|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Dementia and osteoporosis in a geriatric population: Is there a common link?显示文摘AIM To determine the existence of a common pathological link between dementia and osteoporosis through reviewing the current evidence base. METHODS This paper reviews the current literature on osteoporosis and dementia in order to ascertain evidence of a common predisposing aetiology. A literature search of Ovid MEDLINE(1950 to June 2016) was conducted. The keywords 'osteoporosis', 'osteoporotic fracture', 'dementia' and 'Alzheimer's disease'(AD) were used to determine the theoretical links with the most significant evidence base behind them. The key links were found to be vitamins D and K, calcium, thyroid disease, statins, alcohol and sex steroids. These subjects were then searched in combination with the previous terms and the resulting papers manually examined. Theoretical, in vitro and in vivo research were all used to inform this review which focuses on the most well developed theoretical common causes for dementia(predominantly Alzheimer's type) and osteoporosis.RESULTS Dementia and osteoporosis are multifaceted disease processes with similar epidemiology and a marked increase in prevalence in elderly populations. The existence of a common link between the two has been suggested despite a lack of clear pathological overlap in our current understanding. Research to date has tended to be fragmented and relatively weak in nature with multiple confounding factors reflecting the difficulties of in vivo experimentation in the population of interest. Despite exploration of various possible mechanisms in search for a link between the two pathologies, this paper found that it is possible that these associations are coincidental due to the nature of the evidence available. One finding in this review is that prior investigation into common aetiologies has found raised amyloid beta peptide levels in osteoporotic bone tissue, with a hypothesis that amyloid beta disorders are systemic disorders resulting in differing tissue manifestations. However, our findings were that the most compelling evidence of a common yet independent aetiology lies in the APOE4 allele, which is a well-established risk for AD but also carries an independent association with fracture risk. The mechanism behind this is thought to be the reduced plasma vitamin K levels in individuals exhibiting the APOE4 allele which may be amplified by the nutritional deficiencies associated with dementia, which are known to include vitamins K and D. The vitamin theory postulates that malnutrition and reduced exposure to sunlight in patients with AD leads to vitamin deficiencies. CONCLUSION Robust evidence remains to be produced regarding potential links and regarding the exact aetiology of these diseases and remains relevant given the burden of dementia and osteoporosis in our ageing population. Future research into amyloid beta, APOE4 and vitamins K and D as the most promising aetiological links should be welcomed. | Candice L Downey Adam Young Emily F Burton Simon M Graham Robert J Macfarlane Eva-Maria Tsapakis Eleftherios Tsiridis | 2017 | World Journal of Orthopedics2017，8，5： | 6 |
| 2 | California Simulation of Evapotranspiration of Applied Water and Agricultural Energy Use in California显示文摘The California Simulation of Evapotranspiration of Applied Water (Cal-SIMETAW) model is a new tool developed by the California Department of Water Resources and the University of California, Davis to perform daily soil water balance and determine crop evapotranspiration (ET c ), evapotranspiration of applied water (ET aw ), and applied water (AW) for use in California water resources planning. ET aw is a seasonal estimate of the water needed to irrigate a crop assuming 100% irrigation efficiency. The model accounts for soils, crop coefficients, rooting depths, seepage, etc. that influence crop water balance. It provides spatial soil and climate information and it uses historical crop and land-use category information to provide seasonal water balance estimates by combinations of detailed analysis unit and county (DAU/County) over California. The result is a large data base of ET c and ET aw that will be used to update information in the new California Water Plan (CWP). The application uses the daily climate data, i.e., maximum (T x ) and minimum (T n ) temperature and precipitation (P cp ), which were derived from monthly USDA-NRCS PRISM data (PRISM Group 2011) and daily US National Climate Data Center (NCDC) climate station data to cover California on a 4 km×4 km change grid spacing. The application uses daily weather data to determine reference evapotranspiration (ET o ), using the Hargreaves-Samani (HS) equation (Hargreaves and Samani 1982, 1985). Because the HS equation is based on temperature only, ET o from the HS equation were compared with CIMIS ET o at the same locations using available CIMIS data to determine correction factors to estimate CIMIS ET o from the HS ET o to account for spatial climate differences. Cal-SIMETAW also employs near real-time reference evapotranspiration (ET o ) information from Spatial CIMIS, which is a model that combines weather station data and remote sensing to provide a grid of ET o information. A second database containing the available soil water holding capacity and soil depth information for all of California was also developed from the USDA-NRCS SSURGO database. The Cal-SIMETAW program also has the ability to generate daily weather data from monthly mean values for use in studying climate change scenarios and their possible impacts on water demand in the state. The key objective of this project is to improve the accuracy of water use estimates for the California Water Plan (CWP), which provides a comprehensive report on water supply, demand, and management in California. In this paper, we will discuss the model and how it determines ET aw for use in water resources planning. | Morteza N Orang Richard L Snyder Shu Geng Quinn J Hart Sara Sarreshteh Matthias Falk Dylan Beaudette Scott Hayes Simon Eching | 2013 | Journal of Integrative Agriculture2013，12，8： | 3 |
| 3 | Effect of weekend admission on geriatric hip fractures显示文摘BACKGROUND The care discrepancy for patients presenting to a hospital on the weekend relative to the work week is well documented.With respect to hip fractures,however,there is no consensus about the presence of a so-called“weekend effect”.This study sought to determine the effects,if any,of weekend admission on care of geriatric hip fractures admitted to a large tertiary care hospital.It was hypothesized that geriatric hip fracture patients admitted on a weekend would have longer times to medical optimization and surgery and increased complication and mortality rates relative to those admitted on a weekday.AIM To determine if weekend admission of geriatric hip fractures is associated with poor outcome measures and surgical delay.METHODS A retrospective chart review of operative geriatric hip fractures treated from 2015-2017 at a large tertiary care hospital was conducted.Two cohorts were compared:patients who arrived at the emergency department on a weekend,and those that arrived at the emergency department on a weekday.Primary outcome measures included mortality rate,complication rate,transfusion rate,and length of stay.Secondary outcome measures included time from emergency department arrival to surgery,time from emergency department arrival to medical optimization,and time from medical optimization to surgery.RESULTS There were no statistically significant differences in length of stay(P=0.2734),transfusion rate(P=0.9325),or mortality rate(P=0.3460)between the weekend and weekday cohorts.Complication rate was higher in patients who presented on a weekend compared to patients who presented on a weekday(13.3%vs 8.3%;P=0.044).Time from emergency department arrival to medical optimization(22.7 h vs 20.0 h;P=0.0015),time from medical optimization to surgery(13.9 h vs 10.8 h;P=0.0172),and time from emergency department arrival to surgery(42.7 h vs 32.5 h;P<0.0001)were all significantly longer in patients who presented to the hospital on a weekend compared to patients who presented to the hospital on a weekday.CONCLUSION This study provided insight into the“weekend effect”for geriatric hip fractures and found that day of presentation has a clinically significant impact on delivered care. | Jordan B Pasternack Matthew L Ciminero Michael Silver Joseph Chang Ronald J Simon Kevin K Kang | 2020 | World Journal of Orthopedics2020，11，9： | 2 |
| 4 | Electrode compositions for carbon power supercapacitors显示文摘 | BONNEFOI L SIMON P FAUVARQUE J F | 1999 | J Power Sources1999，80，： | 1 |
| 5 | Circadian and ultradian variations of leptin in normal man under continuous enteral nutrition: relationship to sleep and body temperature显示文摘 | SIMON C GRONF1ER C SCHLIENGER J L | 1998 | J Clin Endocrinol Metab1998，83，6： | 1 |
| 6 | Magmatic--hydrothermal origin of Ne- vada~ s Carlin- type gold deposits显示文摘 | Muntean J L J S Cline A C Simon | 2011 | Nature Geoscience2011，4，12： | 1 |
| 7 | Two-phase n-butenes dimerization by nickel complexes in molten salt media显示文摘 | Dupont J de Souza R F | 1998 | Appl Catal A:General1998，775，： | 1 |
| 8 | Supercritical fluid extraction of essential oil components from lemon-scented botanicals显示文摘 | Rozzi N L Phippen W Simon J E | 2002 | Lebensm Wiss U Technol2002，35，： | 1 |
| 9 | Effects of crystalsize and Si/Al ratio on the surface properties of HZSM-5zeolites显示文摘 | Armaroli T Simon L J Digne M | 2006 | Appl Catal A2006，306，： | 1 |
| 10 | Outcomed and clinicopa thologic variables associated with late recurrence after nephrectomy fkr localiged Renal cell carcinoma显示文摘 | SIMON P K CHRISTOPHER J M BRADLEY C L | 2011 | Urology2011，78，5： | 1 |
| 11 | Toxicity of oxysterols to human monocyte-macrophages显示文摘 | Katharine C Simon J H Keri L H | 1995 | Atherosclerosis1995，118，： | 1 |
| 12 | Studies and characterisations of various activated carbons used for carbon/carbon supercapacitors 显示文摘 | Gamby J Taberna P L Simon P | 2001 | J Power Sources2001，101，1： | 1 |
| 13 | Electrochemical characteristics and impedance spectroscopy studies of carbon-carbon supercapacitors显示文摘 | TABERNA P L SIMON P FAUVARQUE J F | 2003 | J Electrochem Soc2003，150，3： | 1 |
| 14 | Constraints on the redshift dependence of the dark energy potential 显示文摘 | Simon J Verde L Jimenez R | 2005 | Phys Rev D2005，71，12： | 1 |
| 15 | DNA amplification from vegetative and sexual tissues of trees using polymerase chain reaction 显示文摘 | Bousquet J Simon L Lolonde M | 1990 | Can J For Res1990，20，： | 1 |
| 16 | Structure and mechanics of integrin-base cell adhesion 显示文摘 | M Amin Arnaout Simon L Goodman J ian-ping Xiong | 2007 | Current Opinion in Cell Biology2007，19，16： | 1 |
| 17 | Cure kinetics of a thermosetting liquiddicyanate ester monomer / high-Tg polycyanate material显示文摘 | Simon S L Giliham J K | 1993 | Journal of Applied Polymer Science1993，47，3： | 1 |
| 18 | Use of aromatase inhibitors to treat endometriosis-related pain symptoms:asystematic review显示文摘 | Simone Ferrero David J Gillott Pier L Venturini | | 0，，： | 1 |
| 19 | De- velopment of polymer-ceramic composites for improved fire resistance显示文摘 | HANU L G SIMON G P MANSOURI J | 2004 | J Mater Process Technol2004，153，： | 1 |
| 20 | Copper-Zinc-Cobalt-Aluminium-Chromium Hydroxycarbonates and Mixed Oxides显示文摘 | Simone G Mariano L J Piero P | 1996 | J SolidState Chem1996，122，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员