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| 1 | Utility of current thrombophilia screening in young patients with stroke and TIA显示文摘Introduction Approximately 40%of strokes in young adults are cryptogenic.The diagnostic yield of thrombophilia screening remains controversial.We aimed to determine utility of current thrombophilia testing for young patients with stroke and transient ischaemic attack(TIA).Methods We present a retrospective review of all patients with stroke and TIA≤60 years presenting to University College London Hospital stroke unit and daily TIA clinic from 1 January 2015 to 1 August 2016.Consecutive clinical records and thrombophilia tests,including factor V Leiden(FVL),prothrombin G20210A mutation(PGM),antiphospholipid antibody(APA),and protein S,C and antithrombin(AT)levels,were reviewed.results The mean age of 628 patients with stroke and TIA was 49.1 years(SD 9.2).Thrombophilia testing was performed in 360(57%)patients,including 171 with stroke and 189 with TIA.Positive tests were found in 50(14%)patients,of whom 24 patients were<50 years.Positive results were found in 36(10%)with acute ischaemic stroke,4(1%)with haemorrhagic stroke and 10(3%)with TIA.Thirteen patients(4%)had homozygous/heterozygous FVL or PGM,and 27(7.5%)had positive APA(anticardiolipin antibody,anti-β2 glycoprotein antibody or lupus anticoagulant).Of 27(7.5%)patients with protein C,S or AT deficiency,10(2.8%)had primary deficiency,presumed hereditary with other secondary causes excluded.9%of patients with protein C,S or AT and 27%with APA were followed by confirmatory testing.Conclusion Thrombophilia testing was positive in only 14%of cases overall.Thrombophilia mutations and protein C,S or AT abnormalities were found rarely and were very uncommon in patients with TIA.Follow-up of abnormal results was generally poor for all groups,which further limited the impact of the thrombophilia testing policy. | Vafa Alakbarzade Alice Taylor Marie Scully Robert Simister Arvind Chandratheva | 2018 | Stroke & Vascular Neurology2018，3，4： | 3 |
| 2 | In vivo short echo time 1H-magnetic resonance spectroscopic imaging(MRSI) of the temporal lobes 显示文摘 | McLean MA Woermann FG Simister RJ | 2001 | Neuroimage2001，14，2： | 1 |
| 3 | Long-term retention rates of new an- tiepileptic drugs in adults with chronic epilepsy and learning disability显示文摘 | Simister ILl Sander JW Koepp MJ | 2007 | Epilepsy Behav2007，10，2： | 1 |
| 4 | Project contract management and a theory of organization 显示文摘 | Turner J R Simister J S | 2001 | International Journal of Project Management2001，19，8： | 1 |
| 5 | Long - term retention rates of new antiepileptic drugs in adults with chronic epilepsy and learning disability 显示文摘 | Simister R J Sander JW Koepp MJ | 2007 | Epilepsy Behav2007，10，2： | 1 |
| 6 | Project contract management and a theory of organization 显示文摘 | J RODNEY TURNER STEPHEN J SIMISTER | 2001 | International Journal of Project Management2001，19，8： | 1 |
| 7 | Long-term retention rates of new antiepileptic drugs in adults with chronic epilepsy and learning disability显示文摘 | Simister RJ Sander JW Koepp MJ | 2007 | Epilepsy Behav2007，10，2： | 1 |
| 8 | Proton MR spectroscopy of metabolite concentrations in temporal lobe epilepsy and effect of temporal lobe resection显示文摘 | Simister RJ McLean MA Barker GJ | 2009 | Epilepsy Res2009，83，2： | 1 |
| 9 | Proton MRS reveals frontal lobe metabolite abnormalities in idiopathic generalized epilepsy显示文摘 | Simister RJ Mclean MA Barker GJ | 2003 | Neurology2003，61，7： | 1 |
| 10 | Project contract management and a theory of or- ganization 显示文摘 | TURNER J R SIMISTER S J | 2001 | International Journal of Project Management2001，，19： | 1 |
| 11 | Proton MRS reveals frontal lobe metabolite abnormalities in idiopathic generalized epilepsy 显示文摘 | Simister RJ McLean MA Barker GJ | 2003 | Neurology2003，61，： | 1 |
| 12 | A proton magnetic resonance spectroscopy study of metabolites in the occipital lobes in epilepsy 显示文摘 | Simister R J McLean MA Barker GJ | 2003 | Epilepsia2003，44，： | 1 |
| 13 | Project Contract Management and a Theory of Organization 显示文摘 | J Rodney Turner Stephen J Simister | 2001 | International Journal of Project Management2001，19，8： | 1 |
| 14 | A Fc receptor structurally related to MHC class I antigens显示文摘 | SIMISTER N E MOSTOV K E | 1989 | Nature1989，337，： | 1 |
| 15 | A proton magnetic resonance spectroscopy study of metabolites in the occipital lobes in epilepsy显示文摘 | Simister RJ Mclean MA Barker GJ | 2003 | Epilepsia2003，44，4： | 1 |
| 16 | An IgG-transporting Fc receptor expressed in the syncytiotrophoblast of human plaeenta显示文摘 | Simister NE Story CM Chen HL | 1996 | Eur J Immunol1996，26，： | 1 |
| 17 | Isolation and characterization of an Fc receptor from neonatal rat small intestine显示文摘 | SIMISTER N E REES A R | 1985 | Eur J Immunol1985，15，： | 1 |
| 18 | Project contract management and a theory of organization 显示文摘 | Turner J R Simister S J | 2001 | International Journal of Project Management2001，19，8： | 1 |
| 19 | Proton MR spectroscopy of metabolite concentrations in temporal lobe epilepsy and effect of temporal lobe resection 显示文摘 | Simister R J McLean MA Barker G J | 2009 | Epilepsy Res2009，83，23： | 1 |
| 20 | An IgG transporting Fc receptor expressed in the syncytiotrophoblast of human placenta显示文摘 | SIMISTER N E STORY C M CHEN H L | 1996 | Eur J Immunol1996，26，： | 1 |
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