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| 1 | Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial显示文摘 | Paul Y Kwo Eric J Lawitz Jonathan McCone Eugene R Schiff John M Vierling David Pound Mitchell N Davis Joseph S Galati Stuart C Gordon Natarajan Ravendhran Lorenzo Rossaro Frank H Anderson Ira M Jacobson Raymond Rubin Kenneth Koury Lisa D Pedicone Clifford | 2010 | The Lancet2010，，9742： | 3 |
| 2 | Ron receptor-dependent gene regulation in a mouse model of endotoxin-induced acute liver failure显示文摘BACKGROUND:Prior experimentation has shown that loss of the tyrosine kinase(TK) signaling domain of the Ron receptor leads to marked hepatocyte protection in a model of lipopolysaccharideinduced acute liver failure(ALF) in D-galactosamine(GalN)sensitized mice.The aim of this study was to identify the role of Ron in the regulation of hepatic gene expression.METHODS:Microarray analyses were performed on liver RNA isolated sequentially from wild-type(WT) and TK-/mice during the progression of ALF.Gene array data were validated using Western and immunohistochemistry analyses as well as with ex vivo culture systems.RESULTS:At baseline,101 genes were differentially expressed between WT and TK-/-livers,which regulate processes involved in hypoxia,proliferation,apoptosis and metabolism.One hour after ALF induction,WT livers exhibited increased cytokine expression compared to TK-/-livers,and after 4 hours,an induction of suppressor of cytokine signaling(SOCS) genes as well as JAK-STAT pathway activation were prominent in TK-/livers compared to controls.CONCLUSION:Our studies suggest a novel hepato-protective mechanism in Ron TK-/-mice wherein increased and sustained SOCS production and JAK-STAT activation in the hepatocyte may inhibit the destructive proinflammatory milieu and promote survival factors which blunt hepatic death and the ensuing development of ALF. | Rishikesh M Kulkarni Louis W Kutcher William D Stuart Daniel J Carson Mike A Leonis Susan E Waltz | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，4： | 3 |
| 3 | Transgenic zebrafish as sentinels for aquatic pollution显示文摘 | Carvan M J Dalton T P Stuart G W | 2000 | Ann N Y Acad Sci2000，919，： | 1 |
| 4 | Long-term follow-up confirms a survival advantage of the paclitax-el-cisplatin regimen over the hamide-cispla-tin combination in advanced ovarian cancer显示文摘 | Piccart M J Bertelsen K Stuart G | 2003 | Int J Gynecol Cancer2003，13，2： | 1 |
| 5 | Replication, integration and stable germ-line transmission offoreign sequences injected into early zebrafish embryos 显示文摘 | STUART G W MCMURRAY J V WESTERFIELD M | 1988 | Development1988，103，： | 1 |
| 6 | Emerging ap- plications of stimuli-response polymer materials 显示文摘 | Stuart M A C Huck W T S Genzer J | 2010 | Nat Mater2010，9，： | 1 |
| 7 | Exponential mean- square stability of numerical solutions to stochastic differ- ential equations 显示文摘 | Higham D J Mao X R Stuart A M | 2003 | LMS Journal of Computation and Mathematics2003，6，： | 1 |
| 8 | Steroid hormone influence on brain calbindin-D28k in male prepubertal and ovariectomized rats显示文摘 | Stuart E B Thompson J M Rhees R W | 2001 | Developmental Brain Research2001，129，2： | 1 |
| 9 | Local search and the evolution of technological capabilities显示文摘 | Stuart T E Podolny J M | 1996 | Strategic Management Journal1996，，： | 1 |
| 10 | Long-term fallow-up confirms a survival advantage of the paclitaxel-cisplatin regimen over thecy combination in advancedovarian cancer显示文摘 | Piccart M J Bertelsen K Stuart G | 2003 | Int J Gynecol Cancer2003，13，2： | 1 |
| 11 | Rival penalized competitive learning (RPCL) : a topology-determining algorithm for analyzing gene expression data 显示文摘 | NAIR T M ZHENG C L FINK J L STUART R O GRIBSKOV M | 2003 | Computational Biology and Chemistry2003，27，6： | 1 |
| 12 | Protein method department of biochemistry university of genera显示文摘 | Stuart J E | 1997 | Genera Switzerland1997，，： | 1 |
| 13 | Stimulation of lipolysis by Tumor Necrosis Factor-a in 3T3-L1 adipocytes is glucose dependent显示文摘 | Green A Rumberger J M Stuart C A | 2004 | Diabetes2004，53，： | 1 |
| 14 | Assessment of eccentric exercise-induced muscle damage of the elbow flexors by tensiomyography 显示文摘 | Angus M Hunter Stuart D R Galloway Iain J S | 2012 | Journal of Electromyography and Kinesiology2012，22，3： | 1 |
| 15 | A gene-coexpression network for global discovery of conserved genetic modules显示文摘 | STUART J M SEGAL E KOLLER D | 2003 | Science2003，302，： | 1 |
| 16 | Nonionic bolaamphiphiles and Gemini surfactants based on carbohydrates显示文摘 | Pestman J M Terpstra K R Stuart M C A | 1997 | Langmuir1997，13，25： | 1 |
| 17 | Role of epigailocatcchin gallate (EGCG) in the treatment of breast and prostste cancer显示文摘 | STUART E C SCANDLYN M J ROSENGREN R J | 2006 | Life Sci2006，79，25： | 1 |
| 18 | Port System Simulation facility with an optimization capability显示文摘 | Keshav P D Stuart J G Gracme M B | 2003 | International Journal of Computational Intelligence and Applications2003，3，4： | 1 |
| 19 | Emerging applications of stimuli-responsive polymer materials显示文摘 | Stuart M A C Huck W T S Genzer J | 2010 | Nature Materials2010，9，： | 1 |
| 20 | Laser extraction of helium isotopes from Antarctic micrometeorites: Source of He and implications for the flux of extraterrestrial 3He to earth显示文摘 | STUART F M HARROP P J KNOTT S | 1999 | Geochim Cosmochim Acta1999，63，： | 1 |
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