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| 1 | 谷氨酰胺和丙氨酰-谷氨酰胺双肽影响人回结肠粘膜增殖的离体实验显示文摘背景/目的谷氨酰胺(Gln)对危重患者小肠上皮有一定营养作用。在肠外营养时由于其不够稳定而限制了它的应用,但此不足可通过使用稳定的丙氨酰-谷氨酰胺双肽(Ala-Gln)而克服。本研究目的是验证如下假设,即谷氨酰胺或丙氨酰-谷氨酰胺双肽不但可以刺激回肠细胞增殖,而且可以刺激结肠细胞增殖,维护肠屏障功能。方法将正常人回肠、近段结肠、乙状结肠及直肠活检标本分别加入谷氨酰胺(2mmol/L)、丙氨酰-谷氨酰胺双肽(2mmol/L)、生理盐水(对照),孵育4小时。S期的细胞用5溴-2脱氧尿苷标记。对被标记的腺管纵向切片和静止期细胞进行记数。结果谷氨酰氨和丙氨酰-谷氨酰胺双肽可以刺激回肠细胞、近段结肠、乙状结肠及直肠腺管细胞的增殖。在回肠标本,整个腺管的细胞均被较好的标记,而在结肠则主要对腺管的基底部分有营养作用。结论谷氨酰胺或丙氨酰-谷氨酰胺双肽不但对回肠细胞,而且对结肠细胞有营养作用,从而可阻止肠外营养时肠粘膜萎缩,维护肠屏障功能。 | Peter Stehle Peter Fuerst 梁存河 | 2002 | 中国临床营养杂志2002，10，1： | 13 |
| 2 | 德国机床工业的创新和趋势显示文摘机床是一个复杂的机电一体化系统。机床的创新离不开新结构、新材料、新的功能部件、新刀具和新的外围设备。加工工艺的发展以及加工过程的仿真和监控也日益受到重视。 | U·Heisel T·Stehle 张曙(译) | 2009 | 航空制造技术2009，52，5： | 2 |
| 3 | Criteria for the growth of large-area adlayer-free monolayer graphene films by chemical vapor deposition显示文摘Homogeneity is important to material applications for good performance of individual devices,for making AB-stacked bilayer graphene in a layer-by-layer stacking order,and from the point of view of industrial production.Among many properties to be controlled,for the case of graphene,the thickness(or layer number)uniformity is the prerequisite.Chemical vapor deposition(CVD)of C precursors on Cu substrates is the most popular method to produce large-area graphene films.To date,precise control on the number of graphene layers as well as the uniformity over a large area is still very challenging.In this work,with a further understanding of the factors affecting adlayer growth,the synthesis of large-area adlayer-free monolayer graphene(MLG)films was achieved up to tens of squared centimeters in area by just using untreated Cu foil and a normal CVD process.We found that keeping equal C precursor concentration on the two sides of the Cu substrate is a criterion in addition to other factors such as the ratio of H:C and the substrate surface morphology for the growth of adlayer-free MLG.This finding is not only of great significance for the industrial production of large-area adlayer-free MLG films but also instructive for the synthesis of homogeneous few-layer graphene. | Changqing Shen Xingzhou Yan Fangzhu Qing Xiaobin Niu Richard Stehle Samuel S.Mao Wanli Zhang Xuesong Li | 2019 | Journal of Materiomics2019，5，3： | 2 |
| 4 | Structure-Function Analysis of Arabidopsis thaliana Histidine Kinase AHK5 Bound to Its Cognate Phosphotransfer Protein AHP1显示文摘多步 phosphorelay (MSP ) 系统在植物和许多优核质定义一条关键信号 transduction 小径。在这个系统,外部刺激首先导致 histidine kinase 的激活,从 kinase (HKRD ) 的接收装置领域由一个 phosphoryl 组的转移列在后面到下游, cytosolic phosphotransfer 蛋白质(HP ) 。为了为这建立特性的决定因素发信号,中继系统,我们解决了植物 HKRD 的第一水晶结构, AHK5RD 在有它的血缘的 HP 之一的建筑群, AHP1。AHP1 经由停靠山脉和一个恐水病的补丁的一张突出的氢契约绑 AHK5RD。这些特征在所有 AHP 蛋白质之中被保存,但是与原核生物的描绘的另外的在结构上和真核细胞的 HP 显著地不同。AHK5RD 绑在 AHP1-3 与的表面电浆子回声实验表演类似, micromolar 亲密关系,与这发信号的建筑群的短暂性质一致。我们结构、功能的数据的关联提供第一卓见在原子水平以及与量的亲密关系数据,在植物管理 MSP 进分子的识别事件。 | Johannes Bauer Kerstin Reiss Manikandan Veerabagu Michael Heunemann Klaus Harter Thilo Stehle | 2013 | Molecular Plant2013，6，3： | 2 |
| 5 | Crystal structure of the extracellular segment of integrin alphaVbeta3 in complex with an Arg-Gly-Asp ligand显示文摘 | Xiong J P Stehle T Zhang R | 2002 | Science2002，296，5565： | 1 |
| 6 | Determination of part-per-trillion concentrations of 2,3,7,8-tetrachlorodibenzo-p-dioxin in fish 显示文摘 | LAMPARSKI L L NESTRICK T J STEHL R H | 1979 | Anal Chem1979，51，9： | 1 |
| 7 | Identification of cancer stem cells in Ewing's sarcoma显示文摘 | Suva M L Riggi N Stehle J C | 2009 | Cancer Res2009，69，5： | 1 |
| 8 | CD44v6: a target for antibody-based cancer therapy 显示文摘 | Heider KH Kuthan H Stehle G | 2004 | Cancer Immunol Immunother2004，53，7： | 1 |
| 9 | Determination of part-per-trillion concentration of 2,3,7,8-tetrachlorodibenzo-p-dioxin in fish显示文摘 | Nestrick T J Stehl R H | 1979 | Anal Chem1979，51，9： | 1 |
| 10 | Melatonin: a clock-output, a clock-input 显示文摘 | Stehle JH Von Gall C Korf HW | 2003 | J Neuroendocrino12003，15，4： | 1 |
| 11 | Laparoscopic-as- sisted cystotomy for urolith removal in geldings显示文摘 | R~cken M Stehle C Mosel G | 2006 | Veterinary Surgery2006，35，： | 1 |
| 12 | Crystal structure of the extracellular segment of integrin alpha V beta3 in complex with an Arg-Gly-Asp ligand 显示文摘 | Xiong JP Stehle T Zhang R | 2002 | Science2002，296，： | 1 |
| 13 | Water, K+, H+, lactate and glucose fluxes during cell volume regulation in perfused rat liver显示文摘 | Florian Lang Thomas Stehle Dieter H?ussinger | 1989 | Pflügers Archiv European Journal of Physiology1989，，3： | 1 |
| 14 | 显示文摘 | Huff T Speed C S | 1981 | J Appl Polym Sci1981，26，： | 1 |
| 15 | Crystal structure of the extracellular segment of integrin αVβ3显示文摘 | Xiong JP Stehle T Diefenbach B | 2001 | Science2001，294，： | 1 |
| 16 | Electrophysiological characterization of the pineal gland of golden hamsters显示文摘 | Stehle J Reuss S Vollrath L | 1987 | Exp Brain Res1987，67，1： | 1 |
| 17 | Arthroscopic repair of subscapularis tendon tear显示文摘 | Musil D Sadovsky P Stehlík J | | 0，，03： | 1 |
| 18 | Melatonin receptors in human hypothalamus and pituitary:Implications for circadian and reproductive responses to melatonin显示文摘 | Weaver D R Stehle J H Stopa E G | 1993 | J Clin Endocrinol Metab1993，76，2： | 1 |
| 19 | Autologous Transfusion显示文摘 | Stehling L | 1990 | International Anesthesiology Clinics1990，28，4： | 1 |
| 20 | Glutamine dipeptides in clinical nutrition显示文摘 | Furst P Pogan K Stehle P | 1997 | Nutri1997，13，78： | 1 |
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