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| 1 | Low-dose tacrolimus ameliorates liver inflammation and fibrosis in steroid refractory autoimmune hepatitis显示文摘AIM: To determine the eff icacy of tacrolimus on clinical status, histopathological status and biochemical markers in patients with steroid refractory autoimmune hepatitis (AIH). METHODS: Retrospectively, clinical parameters, biochemistry and histology were obtained from patient records. RESULTS: Nine patients [8 females/1 male, median age 32 (range 16-64) years] were identified to have received tacrolimus for a median duration of 18 (12-37) mo. Before initiation of tacrolimus treatment the patients were maintained on a prednisolone dose of 20 mg daily (range 20-80 mg/d), which was tapered to 7.5 (5-12.5) mg/d (P = 0.004). Alanine aminotransferase and immunoglobulin-G concentrations decreased from 154 (100-475) to 47(22-61) U/L (P = 0.007), and from 16 (10-30.2) to 14.5 (8.4-20) g/L (P = 0.032), respectively. All patients showed improvement of the liver inflammatory activity, as determined by the Ishak score (P = 0.016), while the degree of f ibrosis tended to decrease (P = 0.049). CONCLUSION: The use of low dose tacrolimus can lead to biochemical and histologic improvement of inflammation with no progression of the stage of f ibrosis in patients with steroid refractory AIH. Low dose tacrolimus therapy also allows substantial reduction of prednisone dose. | Fin Stolze Larsen Ben Vainer Martin Eefsen Peter Nissen Bjerring Bent Adel Hansen | 2007 | World Journal of Gastroenterology2007，13，23： | 15 |
| 2 | Clinical and historical features of emergency department patients with pericardial effusions显示文摘BACKGROUND: Diagnosing pericardial effusion is critical for optimal patient care. Typically, clinicians use physical examination ? ndings and historical features suggesting pericardial effusion to determine which patients require echocardiography. The diagnostic characteristics of these tools are not well described. The objective of this study is to determine the prevalence of historical features and sensitivity of clinical signs to inform clinicians when to proceed with echocardiogram.METHODS: A retrospective review of point-of-care echocardiograms performed over a two and a half year period in two emergency departments were reviewed for the presence of a pericardial effusion. Patient charts were reviewed and abstracted for presenting symptoms, historical features and clinical findings. The prevalence of presenting symptoms and historical features and the sensitivity of classic physical examination ? ndings associated with pericardial effusion and tamponade were determined.RESULTS: One hundred and fifty-three patients with pericardial effusion were identified. Of these patients, the most common presenting complaint was chest pain and shortness of breath. Patients had no historical features that would suggest pericardial effusion in 37.5% of cases. None of the patients with pericardial effusion or pericardial tamponade had all of the elements of Beck's triad. The sensitivity of Beck's triad was found to be 0(0%–19.4%). The sensitivity for one ? nding of Beck's triad to diagnose pericardial tamponade was 50%(28.0%–72.0%).CONCLUSION: History and physical examination findings perform poorly as tests for the diagnosis of pericardial effusion or pericardial tamponade. Clinicians must liberally evaluate patients suspected of having a pericardial effusion with echocardiography. | Lori Stolz Josephine Valenzuela Elaine Situ-LaCasse Uwe Stolz Nicolas Hawbaker Matthew Thompson Srikar Adhikari | 2017 | World Journal of Emergency Medicine2017，8，1： | 4 |
| 3 | Effect of Prometheus liver assist system on systemic hemodynamics in patients with cirrhosis: A randomized controlled study显示文摘AIM: To evaluate treatment safety and hemodynamic changes during a single 6-h treatment with the Prometheus? liver assist system in a randomized, controlled study. METHODS: Twenty-four patients were randomized to either the study group or to one of two control groups: Fractionated Plasma Separation Adsorption and Dialysis, Prometheus? system (Study group; n = 8); Molecular Adsorbent Recirculation System (MARS)? (Control group 1, n = 8); or hemodialysis (Control group 2; n = 8). All patients included in the study had decompensated cirrhosis at the time of the inclusion into the study. Circulatory changes were monitored with a Swan-Ganz catheter and bilirubin and creatinine were monitored as measures of protein-bound and water-soluble toxins. RESULTS: Systemic hemodynamics did not differ between treatment and control groups apart from an increase in arterial pressure in the MARS group (P = 0.008). No adverse effects were observed in any of the groups. Creatinine levels significantly decreased in the MARS group (P = 0.03) and hemodialysis group (P = 0.04). Platelet count deceased in the Prometheus group (P = 0.04).CONCLUSION: Extra-corporal liver support with Prometheus is proven to be safe in patients with end- stage liver disease but does not exert the beneficial effects on arterial pressure as seen in the MARS group. | Thomas Dethloff Flemming Tofteng Hans-Jorgen Frederiksen Michael Hojskov Bent Adel Hansen Fin Stolze Larsen | 2008 | World Journal of Gastroenterology2008，14，13： | 4 |
| 4 | rCOS: a formal model-driven engineering method for component-based software显示文摘模型驱动的建筑学(MDA ) 为软件集中的系统设计成为了一种主要的流技术。在它后面的主要工程原则是软件开发的固有的复杂性能仅仅由造被掌握,分析并且操作系统模型。MDA 也由提供基于部件的设计技术处理系统复杂性,允许基于部件的部件设计,实现和推广,然后系统集成和重构连接的独立人士。在任何阶段的一个系统的模型是不同观点的模型的集成。因此,一个模型驱动的方法有效地被使用,它必须为模型建设,确认,和转变提供技术和工具的一间综合套房的身体。这为不同担心的说明和系统的观点要求很多个当模特儿的符号。这些符号应该正式定义句法和语义的一个统一理论。方法的内在的理论被需要支撑,以及正式在关键应用程序关于系统的性质验证并且推理工具的开发和在软件开发的工具的正确使用。当模特儿的符号,技术,和工具必须被设计以便他们能在在软件设计过程支持发展活动和人工制品的文档无缝地被使用。这篇文章介绍如此的一个方法,叫了 rCOS,在软件开发进程在不同阶段集中于一个系统的模型,他们的语义集成,并且他们怎么被构造,分析,转变,验证,并且验证。 | Wei KE Xiaoshan LI Zhiming LIU Volker STOLZ | 2012 | Frontiers of Computer Science2012，6，1： | 4 |
| 5 | Inhibition of Cdk5 increases osteoblast differentiation and bone mass and improves fracture healing显示文摘Identification of regulators of osteoblastogenesis that can be pharmacologically targeted is a major goal in combating osteoporosis,a common disease of the elderly population. Here, unbiased kinome RNAi screening in primary murine osteoblasts identified cyclin-dependent kinase 5(Cdk5) as a suppressor of osteoblast differentiation in both murine and human preosteoblastic cells. Cdk5 knockdown by si RNA, genetic deletion using the Cre-lox P system, or inhibition with the small molecule roscovitine enhanced osteoblastogenesis in vitro. Roscovitine treatment significantly enhanced bone mass by increasing osteoblastogenesis and improved fracture healing in mice. Mechanistically, downregulation of Cdk5 expression increased Erk phosphorylation, resulting in enhanced osteoblast-specific gene expression. Notably, simultaneous Cdk5 and Erk depletion abrogated the osteoblastogenesis conferred by Cdk5 depletion alone, suggesting that Cdk5 regulates osteoblast differentiation through MAPK pathway modulation. We conclude that Cdk5 is a potential therapeutic target to treat osteoporosis and improve fracture healing. | Mubashir Ahmad Benjamin Thilo Krüger Torsten Kroll Sabine Vettorazzi Ann-Kristin Dorn Florian Mengele Sooyeon Lee Sayantan Nandi Dilay Yilmaz Miriam Stolz Naveen Kumar Tangudu David Carro Vázquez Johanna Pachmayr Ion Cristian Cirstea Maja Vujic Spasic Aspasia Ploubidou Anita Ignatius Jan Tuckermann | 2022 | Bone Research2022，10，3： | 2 |
| 6 | Hydrogeochemical and multi-tracer investigations of arsenic-affected aquifers in semi-arid West Africa显示文摘The semi-arid Sahel regions ofWest Africa rely heavily on groundwater from shallow to moderately deep (<100 m b.g.l.) crystalline bedrock aquifers for drinking water production.Groundwater quality may be affected by high geogenic arsenic (As) concentrations (>10 μg/L) stemming from the oxidation of sulphide minerals (pyrite,arsenopyrite) in mineralised zones.These aquifers are still little investigated,especially concerning groundwater residence times and the influence of the annual monsoon season on groundwater chemistry.To gain insights on the temporal aspects of As contamination,we have used isotope tracers (noble gases,3H,stable water isotopes (2H,18O)) and performed hydrochemical analyses on groundwater abstracted from tube wells and dug wells in a small study area in southwestern Burkina Faso.Results revealed a great variability in groundwater properties (e.g.redox conditions,As concentrations,water level,residence time) over spatial scales of only a few hundred metres,characteristic of the highly heterogeneous fractured underground.Elevated As levels are found in oxic groundwater of circum-neutral pH and show little relation with any of the measured parameters.Arsenic concentrations are relatively stable over the course of the year,with little effect seen by the monsoon.Groundwater residence time does not seem to have an influence on As concentrations,as elevated As can be found both in groundwater with short (<50 a) and long (>10^3 a) residence times as indicated by 3He/4He ratios spanning three orders of magnitude.These results support the hypothesis that the proximity to mineralised zones is the most crucial factor controlling As concentrations in the observed redox/pH conditions.The existence of very old water portions with residence times >10^3 years already at depths of <50 m b.g.l.is a new finding for the shallow fractured bedrock aquifers of Burkina Faso,suggesting that overexploitation of these relatively low-yielding aquifers may be an issue in the future. | Anja Bretzler Lucien Stolze Julien Nikiema Franck Lalanne Elaheh Ghadiri Matthias S. Brennwald Massimo Rolle Mario Schirmer | 2019 | Geoscience Frontiers2019，10，5： | 2 |
| 7 | Concept and proof for an all-silicon MEMS micro speaker utilizing air chambers显示文摘MEMS-based micro speakers are attractive candidates as sound transducers for smart devices,particularly wearables and hearables.For such devices,high sound pressure levels,low harmonic distortion and low power consumption are required for industrial,consumer and medical applications.The ability to integrate with microelectronic circuitry,as well as scalable batch production to enable low unit costs,are the key factors benchmarking a technology.The Nanoscopic Electrostatic Drive based,novel micro speaker concept presented in this work essentially comprises inplane,electrostatic bending actuators,and uses the chip volume rather than the its surface for sound generation.We describe the principle,design,fabrication,and first characterization results.Various design options and governing equations are given and discussed.In a standard acoustical test setup(ear simulator),a MEMS micro speaker generated a sound pressure level of 69 dB at 500 Hz with a total harmonic distortion of 4.4%,thus proving the concept.Further potential on sound pressure as well as linearity improvement is outlined.We expect that the described methods can be used to enhance and design other MEMS devices and foster modeling and simulation approaches. | Bert Kaiser Sergiu Langa Lutz Ehrig Michael Stolz Hermann Schenk Holger Conrad Harald Schenk Klaus Schimmanz David Schuffenhauer | 2019 | Microsystems & Nanoengineering2019，5，1： | 2 |
| 8 | What is the ideal approach for emergent pericardiocentesis using point-of-care ultrasound guidance?显示文摘BACKGROUND:Traditionally performed using a subxiphoid approach,the increasing use of point-of-care ultrasound in the emergency department has made other approaches(parasternal and apical)for pericardiocentesis viable.The aim of this study is to identify the ideal approach for emergency-physician-performed ultrasound-guided pericardiocentesis as determined by ultrasound image quality,distance from surface to pericardial fl uid,and likely obstructions or complications.METHODS:A retrospective review of point-of-care cardiac ultrasound examinations was performed in two urban academic emergency departments for the presence of pericardial eff usions.The images were reviewed for technical quality,distance of eff usion from skin surface,and predicted complications.RESULTS:A total of 166 pericardial effusions were identified during the study period.The mean skin-to-pericardial fl uid distance was 5.6 cm(95%confi dence interval[95%CI]5.2-6.0 cm)for the subxiphoid views,which was signifi cantly greater than that for the parasternal(2.7 cm[95%CI 2.5-2.8 cm],P<0.001)and apical(2.5 cm[95%CI 2.3-2.7 cm],P<0.001)views.The subxiphoid view had the highest predicted complication rate at 79.7%(95%CI 71.5%-86.4%),which was signifi cantly greater than the apical(31.9%;95%CI 21.4%-44.0%,P<0.001)and parasternal(20.2%;95%CI 12.8%-29.5%,P<0.001)views.CONCLUSIONS:Our results suggest that complication rates with pericardiocentesis will be lower via the parasternal or apical approach compared to the subxiphoid approach.The distance from skin to fl uid collection is the least in both of these views. | Lori Stolz Elaine Situ-LaCasse Josie Acuña Matthew Thompson Nicolaus Hawbaker Josephine Valenzuela Uwe Stolz Srikar Adhikari | 2021 | World Journal of Emergency Medicine2021，12，3： | 2 |
| 9 | One-dimensional Schrodinger operators with local point interactions 显示文摘 | Buschmann D Stolz G Weidmann J | 1995 | J Reine Angew Math1995，467，： | 1 |
| 10 | Assessment of intracranial venous hemodynamics in normal individuals and patients with cerebral venous thrombosis显示文摘 | Kaps M Dorndorf W | 1999 | Stroke1999，30，： | 1 |
| 11 | Cross-talk between epidermal growth factor receptor c-Met signal pathways in transformed cells 显示文摘 | Jo M Stolz DB Esplen JE | 2000 | J Biol Chem2000，275，12： | 1 |
| 12 | Plant sucrose-H+symporters mediate the transport of vitamin H显示文摘 | Ludwig A Stolz J Sauer N | 2000 | Plant J2000，24，4： | 1 |
| 13 | Increase of cytosolic calcium results in formation of F-actin aggregates in endothelial cells显示文摘 | STOLZ B BEREITER-HAHN J | 1988 | Cell Biol Int Rep1988，12，： | 1 |
| 14 | Antibiotic treatment of exacerbations of COPD: a randomized, controlled trial comparing procalcitonin-guidance with standard therapy显示文摘 | Stolz D Christ-Crain M Bingisser R | 2007 | Chest2007，131，1： | 1 |
| 15 | Achromobacter, Alcaligenes and related genera 显示文摘 | Busse H Stolz A | 2006 | Prokaryotes2006，，5： | 1 |
| 16 | Complete first-orderRaman spectra of the pyrite structure compounds FeS2,MnS2and SiP2显示文摘 | Vogt H Chattopadhgay T Stolz H J | 1983 | Journal of Physics and Chemistry of Sol-ids1983，44，9： | 1 |
| 17 | Antibiotic treatment of exacerbation of COPD: a randomized, controlled trial comparing procalcitonin guidance with standard therapy显示文摘 | Stolz D Christ-Criain M Bingisser R | 2007 | Chest2007，131，1： | 1 |
| 18 | Essential role of integrin-linked kinase in podocyte biology:bridging the lntegrin and slit diaphragm signaling显示文摘 | Dai C Stolz DB Bastacky SI | 2006 | J Am Soc Nephro12006，17，8： | 1 |
| 19 | Biomarkers in lower respiratory tract infections显示文摘 | BLASI F STOLZ D PIFFER F | 2010 | Pulm Pharmacol Ther2010，23，6： | 1 |
| 20 | Systemic Biomarkers in Exacerbations of COPDSystemic Biomarkers in COPD ExacerbationsThe Evolving Clinical Challenge显示文摘 | Koutsokera A Stolz D Loukides S | 2012 | CHEST Journal2012，141，2： | 1 |
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