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| 1 | Renin-angiotensin system in the pathogenesis of liver fibrosis显示文摘Hepatic fibrosis is considered a common response to many chronic hepatic injuries.It is a multifunctional process that involves several cell types,cytokines,chemokines and growth factors leading to a disruption of homeostatic mechanisms that maintain the liver ecosystem.In spite of many studies regarding the development of fibrosis,the understanding of the pathogenesis remains obscure.The hepatic tissue remodeling process is highly complex,resulting from the balance between collagen degradation and synthesis.Among the many mediators that take part in this process,the components of the Renin angiotensin system(RAS) have progressively assumed an important role.Angiotensin(Ang)□acts as a profibrotic mediator and Ang-(1-7),the newly recognized RAS component,appears to exert a counter-regulatory role in liver tissue.We briefly review the liver fibrosis process and current aspects of the RAS.This review also aims to discuss some experimental evidence regarding the participation of RAS mediators in the pathogenesis of liver fibrosis,focusing on the putative role of the ACE2-Ang-(1-7)-Mas receptor axis. | Regina Maria Pereira Robson Augusto Souza dos Santos Filipi Leles da Costa Dias Mauro Martins Teixeira Ana Cristina Simoes e Silva | 2009 | World Journal of Gastroenterology2009，15，21： | 37 |
| 2 | Current knowledge on esophageal atresia显示文摘Esophageal atresia (EA) with or without tracheoesophageal fistula (TEF) is the most common congenital anomaly of the esophagus. The improvement of survival observed over the previous two decades is multifactorial and largely attributable to advances in neonatal intensive care, neonatal anesthesia, ventilatory and nutritional support, antibiotics, early surgical intervention, surgical materials and techniques. Indeed, mortality is currently limited to those cases with coexisting severe life-threatening anomalies. The diagnosis of EA is most commonly made during the first 24 h of life but may occur either antenatally or may be delayed. The primary surgical correction for EA and TEF is the best option in the absence of severe malformations. There is no ideal replacement for the esophagus and the optimal surgical treatment for patients with long-gap EA is still contro-versial. The primary complications during the postoperative period are leak and stenosis of the anastomosis, gastro-esophageal reflux, esophageal dysmotility, fistula recurrence, respiratory disorders and deformities of the thoracic wall. Data regarding long-term outcomes and follow-ups are limited for patients following EA/TEF repair. The determination of the risk factors for the complicated evolution following EA/TEF repair may positively impact long-term prognoses. Much remains to be studied regarding this condition. This manuscript provides a literature review of the current knowledge regarding EA. | Paulo Fernando Martins Pinheiro Ana Cristina Simoes e Silva Regina Maria Pereira | 2012 | World Journal of Gastroenterology2012，18，28： | 35 |
| 3 | Renin angiotensin system in liver diseases: Friend or foe?显示文摘In the last three decades,the understanding of the renin angiotensin system(RAS)has been changed by the discoveries of functional local systems,novel biologically active peptides,additional specific receptors,alternative pathways of angiotensin(Ang)?Ⅱ?generation,and new roles for enzymes and precursor components other than those in Ang?Ⅱ?synthesis.In this regard,the discovery that Ang-(1-7)opposes the pressor,proliferative,pro-fibrotic,and pro-inflammatory effects mediated by Ang?Ⅱ?has contributed to the realization that the RAS is composed of two axes.The first axis consists of the angiotensin-converting enzyme(ACE),with Ang?Ⅱ?as the end product,and the angiotensin type 1(AT1)receptor as the main effector mediating the biological actions of Ang?Ⅱ.The second axis results from ACE2-mediated hydrolysis of Ang?Ⅱ,leading to the production of Ang-(1-7),with the Mas receptor as the main effector conveying the vasodilatory,antiproliferative,anti-fibrotic,and anti-inflammatory effects of Ang-(1-7).Experimental and clinical studies have shown that both axes of the RAS may take part in the pathogenesis of liver diseases.In this manuscript,we summarize the current evidence regarding the role of RAS in hepatic cirrhosis and its complications,including hemodynamic changes and hepatorenal syndrome.The therapeutic potential of the modulation of RAS molecules in liver diseases is also discussed. | Ana Cristina Simoes e Silva Aline S Miranda Natália P Rocha Antonio L Teixeira | 2017 | World Journal of Gastroenterology2017，23，19： | 12 |
| 4 | Relationship between angiotensin-(1-7) and angiotensin Ⅱ correlates with hemodynamic changes in human liver cirrhosis显示文摘AIM:To measure circulating angiotensins at different stages ofhuman cirrhosis and to further evaluate a possible relationship between renin angiotensin system (RAS) components and hemodynamic changes.METHODS: Patients were allocated into 4 groups: mild-to-moderate liver disease (MLD), advanced liver disease (ALD), patients undergoing liver transplantation, and healthy controls. Blood was collected to determine plasma renin activity (PRA), angiotensin (Ang) , Ang Ⅱ, and Ang-(1-7) levels using radioimmunoassays. During liver transplantation, hemodynamic parameters were determined and blood was simultaneously obtained from the portal vein and radial artery in order to measure RAS components.RESULTS: PRA and angiotensins were elevated in ALD when compared to MLD and controls (P < 0.05). In contrast, Ang was signicantly reduced in MLD. Ang-(1-7)/Ang Ⅱ ratios were increased in MLD when compared to controls and ALD. During transplantation, Ang Ⅱ levels were lower and Ang-(1-7)/Ang Ⅱ ratios were higher in the splanchnic circulation than in the peripheral circulation (0.52 ± 0.08 vs 0.38 ± 0.04, P < 0.02), whereas the peripheral circulating Ang /Ang ratio was elevated in comparison to splanchnic lev-els (0.18 ± 0.02 vs 0.13 ± 0.02, P < 0.04). Ang-(1-7)/Ang Ⅱ ratios positively correlated with cardiac output (r= 0.66) and negatively correlated with systemic vascular resistance (r =-0.70).CONCLUSION: Our ndings suggest that the relation-ship between Ang-(1-7) and Ang Ⅱmay play a role in the hemodynamic changes ofhuman cirrhosis. | Walkíria Wingester Vilas-Boas Antnio Ribeiro-Oliveira Jr Regina Maria Pereira Renata da Cunha Ribeiro Jerusa Almeida Ana Paula Nadu Ana Cristina Simoes e Silva Robson Augusto Souza dos Santos | 2009 | World Journal of Gastroenterology2009，15，20： | 11 |
| 5 | Autoimmune hepatitis in childhood: The role of genetic and immune factors显示文摘Autoimmune hepatitis (AIH) is a rare chronic inflammatory disease of the liver, which affects a group of patients who lost their immunological tolerance to antigens of the liver. It is clinically characterized by hypergammaglobulinemia, elevated liver enzymes, presence of autoantibodies and histological changes. Although being rare in children, it represents a serious cause of chronic hepatic disease that can lead to cirrhosis and hepatic failure. Clinical findings, exclusion of more common liver disorders and the detection of antibodies antinuclear antibodies, smooth muscle antibodies and anti-LKM1 are usually enough for diagnosis on clinical practice. The pathogenic mechanisms that lead to AIH remain obscure, but some research findings suggest the participation of immunologic and genetic factors. It is not yet knew the triggering factor or factors that stimulate inflammatory response. Several mechanisms proposed partially explain the immunologic findings of AIH. The knowledge of immune factors evolved might result in better markers of prognosis and response to treatment. In this review, we aim to evaluate the findings of research about genetic and immune markers and their perspectives of application in clinical practice especially in pediatric population. | Priscila Menezes Ferri Liu Débora Marques de Miranda Eleonora Druve Tavares Fagundes Alexandre Rodrigues Ferreira Ana Cristina Simoes e Silva | 2013 | World Journal of Gastroenterology2013，19，28： | 3 |
| 6 | Dyslexia-specif- ic brain activation profile becomes normal following sue- cessful remedial training显示文摘 | Simos PG Fletcher JM Bergman E | 2002 | Neurology2002，58，8： | 1 |
| 7 | Liposome-mediated delivery of antiviral agents to human immunodeficiency virus-infected cells显示文摘 | Duzgunes N Pretzer E Simoes S | 1999 | Mol Membr Biol1999，16，1： | 1 |
| 8 | Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas显示文摘 | Santos RA Simoes E Silva AC | 2003 | Proc Natl Acad Sci USA2003，100，14： | 1 |
| 9 | Angiogenic and antiangiogenic factors in proliferative diabetic retinopathy显示文摘 | SIMO R CARRASCO E GARCiA-RAMiREZ M | 2006 | Curr Diabetes Rev2006，2，1： | 1 |
| 10 | Trigonometrically fitted fifth-order runge-kutta methods for the numerical solution of the schrtMinger equation显示文摘 | Anastassi Z A Simos T E | 2005 | Mathematical and Computer Modelling2005，42，： | 1 |
| 11 | Focal polymicrogyria in mother and son 显示文摘 | Caraballo RH Cersòsimo RO Mazza E | 2000 | Brain Dev2000，22，5： | 1 |
| 12 | Angiotensin(1-7) is an endogenous ligand for the G protein-coupled receptor Mas显示文摘 | SANTOS RA SIMOES E SILVA AC MARIC C | 2003 | Proc Natl Acad Sci U S A2003，100，14： | 1 |
| 13 | Role of Myostatin in wasting syndrome assciater with chronic diseases 显示文摘 | Zamora E Galan A Simo R | 2008 | Med Clin (Barc)2008，131，15： | 1 |
| 14 | Association between method of delivery, puerperal complication rate and postpartum hysterectomy显示文摘 | Simoes E Kunz S Bosing Schwenkglenks M | 2005 | Yoong W Arch Gynecol Obstet2005，272，1： | 1 |
| 15 | The epidemiology of respiratory syncytial virus lower respiratory tract infectionsin children less than 5 years of age in Indonesia显示文摘 | Simoes E Mutyara K Soh S | 2011 | Pediatr Infect Dis J2011，30，9： | 1 |
| 16 | Recent advances in the angiotensin-converting enzyme 2-angiotensin(1-7)-Mas axis显示文摘 | Santos RA Ferreira AJ Simoes E | 2008 | Exp Physiol2008，93，5： | 1 |
| 17 | Energetics and structure of simvastatin显示文摘 | Simoes R G Bernardes C E Diogo H P | 2013 | Mol Pharmaceut2013，10，7： | 1 |
| 18 | Evolution of ochra- toxin A content from must to wine in Port Wine microvini- fication 显示文摘 | Ratola N Abade E Simoes T | 2005 | Analytical and Bioanalytical Chemistry2005，382，2： | 1 |
| 19 | Strain behavior of lanthanum modified BiFeO3 thin films prepared via soft chemical method显示文摘 | SIMOES A Z AGUIAR E C GOZALEZ A H M | 2008 | J Appl Phys2008，104，10： | 1 |
| 20 | Endotoxinemia in the portal and the systemic circulation in obstructive jaundice显示文摘 | Papakostas C Bezirtzoglou E Pitiakoudis M Polychronidis A Simo poulos C | 2003 | Clin Exp Med2003，3，： | 1 |
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