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| 1 | Origin of CD8^+ Effector and Memory T Cell Subsets显示文摘It is well accepted that CD8 + T cells play a pivotal role in providing protection against infection with intracellular pathogens and some tumors.In many cases protective immunity is maintained for long periods of time (immunological memory).Over the past years,it has become evident that in order to fulfill these multiple tasks, distinct subsets of effector and memory T cells have to be generated.Until today,however,little is known about the underlying mechanisms of subset differentiation and the timing of lineage fate decisions.In this context,it is of special importance to determine at which level of clonal expansion functional and phenotypical heterogeneity is achieved.Different models for T cell subset diversification have been proposed;these differ mainly in the time point during priming and clonal expansion(prior,during,or beyond the first cell division)when differentiation programs are induced.Recently developed single-cell adoptive transfer technology has allowed us to demonstrate that individual precursor cell still bears the full plasticity to develop into a plethora different T cell subsets.This observation targets the shaping of T cell subset differentiation towards factors that are still operative beyond the first cell division.These findings have important implications for vaccine development,as the modulation of differentiation patterns towards distinct subsets could become a powerful strategy to enhance the efficacy and quality of vaccines. | Christian Stemberger Michael Neuenhahn Veit R.Buchholz Dirk H.Busch | 2007 | Cellular & Molecular Immunology2007，4，6： | 2 |
| 2 | Empirical scale of side-chain conformational entropy in protein folding显示文摘 | Pickett SD Stemberg MJ | 1993 | J Mol Biol1993，231，： | 1 |
| 3 | Osteoarthritis:physical medicine and rehabilitation-nonpharmacological management显示文摘 | Stemberger R Kerschan-Schindl K | | 0，，： | 1 |
| 4 | Aguantatine system for staging avascular necrosis显示文摘 | Stemberg ME Hayken GD Stemberg DR | 1995 | J Bone Joint surg Br1995，77，： | 1 |
| 5 | Blood-brain barrier protein recognized by monoclonal antibody显示文摘 | Stemberger NH Stemberger LA | 1987 | Proc Natl Acatl Sci USA1987，84，22： | 1 |
| 6 | Image Analysis Using Mathematical Morphology 显示文摘 | Haralick R M Stemberg S R Zhuang X | 1987 | IEEE Trans Comput1987，9，3： | 1 |
| 7 | Utility of bronchoalveolar lavage in assessing pneumonia in immunosuppressed renal transplant recipients 显示文摘 | Stemberg RI Baughman RP Dohn MN | 1993 | Am J Med1993，95，： | 1 |
| 8 | Body size, food concentration and population growth in planktonic rotifer显示文摘 | Stemberger R S Gilbert J J | 1985 | Ecology1985，66，： | 1 |
| 9 | Towards e-government by business process change - A methodology for public sector显示文摘 | Stemberger M I Jaklic J | 2007 | Internation- al Journal of Information Management2007，27，4： | 1 |
| 10 | C-terminal nucleophosmin mutations are uncommon in chronic myeloid disorders 显示文摘 | Caudill JS Stemberg A J Li CY el al | 2006 | Br J Haemato12006，133，6： | 1 |
| 11 | Water-use patterns of woody species in pineland and hammock communities of South Florida 显示文摘 | Ewe S M L Silveira L D Stemberg L | 1999 | Forest Ecology and Management1999，118，： | 1 |
| 12 | Microscopic study of the initial stages of eggshell calcification 显示文摘 | STEMBERGER B H MUELLER W J LEACH R M | 1977 | Poultry Sci1977，56，： | 1 |
| 13 | Electromyography guides toward subgroups of mutations in muscle channelopathies显示文摘 | FouRNIER E ARZEL M STEMBERG D | 2004 | Ann Neurol2004，56，： | 1 |
| 14 | Entrepreneurship: The role of clusters theoretical perspectives and empirical evidence from Germany显示文摘 | Rocha H O Stemberg R | 2005 | Small Business Economics2005，24，3： | 1 |
| 15 | Abilities are formsof developing expertise显示文摘 | Stemberg R J | 1998 | Educational Researcher1998，27，3： | 1 |
| 16 | Immunoreactivi- ty of p53, Ki67, and cerB - 2 in phyllodes tumors of the breast in correlation with clinical and morphologic features 显示文摘 | Shpitz B Bomstein Y Stemberg A | 2002 | J Surg Oncol2002，79，2： | 1 |
| 17 | Managerial Intelligence: Why IQ isn't enough显示文摘 | STEMBERG R J | 1997 | Journal of Management1997，23，3： | 1 |
| 18 | Bioremoval of lead from water using Lemna minor显示文摘 | RAHMANI G N H STEMBERG S P K | 1999 | Bioresource Technology1999，70，3： | 1 |
| 19 | Testing Common Sense显示文摘 | Stemberg RJ Wagner R Williams WM Horvath J | 1995 | American Psycholog Nt1995，50，4： | 1 |
| 20 | Current therapies and advances in the treatment of pancreatic cancer显示文摘 | Mancuso A Calabro F Stemberg CN | 2006 | Crit Rev Oncol Hemat2006，58，3： | 1 |
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