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| 1 | Immunophenotypic signature of primary glioblastoma multiforme: A case of extended progression free survival显示文摘Glioblastoma-multiforme(GBM), the most aggressive glial tumor, has a worldwide age-adjusted incidence ranging from 0.59-3.69/100000 persons. Despite current multimodal-treatment approach, median-survival time and progression-free survival(PFS) remains short. Glioblastomas display a variety of molecular alterations, which necessitates determining which of these have a prognostic significance. This is a case of a 45-yearold patient who presented with progressive slurring of speech and features of raised intracranial pressure. Computed tomography(CT) scan revealed a large heterogeneously enhancing lesion in the left front-temporalperisylvian region with solid, cystic areas, suggestive of malignant glioma. Partial tumor-excision was followed by concurrent chemo-radiotherapy. Histopathologically, the tumor was astrocytoma grade-IV. Patient had an extended PFS of 12 mo, with an overall survival of 26 mo. Primary-GBM was confirmed using molecular markers and the immunophenotypic signature was defined by evaluating systemic expression of human telomerase reverse transcriptase, interleukin-6, neutrophil-lymphocyte ratio, tissue inhibitor of metalloproteinases-1, human chitinase-3-like-protein-1(YKL-40) and high mobility group-A1. Current findings suggest that this signature can identify worst outcomes, independent of clinical criteria. | Puneet Gandhi Richa Khare Nitin Garg Sandeep Sorte | 2017 | World Journal of Clinical Cases2017，5，6： | 2 |
| 2 | Unique case of oligoastrocytoma with recurrence and grade progression:Exhibiting differential expression of high mobility group-A1 and human telomerase reverse transcriptase显示文摘Mixed gliomas, primarily oligoastrocytomas, account for about 5%-10% of all gliomas. Distinguishing oligoastrocytoma based on histological features alone has limitations in predicting the exact biological behavior, necessitating ancillary markers for greater specificity. In this case report, human telomerase reverse transcriptase(hT ERT) and high mobility group-A1(HMGA1); markers of proliferation and stemness, have been quantitatively analyzed in formalin-fixed paraffin-embedded tissue samples of a 34 years old patient with oligoastrocytoma. Customized florescence-based immunohistochemistry protocol with enhanced sensitivity and specificity is used in the study. The patient presented with a history of generalized seizures and his magnetic resonance imaging scans revealed infiltrative ill-defined mass lesion with calcified foci within the left frontal white matter, suggestive of glioma. He was surgically treated at our center for four consecutive clinical events. Histopathologically, the tumor was identified as oligoastrocytoma-grade Ⅱ followed by two recurrence events and final progression to grade Ⅲ. Overall survival of the patient without adjuvant therapy was more than 9 years. Glial fibrillary acidic protein, p53, Ki-67, nuclear atypia index, pre-operative neutrophillymphocyte ratio, are the other parameters assessed. Findings suggest that hT ERT and HMGA1 are linked to tumor recurrence and progression. Established markers can assist in defining precise histopathological grade in conjuction with conventional markers in clinical setup. | Puneet Gandhi Richa Khare Kavita Niraj Nitin Garg Sandeep K Sorte Hanni Gulwani | 2016 | World Journal of Clinical Cases2016，4，9： | 2 |
| 3 | Knowledge Processing Method of Fault Diagnosis Expert Systems for Letter Sorting Equipment显示文摘Based on the analysis of fault diagnosis knowledge of letter sorting machine, this paper proposes a processing method by which the fault diagnosis knowledge is divided into exact knowledge, inadequate knowledge and fuzzy knowledge. Then their presenting and implementing form in fault diagnosis expert system is discussed and studied. It is proved that the expert system has good feasibility in the field of the diagnosis of letter sorting machine. | LI Dian sheng SUN Wan jun Biography:\ LI Dian sheng (1966-), instructor of Shijiazhuang Postal College, received MS in Shengyang Polytechnic University, majoring in artificial intelligence, maintenance of letter sorting machine. He has published seve | 2001 | The Journal of China Universities of Posts and Telecommunications2001，8，1： | 2 |
| 4 | Novel molecular panel for evaluating systemic inflammation and survival in therapy naïve glioma patients显示文摘BACKGROUND Inflammation is crucial to tumor progression.A traumatic event at a specific site in the brain activates the signaling molecules,which triggers inflammation as the initial response within the tumor and its surroundings.The educated immune cells and secreted proteins then initiate the inflammatory cascade leading to persistent chronic inflammation.Therefore,estimation of the circulating inflammatory indicators kynurenine(KYN),interleukin-6(IL-6),tissue-inhibitor of matrix-metalloproteinase-1 and human telomerase reverse transcriptase(hTERT)along with neutrophil-lymphocyte ratio(NLR)has prognostic value.AIM To assess the utility of chosen inflammatory marker panel in estimating systemic inflammation.METHODS The chosen markers were quantitatively evaluated in 90 naive,molecularly subtyped plasma samples of glioma.A correlation between the markers and confounders was assessed to establish their prognostication power.Follow-up on the levels of the indicators was done 3-mo post-surgery.To establish the validity of circulating KYN,it was also screened qualitatively by dot-immune-assay and by immunofluorescence-immunohistochemistry in tumor tissues.RESULTS Median values of circulating KYN,IL-6,hTERT,tissue-inhibitor of matrixmetalloproteinase-1 and NLR in isocitrate-dehydrogenase-mutant/wildtype and within the astrocytic sub-groups were estimated,which differed from controls,reaching statistical significance(P<0.0001).All markers negatively correlated with mortality(P<0.0001).Applying combination-statistics,the panel of KYN,IL-6,hTERT and NLR achieved higher sensitivity and specificity(>90%)than standalone markers,to define survival.The inflammatory panel could discriminate between WHO grades,and isocitrate-dehydrogenase-mutant/wildtype and define differential survival between astrocytic isocitrate-dehydrogenase-mutant/wildtype.Therefore,its assessment for precise disease prognosis is indicated.Association of KYN with NLR,IL-6 and hTERT was significant.Cox-regression described KYN,IL-6,NLR,and hTERT as good prognostic markers,independent of confounders.Multivariate linear-regression analysis confirmed the association of KYN and hTERT with inflammation marker IL-6.There was a concomitant significant decrease in their levels in a 3-mo follow-up.CONCLUSION The first evidence-based study of circulating-KYN in molecularly defined gliomas,wherein the tissue expression was found to be concomitant with plasma levels.A non-invasive model for assessing indicators of chronic systemic inflammation is proposed. | Puneet Gandhi Richa Shrivastava Nitin Garg Sandeep K Sorte | 2021 | World Journal of Clinical Oncology2021，12，10： | 2 |
| 5 | Application of statistical filtering for optical detection of tool wear 显示文摘 | M Sorting | 2003 | International Journal of Machine Tools and Manufacture2003，43，5： | 1 |
| 6 | Microstructural effects and large microhardness in cobalt processed by high pressure torsion consolidation of ballmilled powders显示文摘 | SORT J ZHILYAEV A ZIELINSKA M | 2003 | Acta Materialia2003，51，： | 1 |
| 7 | Magnetization reversal in submicron disks: exchange biased vortices显示文摘 | Sort J Hoffmann A Chung S H | 2005 | Physical Review Letters2005，95，6： | 1 |
| 8 | Effect of intravenous albumin on renal impairment and mortality in patients with cirrhosis and spontaneous bacterial peritonitis 显示文摘 | Sort P Navasa M Arroyo V | 1999 | N Engl J Med1999，341，6： | 1 |
| 9 | Exchange Bias in Nano-structures显示文摘 | Nogues J Sort J Langlais V | 2005 | Physics Reports-Review Section of Physics Letters2005，422，3： | 1 |
| 10 | Synthesis and Size-Dependent Exchange Bias in Inverted Core-Shell MnO Verti-cal Bar Mn3O4 Nanoparticles显示文摘 | Sahzar-Alvarez G Sort J Surifiach S | 2007 | Journal of the American Chemical Society2007，129，29： | 1 |
| 11 | Comtribution of sewage sludge to erosion control in rehabilitation of limestone quarries显示文摘 | Sort X Alcaniz J M | 1996 | Land Degradution and Development1996，7，1： | 1 |
| 12 | Contribution of sewage sludge to erosion control in the rehabilitation of limestone quar- ries显示文摘 | Sort X Alcaniz J M | 1996 | Land Degradation and Development1996，7，1： | 1 |
| 13 | Exchange-Bias Properties in Permalloy Deposited onto a Pt/Co Multilayer 显示文摘 | Sort J Popa A Rodmacq B | 2004 | Phys Rev B2004，70，17： | 1 |
| 14 | Role of the hypoxia sensing system,acidity and reproductive homones in the variability of vascular endothelial growth factor induction in human breast carcinoma cell lines显示文摘 | Gleadle JM Bicknell R | 1998 | Int J Cancer1998，75，： | 1 |
| 15 | A Polynomial Model for Estimating Water Flow 显示文摘 | Sort Briercheek Bernard Mccoy Wayne Pavalko | 1991 | the UMAP Journal1991，12，3： | 1 |
| 16 | 显示文摘 | Sort J Nogues J Amils X | 1999 | Appl Phys Lett1999，75，： | 1 |
| 17 | Quantitative assessment of DNA damage directly in lens epithelial cells from senile cataract patients显示文摘 | Sorte K Sune P Bhake A | 2011 | Mol Vis2011，17，： | 1 |
| 18 | 显示文摘 | Sort J Nogues J Surinach S | 2001 | Appl Phys Lett2001，79，： | 1 |
| 19 | Microstruetural inhomogeneities introduced in a Zr-based bulk metallic glass upon low-temperature annealing显示文摘 | Van Steenberge N Concustell A Sort J | 2008 | Mat Sci Eng A2008，491，12： | 1 |
| 20 | Effect of intravenous albumin on renal impairment and mortality in patients with cirrhosis and spontaneous bacterial peritonitis显示文摘 | Sort P Navasa M Arroyo V | 1999 | N Engl J Med1999，341，： | 1 |
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