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| 1 | 胆固醇结石病人肝脏胆小管侧膜ATP基因表达差异的研究显示文摘目的:本研究旨在测定比较胆石病人与对照组肝脏胆小管侧膜转运蛋白表达差异,以探讨胆石病发生的分子生物学机制。方法:研究包括20例胆囊胆固醇结石病人和11例无胆石症的对照。测定血清胆固醇和甘油三酯、胆汁胆固醇、胆汁酸和磷脂含量,采用Carey表计算胆汁胆固醇饱和指数。实时定量PCR法测定肝脏胆小管侧膜转运蛋白(ABCG5、ABCG8、ABCBll和ABCB4)mRNA的表达量。结果:胆石组血清胆固醇低于对照组(P<0.05)。胆石组胆汁胆固醇摩尔百分比和胆固醇饱和指数较对照组显著升高(P<0.01)。胆石组肝脏胆小管侧膜胆固醇转运蛋白ABCG5和ABCG8表达高于对照组,且后者差异具有统计学显著性(ABCG5:31.44±3.17Vs25.72±3.27,ABCG8:27.53±3.06vs17.81±2.23)。ABCBll和ABCB4表达在两组间差异无显著性。结论:本研究显示,胆石病主要病理生理异常为胆汁胆固醇过饱和,与肝脏胆小管侧膜胆固醇转运蛋白ABCG5和ABCG8的mRNA表达增加有关。 | 蒋兆彦 韩天权 所广军 袁作彪 姜志宏 商俊 蔡杏兴 Gsta Eggertsen Curt Einarsson 张圣道 | 2005 | 外科理论与实践2005，10，1： | 24 |
| 2 | 胆固醇结石病人肝脏脂质代谢异常的分子生物学研究显示文摘目的:研究导致胆石病人胆汁胆固醇过饱和的肝脏胆固醇和胆汁酸代谢途径中的分子生物学改变。方法:收集22例胆石病人和13例无胆石病的对照病人肝脏活检组织、胆囊胆汁和血浆。采用实时定量PCR检测肝脏基因表达,采用Western印迹法测定蛋白含量。结果:胆石病人较对照组ABCG5/ABCG8和LXRα基因的mRNA表达水平分别增加51%、59%和102%。肝脏SRBI的mRNA和蛋白含量均增加。结论:胆石病人ABCG5/ABCG8基因表达上调,可能与LXRα表达增加促进相关,这些异常是导致胆汁胆固醇过饱和的原因。此外,胆汁中过多的胆固醇可能来源于经肝脏高密度脂蛋白受体SRBI的摄取,而不是由于肝脏合成和酯化的异常。 | 蒋兆彦 姜翀弋 胡海 所广军 Paolo Parini Gsta Eggertsen Matthew A Davis Lawrence L Rudel Curt Einarsson 韩天权 张圣道 | 2007 | 外科理论与实践2007，12，5： | 4 |
| 3 | Endothelial and platelet markers in diabetes mellitus type 2显示文摘Diabetes mellitus(DM) is an extremely common disorder which carries a risk of vascular impairment.DM type 2(DM2) can be characterized by the dysfunction of haemostasis manifesting by stimulated coagulation process,disorder of platelet function and decreased fibrinolytic activity.These all are the reasons why DM2 is the most common acquired thrombophilia.Endothelial dysfunction along with platelet hyperactivity are unquestionably involved in the hyperactivation of platelets and clotting factors in DM.As a natural consequence of continuous investigation,many markers of endothelial dysfunction and diabetic thrombocytopathy have been identified and considered for implementation in clinical practice.Endothelial function can be assessed by the evaluation of endothelial markers,circulating molecules synthesised in various amounts by the endothelium.These markers precede the signs of evident microangiopathy.Platelets have an ethiopathogenic relation to the microangiopathy in DM.Their increased activity was confirmed in both types of DM.Predictors of endothelial and platelet disorder could improve the screening of individuals at increased risk,thus leading to the early diagnosis,appropriate treatment,as well as to the effective prevention of the complications of DM2.In the article we deal with the mechanisms involved in the pathogenesis of endothelial and platelet functional abnormalities,endothelial and platelet markers of DM2 considered for implementation in clinical practice and possibilities of their detection. | Peter Kubisz Lucia Staniaková Ján Stako Peter Galajda Marián Mokáň | 2015 | World Journal of Diabetes2015，6，3： | 3 |
| 4 | The Genetic Architecture of Multiple Myeloma显示文摘 | Steven M. Prideaux Emma Conway O’Brien Timothy J. Chevassut G?sta Gahrton | 2014 | Advances in Hematology2014，，： | 2 |
| 5 | 陆地卫星TM图像用于巴西中西部热液蚀变填图的评价显示文摘本文介绍了陆地卫星TM图像用于非干旱或干旱环境中与金矿化有关的热液蚀变(绢英岩化型)填图。在分析研究区用TM图像进行热液蚀变填图具有干扰因素的情况下,采用“特征定向主成分选择”的主成分分析技术,对热液蚀变图像进行增强处理,之后进行增强解译,为确定蚀变带和圈定靶区提供了依据。 | Alvaro P.Crsta 张义彬 曲家惠 | 1993 | 黄金地质科技1993，，4： | 2 |
| 6 | 用模拟温度传感器更快速更轻松地开发数字温度计显示文摘温度传感器的选择对开发工作具有决定性作用。一款免费的模拟程序使得这项任务变得更加容易,同时有助于节省时间和费用。在开发数字温度测量电路时,必须首先确定在纯机械方面的设计,接下来就要考虑电热方面的诸多因素。由于各种参数表现出复杂的相互作用,即它们彼此影响。通常来说,一个系统的限制因素决定了测量的准确性。 | Bert Weiss Alain Stas | 2019 | 中国电子商情2019，，5： | 2 |
| 7 | Coffee as a source ofantioxidants: An EPR study显示文摘 | BrezovA V ^lebodovd A Sta^ko A | 2009 | Food Chemistry2009，114，3： | 1 |
| 8 | The infection of clover root hairs by nodule bacteria studied by a simple glass slide technique显示文摘 | G(O)STA F(A)HRAEUS F(A)HRAEUS G | | 0，，： | 1 |
| 9 | Context-aware saliency detection显示文摘 | G Stas Z Lihi Ayellet T | 2012 | IEEE transactions on pattern analysis and machine intelligence2012，34，10： | 1 |
| 10 | Circulating vascular endothelial growth factor in the normo- and/ or microalbuminuric patients with type 2 diabetes mel- litus显示文摘 | KUBISZ P CHUDY P STAS KO J | 2010 | Acta Diabetol2010，47，： | 1 |
| 11 | A Comparative Experimental Study of Biomass,Lignite and Hard Coal Steam Gasification显示文摘 | Smoli(n)ski A Howaniec N Sta(n)czyk K | | 0，，6： | 1 |
| 12 | Minerahcortieoid receptor blockade attenuates chronic overcxpression of the renin-angiotensin-aldosterone system stimulation of reduced nieotinamide adenine dinueleotide phosphate oxidase and cardiac remodeling显示文摘 | Stas S Whaley-Connell A Habibi J | 2007 | Endocrinology2007，148，8： | 1 |
| 13 | Mineralocorti-coid receptor blockade attenuates chronic over expressionof the RAAS stimulation of reduced nicotinamide adeninedinucleotide phosphate oxidase and cardiac remodeling显示文摘 | Stas S Whaley-Connell A Habibi J | 2007 | Endocrinology2007，148，8： | 1 |
| 14 | New phenotypical and ultrastructural findings in spindle cell (desmoplastic/neurotropic) melanoma显示文摘 | Winnepenninckx V De Vos R Stas M | 2003 | Appl Immunohistochem Mol Morphol2003，11，4： | 1 |
| 15 | Steam Co-gasification of Coal and Biomass Derived Chars with Synergy Effect as an Innovative Way of Hydrogen-rich Gas Production显示文摘 | Howaniec N Smoli(n)ski A Sta(n)czyk K | | 0，，22： | 1 |
| 16 | Metabolic safety of antihypertensive drugs:myth versus reality显示文摘 | Stas S Appesh L Sowers J | 2006 | Curr Hypertens Rep2006，8，5： | 1 |
| 17 | Limited proteolysis of soybean beta-conglycinin 显示文摘 | Kamata Y Otsuka S Sta M | 1982 | Agric Biol Chem1982，46，11： | 1 |
| 18 | Gene expression changes in melanoma metastases in response to high-dose chemotherapy during isolated limb perfusion显示文摘 | Wouters J Stas M Oord JJ | 2012 | Pigment Cell Melanoma Res2012，25，4： | 1 |
| 19 | Landscape ecology, spatial heterogeneity in ecological system显示文摘 | Pickett STA Cadenasso M L | 1995 | Science1995，269，： | 1 |
| 20 | Ecosystem process along an urban-to-rural gradient显示文摘 | MCDONNELL MJ PICKETT STA POUYAT RV | 1997 | Urban Ecosystems1997，1，： | 1 |
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