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| 1 | 血脂、脂蛋白和载脂蛋白作为心肌梗死风险标志物(INTER-HEART研究):在52个国家进行的一项病例对照研究显示文摘背景载脂蛋白作为冠心痛的标志物是否优于血脂和脂蛋白,目前存在广泛争议。本研究旨在对载脂蛋白和胆固醇作为急性心肌梗死风险指标进行比较.
方法在52个国家的12461例急性心肌梗死患者和14637例年龄(±5岁)、性别匹配的对照者中进行了一项有关急性心肌梗死的大型、标准化病例对照研究。获得了9345例急性心肌梗死患者和12120例对照者的非空腹血液样本。测定了血脂、脂蛋白和载脂蛋白浓度,并计算了胆固醇和栽脂蛋白比值通过比较五分位数的上四位与最低位,计算每一总体测值和每一种族组的优势比(0R)及其95%CI以及人群归因危险度(PAR)。
结果载脂蛋白B100(ApoB)/载脂蛋白A1(ApoA1)比值的PAR最高(54%),其每一标准差差别的OR最高(1.59,95%CI1.53~1.64)。LDL胆固醇/HDL-胆固醇比值的PAR为37%;总胆固醇/HDL-胆固醇的PAR为32%,其显著低于ApoB/A1比值的PAR(P〈0.0001)。这些结果在所有种族组、男女两性组及所有年龄组均一致。
结论在所有种族组、男女两性组及所有年龄组,非空腹ApoB/A1比值在评估急性心肌梗死风险方面优于任何胆固醇比值,其应当被引入全世界的临床实践中。 | Matthew J McQueen Steven Hawken Xingyu Wang Stephanie Ounpuu Allan Sniderman Jeffrey Probstfield Krisela Steyn John E Sanderson Mahammad Hasani Emilia Volkova Khawar Kazmi Salim Yusuf 郭战宏(译) | 2008 | 世界临床医学2008，2，6： | 3 |
| 2 | Shunts, channels and lipoprotein endosomal traffic: a new model of cholesterol homeostasis in the hepatocyte显示文摘The liver directs cholesterol metabolism in the organism.All the major fluxes of cholesterol within the body involve the liver:dietary cholesterol is directed to the liver;cholesterol from peripheral cells goes to the liver;the liver is a major site of cholesterol synthesis for the organism;cholesterol is secreted from the liver within the bile,within apoB lipoproteins and translocated to nascent HDL.The conventional model of cholesterol homeostasis posits that cholesterol from any source enters a common,rapidly exchangeable pool within the cell,which is in equilibrium with a regulatory pool.Increased influx of cholesterol leads rapidly to decreased synthesis of cholesterol.This model was developed based on in vitro studies in the fibroblast and validated only for LDL particles.The challenges the liver must meet in vivo to achieve cholesterol homeostasis are far more complex.Our model posits that the cholesterol derived from three different lipoproteins endosomes has three different fates:LDL-derived cholesterol is largely recycled within VLDL with most of the cholesterol shunted through the hepatocyte without entering the exchangeable pool of cholesterol;high density lipoprotein-derived CE is transcytosed into bile;and chylomicron remnant-derived cholesterol primarily enters the regulatory pool within the hepatocyte.These endosomal channels represent distinct physiological pathways and hepatic homeostasis represents the net result of the outcomes of these distinct channels.Our model takes into account the distinct physiological challenges the hepatocyte must meet,underlie the pathophysiology of many of the apoB dyslipoproteinemias and account for the sustained effectiveness of therapeutic agents such as statins. | Robert Scott Kiss Allan Sniderman | 2017 | The Journal of Biomedical Research2017，31，2： | 2 |
| 3 | Portopulmonary hypertension in decompensated cirrhosis with refractory ascites 显示文摘 | Benjaminov FS Prentice M Sniderman KW | 2003 | Gut2003，52，： | 1 |
| 4 | From Life Space to Polling Place: the Relevance of Personal Concerns for Voting Behavior显示文摘 | Brody R A P M Sniderman | 1977 | British Journal of Political Science1977，，3： | 1 |
| 5 | The adipocyte,fatty acide trapping, and atherogenesis显示文摘 | Sniderman A D Ciaflone K Arner P | 1998 | Arterioscler Thromb Vasc Bio11998，1，8： | 1 |
| 6 | Should we use apoB for risk assessment and as a target for treatment显示文摘 | Brown WV Myers GL Sniderman AD | 2010 | J Clin Lipidol2010，4，3： | 1 |
| 7 | Aproposal to redefine familial combined hyperlipidaemia-third workshop on FCHL held in Barcelona from 3 to 5 may 2001, during the scientific sessions of the European Society for Clinical Investigation显示文摘 | Sniderman AD Castro Cabezas M Ribalta J | 2002 | Eur J Clin Invest2002，32，2： | 1 |
| 8 | Acylation stimulating protein (ASP) deficiency induces obesity resistance and increased energy expenditure in ob/ob mice显示文摘 | Xia Z N Sniderman A D Cianflone K | 2002 | J Biol Chem2002，27，45： | 1 |
| 9 | Apelipeproteins versus lipids as indices of coronary risk and as targets for statin treatment 显示文摘 | Sniderman AD Furberg CD Keech A | 2003 | Lancet2003，361，9359： | 1 |
| 10 | ApoB versus non- HDL-cholesterol: diagnosis and cardiovascular risk management 显示文摘 | DE NIJS T SNIDERMAN A DE GRAAF J | 2013 | Crit Rev Clin Lab Sci2013，50，6： | 1 |
| 11 | Neonatal morbidity according to gestational age and birth weight from five tertiary care centers in the United States, 1983 through 1986显示文摘 | Robertson PA Sniderman SH Laros RK Jr | 1992 | Am J Obstet Gynecol1992，166，15： | 1 |
| 12 | Enhanced revascularization of the ischemic limb by angiogenic therapy显示文摘 | Pu LQ Sniderman AD Brassard R | 1993 | Circulation1993，88，1： | 1 |
| 13 | Putting low- density lipoproteins at a center stage in atherogenesis 显示文摘 | Sniderman A D Pedersen T Kjekshus J | 1997 | Am J Cardiol1997，79，： | 1 |
| 14 | Hypertriglyceridemic hyperapob:the unappreciated at herogenic dys1ipoproteinemia in type 2 diabetes mellitus显示文摘 | Sniderman AD Scantlebury T Cianflone K | 2001 | Ann Intern Med2001，135，6： | 1 |
| 15 | Portopulmonary hypertension in decompensated cirrhosis with refractory ascites 显示文摘 | Benjaminov FS Prentice M Sniderman KW | 2003 | Gut2003，52，4： | 1 |
| 16 | 无人机的摄像机:独特的光学成像方法显示文摘无人机成像技术不仅在无线自拍杆、运动摄像机,乃至摄影摄像等商业领域得到应用,而且正在众多商业、政府和公共安全领域逐步得到推广。目前,越来越多的无人机正在取代直升飞机,用于高压电线的现场检查之中,毕竟直升飞机费用高昂,有时颇为危险。无人机广泛地应用于航空摄影、能源、森林管理、测绘、油气、野生动物监测,以及秘密行动、应急响应、有效载荷交付、安全监控、战术行动、搜寻与救援、执法,甚至于医疗手术等领域。 | DEBBIE SNIDERMAN | 2017 | 今日电子2017，0，6： | 1 |
| 17 | Putting low density lipoproteins at a center stage in atherogenesis 显示文摘 | Sniderman A D Pedersen T Kjekshus J | 1997 | Am J Cardiol1997，79，1： | 1 |
| 18 | A meta-analysis of low-density lipoprotein cholesterol,non-high-density lipoprotein cholesterol,and apolipoprotein B as markers of cardiovascular risk显示文摘 | Sniderman AD Williams K Contois JH | 2011 | Circ Cardiovasc Qual Outcomes2011，4，3： | 1 |
| 19 | Portopulmonary hypertension in decompensated cirrhosis with refractory 显示文摘 | Benjaminov F S Prentice M Sniderman K W | 2003 | Gut2003，52，9： | 1 |
| 20 | Aylation stimulating protein (ASP), an adipocyte autocrine: new directions显示文摘 | Cianflone K Maslowska M Sniderman AD | 1999 | Semin Cell Dev Biol1999，10，： | 1 |
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