，6： | 7 |
| 2 | D-二聚体预测稳定型冠状动脉性心脏病患者的长期病因特异性死亡率、心血管事件和癌症显示文摘交联纤维蛋白的降解产物D-二聚体是高凝状态和血栓形成事件的标志。D-二聚体水平中度升高与血管疾病患者静脉和动脉事件的风险相关。在缺血性疾病长期普伐他汀干预(long-term intervention with pravastatin in ischemic disease,LIPID)试验中,研究者在存在其他危险因素的背景下,评估了D-二聚体水平在预测长期血管转归、病因特异性死亡率和新发癌症中的作用。 | 刘青 叶鹏 Simes J Robledo KP White HD Espinoza D Stewart RA Sullivan DR Zeller T Hague W Nestel PJ Glasziou PP Keech AC Elliott J Blankenberg S Tonkin AM LIPID study investigators | 2018 | 中华高血压杂志2018，26，3： | 6 |
| 3 | Fecal immunochemical test accuracy in average-risk colorectal cancer screening显示文摘AIM:To assess the fecal immunochemical test(FIT)accuracy for colorectal cancer(CRC)and advanced neoplasia(AN)detection in CRC screening.METHODS:We performed a multicentric,prospective,double blind study of diagnostic tests on asymptomatic average-risk individuals submitted to screening colonoscopy.Two stool samples were collected and the fecal hemoglobin concentration was determined in the first sample(FIT1)and the highest level of both samples(FITmax)using the OC-sensor.Areas under the curve(AUC)for CRC and AN were calculated.The best FIT1and FITmax cut-off values for CRC were determined.At this threshold,number needed to scope(NNS)to detect a CRC and an AN and the cost per lesion detected were calculated.RESULTS:About 779 individuals were included.An AN was found in 97(12.5%)individuals:a CRC in 5(0.6%)and an advanced adenoma(≥10 mm,villous histology or high grade dysplasia)in 92(11.9%)subjects.For CRC diagnosis,FIT1 AUC was 0.96(95%CI:0.95-0.98)and FITmax AUC was 0.95(95%CI:0.93-0.97).For AN,FIT1 and FITmax AUC were similar(0.72,95%CI:0.66-0.78 vs 0.73,95%CI:0.68-0.79,respectively,P=0.34).Depending on the number of determinations and the positivity threshold cut-off used sensitivity for AN detection ranged between 28%and 42%and specificity between 91%and 97%.At the best cut-off point for CRC detection(115 ng/mL),the NNS to detect a CRC were 10.2 and 15.8;and the cost per CRC was 1814€and 2985€on FIT1 and FITmax strategies respectively.At this threshold the sensitivity,NNS and cost per AN detected were 30%,1.76,and 306€,in FIT1 strategy,and 36%,2.26€and 426€,in FITmax strategy,respectively.CONCLUSION:Performing two tests does not improve diagnostic accuracy,but increases cost and NNS to detect a lesion. | Vicent Hernandez Joaquin Cubiella M Carmen Gonzalez-Mao Felipe Iglesias Concepción Rivera M Begoa Iglesias Lucía Cid Ines Castro Luisa de Castro Pablo Vega Jose Antonio Hermo Ramiro Macenlle Alfonso Martínez-Turnes David Martínez-Ares Pamela Estevez Estela Cid M Carmen Vidal Angeles López-Martínez Elisabeth Hijona Marta Herreros-Villanueva Luis Bujanda Jose Ignacio Rodriguez-Prada the COLONPREV study investigators | 2014 | World Journal of Gastroenterology2014，20，4： | 4 |
| 4 | Intensive versus conventional glucose control in critically ill patients显示文摘 | The NICE-SUGAR study investigators | | New England Journal of Medicine0，，： | 2 |
| 5 | Stenting of Symptomatic Atherosclerotic Lesions in the Vertebral or Intracranial Arteries (SSYLVIA): study results 显示文摘 | SSYLVIA Study Investigators | 2004 | Stroke2004，35，6： | 1 |
| 6 | MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals:a randomised placebocontrolled trial显示文摘 | Heart Protection Study Investigators | 2002 | Lancet2002，360，9326： | 1 |
| 7 | Effects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus:results of the HOPE study and MICRO-HOPE substudy Heart Outcomes Prevention Evaluation 显示文摘 | (HOPE) Study Investigators | 2000 | Lancet2000，355，： | 1 |
| 8 | Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure显示文摘 | SOLVD (studied of left ventricular dysfunction) investigators | 1991 | N Eng J Med1991，325，： | 1 |
| 9 | Stenting of Symtomatic Atheros- clerotic Lesions in the Vertebral or Intracranial Arteries(SSYLVl- A):study results显示文摘 | SSYLVlA Study Investigators | 2004 | Stroke2004，35，06： | 1 |
| 10 | Stenting of symptomatic ath- erosclerotic lesions in the vertebral or intercianial arteris (SSYLVIA) : study results 显示文摘 | SSYLVIA Study Investigators | 2004 | Stroke2004，35，6： | 1 |
| 11 | Thrombolysis for acute ischemic stroke : results of the Canadian Aheplase for Stroke Effectiveness Study显示文摘 | Hill MD Buchan AM Canadian Aheplase for Stroke Effectiveness Study (CASES) Investigators | 2005 | CMAJ2005，172，10： | 1 |
| 12 | A comparison of aspirin plus tirofiban with aspirin plus heparin for unstable angina:platelet receptor inhibition in ischemic syndrome management(PRISM)study investigators显示文摘 | The PRISM study Investigators | 1998 | N Engl J Med1998，338，21： | 1 |
| 13 | Intensive versus conventional glucose control in critically ill patients 显示文摘 | NICE - SUGAR Study Investigators Finfer S Chittock DR | 2009 | N Engl J Med2009，360，13： | 1 |
| 14 | Effects of Clopidogrel in addition to aspirin in patients with non-ST elevation acute coronary syndromes显示文摘 | CURE Study Investigators | 2001 | N Eng Med2001，345，： | 1 |
| 15 | Long-term cost-effectiveness of clopidogrel given for up to one year in patients with acute coronary syndromes without ST-segment elevation显示文摘 | CURE Study Investigators | 2005 | J Am Coll Cardiol2005，45，6： | 1 |
| 16 | Randomized double-blind trial of fixed low dose warfarin with aspirin after myocardial infarction 显示文摘 | Coumadin Aspirin Re-infarction Study(CHRS) Investigators | 1997 | Lancet1997，350，9049： | 1 |
| 17 | Stenting of symptomatic atherosclerotic lesions in the vertebral or intracranial arteries (SSYLVIA):study results显示文摘 | The SSYLVIA Study Investigators | 2004 | Stroke2004，35，6： | 1 |
| 18 | Effects of an angiotensin-converting enzyme inhibitor,ramipril,on cardiovascular events in high-risk patients显示文摘 | The Heart Outcomes Prevention Evaluation Study Investigators | 2000 | N Engl J Med2000，342，： | 1 |
| 19 | Evaluation study of congestive heart failure and pulmonary artery catheterization effectiveness 显示文摘 | The ESCAPE Investigators and ESCAPE Study Coordinators | 2005 | JAMA2005，13，4： | 1 |
| 20 | Hemorrhage in the Interventional Manage-ment of Stroke study显示文摘 | IMS Study Investigators | 2006 | Stroke2006，37，3： | 1 |
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