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| 1 | The therapeutic potential of targeting exchange protein directly activated by cyclic adenosine 3',5'-monophosphate(Epac)for central nervous system trauma显示文摘Millions of people worldwide are affected by traumatic spinal cord injury,which usually results in permanent sensorimotor disability.Damage to the spinal cord leads to a series of detrimental events including ischaemia,haemorrhage and neuroinflammation,which over time result in further neural tissue loss.Eventually,at chronic stages of traumatic spinal cord injury,the formation of a glial scar,cystic cavitation and the presence of numerous inhibitory molecules act as physical and chemical barriers to axonal regrowth.This is further hindered by a lack of intrinsic regrowth ability of adult neurons in the central nervous system.The intracellular signalling molecule,cyclic adenosine 3′,5′-monophosphate(cAMP),is known to play many important roles in the central nervous system,and elevating its levels as shown to improve axonal regeneration outcomes following traumatic spinal cord injury in animal models.However,therapies directly targeting cAMP have not found their way into the clinic,as cAMP is ubiquitously present in all cell types and its manipulation may have additional deleterious effects.A downstream effector of cAMP,exchange protein directly activated by cAMP 2(Epac2),is mainly expressed in the adult central nervous system,and its activation has been shown to mediate the positive effects of cAMP on axonal guidance and regeneration.Recently,using ex vivo modelling of traumatic spinal cord injury,Epac2 activation was found to profoundly modulate the post-lesion environment,such as decreasing the activation of astrocytes and microglia.Pilot data with Epac2 activation also suggested functional improvement assessed by in vivo models of traumatic spinal cord injury.Therefore,targeting Epac2 in traumatic spinal cord injury could represent a novel strategy in traumatic spinal cord injury repair,and future work is needed to fully establish its therapeutic potential. | Alba Guijarro-Belmar Dominik Mateusz Domanski Xuenong Bo Derryck Shewan Wenlong Huang | 2021 | Neural Regeneration Research2021，16，3： | 3 |
| 2 | Myosin 2 is a key Rho kinase target necessary for the local concentration of E-cadherin at cell-cell contacts显示文摘 | Shewan A M Maddugoda M Kraemer A | 2005 | Mol Biol Cell2005，16，10： | 1 |
| 3 | Differential regulation of secretory compartments containingthe insulin -responsive glucose transporter 4 in 3T3 -LIadipocytes显示文摘 | Millar CA Shewan A Hickson GR James DE Gould GW | 1999 | Mol Biol Cell1999，10，11： | 1 |
| 4 | Growthcone attraction to netrin-1 is converted to repulsion by laminin-1 显示文摘 | Hopker VH Shewan D Tessier-Lavigne M | 1999 | Nature1999，401，： | 1 |
| 5 | Ena/VASP proteins can regulate distinct modes of actin organization at cadherin-adhesive contacts显示文摘 | Scott JA Shewan AM Den Elzen NR | 2006 | Mol Biol Cell2006，17，3： | 1 |
| 6 | Tenascin synthesis,deposition and isoforms in monocrotaline 2 induced pulmonary hypertensive rat lungs 显示文摘 | David L Shewan M Jane A | 1996 | Am J Hysiol1996，271，2： | 1 |
| 7 | Differential regulation of secretory compartments containing the insulin-responsive glucose transporter 4 in 3T3-L1 adipocytes显示文摘 | Millar CA Shewan A Hickson GR | 1999 | Mol Biol Cell1999，10，： | 1 |
| 8 | Effects of speech and language treatment on recovery from aphasia显示文摘 | SHEWAN VM KERTESZ A | 1984 | Brain Lang1984，23，： | 1 |
| 9 | The microbiology of fish and fishery products显示文摘 | SHEWAN J M | 1971 | Appl Bacteriol1971，34，： | 1 |
| 10 | Differential regulation of secretory compartments containing the insulin- responsive glucose transporter 4 in 3T3-L1 adipopytes 显示文摘 | Millar CA Shewan A Hickson GR | 1999 | Mol Biol Cell1999，10，11： | 1 |
| 11 | New perspectives in cyclic AMP-mediatedaxon growth and guidance : The emerging epoch of Epac显示文摘 | Peace A G Shewan D A | 2011 | Brain ResBull2011，84，45： | 1 |
| 12 | Reliability and validity characteris-tics of the Western Aphasia Battery (WAB) 显示文摘 | Shewan CM Kertesz A | 1980 | J Speech HearDisord1980，45，3： | 1 |
| 13 | The microbiology of fish and fishery products显示文摘 | SHEWAN J M | 1971 | AppliedBacteriology1971，34，2： | 1 |
| 14 | The Microbiology of fish and fishery products : aprogress report 显示文摘 | Shewan JM | 1971 | Journal of Applied Microbiology1971，34，2： | 1 |
| 15 | A determinative scheme for the identification of certain genera of gram-negative bacteria with special reference to Pseudomonodaceae显示文摘 | Shewan J M Hobbs G Hodgkiss W | 1960 | Journal of Applied Bacteriology1960，23，： | 1 |
| 16 | Age-related chan-ges underlie switch in Netrin-1responsiveness as growth cones advance along visual pathway显示文摘 | Shewan D Dwivedy A Anderson R | 2002 | Nature Neuroscience2002，5，10： | 1 |
| 17 | The microbiology of fish and fishery products显示文摘 | Shewan J M | 1971 | Appl Bacteriol1971，34，： | 1 |
| 18 | Age- related changes underlie switch in netrin-1 responsiveness as growth cones advance along visual pathway显示文摘 | Shewan D Dwivedy A Anderson R | 2002 | Nat Neurosci2002，5，10： | 1 |
| 19 | Isolation and identification of the volatile sulfides produced during chill-storage of North Sea cod显示文摘 | HERBERT R A ELLIS J R SHEWAN J M | 1975 | J Sei Food Agr1975，26，： | 1 |
| 20 | The microbiology of fish and fishery proudcts--a progress report 显示文摘 | Shewan J M | 1971 | Journal of Applied Microbiology1971，34，2： | 1 |
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