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| 1 | Understanding mechanisms of the pathogenesis of nonalcoholic fatty liver disease显示文摘A central issue in the understanding of the pathogenesis of nonalcoholic fatty liver disease is the problem of the underlying mechanisms which are not fully understood.In the setting of excessive central adiposity,insulin resistance is the major underlying cause of fat accumulation in hepatocytes.Because of the difficulties with human trials,several animal models have been developed for this purpose mainly characterized as follows:genetically disturbed or murine fatty liver,methionine-choline deficient diet fed or murine steatohepatitis,and high-fat or sucrose diet fed models.Although these animal models have provided useful information,none of them accurately reflect genetic,metabolic and biochemical characteristics of the human disease. | Metin Basaranoglu Serra Kayacetin Nevin Yilmaz Ertugrul Kayacetin Orhan Tarcin Abdullah Sonsuz | 2010 | World Journal of Gastroenterology2010，16，18： | 14 |
| 2 | Mallory-Denk Bodies in chronic hepatitis显示文摘Mallory-Denk Bodies(MDB) are important as investigators,suggesting MDB as an indicator of the histologic severity of chronic hepatitis,causes of which include hepatitis C,primary biliary cirrhosis(PBC),and nonalcoholic fatty liver disease(NAFLD).Matteoni et al scored MDB in patients with NAFLD as none,rare and many,and reported that MDB plays a prominent role in this classification scheme in an earlier classification system.In this study,we evaluated 258 patients with chronic hepatitis due to metabolic,autoimmune and viral etiologies.Liver biopsy samples were evaluated with hematoxylin and eosin,periodic acid-Schiff-diastase,Gordon and Sweet's reticulin,Masson's trichrome,and iron stains.Both staging and grading were performed.Additionally,MDB were evaluated and discussed for each disease.We examined patients with nonalcoholic steatohepatitis(NASH;50 patients),alcoholic hepatitis(10 patients),PBC(50 patients),Wilson disease(WD;20 patients),hepatitis B(50 patients),hepatitis C(50 pati-ents) and hepatocellular carcinoma(HCC;30 patients).Frequency of MDB was as follows;NASH:10 patients with mild in 60% and moderate in 40% and observed in every stage of the disease and frequently seen in zone 3.PBC:11 patients with mild in 10%,moderate in 70%,and cirrhosis in 20%,and frequently seen in zone 1.WD:16 patients with moderate and severe in 60% and cirrhosis in 40% and frequently seen in zone 1.Hep B:3 patients with mild in 66% and severe in 34%.Hep C:7 patients with mild in 40% and moderate in 60% and observed in every stage.HCC:3 patients with hep B in 2 patients.We found that there is no relationship between MDB and any form of chronic hepatitis regarding histologic severity such as alcoholic steatohepatitis and NAFLD and variable zone distribution by etiology. | Metin Basaranoglu Nesrin Turhan Abdullah Sonsuz Gkcen Basaranoglu | 2011 | World Journal of Gastroenterology2011，17，17： | 6 |
| 3 | Serum iron level and hepatic iron overload in nonalcoholic steatohepatitis and chronic viral hepatitis 显示文摘 | Uraz S Aygun C Sonsuz A | 2005 | Dig Dis Sci2005，50，5： | 1 |
| 4 | Optimization of supercritical CO2 extraction of Thymbra spicata oil显示文摘 | SONSUZER S SAHIN S YILMAZ L | 2004 | Journal of Supercritical Fluids2004，30，： | 1 |
| 5 | Optimization of supercritical CO2 extraction of Thymbra spicata oil显示文摘 | Sonsuzer S Sahin S Yilmaz L | 2004 | Journal of Supercritical Fluids2004，，30： | 1 |
| 6 | A controlled trial of gemfibrozil in the treatment of patients with nonalcoholic steatohepatitis显示文摘 | Basaranoglu M Acbay D Sonsuz A | 1999 | Hepatol1999，31，2： | 1 |
| 7 | The fluctuation of serum levels of aminotransferase in patients with nonalcoholic steatohepatitis 显示文摘 | Ipekci SH Basaranoglu M Sonsuz A | 2003 | J Clin Gastroenterol2003，36，4： | 1 |
| 8 | Optimization of supercritical C02 extraction of Thymbra spicata oil显示文摘 | Sonsuzer S Sahin S Yilmaz L | 2004 | The Journalof Supercritical Fluids2004，30，2： | 1 |
| 9 | Optimization of super- critical CO2 extraction of Thymbra spicata oil 显示文摘 | SONSUZER S SAHIN S YILMAZ L | 2004 | The Jour- nal of Supercritical Fluids2004，30，2： | 1 |
| 10 | Optimization of supercritical CO2 extraction of Thymbra spicata oil显示文摘 | Sonsuzer S Sahin S Yilmaz L | 2004 | The Journal of Supercritical Fluids2004，30，2： | 1 |
| 11 | A controlled trial of gemfibrol in the treatment of patients with nonalcoholic steatohepatitis显示文摘 | BASARANOGLU M ACBAY O SONSUZ A | 1999 | J Hepatol1999，31，： | 1 |
| 12 | The effect of mannitol infusion on the response to diuretic therapy in cirrhotic patients with ascites显示文摘 | Pamuk ON Sonsuz A | 2002 | J Clin Gastroenterol2002，35，5： | 1 |
| 13 | Optimization of supercritical CO2 extraction of Thymbra spicata oil显示文摘 | SONSUZER S SAHIN S YILMAZ L | 2004 | The Journal of Supercritical Fluids2004，30，2： | 1 |
| 14 | Serum iron level and hepatic iron overload in nonalcoholic steatohepatitis and chronic viral hepatitis显示文摘 | Uraz S Aygun C Sonsuz A | 2005 | Dig Dis Sci2005，50，5： | 1 |
| 15 | Serum iron levels and hepatic iron overload in nonalcoholic steatohepatitis and chronic viral hepatitis显示文摘 | Uraz S Aygun C Sonsuz A | 2005 | Dig Dis Sci2005，50，5： | 1 |
| 16 | A controlled trial of gemfibrozil in the treatment of patient with nonalcoholic steatohepatitis显示文摘 | Basaranoglu M Acbay O Sonsuz A | 1999 | J Hepatol1999，31，： | 1 |
| 17 | The fluctuation of serum levels of aminotransferase in patients with nonalcoholic steatohepatitis 显示文摘 | Ipekci SH Basaranoglu M Sonsuz A | 2003 | J Clin Gastroenterol2003，36，4： | 1 |
| 18 | The fluctuation of serum levels of aminotransferase in patients with nonalcoholic steatohepatitis 显示文摘 | Ipekci SH Basaranoglu M Sonsuz A | 2003 | J Clin Gastroenterol2003，36，： | 1 |
| 19 | The effect of mannitol infusion on the respnse to diuretic therapy in cirrhotic patients with ascites显示文摘 | Pamuk ON Sonsuz A | 2002 | Journal of Clinical Gastroenterology2002，35，5： | 1 |
| 20 | Optimization of super- critical CO2 extraction of Thymbra spicata oil显示文摘 | Sonsuzer S Sahin S Yilmaz L | 2004 | The Journal of Supercritical Fluids2004，30，2： | 1 |
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