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| 1 | Hepatitis C virus in the new era:Perspectives in epidemiology,prevention,diagnostics and predictors of response to therapy显示文摘Despite the great successes achieved in the fields of virology and diagnostics,several difficulties affect improvements in hepatitis C virus(HCV)infection control and eradication in the new era.New HCV infections still occur,especially in some of the poorest regions of the world,where HCV is endemic and long-term sequelae have a growing economic and health burden.An HCV vaccine is still no available,despite years of researches and discoveries about the natural history of infection and host-virus interactions:several HCV vaccine candidates have been developed in the last years,targeting different HCV antigens or using alternative delivery systems,but viral variability and adaption ability constitute major challenges for vaccine development.Many new antiviral drugs for HCV therapy are in preclinical or early clinical development,but different limitations affect treatment validity.Treatment predictors are important tools,as they provide some guidance for the management of therapy in patients with chronic HCV infection:in particular,the role of host genomics in HCV infection outcomes in the new era of direct-acting antivirals may evolve for new therapeutic targets,representing a chance for modulated and personalized treatment management,when also very potent therapies will be available.In the present review we discuss the most recent data about HCV epidemiology,the new perspectives for the prevention of HCV infection and the most recent evidence regarding HCV diagnosis,therapy and predictors of response to it. | Filippo Ansaldi Andrea Orsi Laura Sticchi Bianca Bruzzone Giancarlo Icardi | 2014 | World Journal of Gastroenterology2014，20，29： | 16 |
| 2 | Lone and secondary nonvalvular atrial fibrillation: role of a genetic suseeptibility显示文摘 | FATINI C STICCHI E GENSINI F | 2007 | Int J Cardiol2007，120，： | 1 |
| 3 | ACE DD genotype: an independent predisposition factor to venous thromboembolism显示文摘 | FATINI C GENSINI F STICCHI E | 2003 | Eur J Clin Invest2003，33，： | 1 |
| 4 | Analysis of mink and eNOS genes as candidate loci for predisposition to non- valvular atrial fibrillation显示文摘 | Fatini C Sticchi E Genuardi M | 2006 | Eur Heart J2006，27，14： | 1 |
| 5 | eNOS G894T polymorphism as a mild predisposing factor for abdominal aortic aneurysm 显示文摘 | Fatini C Sofi F Sticchi E | 2005 | J Vasc Surg2005，42，3： | 1 |
| 6 | Analysis ofminK and eNOS genes as candidate loci for predisposi-tion to non- valvular atrial fibrillation 显示文摘 | Fatini C Sticchi E Genuardi M | 2006 | Eur HeartJ2006，27，14： | 1 |
| 7 | Plasma adiponectin for prediction of cardiovascular events and mortality in high risk patients 显示文摘 | Maiolino G Cesari M Sticchi D | 2008 | J Clin Endocrinol Metab2008，93，： | 1 |
| 8 | Analysis of minK and eNOS genes as candidate loci for predisposition to non-valvular atrial fibrillation显示文摘 | Fatini C Sticchi E Genuardi M | 2006 | Eur Heart J2006，27，14： | 1 |
| 9 | Influence of endo- thelial nitric oxide synthase gene polymorphisms (G894T, 4a4b, T-786C) and hyperhomocysteine- m~a on the predisposition to acute coronary syn- dromes 显示文摘 | Fatini C Sofi F Sticchi E | 2004 | Am Heart J2004，147，3： | 1 |
| 10 | Protein Z gene polymor- phisms ( intron F 79 G > A; -13 A > G) are not associated with acute coronary syndromes 显示文摘 | CESARI F FATINI C STICCHI E | 2006 | Thromb Haemost2006，96，1： | 1 |
| 11 | Is homocysteine important as risk factor for cornary heart diseases 显示文摘 | Cesari I Rossi GP Sticchi D | 2005 | Nutr Metab Carduivasc Dis2005，15，2： | 1 |
| 12 | Fish intake and LPA93C > T polymorphism: gene -enviroment interation in modulating lipoprotein (a) concentration 显示文摘 | Sofi F Fatini C Sticchi E | 2007 | Atherosclerosis2007，195，2： | 1 |
| 13 | Influence of endothelial nitric oxide synthase gene polymorphisms(G894T,4a4b,T786C) and hyperhomocysteinemia on the predisposition to acute coronary syndromes显示文摘 | Fatini C Sofi F Sticchi E | 2004 | Am Heart J2004，147，3： | 1 |
| 14 | LPA + 93C > T and + 121Gtu > A polymorphims detection by electrochip tecnology 显示文摘 | Sticchi E Left M Giusti B | 2007 | Mol Genet Metab2007，91，1： | 1 |
| 15 | Analysis of minK and eNOS genes as candidate loci for predisposi?tion to non - valvular atrial fibrillation显示文摘 | Fatini C Sticchi E Genuardi M | 2006 | Eur HeartJ2006，27，14： | 1 |
| 16 | Decline in pneumonia andacute otitis media after the introduction of childhood pneumococcalvaccination in Liguria, Italy 显示文摘 | Ansaldi F Sticchi L Durando P | 2008 | J Int Med Res2008，36，6： | 1 |
| 17 | Lone and secondary nonvalvu- lar atrial fibrillation: role of a genetic susceptibility 显示文摘 | Fatini C Sticchi E Gensini F | 2007 | Int J Cardi- ol2007，120，1： | 1 |
| 18 | Lone and secondary nonvalvular atrial fibrillation : role of a genetic susceptibility显示文摘 | Fatini C Sticchi E Gensini F | 2007 | International Journal of Cardiology2007，120，： | 1 |
| 19 | Adiponectin receptor expression in the human adrenal cortex and aldosterone- producing adenoma显示文摘 | Rossi GP Sticchi D GiulianiL | 2006 | Int J Mol Med2006，17，6： | 1 |
| 20 | Is homocysteine important as risk factor for coronary heart diseases? 显示文摘 | Cesari M Rossi GP Sticchi D | 2005 | Nutr Metab Cardiovasc Dis2005，15，2： | 1 |
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