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| 1 | 中国东部富钾埃达克岩成因的实验约束(英文)显示文摘Adakite在地球化学上具明显特征的火山岩和深成花岗岩类岩石 ,见于洋内岛孤环境和大陆孤 ,如安底斯孤。在洋内岛孤 ,由热的消减的年轻大洋岩石圈熔融形成 (叫做“板片熔融”) ,而在大陆孤 ,熔融曾发生在构造或岩浆加厚的下地壳底(叫做“下地壳熔融”)。在这两种产状环境中 ,adakite的鲜明地球化学特征被认为是起因于 ,一种不同程度含水的变质基性原岩在足够深度上的部分熔融 ;这里的足够深度是指可使石榴子石在残余结晶组合 (即石榴角闪石和 /或榴辉石的残余 )中保持稳定的深度。“原始”或“母”adakite熔体一旦形成 ,便可能在其向上运移和侵位到中上地壳期间受到同化作用 (或是地幔 ,或是大陆物质 )和结晶分异作用的改造。中国东部晚中生代 (早中白垩世 ,16 0 - 110 Ma)的 adakite,与见于同一地区和其它地方的钠质 adakite相比 ,通常富含钾 (K2 O)和其它大离子亲石元素 (如 Ba、Th、U) ,有较低的 Na2 O/K2 O比值 (~ 1.0 - 1.1) ,类似于玄武岩在石榴角闪岩 -榴辉岩相含水熔融实验中所产生的 adakite熔体 ,要么是由洋壳板片熔融所形成 ,要么是由不同成分的玄武质下地壳原岩部分熔融所形成。尽管有这些成分差异 ,它们的总体化学特征仍然可将中国东部的富钾花岗岩类岩石定为adakite。我们把这些富钾的 | Robert P.RAPP 肖龙 Nobu SHIM IZU | 2002 | 岩石学报2002，18，3： | 100 |
| 2 | 土壤中总石油烃污染(TPH)的微生物降解与修复研究进展显示文摘微生物降解和修复是处理土壤中总石油烃(TPH)污染最简单、有效的方法之一.论文阐述了土壤TPH污染的产生、危害以及物理、化学、生物等修复方法的各自特点,其中重点介绍了微生物修复方法,论述了土壤中TPH在微生物表面的吸附、转运,在微生物体内的降解以及相关降解酶及基因;详细介绍了电子受体、温度、pH、营养元素等外界因素对微生物修复TPH污染的影响,在此基础上对土壤TPH污染的微生物修复现状和发展趋势进行了讨论. | 马强 林爱军 马薇 CHOI Derek SHIM Hojae 朱永官 | 2008 | 生态毒理学报2008，3，1： | 38 |
| 3 | Clinicopathologic factors and molecular markers related to lymph node metastasis in early gastric cancer显示文摘AIM: To analyze predictive factors for lymph node metastasis in early gastric cancer.METHODS: We analyzed 1104 patients with early gastric cancer(EGC) who underwent a gastrectomy with lymph-node dissection from May 2003 through July 2011. The clinicopathologic factors and molecular markers were assessed as predictors for lymph node metastasis. Molecular markers such as microsatellite instability, human mut L homolog 1, p53, epidermal growth factor receptor(EGFR) and human epidermal growth factor receptor 2(HER2) were included. The χ2 test and logistic regression analysis were used to determine clinicopathologic parameters.RESULTS: Lymph node metastasis was observed in 104(9.4%) of 1104 patients. Among 104 cases of lymph node positive patients, 24 patients(3.8%) were mucosal cancers and 80 patients(16.7%) were submucosal. According to histologic evaluation, the number of lymph node metastasis found was 4(1.7%) for well differentiated tubular adenocarcinoma, 45(11.3%) for moderately differentiated tubular adenocarcinoma, 36(14.8%) for poorly differentiated tubular adenocarcinoma, and 19(8.4%) for signet ring cell carcinoma. Of 690 EGC cases, 77 cases(11.2%) showed EGFR overexpression. HER2 overexpression was present in 110 cases(27.1%) of 406 EGC patients. With multivariate analysis, female gender(OR = 2.281, P = 0.009), presence of lymphovascular invasion(OR = 10.950, P < 0.0001), diameter(≥ 20 mm, OR = 3.173, P = 0.01), and EGFR overexpression(OR = 2.185, P = 0.044) were independent risk factors for lymph node involvement.CONCLUSION: Female gender, tumor size, lymphovascular invasion and EGFR overexpression were predictive risk factors for lymph node metastasis in EGC. | Eun Hyo Jin Dong Ho Lee Sung-Ae Jung Ki-Nam Shim Ji Yeon Seo Nayoung Kim Cheol Min Shin Hyuk Yoon Hyun Chae Jung | 2015 | World Journal of Gastroenterology2015，21，2： | 30 |
| 4 | Photodynamic therapy prolongs metal stent patency in patients with unresectable hilar cholangiocarcinoma显示文摘AIM:To evaluate the effect of photodynamic therapy (PDT) on metal stent patency in patients with unresectable hilar cholangiocarcinoma (CC). METHODS:This was a retrospective analysis of patients with hilar CC referred to our institution from December, 1999 to January, 2011. Out of 232 patients, thirty-three patients with unresectable hilar CC were treated. Eighteen patients in the PDT group were treated with uncovered metal stents after one session of PDT. Fifteen patients in the control group were treated with metal stents alone. Porfimer sodium (2 mg/kg) was administered intravenously to PDT patients. Fortyeight hours later, PDT was administered using a diffusing fiber that was advanced across the tumor by either endoscopic retrograde cholangiopancreatography or percutaneous cholangiography. After performance of PDT, uncovered metal stents were inserted to ensure adequate decompression and bile drainage. Patient survival rates and cumulative stent patency were calculated using Kaplan-Meier analysis with the log-rank test. RESULTS:The PDT and control patients were comparable with respect to age, gender, health status, pretreatment bilirubin, and hilar CC stage. When compared to control, the PDT group was associated with significantly prolonged stent patency (median 244 ± 66 and 177 ± 45 d, respectively, P = 0.002) and longer patient survival (median 356 ± 213 and 230 ± 73 d, respectively, P = 0.006). Early complication rates were similar between the groups (PDT group 17%, control group 13%) and all patients were treated conservatively. Stent malfunctions occurred in 14 PDT patients (78%) and 12 control patients (80%). Of these 26 patients, twenty-two were treated endoscopically and four were treated with external drainage. CONCLUSION:Metal stenting after one session of PDT may be safe with acceptable complication rates. The PDT group was associated with a significantly longer stent patency than the control group in patients with unresectable hilar CC. | Tae Yoon Lee Young Koog Cheon Chan Sup Shim Young Deok Cho | 2012 | World Journal of Gastroenterology2012，18，39： | 28 |
| 5 | Targeted and effective photodynamic therapy for cancer using functionalized nanomaterials显示文摘Photodynamic therapy(PDT) is an emerging, non-invasive therapeutic strategy that involves photosensitizer(PS) drugs and external light for the treatment of diseases. Despite the great progress in PS-mediated PDT, their clinical applications are still hampered by poor water solubility and tissue/cell specificity of conventional PS drugs. Therefore, great efforts have been made towards the development of nanomaterials that can tackle fundamental challenges in conventional PS drug–mediated PDT for cancer treatment. This review highlights recent advances in the development of nano-platforms, in which various functionalized organic and inorganic nanomaterials are integrated with PS drugs, for significantly enhanced efficacy and tumor-selectivity of PDT. | Eun Ji Hong Dae Gun Choi Min Suk Shim | 2016 | Acta Pharmaceutica Sinica B2016，6，4： | 22 |
| 6 | 芘高效降解菌的分离鉴定及其降解特性研究显示文摘采用富集培养的方法从多环芳烃污染的土壤中分离到3株能高效降解四环芳烃芘的细菌J1、J2、J3,经形态观察、生理生化和16SrDNA鉴定,J1属于铜绿假单胞菌属(Pseudomonas aeruginosa),J2属于黄杆菌属(Flavobacterium mizutaii),J3属于短短芽孢杆菌属(Brevibacillus parabrevis).3株细菌均能以芘作为碳源生长,在含芘50、100、200、500、1 000 mg/L的无机盐液体培养基中培养7 d后细菌总数达到最高,在含芘200 mg.L-1的无机盐液体培养基中7d的降解效率分别达到53.04%、65.03%、51.02%.3株细菌对培养基具有较广泛的pH适应范围,在芘浓度200 mg/L,pH为4~9的液体条件下,均可生长,且对芘有很好的降解.虽然可以采用芘的二氯甲烷溶液或者N,N-二甲基甲酰胺(DMF)溶液向培养液中添加芘,但是以N,N-二甲基甲酰胺添加的方式芘在水溶液中起到很好的分散作用,更有利于3株细菌对芘的降解. | 张宏波 林爱军 刘爽 乔敏 冯流 Shim Hojae 金京华 | 2010 | 环境科学2010，31，1： | 20 |
| 7 | 基于随钻地震测井的地震导向钻井技术——以塔里木油田哈拉哈塘区块缝洞型储集体为例显示文摘针对塔里木油田哈拉哈塘地区超深高温碳酸盐岩缝洞型岩溶储集层溶洞在三维空间归位不准确的问题,提出了陆地随钻地震测井(SVWD)和地震导向钻井(SGD)技术相结合的综合解决方案。地震导向钻井技术利用随钻地震测井获取的地层速度更新速度模型,对所钻目标体的三维空间位置重新归位,降低了目标体的不确定性。该方案应用于哈拉哈塘地区两口井,首次在国内陆上油田采集随钻地震数据,根据预测结果实时指导和调整钻井轨迹,两口井均顺利命中目标。实践证明该套技术方案在解决由于速度不确定性以及地质模型的不确定性导致的储集体归位不准确等难题时切实可行。 | 史鸿祥 李辉 郑多明 邹克元 耿长波 刘伟 刘延梅 甄玲霞 张辉 SHIM Y H | 2016 | 石油勘探与开发2016，43，4： | 19 |
| 8 | 土壤石油烃污染的植物毒性及植物-微生物联合降解显示文摘通过盆栽实验研究了土壤石油烃污染对玉米和水稻根伸长的影响,并在土壤中接种经过筛选得到的石油烃降解菌,研究石油烃降解菌对石油烃毒性的影响以及对土壤中石油烃的降解。研究结果表明,石油烃浓度低于1000 mg/kg时对玉米的根系生长有一定的刺激生长作用,随着石油烃浓度的增加,刺激根长生长的作用逐渐降低,研究结果表明,水稻根长受石油烃影响较小。通过对不同处理土壤中石油烃降解的研究结果表明,土壤中种植水稻对石油烃有一定的降解作用,但是不同处理下土壤中的石油烃降解率不同,其中水稻-微生物联合处理下土壤中石油烃的降解速率最快,培养期内的降解效率达到53.3%。 | 马强 张旭红 林爱军 马薇 Shim Hojae 金京华 | 2009 | 环境工程学报2009，3，3： | 18 |
| 9 | Mitochondria-targeting drug conjugates for cytotoxic, anti-oxidizing and sensing purposes:current strategies and future perspectives显示文摘mitochondrial-targeting moieties to anticancer drugs, antioxidants and sensor molecules. Among them, the most widely applied mitochondrial targeting moiety is triphenylphosphonium(TPP), which is a delocalized cationic lipid that readily accumulates and penetrates through the mitochondrial membrane due to the highly negative mitochondrial membrane potential. Other moieties, including short peptides,dequalinium, guanidine, rhodamine, and F16, are also known to be promising mitochondrial targeting agents. Direct conjugation of mitochondrial targeting moieties to anticancer drugs, antioxidants and sensors results in increased cytotoxicity, anti-oxidizing activity and sensing activity, respectively,compared with their non-targeting counterparts, especially in drug-resistant cells. Although many mitochondria-targeted anticancer drug conjugates have been investigated in vitro and in vivo, further clinical studies are still needed. On the other hand, several mitochondria-targeting antioxidants have been analyzed in clinical phases I, II and III trials, and one conjugate has been approved for treating eye disease in Russia. There are numerous ongoing studies of mitochondria-targeted sensors. | Gantumur Battogtokh Yeon Su Choi Dong Seop Kang Sang Jun Park Min Suk Shim Kang Moo Huh Yong-Yeon Cho Joo Young Lee Hye Suk Lee Han Chang Kang | 2018 | Acta Pharmaceutica Sinica B2018，8，6： | 17 |
| 10 | Spontaneous transformation of human adult non-tumorigenic stem cells to cancer stem cells is driven by genomic instability in a human model of glioblastoma显示文摘 | Shims A Chettiar S Shepal V Rajendran G Prasad R Shastry P | 2007 | 中国神经肿瘤杂志2007，5，1： | 16 |
| 11 | 倒置A^2/O—MBR工艺处理低C/N生活污水脱氮性能研究显示文摘合肥塘西河再生水厂采用倒置A2/O(缺氧/厌氧/好氧—预缺氧)—MBR工艺处理低C/N城市生活污水。研究了投加碳源前后各生化反应池中有机物及氮元素的变化规律,结果表明未投加外碳源时TN的去除率为52.3%,脱氮效果不理想。通过比较乙酸钠、甲醇和乙酸三种不同外加碳源的脱氮效果,可知乙酸钠反硝化速率最高,效果最好。当乙酸钠作外碳源,投加量为50mgCOD/L时,TN的去除率明显提高,达到74.5%。此外,还分析了投加外碳源后整个工艺系统内COD、TN物质流动情况,结果表明,缺氧池和厌氧池是COD去除的主要单元体,好氧池对COD的去除贡献增强,体系中的TN去除总量在投加外碳源后有了明显的增加,较未投加外碳源时增加了26.5%。 | 崔新伟 谢丽 毕晔 张善发 杨殿海 Shim H J | 2012 | 给水排水2012，38，9： | 15 |
| 12 | Endoscopic ultrasonography does not differentiate neoplastic from non-neoplastic small gallbladder polyps显示文摘AIM:To assess the ability of endoscopic ultrasonography(EUS) to differentiate neoplastic from non-neoplastic polypoid lesions of the gallbladder(PLGs) .METHODS:The uses of EUS and transabdominal ultrasonography(US) were retrospectively analyzed in 94 surgical cases of gallbladder polyps less than 20 mm in diameter.RESULTS:The prevalence of neoplastic lesions with a diameter of 5-10 mm was 17.2%(10/58) ;11-15 mm,15.4%(4/26) ,and 16-20 mm,50%(5/10) .The overall diagnostic accuracies of EUS and US for small PLGs were 80.9% and 63.9%(P < 0.05) ,respectively.EUS correctly distinguished 12(63.2%) of 19 neoplastic PLGs but was less accurate for polyps less than 1.0 cm(4/10,40%) than for polyps greater than 1.0 cm(8/9,88.9%) (P = 0.02) .CONCLUSION:Although EUS was more accurate than US,its accuracy for differentiating neoplastic from non-neoplastic PLGs less than 1.0 cm was low.Thus,EUS alone is not suffi cient for determining a treatment strategy for PLGs of less than 1.0 cm. | Young Koog Cheon Won Young Cho Tae Hee Lee Young Deok Cho Jong Ho Moon Joon Seong Lee Chan Sup Shim | 2009 | World Journal of Gastroenterology2009，15，19： | 12 |
| 13 | Impact of tumor location on clinical outcomes of gastric endoscopic submucosal dissection显示文摘AIM:To determine whether there is a correlation between the location of the lesion and endoscopic submucosal dissection(ESD)outcome.METHODS:From January 2008 to December 2010,ESD of 1443 gastric tumors was performed.En bloc resection rate,complete resection rate,procedure time and complication rate were analyzed according to the tumor location.RESULTS:The rates of en bloc resection and complete resection were 91%(1318/1443)and 89%(1287/1443),respectively.The post-ESD bleeding rate was 4.3%,and perforation rate was 2.7%.Tumors located in the upper third of the stomach were associated with a longer procedure time and significantly higher rates of incomplete resection,piecemeal resection,and perforation than tumors below the upper third of the stomach.Posterior wall lesions had significantly longer procedure times and higher rates of incomplete resection and piecemeal resection than lesions in other locations.In multivariate analysis,posterior wall lesions and upper third lesions were significantly associated with incomplete resection and perforation,respectively.In post-ESD bleeding analysis,location was not a significant related factor.CONCLUSION:More advanced endoscopic techniques are required during ESD for lesions located in the upper third or posterior wall of the stomach to decrease complications and improve therapeutic outcomes. | Ji Young Yoon Choong Nam Shim Sook Hee Chung Wan Park Hyunsoo Chung Hyuk Lee Sung Kwan Shin Sang Kil Lee Yong Chan Lee Jun Chul Park | 2014 | World Journal of Gastroenterology2014，20，26： | 10 |
| 14 | Endoscopic submucosal dissection for undifferentiated-type early gastric cancer: Do we have enough data to support this?显示文摘Although endoscopic submucosal dissection(ESD)is now accepted for treatment of early gastric cancers(EGC)with negligible risk of lymph node(LN)metastasis,ESD for intramucosal undifferentiated type EGC without ulceration and with diameter≤2 cm is regarded as an investigational treatment according to the Japanese gastric cancer treatment guidelines.This consideration was largely based on the analysis of surgically resected EGCs that contained undifferentiated type EGCs;however,results from several institutes showed some discrepancies in sample size and incidence of LN metastasis.Recently,some reports about the safety and efficacy of ESD for undifferentiated type EGC meeting the expanded criteria have been published.Nonetheless,only limited data are available regarding long-term outcomes of ESD for EGC with undifferentiated histology so far.At the same time,endoscopists cannot ignore the patients’desire to guarantee quality of life after the relatively non-invasive endoscopic treatment when compared to conventional surgery.To satisfy the needs of patients and provide solid evidence to support ESD for undifferentiated EGC,we need more delicate tools to predict undetected LN metastasis and more data that can reveal predictive factors for LN metastasis. | Choong Nam Shim Sang Kil Lee | 2014 | World Journal of Gastroenterology2014，20，14： | 10 |
| 15 | 一株降解芘的苍白杆菌的分离、鉴定及性能表征显示文摘采用富集培养的方法从北京焦化厂多环芳烃(PAHs)污染土壤中筛选到一株高效降解芘的微生物,命名为PW,分子生物学等手段鉴定此菌株属于苍白杆菌属(Ochrobactrum sp.)。经一次性大剂量方法对此菌株进行驯化后,考察了摇瓶条件下环境因素对此菌株降解芘效率的影响。结果表明,驯化培养使得菌株5d内对0.5mmol/L芘的降解率由62.3%提高到92.7%。此外,该菌株的环境耐受性好,在环境温度为20~40℃下该菌株对芘均具有一定的降解能力,30℃培养时降解效果最好;在pH为5~10的培养基中,PW对芘的降解率均在45%以上;当盐度小于3%时,此菌株对芘降解率在60%以上;同时菌株PW还可耐受一定浓度的重金属。 | 谢文娟 林爱军 杨晓进 王凤花 SHIM Hojae | 2011 | 北京化工大学学报(自然科学版)2011，38，3： | 9 |
| 16 | Friction stir welding of 5052 aluminum alloy plates显示文摘Friction stir welding between 5052 aluminum alloy plates with a thickness of 2 mm was performed. The tool for welding was rotated at speeds ranging from 500 to 3000 r/min under a constant traverse speed of 100 mm/min. The results show that at all tool rotation speeds, defect-free welds are successfully obtained. Especially at 1000, 2000 and 3000 r/min, the welds exhibit very smooth surface morphologies. At 500, 1000, and 2000 r/min, onion ring structure is clearly observed in the friction-stir-welded zone (SZ). In addition, the onion ring structure region becomes wider as the tool rotation speed is increased. The gain size in the SZ is smaller than that in the base metal, and is decreased with a decrease of the tool rotation speed. In all tool rotation speeds, the SZ exhibits higher average hardness than the base metal. Especially at 500 r/min, the average hardness of the SZ reaches a level about 33% greater than that of the base metal. At 500, 1 000 and 2 000 r/min, the tensile strength of the friction stir welded (FSWed) plates is similar to that of the base metal (about 204 MPa). The elongation of the FSWed plates is lower than that of the base metal (about 22%). However, it is noticeable that the maximum elongation of about 21% is obtained at 1 000 r/min. | Yong-Jai KWON Seong-Beom SHIM Dong-Hwan PARK | 2009 | 中国有色金属学会会刊:英文版2009，19，B09： | 8 |
| 17 | Recurrent massive bleeding due to dissecting intramural hematoma of the esophagus: Treatment with therapeutic angiography显示文摘Spontaneous or traumatic intramural bleeding of the esophagus, which is often associated with overlying mucosal dissection, constitutes a rare spectrum of esophageal injury called dissecting intramural hematoma of the esophagus (DIHE). Chest pain, swallowing diffi culty, and minor hematemesis are common, which resolve spontaneously in most cases. This case report describes a patient with spontaneous DIHE with recurrent massive bleeding which required critical management and highlights a potential role for therapeutic angiography as an alternative to surgery. | Jaejun Shim Jae Young Jang Young Hwangbo Seok Ho Dong Joo Hyeong Oh Hyo Jong Kim Byung-Ho Kim Young Woon Chang Rin Chang | 2009 | World Journal of Gastroenterology2009，15，41： | 8 |
| 18 | 缺氧/厌氧/好氧/预缺氧-MBR组合工艺对低碳氮比市政污水中营养盐去除的研究(英文)显示文摘A novel full scale modified A2O(anoxic/anaerobic/aerobic/pre-anoxic)-membrane bioreactor(MBR) plant combined with the step feed strategy was operated to improve the biological nutrient removal(BNR) from low C/N ratio municipal wastewater in Southern China. Transformation of organic carbon, nitrogen and phosphorus, and membrane fouling were investigated. Experimental results for over four months demonstrated good efficiencies for chemical oxygen demand(COD) and 4NH-N? removal, with average values higher than 84.5% and 98.1%, respectively. A relatively higher total nitrogen(TN) removal efficiency(52.1%) was also obtained at low C/N ratio of 3.82, contributed by the configuration modification(anoxic zone before anaerobic zone) and the step feed with a distribution ratio of 1︰1. Addition of sodium acetate into the anoxic zone as the external carbon source, with a theoretical amount of 31.3 mg COD per liter in influent, enhanced denitrification and the TN removal efficiency in-creased to 74.9%. Moreover, the total phosphate(TP) removal efficiency increased by 18.0%. It is suggested that the external carbon source is needed to improve the BNR performance in treating low C/N ratio municipal wastewater in the modified A2O-MBR process. | 胡香 谢丽 SHIM Hojae 张善发 杨殿海 | 2014 | Chinese Journal of Chemical Engineering2014，22，4： | 8 |
| 19 | Complement activation in obesity, insulin resistance, and type 2 diabetes mellitus显示文摘Amplified inflammatory reaction has been observed to be involved in cardiometabolic diseases such as obesity,insulin resistance,diabetes,dyslipidemia,and atherosclerosis.The complement system was originally viewed as a supportive first line of defense against microbial invaders,and research over the past decade has come to appreciate that the functions of the complement system extend beyond the defense and elimination of microbes,involving in such diverse processes as clearance of the immune complexes,complementing T and B cell immune functions,tissue regeneration,and metabolism.The focus of this review is to summarize the role of the activation of complement system and the initiation and progression of metabolic disorders including obesity,insulin resistance and diabetes mellitus.In addition,we briefly describe the interaction of the activation of the complement system with diabetic complications such as diabetic retinopathy,nephropathy and neuropathy,highlighting that targeting complement system therapeutics could be one of possible routes to slow down those aforementioned diabetic complications. | Kyumin Shim Rayhana Begum Catherine Yang Hongbin Wang | 2020 | World Journal of Diabetes2020，11，1： | 8 |
| 20 | Early treadmill exercise increases macrophage migration inhibitory factor expression after cerebral ischemia/reperfusion显示文摘The neuroprotective function of macrophage migration inhibitory factor(MIF) in ischemic stroke was rarely evaluated.This study aimed to investigate the effects of early treadmill exercise on recovery from ischemic stroke and to determine whether these effects are associated with the expression levels of MIF and brain-derived neurotrophic factor(BDNF) in the ischemic area.A total of 40 male Sprague-Dawley rats were randomly assigned to the ischemia and exercise group [middle cerebral artery occlusion(MCAO)-Ex,n = 10),ischemia and sedentary group(MCAO-St,n = 10),sham-surgery and exercise group(Sham-Ex,n= 10),or sham-surgery and sedentary group(Sham-St,n = 10).The MCAO-Ex and MCAO-St groups were subjected to MCAO for 60 minutes,whereas the Sham-Ex and Sham-St groups were subjected to an identical operation without MCAO.Rats in the MCAO-Ex and Sham-Ex groups then ran on a treadmill for 30 minutes once a day for 5 consecutive days.After reperfusion,the hanging time tested by the wire hang test was longer and the relative fractional anisotropy determined by MRI was higher in the peri-infarct region of the MCAO-Ex group compared with the MCAO-St group.The expression levels of MIF and BDNF in the peri-infarct region were upregulated in the MCAO-Ex group.Increased MIF and BDNF levels were positively correlated with relative fractional anisotropy changes in the peri-infarct region.There was no significant difference in the levels of MIF and BDNF in the peri-infarct region between the Sham-Ex and Sham-St groups.Our study demonstrated that early exercise(initiated 48 hours after the MCAO) could improve motor and neuronal recovery after ischemic stroke.Furthermore,the increased levels of MIF and BDNF in the peri-infarct region(penumbra) may be one of the mechanisms of enhanced neurological function recovery.All experiments were approved by the Institutional Animal Care and Use Committee in Asan Medical Center in South Korea(2016-12-126). | Min Cheol Chang Chae Ri Park Seung Hwa Rhie Woo Hyun Shim Dae Yul Kim | 2019 | Neural Regeneration Research2019，14，7： | 7 |
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