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| 1 | 经皮经导管射频消融去肾交感神经术与螺内酯对难治性高血压昼夜节律和血压变异性的影响显示文摘经皮经导管射频消融去肾交感神经术(sympathetic renal denervation,SRD)可作为药物控制不佳的难治性高血压患者的一种替代治疗方法,SRD对减少短期血压变异性(blood pressure variability,BPV)有效。然而,这个作用尚未在随机对照试验中证实。本研究旨在比较螺内酯和SRD对昼夜血压和BPV的影响。方法:对一项随机试验进行析因分析, | de la Sierra A Pareja J Armario P Barrera Yun S Vázquez S Sans L Pascual J Oliveras A 陈云 叶鹏 | 2017 | 中华高血压杂志2017，25，8： | 3 |
| 2 | H pylori receptor MHC classⅡcontributes to the dynamic gastric epithelial apoptotic response显示文摘AIM: To investigate the role of MHC classⅡin the modulation of gastric epithelial cell apoptosis induced by H pylon infection. METHODS: After stimulating a human gastric epithelial cell line with bacteria or agonist antibodies specific for MHC classⅡand CD95, the quantitation of apoptotic and anti-apoptotic events, including caspase activation, BCL-2 activation, and FADD recruitment, was performed with a fluorometric assay, a cytometric bead array, and confocal microscopy, respectively. RESULTS: Pretreatment of N87 cells with the anti-MHC classⅡIgM antibody RFD1 resulted in a reduction in global caspase activation at 24 h of H pylori infection. When caspase 3 activation was specifically measured, crosslinking of MHC class n resulted in markedly reduced caspase activation, while simple ligation of MHC classⅡdid not. Crosslinking of MHC class n also resulted in an increased activation of the anti-apoptosis molecule BCL-2 compared to simple ligation. Confocal microscope analysis demonstrated that the pretreatment of gastric epithelial cells with a crosslinking anti-MHC classⅡIgM blocked the recruitment of FADD to the cell surface. CONCLUSION: The ability of MHC class n to modulate gastric epithelial apoptosis is at least partially dependent on its crosslinking. The crosslinking of this molecule has anti-apoptotic effects during the earlier time points of H pylori infection. This effect is possibly mediated by the ability of MHC classⅡto modulate the activation of the pro-apoptotic receptor Fas by blocking the recruitment of the accessory molecule FADD, and this delay in apoptosis induction could allow for prolonged cytokine secretion by H pylori-infected gastric epithelial cells. | David A Bland Giovanni Suarez Ellen J Beswick Johanna C Sierra Victor E Reyes | 2006 | World Journal of Gastroenterology2006，12，29： | 3 |
| 3 | Relation of atrophic gastritis with Helicobacter pylori-CagA^+ and interleukin-1 gene polymorphisms显示文摘AIM: To determine the association of Helicobacter pylori (H pylori) CagA+ infection and pro-inflammatory poly-morphisms of the genes interleukin (IL)-1RN and IL-1B with the risk of gastric atrophy and peptic ulcers in a dyspeptic population in Costa Rica, a country with high incidence and mortality of gastric cancer. METHODS: Seven biopsy specimens, a fasting blood sample and a questionnaire concerning nutritional and sociodemographic factors were obtained from 501 con-secutive patients who had undergone endoscopy for dyspeptic symptoms. A histopathological diagnosis was made. Pepsinogen concentrations were analyzed by enzyme linked immunosorbent assay (ELISA). Infection with H pylori CagA+ was determined by serology and polymerase chain reaction (PCR). IL-1B and IL-1RN polymorphisms genotyping was performed by PCR-restriction fragment length polymorphism (PCR-RFLP)and PCR respectively. RESULTS: In this dyspeptic population, 86% were H pylori positive and of these, 67.8% were positive for CagA. Atrophic antral gastritis (AAG) was associated with CagA+ status [odd ratio (OR) = 4.1; P < 0.000] and fruit consumption (OR = 0.3; P < 0.00). Atrophic body gastritis (ABG) was associated with pepsinogen PGI/PGII < 3.4 (OR = 4.9; P < 0.04) and alcohol consumption (OR = 7.3; P < 0.02). Duodenal ulcer was associated with CagA+ (OR = 2.9; P < 0.04) and smoking (OR = 2.4; P < 0.04). PGI < 60 μg/L as well as PGI/PGII < 3.4 were associated with CagA+. CONCLUSION: In a dyspeptic population in Costa Rica, H pylori CagA+ is not associated with ABG, but it is a risk factor for AAG. The pro-inflammatory cytokine poly-morphisms IL-1B + 3945 and IL-1RN are not associated with the atrophic lesions of this dyspeptic population. | Rafaela Sierra Clas Une Vanessa Ramírez Warner Alpízar-Alpízar María I González José A Ramírez Antoine de Mascarel Patricia Cuenca Guillermo Pérez-Pérez Francis Mégraud | 2008 | World Journal of Gastroenterology2008，14，42： | 2 |
| 4 | H pylori receptor MHC class Ⅱ contributes to the dynamic gastric epithelial apoptotic response显示文摘AIM: To investigate the role of MHC class Ⅱ in the modulation of gastric epithelial cell apoptosis induced by H pylori infection.METHODS: After stimulating a human gastric epithelial cell line with bacteria or agonist antibodies specifi c for MHC class Ⅱ and CD95, the quantitation of apoptotic and anti-apoptotic events, including caspase activation, BCL-2 activation, and FADD recruitment, was performed with a ? uorometric assay, a cytometric bead array, and confocal microscopy, respectively.RESULTS: Pretreatment of N87 cells with the anti-MHC class Ⅱ IgM antibody RFD1 resulted in a reduction in global caspase activation at 24 h of H pylori infection. When caspase 3 activation was specifically measured, crosslinking of MHC class Ⅱ resulted in a marked re-duced caspase activation, while simple ligation of MHC class Ⅱ did not. Crosslinking of MHC class Ⅱ also re-sulted in an increased activation of the anti-apoptosis molecule BCL-2 compared to simple ligation. Confocal microscope analysis demonstrated that the pretreatment of gastric epithelial cells with a crosslinking anti-MHC class Ⅱ IgM blocked the recruitment of FADD to the cell surface.CONCLUSION: The results presented here demonstrate that the ability of MHC class Ⅱ to modulate gastric epi-thelial apoptosis is at least partially dependent on its crosslinking. Furthermore, while previous research has demonstrated that MHC class Ⅱ signaling can be pro-apoptotic during extended ligation, we have shown that the crosslinking of this molecule has anti-apoptotic ef-fects during the earlier time points of H pylori infection. This effect is possibly mediated by the ability of MHC class Ⅱ to modulate the activation of the pro-apoptotic receptor Fas by blocking the recruitment of the accessory molecule FADD, and this delay in apoptosis induction could allow for prolonged cytokine secretion by H pylori-infected gastric epithelial cells. | David A Bland Giovanni Suarez Ellen J Beswick Johanna C Sierra Victor E Reyes | 2006 | World Journal of Gastroenterology2006，12，33： | 2 |
| 5 | Cerebral hemodynamics and silent cerebral white matter lesions in middle-aged essential hypertensive patients显示文摘 | Sierra C de la Sierra A Chamorro A | 2004 | Blood Press2004，13，： | 1 |
| 6 | Blood pressure variability and silent cerebral damage in essential hypertension显示文摘 | Gómez-Angelats E de La Sierra A Sierra C | 2004 | Am J Hypertens2004，17，7： | 1 |
| 7 | Early detection and management of the high-risk patient with elevated blood pressure 显示文摘 | Sierra C de la Sierra A | 2008 | Vase Health Risk Manag2008，4，2： | 1 |
| 8 | Phytic Acid Level in Wheat Flours显示文摘 | C I Febles A Arias A Hardisson C Rodríguez-Alvarez A Sierra | 2002 | Journal of Cereal Science2002，36，1： | 1 |
| 9 | Relation of increased leptin concentrations to history of myocardial infarction and stroke in the United States population 显示文摘 | Sierra 11 Romero-Corral A Lopez-Jimenez F | 2007 | Am J Cardiol2007，100，2： | 1 |
| 10 | Astrocyte-derived cytokines contribute to the metastatic brain specificity of breast cancer cells显示文摘 | Sierra A | | 0，，04： | 1 |
| 11 | The role of microglia in the healthy brain显示文摘 | Tremblay ME Stevens B Sierra A | 2011 | The Journal of neuroscience:the official journal of the Society for Neuroscience2011，31，16： | 1 |
| 12 | Methodology to screen new iron chelates:prediction of their behavior in nutrient solution and soil conditions显示文摘 | YUNTA F SIERRA M A GMEZ-GALLEGO M | 2003 | Journal of Plant Nutrition2003，26，： | 1 |
| 13 | Relationships of job and some individual characteristics to occupational injuries in employed people: a community-based study 显示文摘 | BHATTACHERJEE A CHAU N SIERRA C O | 2003 | J Occup Health2003，45，6： | 1 |
| 14 | Primary CNS lymphoma in immunocompetent patients 显示文摘 | Sierra del Rio M Rousseau A Soussain C | 2009 | Oncolo- gist2009，14，5： | 1 |
| 15 | Bcl-2 with loss of apoptosis allows accumulation of genetic alterations: a pathway to metastatic progression in human breast cancer显示文摘 | Sierra A Castellsague X Eseobedo A | 2000 | Int J Cancer2000，89，2： | 1 |
| 16 | Synergistic cooperation between c-myc and Bcl-2 in lymph node progression of T1 human breast carcinoma显示文摘 | Sierra A Castellsague A Escobedo A | 1999 | Breast Cancer Research and Treatment1999，54，： | 1 |
| 17 | Pedraza S: C-reactive Protein Used as an Early Indicator of Infection in Patients with Systemic Inflammatory Response Syndrome显示文摘 | Sierra R Rello J Bailen M A | 2004 | Intensive Care Med2004，30，： | 1 |
| 18 | Primary CNSlymphoma in immunocompetent patients显示文摘 | Sierra del Rio M Rousseau A Soussain C | 2009 | Oncologist2009，14，5： | 1 |
| 19 | Cardioprotective effects of acute normovolemic hemodilution in patients with severe aortic s tenosis undergoing valve replacement 显示文摘 | Licker M Sierra J Kalangos A | 2007 | Transfusion2007，47，2： | 1 |
| 20 | Reactivity of synthetic Fe chelates with soils and soil components显示文摘 | Ana Alvarez-Fernandez Miguel A Sierra Juan J Lucena | 2002 | Plant and Soil2002，，241： | 1 |
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