|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Dementia and geriatric cognitive disorders 显示文摘 | Cepek L Brechlin P Steinacker P | 2007 | Dement Geriatr Cogn Disord2007，23，1： | 1 |
| 2 | On the interpolation of precipitation data over complex terrain显示文摘 | Dorninger M Schneider S Steinacker R | 2008 | Meteorol Atmos Phys2008，101，： | 1 |
| 3 | Changes in skeletal muscle heat shock proteins : pathologial significance显示文摘 | Liu Y Steinacker JM | 2001 | Front Biosc2001，6，1： | 1 |
| 4 | Training of junior rowers before world championships: effects on performance, mood state and selected hormonal and metabolic responses显示文摘 | STEINACKER J M LORMES W KELLMANN M | 2000 | J Sports IVied Phys Fitn2000，40，： | 1 |
| 5 | New aspects of the hormone and cytokine response to training 显示文摘 | Steinacker JM Lormes W Reissnecker S | 2004 | Eur J Appl Physiol2004，91，： | 1 |
| 6 | Effect of'living hish-traininglow'on the cardiac functions at sea level显示文摘 | Liu Y Steinacker JM Dehnert C | 1998 | Int J Sports Med1998，19，6： | 1 |
| 7 | New Aspects of the Hormone and Cytokine Response to Training显示文摘 | Steinacker JM Lormes W Reissnecker S | 2004 | Eur J Appl Physiol JT2004，91，4： | 1 |
| 8 | Erythropoiesis andperformance after two weeks of living high andtraining low in welltrained triathletes显示文摘 | DehnertC Hutler M Liu Y Menold E Netzer C Schick R Kubanek B Lehmann M Boning D Steinacker JM | 2002 | Int J Sports Med2002，23，8： | 1 |
| 9 | Changes in skeletal muscle heat shock proteins: pathological significance显示文摘 | Steinacker JM | 2001 | Front Biosci2001，6，： | 1 |
| 10 | New aspects of the hormone and cytokine response to training 显示文摘 | Steinacker J M Lormes W Reissnecker S | 2004 | Eur J Appl Physiol2004，91，4： | 1 |
| 11 | 14-3-3 proteins in neurodegenera- tion显示文摘 | Steinacker P Aitken A Otto M | 2011 | Semin Cell Dev Biol2011，22，： | 1 |
| 12 | Changes in skeletal muscle heat shock proteins:pathological significance显示文摘 | Liu Y Steinacker J M | 2001 | Fromtiers in Bioscience2001，6，： | 1 |
| 13 | Ruderspiroergometrische Laengesschnittuntersuchungen Ueber 2 Jahre Bei Zwei Wetlmeisterschaftsteinehmern显示文摘 | MARX U J M STEINACKER | 1988 | Rudern (Buch)1988，，： | 1 |
| 14 | Thyroid hormones, cytokines, physical training and metabolic control显示文摘 | Steinacker J M Brkic M Simsch M | 2005 | Hormone and Metabolic Research2005，37，9： | 1 |
| 15 | Changes in skeletal muscle heat shock proteins:Pathological significance显示文摘 | Liu Y Steinacker JM | 2010 | Front Biosci2010，6，： | 1 |
| 16 | Follow-up investigations of tau protein and S-100B levels in cerebrospinal fluid of patients with Creutzfeidt-Jakob disease显示文摘 | Cepek L Steinacker P Mollenhauer B | 2005 | Dement Geriatr Cogn Disord2005，19，56： | 1 |
| 17 | Heart fatty acid binding protein as a potential diagnostic marker for neurodegenerative diseases显示文摘 | Steinacker P Mollenhauer B Bibl M | 2004 | Neurosci Lett2004，370，1： | 1 |
| 18 | Follow-up investigations of tau protein and S-100B levels in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease显示文摘 | Cepek L Steinacker P Mollenhauer B | 2005 | Dement Geriatr Cogn Disord2005，19，56： | 1 |
| 19 | Changes in skeletal muscle heat shock proteins:pathological significance显示文摘 | Liu Y Steinacker JM | 2001 | Front Biosci2001，6，： | 1 |
| 20 | Neuroflament light and heterogeneity of disease progression in amyotrophic lateral sclerosis:development and validation of a prediction model to improve interventional trials显示文摘Background:Interventional trials in amyotrophic lateral sclerosis(ALS)sufer from the heterogeneity of the disease as it considerably reduces statistical power.We asked if blood neuroflament light chains(NfL)could be used to antici‑pate disease progression and increase trial power.Methods:In 125 patients with ALS from three independent prospective studies-one observational study and two interventional trials-we developed and externally validated a multivariate linear model for predicting disease pro‑gression,measured by the monthly decrease of the ALS Functional Rating Scale Revised(ALSFRS-R)score.We trained the prediction model in the observational study and tested the predictive value of the following parameters assessed at diagnosis:NfL levels,sex,age,site of onset,body mass index,disease duration,ALSFRS-R score,and monthly ALSFRS-R score decrease since disease onset.We then applied the resulting model in the other two study cohorts to assess the actual utility for interventional trials.We analyzed the impact on trial power in mixed-efects models and compared the performance of the NfL model with two currently used predictive approaches,which anticipate disease progression using the ALSFRS-R decrease during a three-month observational period(lead-in)or since disease onset(ΔFRS).Results:Among the parameters provided,the NfL levels(P<0.001)and the interaction with site of onset(P<0.01)contributed signifcantly to the prediction,forming a robust NfL prediction model(R=0.67).Model application in the trial cohorts confrmed its applicability and revealed superiority over lead-in andΔFRS-based approaches.The NfL model improved statistical power by 61%and 22%(95%confdence intervals:54%-66%,7%-29%).Conclusion:The use of the NfL-based prediction model to compensate for clinical heterogeneity in ALS could signif‑cantly increase the trial power.NCT00868166,registered March23,2009;NCT02306590,registered December 2,2014. | Simon Witzel Felix Frauhammer† Petra Steinacker David Devos Pierre‑François Pradat Vincent Meininger Stefen Halbgebauer Patrick Oeckl Joachim Schuster Simon Anders Johannes Dorst Markus Otto Albert C.Ludolph | 2021 | Translational Neurodegeneration2021，10，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员