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| 1 | ATP-binding cassette subfamily B member 1 (ABCB1) and subfamily C member 10(ABCC1O) are not primary resistance factors for cabazitaxel显示文摘Introduction:ATP-binding cassette subfamily B member 1(ABCB1) and subfamily C member 10(ABCCIO) proteins are efflux transporters that couple the energy derived from ATP hydrolysis to the translocation of toxic substances and chemotherapeutic drugs out of cells.Cabazitaxel is a novel taxane that differs from paclitaxel by its lower affinity for ATP-binding cassette(ABC) transporters.Methods:We determined the effects of cabazitaxel,a novel tubulin-binding taxane,and paclitaxel on paclitaxelresistant,ABCB1-overexpressing KB-C2 and LLC-MDR1-WT cells and paclitaxel-resistant,ABCC10-overexpressing HEK293/ABCC10 cells by calculating the degree of drug resistance and measuring ATPase activity of the ABCB1 transporter.Results:Decreased resistance to cabazitaxel compared with paclitaxel was observed in KB-C2,LLC-MDR1-WT,and HEK293/ABCC10 cells.Moreover,cabazitaxel had low efficacy,whereas paclitaxel had high efficacy in stimulating the ATPase activity of ABCB1,indicating a direct interaction of both drugs with the transporter.Conclusion:ABCB1 and ABCC10 are not primary resistance factors for cabazitaxel compared with paclitaxel,suggesting that cabazitaxel may have a low affinity for these efflux transporters. | Rishil J Kathawala Yi-Jun Wang Suneet Shukla Yun-Kai Zhang Saeed Alqahtani Amal Kaddoumi Suresh V Ambudkar Charles R Ashby Jr Zhe-Sheng Chen | 2015 | Chinese Journal of Cancer2015，34，3： | 4 |
| 2 | Mechanical transmission of Galinsoga mosaic virus in soil 显示文摘 | Shukla D D Shanks G J | 1979 | Aust J Biol Sci1979，32，3： | 2 |
| 3 | Influence of land surface evapotranspiration on the earth' s climate显示文摘 | Shukla J Mintz Y | 1982 | Science1982，215，3： | 1 |
| 4 | Development and evaluation of antigen capture ELISA for early clinical diagnosis of chikungunya显示文摘 | Shukla J Khan M Tiwari M | 2009 | Diagn Microbiol Infec Dis2009，65，2： | 1 |
| 5 | An apparent relationship between Eurasian snow cover and Indian monsoon rainfall 显示文摘 | Hahn D G Shukla J | 1976 | Journal of Atmos- pheric Science1976，33，： | 1 |
| 6 | Removal ofnickel from aqueous solutions by sawdust显示文摘 | SHUKLA S S YU L J DORRIS K L | 2005 | Journal ofHazardous Materials2005，121，123： | 1 |
| 7 | Newlithium-ion conductors based on the NASICON structure显示文摘 | Thangadurai V Shukla A K Gopalakrishnan J | 1999 | Journal of Materials Chemistry1999，9，3： | 1 |
| 8 | Recent advances in large-scale production of monoclonal antibodies and related proteins显示文摘 | Shukla A A Thommes J | 2010 | Trends in Biotechnology2010，28，5： | 1 |
| 9 | Influence of Land - surface Evapotranspiration on the Earth' s Climate 显示文摘 | Shukla J Mintz Y | 1982 | Science1982，215，4539： | 1 |
| 10 | Removal of nickel fromaqueous solutions by sawdust显示文摘 | Shukla S S Yu L J Dorris K L | 2005 | Journal of Hazardous Materials2005，121，123： | 1 |
| 11 | Static and dynamic behavior of concrete and granite in tension with damage显示文摘 | Gomez J T Shukla A Sharma A | 2001 | Theoretical and Applied Fracture Mechanics2001，36，： | 1 |
| 12 | Emerging Dimension of Coastal Eco-Tourism Resources along lhe Coast of West Bengal, India 显示文摘 | MANDAL M DANDAPATH P K SHUKLA J | 2013 | International Journal of Advanced Research in Management and SoeialSciences2013，2，1： | 1 |
| 13 | Familial exudative vitreoretinopathy(FEVR): clinical profile and managemenl 显示文摘 | Shukla D Singh J Sudheer G | 2003 | Indian J Ophthalmol2003，51，4： | 1 |
| 14 | Outcome and at- tributable cost of ventilator-associated pneumonia among in- tensive care unit patients in a suburban medical center显示文摘 | Warren D K Shukla S J Olsen M A | 2003 | Crit Care Med2003，31，5： | 1 |
| 15 | Influence of land-surface evapotranspiration on the earth climate显示文摘 | | 1982 | Science1982，215，： | 1 |
| 16 | Predictability in the midst of chaos: a scientific basis for climate forecasting显示文摘 | SHUKLA J | 1998 | Science1998，282，： | 1 |
| 17 | Fungal morphology andfragmentation behavior in a fed- batch Aspergillus oryzae fermentation at the production scale 显示文摘 | Li Z J Shukla V Fordyce A P | 2000 | Biotechnol Bioeng2000，70，3： | 1 |
| 18 | Urbanization, Energy Use and Greenhouse Effects in Economic Development 显示文摘 | Parikh J Shukla V | 1995 | Global Environmental Change1995，5，2： | 1 |
| 19 | Activation tagging of the floral Inducer FT显示文摘 | Kardailsky I Shukla V K Ahn J H | 1999 | Science1999，286，： | 1 |
| 20 | Predictability in the midst of Chaos: A scientific ba sis for climate forecasting 显示文摘 | SHUKLA J | 1998 | Science1998，282，31： | 1 |
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