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| 1 | Diagnosis and management of pancreatic neuroendocrine tumor in von Hippel-Lindau disease显示文摘The pancreatic manifestations seen in patients with von Hippel-Lindau(VHL) disease are subdivided into 2 categories:pancreatic neuroendocrine tumors(NET),and cystic lesions,including simple cyst and serous cystadenoma.The VHL-associated cystic lesions are generally asymptomatic and do not require any treatment,unless they are indistinguishable from other cystic tumor types with malignant potential.Because pancreatic NET in VHL disease are non-functioning and have malignant potential,it is of clinical importance to find and diagnose these as early as possible.It will be recommended that comprehensive surveillance using dynamic computed tomography for abdominal manifestations,including pancreatic NET,should start from the age of 15 years in VHL patients.Unlike sporadic non-functioning NET without VHL disease,in which surgical resection is generally recommended,VHL patients at lower metastatic risk of pancreatic NET should be spared the risks of operative resection. | Kenji Tamura Isao Nishimori Tetsuhide Ito Ichiro Yamasaki Hisato Igarashi Taro Shuin | 2010 | World Journal of Gastroenterology2010，16，36： | 6 |
| 2 | Clinical applications of 5-aminolevulinic acid-mediated fluorescence for gastric cancer显示文摘5-aminolevulinic acid(ALA) is a naturally occurring amino acid that is a protoporphyrin IX(Pp IX) precursor and a next-generation photosensitive substance. After exogenous administration of ALA, Pp IX specifically accumulates in cancer cells owing to the impaired metabolism of ALA to Pp IX in mitochondria, which results in a red fluorescence following irradiation with blue light and the formation of singlet oxygen. Fluorescence navigation by photodynamic diagnosis(PDD) using ALA provides good visualization and detection of gastric cancer lesions and is a potentially valuable diagnostic tool for gastric cancer for evaluating both the surgical resection margins and extension of the lesion. Furthermore, PDD using ALA might be used to detect peritoneal metastases during preoperative staging laparoscopy, where it could provide useful information for the selection of a therapeutic approach. Another promising application for this modality is in the evaluation of lymph node metastases. Photodynamic therapy(PDT) using ALA to cause selective damage based on the accumulation of a photosensitizer in malignant tissue is expected to be a non-invasive endoscopic treatment for superficial early gastric cancer. ALA has the potential to be used not only as a diagnostic agent but also as a therapeutic drug, resulting in a new strategy for cancer diagnosis and therapy. Here, we review the current use of PDD and PDT in gastric cancer and evaluate its future potential beyond conventional modalities combined with a light energy upconverter, a light-emitting diode and nearinfrared rays as light sources. | Tsutomu Namikawa Tomoaki Yatabe Keiji Inoue Taro Shuin Kazuhiro Hanazaki | 2015 | World Journal of Gastroenterology2015，21，29： | 6 |
| 3 | Spontaneous rupture of adrenal pheochromocytoma: a case report 显示文摘 | Noguchi S Shuin T | 1994 | J Urol1994，151，1： | 1 |
| 4 | Induction of cytotox- icity by photoexcited TiO2 particles 显示文摘 | Cai RX Kubota Y Shuin T | 1992 | J Cancer Res1992，52，： | 1 |
| 5 | Overexpression of p53 protein in human tumors显示文摘 | Inoue K Kurabayashi A Shuin T | 2012 | Med Mol Morphol2012，45，3： | 1 |
| 6 | Cell cycle-associated changes in slingshot phosphatase activity and roles in cytokinesis in animal cells显示文摘 | Kaji N Ohashi K Shuin M | 2003 | J Biol Chem2003，278，33： | 1 |
| 7 | Overexpression of p53 protein in human tumor 显示文摘 | Inoue K Kurabayashi A Shuin T | 2012 | Med Mol Morphol2012，45，3： | 1 |
| 8 | Frequent somatic mutations and loss of heterozygosity of the von Hippel-Lindau tumor suppressor gene in primary human renal cell carcinomas显示文摘 | Shuin T Kondo K Torigoe S | 1994 | Cancer Res1994，54，11： | 1 |
| 9 | Overexpression of p53 pro- tein in human tumors显示文摘 | Inoue K Kurabayashi A Shuin T | 2012 | Med Mol Morphol2012，45，3： | 1 |
| 10 | Differential expression of protoon-cogenes in human germ cell tumors of the testis显示文摘 | Shuin T Misaki H Kubota Y | 1994 | Cancer1994，73，6： | 1 |
| 11 | Yon hippel tnd, an disease: molecular patIlolocal basis, clinical criteria, genetic testing, clinical rearms of lunlolx and treatment显示文摘 | Shuin T Yamasaki I Tamura K | 2006 | Jim J Clin Oneol2006，36，： | 1 |
| 12 | Frequent somatic mutations and loss of heterozygosity of the yon Hippel-Lindau tumor suppressor gene in primary human renal cell carcinomas显示文摘 | Shuin T Kondo K Zbar B | 1994 | Cancer Res1994，54，： | 1 |
| 13 | Differential expression of protooncogenes in human germ cell tumors of the testis显示文摘 | Shuin HL Misaki H Kubota Y | 1994 | Cancer1994，73，3： | 1 |
| 14 | Loss of heterozygosity at the p53,RB,DCC and APC tumor suppressor gene loci in human bladder cancer显示文摘 | Miyamoto H Shuin T Ikeda I | 1996 | J Urol1996，155，4： | 1 |
| 15 | Induction of cytotoxicity by photoexcited TiO2 particles 显示文摘 | Cai R Kubota Y Shuin T | 1992 | Cancer Res1992，52，8： | 1 |
| 16 | Von Hippel-Lindau disease : molecular pathological basis, clinical criteria, genetic testing, clinical features of tumors and treatment 显示文摘 | Shuin T Yamasaki I Tamura K | 2006 | Jpn J Clin Oncol2006，36，6： | 1 |
| 17 | Cell cycle-associated changes in slingshot phosphatase activity and roles in cytokinesis in animal cells显示文摘 | Kaji N Ohashi K Shuin M | 2003 | J Biol Chem2003，278，33： | 1 |
| 18 | Giant adrenal calcification 显示文摘 | Taguchi T Inoue K Shuin T | 2011 | Intern Med2011，50，16： | 1 |
| 19 | Paxillin: Application of immunohistochemistry to the diagnosis of chromophobe renal cell carcinoma and oncocytoma 显示文摘 | Guo L Toi M Naruse K Miyazaki E Hayashi Y Yoshikawa C Ashida S Shuin T Enzan H | 2001 | Appl Immunohistochem Mol Morphol2001，9，4： | 1 |
| 20 | Differential expression of protooncogenes in human germ cell tumors of the testis 显示文摘 | Shuin T Misaki H Kubota Y | 1994 | Cancer1994，73，6： | 1 |
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