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| 1 | Considerations of elderly factors to manage the complication of liver cirrhosis in elderly patients显示文摘The aging of the organ function causes sensitivity to the disease progression and need careful consideration for the medical treatment. With the increase of aging population, the opportunity to provide medical treatment for people in very old age is rapidly increasing therefore, the understanding of the various physiological changes of cellular function, size and function of organs are essential for the decision of therapeutic options. Among the various chronic conditions seen in elderly people, we have focused on liver cirrhosis, since despite specific therapeutic options for many of liver diseases including direct acting antivirals for hepatitis C virus, nucleoside analogs for hepatitis B, and corticosteroids for autoimmune hepatitis, there is currently no standard therapy to treat liver cirrhosis, which is the final stage of these liver diseases. Therefore,management of the various symptoms of liver cirrhosis is essential, and agingrelated parameters must be considered in the decision making for therapeutic strategies and dosage of the available medicine. In this mini-review, we have summarized the therapeutic options to manage various symptoms of liver cirrhosis, carefully considering the physiological changes of various organs associated with aging. | Kenya Kamimura Akira Sakamaki Hiroteru Kamimura Toru Setsu Takeshi Yokoo Masaaki Takamura Shuji Terai | 2019 | World Journal of Gastroenterology2019，25，15： | 9 |
| 2 | Fractionation of gamma-glutamyltransferase in patients with nonalcoholic fatty liver disease and alcoholic liver disease显示文摘AIM To assess how serum gamma-glutamyltransferase(GGT) fractions vary in patients with alcoholic liver disease(ALD) and non-alcoholic fatty liver disease(NAFLD). METHODS Serum samples were obtained from 14 patients with biopsy-proven alcoholic liver diseases and 9 patients with biopsy proven non-alcoholic fatty liver disease. In addition to these biopsy-proven cases, 16 obese(body mass index > 25) patients without any history of alcohol consumption but with a fatty liver on ultrasound examination and with elevated GGT were included for an additional analysis. Serum GGT fractionation was conducted by high-performance gel filtration liquid chromatography and was separated into the four fractions, big-GGT, medium-GGT, small-GGT(s-GGT), and free-GGT(f-GGT).RESULTS The results were expressed as a ratio of each fraction including the total GGT(t-GGT). The s-GGT/t-GGT ratioswere lowest for the control group and highest for the ALD group. The differences between the control and NAFLD groups and also between the NAFLD and ALD groups were statistically significant. In contrast, the f-GGT/t-GGT ratios were highest in the control group and lowest in the ALD group, with the differences being statistically significant. As a result, the s-GGT/f-GGT ratios were markedly increased in the NAFLD group as compared with the control group. The increase of the s-GGT/t-GGT ratios, the decrease of the f-GGT/t-GGT ratios, and the increase of s-GGT/F-GGT ratios as compared with the control group subjects were also found in obese patients with clinically diagnosed fatty change of the liver.CONCLUSION Serum GGT fractionation by high-performance gel filtration liquid chromatography is potentially useful for the differential diagnosis of ALD and NAFLD. | Shigeo Sueyoshi Setsu Sawai Mamoru Satoh Masanori Seimiya Kazuyuki Sogawa Atsushi Fukumura Mikihiro Tsutsumi Fumio Nomura | 2016 | World Journal of Hepatology2016，8，36： | 2 |
| 3 | Antidepressant principles of Valeriana fauriei roots显示文摘 | Yoshiteru O Setsu M Yasushi O | 1995 | Chem Pharm Bull1995，43，1： | 1 |
| 4 | 1 Ongoing myocardial damagein chronic heart failure is related to activated turn or necrosis factorand Fas/Fas ligand system 显示文摘 | Setsu ta K Seino Y Ogawa T eta | 2004 | C ircj2004，68，8： | 1 |
| 5 | Fiber tract based atlas of human white matter anatomy 显示文摘 | SETSU W HANG Y J LINDIA M | 2004 | Radiology2004，230，： | 1 |
| 6 | Pustular psoriasis induced by terbinafine:differential diagnosis from acute generalized exanthematous pustulosis显示文摘 | Tokuyama Y Senoh A Setsu N | 2008 | Eur J Dermatol2008，18，6： | 1 |
| 7 | Usefulness of autotaxin for the complications of liver cirrhosis显示文摘BACKGROUND Autotaxin(ATX)has been reported as a direct biomarker for estimating the evaluation of liver fibrosis.But available data on ATX as a useful biomarker for the complications of liver cirrhosis(LC)are scant.AIM To assess the clinical usefulness of ATX for assessing the complications of LC.METHODS This multicenter,retrospective study was conducted at six locations in Japan.We include patients with LC,n=400.The ATX level was evaluated separately in men and women because of its high level in female patients.To assess the clinical usefulness of ATX for the complications of LC,the area under the curve(AUC)of ATX assessing for the severe complications was analyzed in comparison with the model for end-stage liver disease score,albumin-bilirubin(ALBI)score,fibrosis-4 index,and aspartate aminotransferase-to-platelet ratio index.RESULTS The mean age was 68.4±11.4 years,240 patients(60.0%)were male.A total of 213(53.3%)and 187(46.8%)patients were compensated and decompensated,respectively.The numbers of patients with varix rupture,hepatic ascites,and hepatic encephalopathy were 35(8.8%),131(32.8%),and 103(25.8%),respectively.The AUCs of ATX in men for hepatic encephalopathy,hepatic ascites,and varix ruptures were 0.853,0.816,and 0.706,respectively.The AUCs of ATX in women for hepatic encephalopathy,hepatic ascites,and varix rupture were 0.759,0.717,and 0.697,respectively.The AUCs of ATX in men were higher than those in women,as were all the other biomarkers used to detect encephalopathy and varix ruptures.However,for detecting ascites,the AUC of ALBI in men was more effective than using ATX.CONCLUSION ATX in men was more effective than any other biomarkers for detecting hepatic encephalopathy and varix ruptures. | Xue Shao Haruki Uojima Toru Setsu Tomomi Okubo Masanori Atsukawa Yoshihiro Furuichi Yoshitaka Arase Hisashi Hidaka Yoshiaki Tanaka Takahide Nakazawa Makoto Kako Tatehiro Kagawa Katsuhiko Iwakiri Shuji Terai Wasaburo Koizumi | 2020 | World Journal of Gastroenterology2020，26，1： | 1 |
| 8 | Nic- orandil prevents troponin T release in patients with acute heartfailure显示文摘 | Migaku Kikuchi Setsu Nishino Shu ichi Yoneda | 2013 | Circulation2013，128，16： | 1 |
| 9 | Serum triacylglycerol-lowering effect of soybean i3-conglycinin in mildly hypertriacylglycerolemic individuals e-SPEN 显示文摘 | SETSU O YASUNORI M MAKOTO T | 2007 | Eur J Clin Nutr Metab2007，2，1： | 1 |
| 10 | Prognostic significance of pl4ARF, pl51NK4b, and pl61NK4a inactivation in malignant periph- eral nerve sheath tumors显示文摘 | Endo M Kobayashi C Setsu N | 2011 | Clin Cancer Res2011，17，11： | 1 |
| 11 | Antidepressant Principles of Valeriana fauriei Roots显示文摘 | Oshima Y H Setsu M Yasushi O | 1995 | Chem Pharm Bull(Tokyo)1995，43，1： | 1 |
| 12 | Fiber tract-based atlas of human white matter anatomy显示文摘 | Setsu W Hangyi J Lidia M | 2004 | Radiology2004，230，1： | 1 |
| 13 | Combination chemoimmunotherapy of murine solid tumor with OK-432,G-CSF,IL-2,and chemotherapeutics显示文摘 | Shinichiro I Setsu M Chie K | 1995 | Int J Immunopharm1995，17，： | 1 |
| 14 | ()ngo- ing myocardial damage in chronic heart failure is re- lated to activated tumor necrosis factor and Fas/ Fas ligand system显示文摘 | SETSU TA K SEINO Y OGAWA T | 2004 | CircJ2004，68，： | 1 |
| 15 | Modification of the gluteus maximus V - Y advancement flap for sacral ulcers: the gluteal fasciocutaneous flap method显示文摘 | Ohjimi H Ogata K Setsu Y | 1996 | Plast Reconstr Surg1996，98，7： | 1 |
| 16 | Nicorandil prevents troponin T release in patients with acute heartfailure 显示文摘 | Migaku K Setsu N Shu-ichi Y | 2013 | Circulation2013，128，16： | 1 |
| 17 | Cerebrospinal fluid interleukin-6 and glial fibrillary acidic protein levels are increased during initial neuromyelitis optica attacks显示文摘 | Akiyuki U Masahiro M Setsu S | 2013 | J Clinica Chimica Aeta2013，421，： | 1 |
| 18 | Modification of the glu- teal maximus V-Y advancement flap for sacral ulcers: the gluteal fasciocutaneous flap method显示文摘 | OHJIMI H OGATA K SETSU Y | 1996 | Plast Reconstr Surg1996，98，7： | 1 |
| 19 | Protective effect quereetin on FaR stress caused by ealciura dymmics dysreodaon in intestinal epitheliel edls 显示文摘 | Natsume Y Ito S Setsu H | 2009 | Toxicology2009，258，2： | 1 |
| 20 | Modification of the gluteus maximus V-Y advancement flap for sacral ulcers:The gluteal fasciocutaneous flap method 显示文摘 | Ohjimi H Ogata K Setsu Y | 1996 | Plast Reconstr Surg1996，98，： | 1 |
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