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| 1 | 乙醇生产的技术进步——新型酶技术给乙醇生料发酵生产带来的突破显示文摘由于能源价格的增长和乙醇的广泛应用,发酵乙醇日益具有竞争力。文中对发酵法生产乙醇的状况和技术进行了简单回顾,着重介绍了新型生料水解酶的作用原理及其研究进展,并对该项技术的使用和对生产带来的益处进行了分析。 | 段钢 许宏贤 孙长平 钱莹 李艳萍 周红伟 姜锡瑞 Jay Shetty Oresto Lantero | 2006 | 食品与发酵工业2006，32，7： | 34 |
| 2 | Trends in prevalence of diabetes in Asian countries显示文摘Diabetes is a major lifestyle disorder,the prevalence of which is increasing globally.Asian countries contribute to more than 60% of the world's diabetic population as the prevalence of diabetes is increasing in these countries.Socio-economic growth and industrialization are rapidly occurring in many of these countries.The urban-rural divide in prevalence is narrowing as urbanization is spreading widely,adversely affecting the lifestyle of populations.Asians have a strong ethnic and genetic predisposition for diabetes and have lower thresholds for the environmental risk factors.As a result,they develop diabetes at a younger age and at a lower body mass index and waist circumference when compared with the Western population.The adverse effect of physical inactivity and fatty food are manifested as the increasing rate of overweightness and obesity,even among children.The health care budgets for the disease management are meager and the health care outcome is far from the optimum.As a result,complications of diabetes are common and the economic burden is very high,especially among the poor strata of the society.National endeavors are urgently needed for early diagnosis,effective management and for primary prevention of diabetes.This editorial aims to highlight the rising trend in prevalence of diabetes in Asia,its causative factors and the urgent need to implement national strategies for primary prevention of type 2 diabetes. | Ambady Ramachandran Chamukuttan Snehalatha Ananth Samith Shetty Arun Nanditha | 2012 | World Journal of Diabetes2012，3，6： | 23 |
| 3 | 新鲜木薯直接转化生产乙醇显示文摘介绍了利用新鲜木薯生产乙醇的新工艺:用真菌α淀粉酶和降粘酶预处理新鲜木薯醪液,后加入颗粒淀粉水解酶STARGENTM进行酵母酒精发酵。该工艺可直接利用新鲜木薯进行酒精发酵;相比传统高温工艺,该发酵新工艺过程中新鲜木薯醪液粘度显著降低,有更多可发酵性糖被利用,并且最终发酵效率显著提高。 | 段钢 许宏贤 阮振华 Jay Shetty | 2009 | 食品与生物技术学报2009，28，3： | 17 |
| 4 | Human hepatic sinusoidal endothelial cells can be distinguished by expression of phenotypic markers related to their specialised functions in vivo显示文摘The hepatic sinusoids are lined by a unique population of hepatic sinusoidal endothelial cells (HSEC), which is one of the first hepatic cell populations to come into contact with blood components. However, HSEC are not simply barrier cells that restrict the access of blood- borne compounds to the parenchyma. They are func- tionally specialised endothelial cells that have complex roles, including not only receptor-mediated clearance of endotoxin, bacteria and other compounds, but also the regulation of inflammation, leukocyte recruitment and host immune responses to pathogens. Thus understand- ing the differentiation and function of HSEC is critical for the elucidation of liver biology and pathophysiology. This article reviews methods for isolating and studying human hepatic endothelial cell populations using in vitro models. We also discuss the expression and functions of phe- notypic markers, such as the presence of fenestrations and expression of VAP-1, Stabilin-1, L-SIGN, which can be used to identify sinusoidal endothelium and to permit discrimination from vascular and lymphatic endothelial cells. | PF Lalor SM Curbishley S Shetty DH Adams | 2006 | World Journal of Gastroenterology2006，12，34： | 11 |
| 5 | Relationship of Periodontal Status and Dental Caries Status with Oral Health Knowledge, Attitude and Behavior among Professional Students in India显示文摘Aim To find the relationship of periodontal status and dental caries status with oral health knowledge, attitude, behavior, among professional students in India. Methodology In a cross sectional study, a total of 825 students (males: 577, females: 248) from six professions were surveyed using a self administered structured questionnaire including 41 multiple choice questions and the WHO Oral Health Assessment Form (1997). The data was analyzed using the SPSS version 13.0 to perform the Student's t-test, ANOVA test, Scheffe's test and Chi-square test, linear regression analysis. Results The mean percentage scores of the students for knowledge were 53.25 ± 15.05; for attitude 74.97 ±20.48; and for behavior 59.09 ± 18.77. The percentage of students with calculus score was found to be significantly high (43.8%). The percentage of professional students with DMFT>4 was 14.1% and the percentage of students with decayed teeth was 46.2%. The regression analysis showed that the oral health behavior of the students was dependent on the attitude (P<0.001), but showed no significant linear relation with the knowledge. Also, that the mean DMFT score was dependent on the oral health behavior (P<0.05), but showed no significant relationship with the knowledge and attitude of the students. The periodontal status was independent on the knowledge, but showed a significant relationship with attitude and behavior of the students. Conclusion A positive attitude and adherence to good oral hygiene behaviors is associated with better oral health. | Archana J. Sharda Srinath Shetty | 2009 | International Journal of Oral Science2009，1，4： | 8 |
| 6 | Carcinogenesis on the background of liver fibrosis: Implications for the management of hepatocellular cancer显示文摘Hepatocellular carcinoma(HCC) is now the second leading cause of cancer-related deaths globally and many patients have incurable disease. HCC predominantly occurs in the setting of liver cirrhosis and is a paradigm for inflammation-induced cancer. The causes of chronic liver disease promote the development of transformed or premalignant hepatocytes and predisposes to the development of HCC. For HCC to grow and progress it is now clear that it requires an immunosuppressive niche within the fibrogenic microenvironment of cirrhosis. The rationale for targeting this immunosuppression is supported by responses seen in recent trials with checkpoint inhibitors. With the impact of immunotherapy, HCC progression may be delayed and long term durable responses may be seen. This makes the management of the underlying liver cirrhosis in HCC even more crucial as studies demonstrate that measures of liver function are a major prognostic factor in HCC. In this review, we discuss the development of cancer in the setting of liver inflammation and fibrosis, reviewing the microenvironment that leads to this tumourigenic climate and the implications this has for patient management. | Joanne Marie O'Rourke Vandana Mridhu Sagar Tahir Shah Shishir Shetty | 2018 | World Journal of Gastroenterology2018，24，39： | 8 |
| 7 | 电视辅助胸腔镜钳闭治疗动脉导管未闭显示文摘目的 总结电视辅助胸腔镜钳闭未闭动脉导管的经验。 方法 用电视辅助胸腔镜技术对 130例动脉导管未闭患儿进行了手术。在全麻和单侧肺通气的情况下 ,在左侧第 3肋间脊柱肩胛骨旁做 2cm的切口 ,用以导入器械。在左侧第 4肋间腋中线做相似的切口以导入镜头。在左侧第3肋间胸骨旁 2cm和左侧第 4肋间胸骨旁 1cm各做 1孔 ,用以放入长而钝的神经钩暴露术野。通过器械窗导入持Ethicon 1cm钛夹的持夹器钳闭未闭的动脉导管。整个手术过程在电视荧屏上观看 ,食管B超和床边B超监测术中和术后的效果。 结果 本组患儿 ,平均年龄 (2 8± 1 2 )岁 ,平均体重(7 9± 4 5 )kg,平均肺动脉压 (35± 7)mmHg。合并心内畸形包括 :房间隔缺损 2例 ,室间隔缺损 3例。平均动脉导管直径 (6 8± 3 1)mm。手术平均时间 (30± 19)min。术后残余分流 4例 ,开胸结扎残余分流导管 3例 ,喉返神经麻痹 3例 ,5例转为开胸结扎。本组无手术死亡病例 ,无术后出血、手术输血、乳糜胸患儿。 结论 电视辅助胸腔镜钳闭未闭的动脉导管是治疗动脉导管未闭的一种较好方法 ,具有安全、快速、费用少、效果好。 | 谢斌 张镜芳 庄健 Devi Shetty | 2001 | 中华外科杂志2001，39，6： | 8 |
| 8 | 左心室室壁瘤的外科治疗显示文摘目的 探讨左心室室壁瘤 (left ventricular aneurysm,L VA)的外科治疗效果。 方法 33例 L VA患者行闭式折叠术 1例 ,L VA切除后行标准线性修补术 14例 ,心内膜荷包环缩法 10例 ,心内室壁瘤缝合法 8例。其中 2 0例在心脏不停跳下完成手术。所有患者均同期行冠状动脉旁路移植术 (CABG) ,每例移植血管 3.2± 1.1支。应用主动脉内球囊反搏 (IABP) 6例。 结果 32例手术成功 ,手术死亡 1例 ;术后发生并发症 9例 ,其中低心排血量 6例、室性心律失常 2例、脑并发症 1例。术后早期随访 1~ 3个月 ,超声心动图示患者心功能均获改善 ,心绞痛缓解或消失。结论 L VA的外科治疗中 ,应用左心室几何重建技术和心脏不停跳及同期行 CABG能获得较好的临床治疗效果 。 | 王玺胜 何学志 Devi Shetty | 2004 | 中国胸心血管外科临床杂志2004，11，4： | 7 |
| 9 | Study comparing the clinical profile of complicated cases of Plasmodium falciparum malaria among adults and children显示文摘 | George Peter Alexander Lobo Manuel Anil Shetty | 2011 | Asian Pacific Journal of Tropical Disease2011，，1： | 7 |
| 10 | Retinal structural-vascular-functional relationship using optical coherence tomography and optical coherence tomography -angiography in myopia显示文摘Background:To examine the retinal structure–vascular-function relationship using optical coherence tomography(OCT)and optical coherence tomography angiography(OCTA)in myopia.Methods:This was a prospective cross-sectional study comprising 86 eyes of 45 individuals with varying axial lengths and spherical equivalents and no posterior segment abnormalities.All eyes underwent optical coherence tomography with the Spectralis SD-OCT and OCTA with RTVue-XR Avanti;Optovue.Individual macular retinal layer thicknesses and flow areas and vessel densities were measured on OCT and OCTA,respectively.Linear correlations were made between the macular layer thicknesses,flow areas and vessel densities with axial length,spherical equivalent and visual acuity.Results:The participants’mean ages were 33.34±14.45 years,mean spherical equivalent refractions were−7.17±5.71 D and axial lengths were 25.95±2.41 mm.There were significant positive correlations of foveal angle(r=0.757,p=0.001),inner retinal(r=0.764,p=0.001)and outer plexiform layer(r=0.771,p=0.001)thickness on OCT and vessel densities in deep capillary plexus(r=0.313,p=0.003)on OCTA with axial length and negative correlations with spherical equivalents and visual acuity.Significant negative correlations of outer nuclear layer(r=−0.560,p=0.03)and photoreceptor outer segment layer thickness(r=−0.856,p<0.001)were noted on OCT with axial length and positive correlations with spherical equivalents and visual acuity.Conclusion:The lateral retinal stretching in myopia could possibly explain the correlation between retinal layer thickness,vascular density and visual acuity in these eyes.Further research is required to investigate this. | Ramesh Venkatesh Shivani Sinha Deepika Gangadharaiah Santosh G.K.Gadde Ashwin Mohan Rohit Shetty Naresh Kumar Yadav | 2019 | Eye and Vision2019，6，1： | 7 |
| 11 | Effect of β-blocker therapy in diabetic patients with stable coronary heart disease: a meta-analysis显示文摘Background β-blocker (BB) therapy is a cornerstone for the treatment of coronary heart disease (CHD).The evidence of the benefit from long-term BB therapy in diabetic patients with stable CHD is scarce.This meta-analysis summarizes the evidence relating to the BB therapy in diabetic patients with stable CHD.Methods A meta-analysis was performed according to PRISMA and MOOSE guidelines for reporting of systematic reviews of observational studies.PubMed,Embase,and Cochrane central were searched and two authors independently screened studies for eligibility.The quality of studies was assessed with the Newcastle Ottawa scale.The primary outcome of interest was all-cause mortality,cardiovascular (CV) mortality and major adverse cardiovascular events (MACE) in diabetic patients with and without BB therapy.A generic inverse variance model was used to pool odds ratio or hazards ratio from included studies to calculate the overall effect estimate.The significance threshold was set at P-value < 0.05.Heterogeneity was assessed by I2.Results Four non-randomized studies with 9515 participants were selected for the analyses.Four studies were post-hoc analyses of randomized controlled trials,and one article was an analysis of a nationally representative survey.In a fixed effects model,BB therapy in diabetic patients with stable CHD was found to be associated with increased risk of CV mortality,and MACE (27% and 32% respectively;P-value < 0.05) and was not associated with a reduction in all-cause mortality (HR 1.12;95% CI: 0.94–1.33;P-value = 0.22).Conclusion BB therapy in diabetic patients with stable CHD appears to be linked to higher mortality.Large randomized trials are needed in this population to confirm these findings. | Aaqib H Malik Suchith Shetty Kausik Kar Ramzi El Accaoui | 2019 | Journal of Geriatric Cardiology2019，16，3： | 7 |
| 12 | The corrosion behavior of AZ31 alloy in chloride and sulfate media-A comparative study through electrochemical investigations显示文摘The magnesium alloys are considered to be the best structural materials,because of their advantageous weight to strength ratio.But,the limitation in their real field applications lies on the fact that magnesium alloys are highly susceptible for corrosion.The corrosion behaviour of AZ31 alloy was investigated by electrochemical methods in sodium chloride and sodium sulphate of different concentrations at different temperatures.The corrosion rate was monitored by potentiodynamic polarization technique and electrochemical impedance spectroscopy method.The surface morphology and surface composition of the freshly polished surface of the alloy was compared with that of the corroded surface by recording their SEM images and EDS,respectively.The results showed that the corrosion rate of AZ31 alloy increased with the increase in the temperature of the medium and also with the increase in the salt concentration of the medium.The activation parameters for the corrosion process were calculated and interpreted. | M.Gururaj Acharya A.Nityananda Shetty | 2019 | Journal of Magnesium and Alloys2019，7，1： | 7 |
| 13 | 木薯--生物乙醇生产的新原料显示文摘从全球范围来看,生物乙醇的生产导致了对农作物需求的持续增长。过去大部分农作物主要用于食品和饲料,种植规模受到限制;现在随着生物乙醇生产对原料的需求,使农作物得到了新的应用,而种植规模的扩大将给农民带来更多的收入。木薯,在热带和亚热带,特别是在土地相对贫瘠,其他农作物产量相对较低的地区广泛种植,过去常常被当作食品和饲料。文中的经济分析和新技术的介绍表明,木薯是一种非常有竞争力的生物乙醇生产原料。 | 段钢 许宏贤 Shetty J K | 2008 | 食品与发酵工业2008，34，8： | 6 |
| 14 | Electrochemical investigations on the corrosion behaviour of magnesium alloy ZE41 in a combined medium of chloride and sulphate显示文摘The magnesium alloy ZE41 encompasses a wide spectrum of applications as a structural material.An extremely high susceptibility to corrosion limits widespread utility of ZE41.In the present study it has been attempted to understand the corrosion behaviour of ZE41 alloy employing electrochemical techniques like Tafel extrapolation and electrochemical impedance spectroscopy(EIS)in aqueous salt solutions containing mixture of sodium chloride and sodium sulphate over a varying range of electrolyte concentrations and solution temperatures.The morphology of the metal surface has been established by means of scanning electron microscopy(SEM).The results indicate that the rate of corrosion of ZE41 alloy increases with the increase in temperature and ionic concentration of the medium.The results of corrosion rates at varying temperatures have been utilized in the calculation of activation parameters such as activation energy,enthalpy of activation and entropy of activation for the corrosion process. | Nandini Dinodi A.Nityananda Shetty | 2013 | Journal of Magnesium and Alloys2013，1，3： | 4 |
| 15 | 葡萄糖异构化酶对果糖生产的影响显示文摘对果葡糖浆的生产现状进行了评述,阐述了各种酶制剂,特别是葡萄糖异构化酶对果糖生产的影响,包括葡萄糖异构化酶对生产率的影响、反应器的设计及其操作影响因素. | 段钢 刘钟栋 Jay Shetty | 2005 | 河南工业大学学报(自然科学版)2005，26，5： | 4 |
| 16 | Tear biomarkers for keratoconus显示文摘Keratoconus is a progressive corneal thinning,ectatic condition,which affects vision.Recent advances in corneal topography measurements has helped advance proper diagnosis of this condition and increased research and clinical interests in the disease etiopathogenesis.Considerable progress has been achieved in understanding the progression of the disease and tear fluid has played a major role in the progress.This review discusses the importance of tear fluid as a source of biomarker for keratoconus and how advances in technology have helped map the complexity of tears and thereby molecular readouts of the disease.Expanding knowledge of the tear proteome,lipidome and metabolome opened up new avenues to study keratoconus and to identify probable prognostic or diagnostic biomarkers for the disease.A multidimensional approach of analyzing tear fluid of patients layering on proteomics,lipidomics and metabolomics is necessary in effectively decoding keratoconus and thereby identifying targets for its treatment. | Krishnatej Nishtala Natasha Pahuja Rohit Shetty Rudy M.M.A.Nuijts Arkasubhra Ghosh | 2016 | Eye and Vision2016，3，1： | 4 |
| 17 | Phenolic compounds, antioxidant activity and in vitro inhibitory potential against key enzymes relevant for hyperglycemia and hypertension of commonly used medicinal plants, herbs and spices in Latin America显示文摘 | Lena Galvez Ranilla Young-In Kwon Emmanouil Apostolidis Kalidas Shetty | 2010 | Bioresource Technology2010，，12： | 4 |
| 18 | Electrochemical investigation on the effects of sulfate ion concentration,temperature and medium pH on the corrosion behavior of Mg-Al-Zn-Mn alloy in aqueous ethylene glycol显示文摘The effects of sulfate ion concentration,temperature and medium pH on the corrosion of Mg–Al–Zn–Mn alloy in 30%aqueous ethylene glycol solution have been investigated by electrochemical techniques such as potentiodynamic polarization and electrochemical impedance spectroscopy methods.Surface morphology of the alloy was examined before and after immersing in the corrosive media by scanning electron microscopy(SEM)and energy dispersion X-ray(EDX)analysis.Activation energy,enthalpy of activation and entropy of activation were calculated from Arrhenius equation and transition state theory equation.The obtained results indicate that,the rate of corrosion increases with the increase in sulfate ion concentration and temperature of the medium and decreases with the increase in the pH of the medium. | H.Medhashree A.Nityananda Shetty | 2017 | Journal of Magnesium and Alloys2017，5，1： | 3 |
| 19 | 蛋白酶对生料酒精发酵清液回配比例的影响显示文摘研究了在生料发酵生产酒精时,清液回配比例和蛋白酶使用对发酵的影响。结果表明,生料发酵过程,可提高清液回配比例,特别是在蛋白酶的帮助下,清液的回配比例可大大增加;在30%干物配料浓度下,清液比例最高至60%,而发酵残淀粉的情况基本与不回配的情况相似。 | 段钢 JK Shetty | 2009 | 酿酒科技2009，，8： | 3 |
| 20 | Phenolic-linked variation in strawberry cultivars for potential dietary management of hyperglycemia and related complications of hypertension显示文摘 | Susan Cheplick Young-In Kwon Prasanta Bhowmik Kalidas Shetty | 2009 | Bioresource Technology2009，，1： | 2 |
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