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| 1 | Axillary lymph node management in breast cancer with positive sentinel lymph node biopsy显示文摘The surgical treatment of localized breast cancer has become progressively less aggressive over the years.The management of the axillary lymph nodes has been modified by the introduction of sentinel lymph node biopsy. Axillary dissection can be avoided in patients with sentinel lymph node negative biopsies. Based on randomized trials data, it has been proposed that no lymph node dissection should be carried out even in certain patients with sentinel lymph node positive biopsies. This commentary discusses the basis of such recommendations and cautions against a general omission of lymph node dissection in breast cancer patients with positive sentinel lymph node biopsies. Instead, an individualized approach based on axillary tumor burden and biology of the cancer should be considered. | Ioannis A Voutsadakis Silvana Spadafora | 2015 | World Journal of Clinical Oncology2015，6，1： | 7 |
| 2 | Structure modification,antialgal,antiplasmodial,and toxic evaluations of a series of new marine-derived 14-membered resorcylic acid lactone derivatives显示文摘Marine natural products play critical roles in the chemical defense of many marine organisms and are essential,reputable sources of successful drug leads.Sixty-seven 14-membered resorcylic acid lactone derivatives 3–27 and 30–71 of the natural product zeaenol(1)isolated from the marine-derived fungus Cochliobolus lunatus were semisynthesized by chlorination,acylation,esterification,and acetalization in one to three steps.The structures of these new derivatives were established by HRESIMS and NMR techniques.All the compounds(1–71)were evaluated for their antialgal and antiplasmodial activities.Among them,14 compounds displayed antifouling activities against adhesion of the fouling diatoms.In particular,9 and 34 exhibited strong and selective inhibitory effects against the diatoms Navicula laevissima and Navicula exigua(EC50=6.67 and 8.55μmol/L),respectively,which were similar in efficacy to those of the positive control SeaNine 211(EC50=2.90 and 9.74μmol/L).More importantly,38,39,and 69–71 showed potent antiplasmodial activities against Plasmodium falciparum with IC50 values ranging from 3.54 to 9.72μmol/L.Very interestingly,the five antiplasmodial derivatives displayed non-toxicity in the cytotoxicity assays and the zebrafish embryos model,thus,representing potential promising antiplasmodial drug agents.The preliminary structure–activity relationships indicated that biphenyl substituent at C-2,acetonide at positions C-5′and C-6′,and tri-or tetra-substituted of acyl groups increased the antiplasmodial activity.Therefore,combining evaluation of chemical ecology with pharmacological models will be implemented as a systematic strategy,not only for environmentally friendly antifoulants but also for structurally novel drugs. | Wei-Feng Xu Na-Na Wu Yan-Wei Wu Yue-Xuan Qi Mei-Yan Wei Laura M.Pineda Michelle G.Ng Carmenza Spadafora Ji-Yong Zheng Ling Lu Chang-Yun Wang Yu-Cheng Gu Chang-Lun Shao | 2022 | Marine Life Science & Technology2022，4，1： | 3 |
| 3 | Sperm cells ang foreign DNA:a controversial relation显示文摘 | Spadafora C | 1998 | Bioessays1998，20，11： | 1 |
| 4 | Continental collision history from arenites of episutural basins in the Northern Apennines, Italy 显示文摘 | Cibin U Spadafora E Zuffa G G | 2001 | Geological Society of America Bulletin2001，113，： | 1 |
| 5 | Microbial biomineral- ization processes forming modem Ca: Mg carbonate stromatolites 显示文摘 | Spadafora A Perri E McKenzie J A | 2010 | Sedimentology2010，57，1： | 1 |
| 6 | DoD Policy for Corrosion Prevention and Control (CPC)显示文摘 | SPADAFORA Stephen J | 2005 | Materials Engineering2005，，： | 1 |
| 7 | Continental collision history from arenites of episutural basins in the Northern Apennines显示文摘 | Cibin U Spadafora E Zuffa G G | 2001 | Italy GSA Bulletin2001，113，： | 1 |
| 8 | A 3-year follow-up study of various types of orthodontic canine-to-canine retainers显示文摘 | Artun J Spadafora AT Shapiro PA | 1997 | Eur J Orthod1997，19，5： | 1 |
| 9 | Sperm cells and foreign DNA:a controversial relation显示文摘 | Spadafora C | 1998 | Bioessays1998，20，11： | 1 |
| 10 | Constitutive phosphorylation of the VSV Pprotein modulates polymerase complex formation but is not essential for transcription or replication显示文摘 | Canter DM Jackson RL | 1996 | J Virol1996，70，7： | 1 |
| 11 | Sperm-Mediated Gene Transfer in Mice 显示文摘 | Maione B Lavitrano M Spadafora C | 1998 | Mol Reprod Dev1998，50，4： | 1 |
| 12 | The effects of switching from oral to LAI antipsychotic treatment on subjective experience of schizophrenic and schizoaffective patients: preliminary results 显示文摘 | Pietrini F Spadafora M Talamba GA | 2015 | Int J Psychiatry Clin Pract2015，20，： | 1 |
| 13 | Proteome from Lemon Fruit Fla'edo Reveals That This Tissue Produces High Amounts of the Cit sl Germin- like Isoforms 显示文摘 | Pignataro V Canton C Spadafora A | 2010 | Journal of Agricultural and Food Chemistry2010，58，12： | 1 |
| 14 | A 3-year follow-up study of various types of orthodontic canine-to-canine retainers显示文摘 | Artun J Spadafora AT Shapiro PA | 1997 | Eur J Ortho1997，19，5： | 1 |
| 15 | A reverse transcriptase-dependent mechanism plays central roles in fundamental biological processes显示文摘 | Spadafora C | 2008 | Syst Biol Reprod Med2008，54，1： | 1 |
| 16 | Structure and mechanism of Cu- and Ni-substituted analogs of metallo-β- lactamase L 1 显示文摘 | Hu ZX Spadafora LJ Hajdin CE | 2009 | Biochemistry2009，48，13： | 1 |
| 17 | Sperm cells and foreign DNA:a controversial relation显示文摘 | Spadafora Spadafora C | 1998 | BioEssays1998，20，： | 1 |
| 18 | A Comparison of Boric-Sulfu- ric Acid Anodize and Chromic Acid Anodize Processes 显示文摘 | SPADAFORA S J PEPE F R | 1994 | Metal Finishing1994，92，4： | 1 |
| 19 | Anti- trypanosomal alkaloids from the Marine Bacterium Bacillus pumilus显示文摘 | Martinez-Luis S Gomez J F Spadafora C | 2012 | Molecules2012，17，11： | 1 |
| 20 | Integration of foreign DNA sequences into mouse sperm genome显示文摘 | Zoraqi G Spadafora C | 1997 | DNA Cell Biol1997，16，3： | 1 |
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