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173篇 您的检索式：作者名="Soan"

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	题名	作者	年代	出处	被引量
1	Sulforaphane Protects Astrocytes Against Oxidative Stress and Delayed Death Caused by Oxygen and Glucose Deprivation显示文摘氧化应激是缺血再灌注后星形胶质细胞损伤和死亡的重要分子机制之一,可能成为有效的干预靶点。下述治疗策略可减轻缺血再灌注条件下产生的多种反应性氮氧化合物损伤。这种方法可通过使用化学试剂或适当条件促进转录活化因子NRF2从细胞浆转入细胞核,并与抗氧化基因反应位点结合,来诱导缺血再灌注后损伤细胞的Ⅱ期基因反应。本研究将验证如下假说:NRF2基因表达通路激活剂sulforaphane能对体外无氧无糖环境处理的培养皮质星形胶质细胞起神经保护作用。将皮质星形胶质细胞暴露于无氧无糖环境(OGD)4 h,于干预前48 h或干预后给予5μMsulforaphane(NRF2基因表达通路激活剂)培养48 h,两种培育条件下细胞死亡均明显减少。免疫细胞化学结果表明干预前给予sulforaphane处理,细胞中DNA/RNA氧化标志物8-hydroxy-2-deox-yguanosine的表达在恢复给氧4 h后降低,两种培育条件下胞浆内及胞核内NRF2的免疫反应均增强且NQO1(NRF2转录活化基因产物)的表达和酶活性均增强。本研究提示sulforaphane可通过激活NRF2抗氧化基因表达通路,减少体外缺氧再灌注后星形胶质细胞的死亡。	CAMELIA A.DANILOV KRISH CHANDRASEKARAN JENNIFER RACZ LUCIAN SOANE CAROL ZIELKE AND GARY FISKUM	2009	神经损伤与功能重建2009，4，2：	12
2	H elicobacter pylori infection associated with high H b A 1c and type 2 diabetes显示文摘	Ming‐Chia Hsieh Sophie S. W. Wang Yi‐Ting Hsieh Fu‐Chen Kuo Maw‐Soan Soon Deng‐Chyang Wu	2013	Eur J Clin Invest2013，，9：	4
3	Are risk preferences consistent? The influence of decision domain and personality 显示文摘	Soane E Chmiel N	2005	Personality and Individual Differences2005，35，5：	1
4	Remission of metastatic lesions following cryosurgery in prostatic cancer: immunologic considerations 显示文摘	Soanes WA Ablin ILl Gonder MJ	1970	J Urol1970，104，1：	1
5	Experimental and theoretical studies of DNA separations by capillary, electrophoresis in entangled polymer solutions 显示文摘	Grossman PD Soane DS	1991	Biopolymers1991，31，10：	1
6	A transient entanglement coupling mechanism for DNA separation by capillary electrophoresis in ulradilute polymer solutions 显示文摘	Barron AE Blanch HW Soane DS	1994	Electrophoresis1994，15，5：	1
7	Evaluation of the clearance characteristics of bioadhesive systems in humans显示文摘	Frier M Perkins AC	1999	Int J Pharm1999，178，1：	1
8	Elution of in vivobound antiprostatic epithelial antibodies following multiple cryotherapy of carcinoma of rostate显示文摘	Ablin RJ Soanes WA Gonder MJ	1973	Urology1973，2，7：	1
9	Eukaryotic initiation factor 6 selectively regulates Wnt signaling and beta - catenin protein synthesis 显示文摘	Ji Y Shah S Soanes K	2008	Oncogene2008，27，6：	1
10	Characterization of the zebrafish matrix metalloproteinase 9 gene and its developmental expression pattern显示文摘	Yoong S OConnell B Soanes A	2007	Gene Expr Patterns2007，7，：	1
11	The potential role of mitochondrial in pediatric traumatic brain injury显示文摘	Robertson CL Soane L Siegel ZT		0，，4：	1
12	Evaluation of the clearance characteristics of bioadhesive systems in humans显示文摘	Soane R Frier M Perkins A	1999	IntJ Pharm1999，178，：	1
13	Serum proteins in patients with benign and malignant diseases of the prostate显示文摘	Ablin RJ Soanes WA Bronson PM	1971	Neoplasma1971，18，3：	1
14	A new view of the lethal ap- optotie pore显示文摘	Basa ez G Soane L Hardwiek JM	2012	PI oS Biol2012，10，10：	1
15	Evaluation of the clearance characteristics of bioadhesive systems in human -s 显示文摘	Soane RJ Frier M Perkins AC	1999	lnt J Pharm1999，178，1：	1
16	Comparative genomic analysis of phytopathogenic fungi using expressed sequence tag (EST) col- lections显示文摘	SOANES D M Talbot N J	2006	Molecular Plant Pathology2006，7，1：	1
17	Comparative genomies of MAP kinase and calcium calcineurin signaling components in plant and human pathogenic fungi 显示文摘	Rispail N Soanes D M Ant C et cd	2009	Fung Genet Biol2009，46，2：	1
18	Evaluation of the clearance characteristics of bioadhesive systems in humans显示文摘	Soane R J Frier M Perkins A C	1999	Int J Pharm1999，178，1：	1
19	Implications of soil compaction in crop production for the quality of the environment显示文摘	SOANE BD VAN OUWERKERK C	1995	Soil&Tillage Research1995，35，：	1
20	Clearance characteristics of chitosan based formulations in the sheep nasal cavity 显示文摘	Soane RJ Hinchcliffe M Davis SS	2001	IntJPharm2001，217，12：	1

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