|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Towards an evaluation of alcoholic liver cirrhosis and nonalcoholic fatty liver disease patients with hematological scales显示文摘BACKGROUND Seeking potentially novel blood markers of liver fibrosis and steatosis is constantly of crucial importance.Despite a growing number of studies in this field of hepatology,a certain role of hematological indices in the course of liver disorders has not been fully elucidated,yet.AIM To evaluate a diagnostic accuracy of neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR)and mean platelet volume-to-platelet-ratio(MPR)in the course of alcoholic liver cirrhosis(ALC)and nonalcoholic fatty liver disease(NAFLD).METHODS One hundred forty-two patients with ALC,92 with NAFLD and 68 persons in control group were enrolled in the study.Hematological indices(NLR,PLR and MPR),indirect and direct markers of liver fibrosis(aspartate transaminase to alkaline transaminase ratio,aspartate transaminase to platelet ratio index,fibrosis-4,gamma-glutamyl transpeptidase to platelet ratio,procollagen Ⅰ carboxyterminal propeptide,procollagen Ⅲ aminoterminal propeptide,transforming growth factor-α,platelet-derived growth factor AB,laminin)were measured in each person.Model for end-stage liver disease(MELD)score in ALC group and NAFLD fibrosis score together with BARD score were calculated in NAFLD patients.Receiver operating characteristic(ROC)curves and area under the curve(AUC)values were applied to assess the sensitivity and specificity of examined markers and to evaluate proposed cut-offs of measured indices in the course of ALC and NAFLD.RESULTS MPR and NLR values in ALC patients were significantly higher in comparison to control group;PLR level was significantly lower.MPR and PLR correlated with assessed indirect and direct markers of liver fibrosis.MPR,NLR and PLR correlated with MELD score.NLR level in NAFLD patients was significantly higher in comparison to controls.MPR correlated with indirect markers of liver fibrosis and NAFLD fibrosis score.AUC values and proposed cut-offs for NLR,PLR and MPR in ALC patients were:0.821(>2.227),0.675(<70.445)and 0.929(>0.048),respectively.AUC values and proposed cut-offs for NLR,PLR and MPR in NAFLD group were:0.725(>2.034),0.528(>97.101)and 0.547(>0.038),respectively.CONCLUSION Hematological markers are inseparably connected with serological indices of liver fibrosis in ALC and NAFLD patients.MPR and NLR turned out to be the most powerful parameters in ALC patients. | Agata Michalak Halina Cichoz-Lach Malgorzata Guz Joanna Kozicka Marek Cybulski Witold Jeleniewicz Andrzej Stepulak | 2020 | World Journal of Gastroenterology2020，26，47： | 6 |
| 2 | Squamous cell carcinoma antigen levels in patients with laryn- geal cancer 显示文摘 | POLBERG K STEPULAK A STRYJECKA-ZIMMER M | 2005 | Pol Merkur Lekarski2005，19，111： | 1 |
| 3 | Squamous cell carcinoma antigen levels in patients with larngeal cancer 显示文摘 | Polberg K Stepulak A Stryjecka Z | 2005 | Pol Merkur Lekarski2005，19，111： | 1 |
| 4 | Squamous cell carcino-ma antigeri levels ii patients with laryngeal cancer 显示文摘 | Polberg K Stepulak A Zawislak J | 2005 | PolMerkuriusz Lek2005，19，111： | 1 |
| 5 | Squa- mous cell carcinoma antigen levels in patients with laryngeal caneer polmerkuriusz显示文摘 | Polberg K Stepulak A Strviecka Zimmer M | 2005 | LEK2005，19，111： | 1 |
| 6 | Sequamous cell carcinoma antigen levels in patients with liver cancer 显示文摘 | Polberg K Stepulak A Zawislak J | 2011 | Pol Merku2011，19，111： | 1 |
| 7 | Squamous cell carcinoma antigen levels in patients with laryngeal cancer显示文摘 | Polberg K Stepulak A Zawislak J | 2005 | Pol Merkuriusz Lek2005，19，111： | 1 |
| 8 | Expression of glutamate receptor subunits in human cancers显示文摘 | Stepulak A Luksch H Gebhardt C | 2009 | Histochem Cell Biol2009，132，： | 1 |
| 9 | Expression of glutamate receptor subunits in human cancers显示文摘 | Stepulak A Luksch H Gebhardt C | 2009 | Histochem Cell Biol2009，132，4： | 1 |
| 10 | The intermediate filament protein keratin 8 is a novel cytoplasmic substrate for c-jun N-terminal kinase 显示文摘 | He T Stepulak A Holmstrom TH | 2002 | J Biol Chem2002，29，10： | 1 |
| 11 | Histone deacetylase inhibitors as a new generation of anti-cancer agents 显示文摘 | Stepulak A Stryjecka-Zimmer M Kupisz K | 2005 | Postepy Hig Med Dosw2005，11，59： | 1 |
| 12 | Squamous cell carcinoma antigen levels in patients with laryngeal cancer显示文摘 | Polberg K Stepulak A Stryjecka-Zimmer M | 2005 | Pol Merkur Lekarski2005，19，111： | 1 |
| 13 | Squamous cell carcinoma antigen levels in patients with laryngeal cancer显示文摘 | Polberg K Stepulak A Zawislak J | 2005 | Pol Merkur Lekarski2005，19，111： | 1 |
| 14 | NMDA antagonist inhibits the extracellular signal-regulated kinase pathway and suppresses cancer growth显示文摘 | Stepulak A Sifringer M Rzeski W | 2005 | Proc Natl Acad Sci U S A2005，102，15： | 1 |
| 15 | Expression of glutamate receptor subunits in human cancers 显示文摘 | Stepulak A Luksch H Gebhardt C | 2009 | Histochem Cell Biol2009，132，4： | 1 |
| 16 | Squamous cell carcinoma antigen levels in patients with laryngeal cancer 显示文摘 | Polberg K Stepulak A Zawislak J | 2005 | Pol Merkur Lekarski2005，19，： | 1 |
| 17 | Squamous cell carcinoma antigen levels in patients with laryngealcancer显示文摘 | POLBERG K STEPULAK A STRYJECKA ZIMMER M | 2005 | Pol Merkur Lekarski2005，19，111： | 1 |
| 18 | The intermediate filament protein keratin 8 is a novel cytoplasmic substrate for c-Jun N-terminal kinase 显示文摘 | HE T STEPULAK A HOLMSTR M TH | 2002 | J Biol Chem2002，277，10： | 1 |
| 19 | Squamous cell carcinoma antigen levels in patients with laryngeal caneer显示文摘 | Polberg K Stepulak A Stryjecka-Zimmer M | 2005 | Pal Merkuriusz Lek2005，19，111： | 1 |
| 20 | Squamous cell carcinoma antigen levels in patients with different stages of laryngeal cancer显示文摘 | Polberg K Stepulak A Stryjecka-Zimmer M | 2005 | Pol Merkur Lekarski2005，19，111： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员