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| 1 | Microscopic inspection and tracking of single upconversion nanoparticles in living cells显示文摘Nanoparticles have become new tools for cell biology imaging1,sub-cellular sensing2,super-resolution imaging3,4 and drug delivery5.Long-term 3D tracking of nanoparticles and their intracellular motions have advanced the understanding of endocytosis and exocytosis as well as of active transport processes6–8.The sophisticated operation of correlative optical-electron microscopy9,10 and scientific-grade cameras is often used to study intercellular processes.Nonetheless,most of these studies are still limited by the insufficient sensitivity for separating a single nanoparticle from a cluster of nanoparticles or their aggregates8,11,12.Here we report that our eyes can track a single fluorescent nanoparticle that emits over 4000 photons per 100 milliseconds under a simple microscope setup.By tracking a single nanoparticle with high temporal,spectral and spatial resolution,we show the measurement of the local viscosity of the intracellular environment.Moreover,beyond the colour domain and 3D position,we introduce excitation power density as the fifth dimension for our eyes to simultaneously discriminate multiple sets of single nanoparticles. | Fan Wang Shihui Wen Hao He Baoming Wang Zhiguang Zhou Olga Shimoni Dayong Jin | 2018 | Light(Science & Applications)2018，7，1： | 9 |
| 2 | A longitudinal assessment of retinal function and structure in the APP/PS1 transgenic mouse model of Alzheimer’s disease显示文摘Background:A great body of evidence suggests that there are retinal functional and structural changes that occur in Alzheimer’s disease(AD).However,whether such changes are primary or secondary remains to be elucidated.We studied a range of retinal functional and structural parameters in association with AD-specific pathophysiological markers in the double transgenic APP/PS1 and control mice across age.Methods:Electroretinogram(ERG)and optical coherence tomography(OCT)was performed in APP/PS1 and wild type(WT)control mice every 3 months from 3 to 12 months of age.For functional assessment,the a-and b-wave of the ERG,amplitude of oscillatory potentials(OP)and the positive scotopic threshold response(pSTR)were quantified at each time point.For structural assessment,the inner and outer retinal thickness was segmented and measured from OCT scans.Episodic memory was evaluated at 6,9 and 12 months of age using the novel object recognition test.Amyloid beta(Aβ)distribution in the hippocampus and the retina were visualised at 3,6 and 12 months of age.Interand intra-group analysis was performed to study rate of change for each parameter between the two groups.Results:Inter-group analysis revealed a significant difference in b-wave and OPs of APP/PS1 compared to WT controls starting from 3 months(p<0.001).There was also a significant difference in the amplitude of pSTR between the two groups starting from 6 months(p<0.001).Furthermore,a significant difference in the inner retinal thickness,between the two groups,was observed starting from 9 months(p<0.001).Conclusions:We observed an age-related decline in retinal functional and structural parameters in both APP/PS1 and WT controls,however,inter-group analysis revealed that inner retinal functional and structural decline is exacerbated in APP/PS1 mice,and that retinal functional changes precede structural changes in this strain.Further studies are required to confirm whether such phenomenon occurs in humans and if studying retinal functional changes can aid-in early assessment of AD. | Dana Georgevsky Stephanie Retsas Newsha Raoufi Olga Shimoni S.Mojtaba Golzan | 2019 | Translational Neurodegeneration2019，8，1： | 3 |
| 3 | Effects of long chain fatty acid unsaturation on the structure and controlled release properties of amylose complexes显示文摘 | Uri Lesmes Shahar H. Cohen Yizhak Shener Eyal Shimoni | 2008 | Food Hydrocolloids2008，，3： | 2 |
| 4 | Bell' s theorem without inequalities显示文摘 | GREENBERGER D M HORNE M A SHIMONY A | 1990 | American Journal of Physics1990，58，12： | 1 |
| 5 | Normal brain matu- ration during childhood: developmental trends characterized with diffusion-tensor MR imaging显示文摘 | Mukherjee P Miller J H Shimony J S | 2001 | Radiology2001，221，2： | 1 |
| 6 | Meta - analysis of randomized controlled trials of intracoronary versus intravenous adminis- tration of glycoprotein Ilb/IIIa inhibitors during percutaneous coronary intervention for acute coronary syndrome 显示文摘 | Friedland S Eisenberg M J Shimony A | 2011 | Am J Cardiol2011，108，9： | 1 |
| 7 | Identification of hibernating myocardium with quantitative intravenous myocardial contrast echocardiographcy,comparison with dobutamine Echocardiography and Thallium-201 scintigraphy显示文摘 | Shimoni S Frangogiannis NG Aggeli CJ | 2003 | Circulation2003，107，4： | 1 |
| 8 | Role of an inwardly rectifying potassium current in rabbit ventricular action potential 显示文摘 | SHIMONI Y CLARK R B GILES W R | 1992 | J Physiol( Lond)1992，448，1： | 1 |
| 9 | Identification of hibernating myocardium ntravenous myocardial contrast with quantitative echocardiography: comparison with dobutamine echocardiography and thallium- 201 scintigraphy 显示文摘 | Shimoni S Frangogiannis NG Aggeli CJ | 2003 | Circulation2003，107，： | 1 |
| 10 | Halofuginone inhibits NF-kappa B and p38 MAPK in activated T ceils 显示文摘 | Leiba M Cahalon L Shimoni A | 2006 | JLeukoc Biol2006，80，2： | 1 |
| 11 | Diffusion-tensor MR imaging of gray and white matter development during normal human brain maturation显示文摘 | Mukherjee P Miller JH Shimony JS | 2002 | AJNR Am J Neuroradiol2002，23，9： | 1 |
| 12 | The abdominal compartment syndrome: CT findings显示文摘 | Pickhardt PJ Shimony JS Heiken JP | 1999 | Am J Roentgenol1999，173，3： | 1 |
| 13 | Harnessing graft-versus-malignancy: non-myeloablative preparative regimens for allogeneichaematopoietic transplantation, an evolving strategy for adoptive im-munotherapy 显示文摘 | Champlin R Khouri I Shimoni A | 2000 | Br J Haematol2000，111，1： | 1 |
| 14 | Disrup- tion of Napl4, a plastid - localized non-intrin- sic ABC protein in krabidopsis thaliana results in the over-accumulation of transition metals and in aberrant chloroplast structures 显示文摘 | Shimoni S E Hassidim M Yuval N N | 2010 | Plant Cell&Environment2010，33，6： | 1 |
| 15 | Noninvasive functional and structural connectivity mapping of the human thalamocortieal system显示文摘 | Zhang Dong-yang Snyder AZ Shimony JS | 2010 | Cereb Cortex2010，20，5： | 1 |
| 16 | Yttrium-90–ibritumomab tiuxetan (Zevalin) combined with high-dose BEAM chemotherapy and autologous stem cell transplantation for chemo-refractory aggressive non-Hodgkin’s lymphoma显示文摘 | Avichai Shimoni S. Tzila Zwas Yakov Oksman Izhar Hardan Noga Shem-Tov Ronit Yerushalmi Abraham Avigdor Isaac Ben-Bassat Arnon Nagler | 2007 | Experimental Hematology2007，，4： | 1 |
| 17 | Modeling pathogen growth in meat products:future challenges显示文摘 | SHIMONI E LABUZA T P | 2000 | Trends Food Sci Technol2000，11，： | 1 |
| 18 | Diffusion tensor fiber tracking of human brain connectivity:aquisition methods,reliability analysis and biological results显示文摘 | Lori NF Akbudak E Shimony JS | 2002 | NMR Biomed2002，15，： | 1 |
| 19 | Incidence,risk factors,management and outcomes of coronary artery perforation during percutaneous coronary intervention显示文摘 | Shimony A Zahger D Van Straten M | 2009 | Am J Cardiol2009，104，2： | 1 |
| 20 | Safety of laparoscopic vs open bariatric surgery:a systematic review and meta-analysis显示文摘 | Reoch J Mottillo S Shimony A | | 0，，11： | 1 |
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