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| 1 | Renin angiotensin system in liver diseases: Friend or foe?显示文摘In the last three decades,the understanding of the renin angiotensin system(RAS)has been changed by the discoveries of functional local systems,novel biologically active peptides,additional specific receptors,alternative pathways of angiotensin(Ang)?Ⅱ?generation,and new roles for enzymes and precursor components other than those in Ang?Ⅱ?synthesis.In this regard,the discovery that Ang-(1-7)opposes the pressor,proliferative,pro-fibrotic,and pro-inflammatory effects mediated by Ang?Ⅱ?has contributed to the realization that the RAS is composed of two axes.The first axis consists of the angiotensin-converting enzyme(ACE),with Ang?Ⅱ?as the end product,and the angiotensin type 1(AT1)receptor as the main effector mediating the biological actions of Ang?Ⅱ.The second axis results from ACE2-mediated hydrolysis of Ang?Ⅱ,leading to the production of Ang-(1-7),with the Mas receptor as the main effector conveying the vasodilatory,antiproliferative,anti-fibrotic,and anti-inflammatory effects of Ang-(1-7).Experimental and clinical studies have shown that both axes of the RAS may take part in the pathogenesis of liver diseases.In this manuscript,we summarize the current evidence regarding the role of RAS in hepatic cirrhosis and its complications,including hemodynamic changes and hepatorenal syndrome.The therapeutic potential of the modulation of RAS molecules in liver diseases is also discussed. | Ana Cristina Simoes e Silva Aline S Miranda Natália P Rocha Antonio L Teixeira | 2017 | World Journal of Gastroenterology2017，23，19： | 12 |
| 2 | Three-port bidirectional converter for hybrid fuel cell systems 显示文摘 | Duarte J L Hendrix M Simoes M G | 2007 | Power Electronics IEEE Transactions on2007，22，2： | 1 |
| 3 | A perturbed Lagrangian formulation for the finite element solution of contact problems显示文摘 | Wriggers P Taylor R L | 1985 | Comp Meth Appl Mech Engng1985，50，： | 1 |
| 4 | A perturbed Lagrangian formulation for the finite element solution of contact problems显示文摘 | SIMO J C WRIGGER P TAYOR R L | 1985 | Computer Methods in Applied Mechanics and Engineering1985，50，16： | 1 |
| 5 | Integration of the e - Learning into the Medical University Curricula 显示文摘 | Rusnakova V Bacharova L Simo J | 2012 | Bratislava Medical Journal - Bratislavske Lekarske Listy2012，113，5： | 1 |
| 6 | Proinflammatory responses of heine in alveolar macrophages: repercussion in lung hemorrhagic episodes显示文摘 | Simoes R L Arruda M A Canetti C | 2013 | Mediators Infiamm2013，2013，94： | 1 |
| 7 | A natural bioflavonoid product containing luteolin(II)显示文摘 | Simoes CM Schenkel EP Bauer L | 1988 | Ethnopharmacol1988，22，3： | 1 |
| 8 | Acute myeloid leukemia (AML-M2) witht(5; 11 )(q35: q 13 )and normal expression of cyclin Dl显示文摘 | DE OLIVEIRA F M TONE L G SIMOES BP | 2007 | Cancer Genet Cytogenet2007，172，2： | 1 |
| 9 | Entropy-based Synthesis of Pretensioned Cable Net Structures显示文摘 | Simoes L M C Templeman A B | 1989 | Engineering Optimization1989，15，2： | 1 |
| 10 | A return mapping algorithm for plane stress elastoplasticity 显示文摘 | Simo J C Taylor R L | 1986 | International Journal for Numerical Methods in Engineering1986，22，： | 1 |
| 11 | Serum concentrations of laminin-P1 in diabetes mellitus:usefulness as an index of diabetic microangiopathy 显示文摘 | Simo M L Masmiquel L Garcia P L | 1996 | Diabetes Res Clin Pract1996，32，： | 1 |
| 12 | Consistent tangent operator for rate-independent elastoplasticity 显示文摘 | Simo J C Taylor R L | 1985 | Computers Methods in Applied Mechanics and Engineering1985，48，： | 1 |
| 13 | On the Dynamics in space of rods undergoing large motions-a geometrically exact approach显示文摘 | Simo J C Vu-Quoc L | | 0，，02： | 1 |
| 14 | Cullin 5 regulates Dabl protein levels and neuron positioning during cortical development 显示文摘 | Feng L Allen NS Simo S | 2007 | Genes Dev2007，21，21： | 1 |
| 15 | A note on the dissipation due to generaized diffusion with electro - chemo- mechanical couplings in heteroionec clays 显示文摘 | Simoes L B Gajo A Fernando M F | 2004 | European Journal of Mechanics A/Solids2004，23，： | 1 |
| 16 | A return mapping algorithm for plane stress elastoplastieity 显示文摘 | Simo J C Taylor R L | 1986 | International Journal for Numerical Methods in Engineering1986，22，3： | 1 |
| 17 | Experimental behaviour of end-plate beam-to-column composite joints under monotonical loading显示文摘 | Simoes da Silva L Simoes R D Cruz P J S | 2001 | Engineering Structures2001，23，： | 1 |
| 18 | Quasi incompressible finite elasticity in principal stretches : continuum basis and numerical algorithms显示文摘 | SIMO J C TAYLOR R L | 1991 | Computational Methods in Applied Mechanics and Engineering1991，85，： | 1 |
| 19 | Consistent tangent operators for rate-independent elastoplasticity 显示文摘 | Simo J C Taylor R L | 1985 | Computer Methods in Applied Mechanics and Engineering1985，48，： | 1 |
| 20 | Species association increases biofilm resistance to chemical and mechanical treatments 显示文摘 | Simoes M Simoes L C Vieira M J | 2009 | Water Research2009，43，1： | 1 |
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