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| 1 | Development of hepatorenal syndrome in bile duct ligated rats显示文摘AIM: To evaluate in bile duct ligated rats whether there were progressive alterations of renal function without changes in histopathology. METHODS: Male Wistar rats were submitted to sham-surgery or bile duct ligation (BDL) and divided according to the post-procedure time (2, 4 and 6-wk). To determine renal function parameters, rats wereplaced in metabolic cages and, at the end of the experiment, blood and urine samples were obtained. Histology and hydroxyproline content were analyzed in liver and renal tissue. RESULTS: Rats with 2 wk of BDL increased free water clearance (P = 0.02), reduced urinary osmolality (P = 0.03) and serum creatinine (P = 0.01) in comparison to the sham group. In contrast, rats at 6 wk of BDL showed features of HRS, including signif icant increase in serum creatinine and reductions in creatinine clearance, water excretion and urinary sodium concentration. Rats with 4 wk of BDL exhibited an intermediate stage of renal dysfunction. Progressive hepatic f ibrosis according to post-procedure time was confirmed by histology. The increased levels of liver hydroxyproline contrasted with the absence of structural changes in the kidney, as assessed by histology and unchanged hydroxyproline content in renal tissue. CONCLUSION: Our data show that BDL produced progressive renal dysfunction without structural changes in the kidney, characterizing HRS. The present model will be useful to understand the pathophysiology of HRS. | Regina M Pereira Robson AS dos Santos Eduardo A Oliveira Virgínia HR Leite Filipi LC Dias Alysson S Rezende Lincoln P Costa Lucíola S Barcelos Mauro M Teixeira Ana Cristina Sim■es e Silva | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 2 | Concepts of plant biotic stress: Some insights into the stress physiology of virus-infected plant from the perspective of photosynthesis 显示文摘 | Balachandran S Hurry V M Kelley S E Osmond C B Robinson S A Rohozinski J Seaton G G R Sims D A | 1997 | Physiologia Plantarum1997，100，： | 1 |
| 3 | Chelate-assisted Phytoextraction of Lead from Contaminated Soils显示文摘 | Cooper E M Sims J T Cumningham S D | 1999 | Environ Qual1999，28，： | 1 |
| 4 | Angiogenic and antiangiogenic factors in proliferative diabetic retinopathy显示文摘 | Simó R Carrasco E García-Ramírez M | | 0，，： | 1 |
| 5 | The COOH terminus of arylamine N-acetyltransferase from Salmonella typhimurium controls enzymic activity显示文摘 | Mushtaq A Payton M Sim E | 2002 | J Biol Chem2002，277，12： | 1 |
| 6 | IFITM3 inhibits influenza A virus infection by preventing cytosolic entry显示文摘 | Feeley E M Sims J S John S P | 2011 | PLo S Pathogens2011，7，10： | 1 |
| 7 | Chelate-assisted phytoextraction of lead from contaminated soils显示文摘 | COOPER E M SIMS J T CUNNINGHAM S D | 1999 | Journal of Environmental Quality1999，28，： | 1 |
| 8 | A market-driven model for designing negotiation agents显示文摘 | SIM K M WONG E | 2002 | Computational Intelligence2002，18，4： | 1 |
| 9 | Chelate-assisted phytoextraction of lead from contaminated soils显示文摘 | Cooper E M Sims J T Cunningham S D | 1999 | Journal of Environment Quality1999，28，6： | 1 |
| 10 | Electrochemical behaviour of a Mg-rich primer in the protection of Alalloys 显示文摘 | Battocchi D Sim?es A M Tallman D E Bierwagen G P | 2006 | Corrosion Science2006，48，5： | 1 |
| 11 | Chelate-assisted phytoextraction of lead from contaminated soils显示文摘 | Cooper E M Sims J T Cunningham S D | 1999 | J Environ Qual1999，28，： | 1 |
| 12 | Skin morphology and bumoral non-specific defence parameters of mucus and plasma in rainbow trout, coho and Atlantic salmon 显示文摘 | Fast M D Sims D E Burka J F | 2002 | Comp Biochem Physiol2002，13，： | 1 |
| 13 | Genomic and expression analyses of alternatively spliced transcripts of the MLL septin-like fusion gene(MSF)that map to a 17q25region of loss in breast and ovarian tumors显示文摘 | Kalikin L M Sims H L Petty E M | 2000 | Genomics2000，63，2： | 1 |
| 14 | Comparisonof testing solutions on the protection of Al-alloys using a Mg-richprimer 显示文摘 | Battocchi D Sim?es A M Tallman D E Bierwagen G P | 2006 | Corrosion Science2006，48，8： | 1 |
| 15 | Reusable,lifelike virtual humans for mentoring and roleplaying显示文摘 | SIMS M E | 2007 | Computers and Education2007，49，75： | 1 |
| 16 | Skin morphology and humoral non-specific defence parameters of mucus and plasma in rainbow trout,coho and Atlantic salmon显示文摘 | Fast M D Sims D E Burka J F | 2002 | Comp Biochem Physiol2002，132，： | 1 |
| 17 | TNFRl-dependent VCAM-1 expression by astrocytes exposes the CNS to destructive inflammation 显示文摘 | Gimenez M A Sim J E Russell J H | 2004 | J Neuroimmunol2004，151，12： | 1 |
| 18 | Annotating genes with potential roles in the immune system显示文摘 | Dunn E Sims J E Nicklin M J H | 2001 | Trends Immunol2001，22，： | 1 |
| 19 | A heuristic to solve a sea cargo revenue management problem 显示文摘 | LEE L H CHEW E P SIM M S | 2007 | OR Spectrum2007，29，1： | 1 |
| 20 | Pollution of soils by the toxic spill of a pyrite mine (Aznalcollar, Spain)显示文摘 | M Simón I Ortiz I Garc??a E Fernández J Fernández C Dorronsoro J Aguilar | 1999 | Science of the Total Environment1999，，1： | 1 |
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