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| 1 | Liver Nuclear Activation of Carbon Tetrachloride or Bromotrichloromethane to Trichloromethyl and Trichloromethylperoxyl Free Radicals.Their Reactions With Lipids and Proteins显示文摘The formation of·CCl3 radicals in liver nuclei was suggested by spin trapping of them with N-t-butyl-α-phenylnitrone followed by GC/MS detection of the resulting adduct. Comparison of its formation in microsomal biotransformation of CCl4 was made. In aerobic nuclear activation mixtures containing NADPH and CCl4, significant decrease in the arachidonic acid content of nuclear lipids was observed (27. 8%, compared to control), the intensity of this decrease was lower than that occurring in the corresponding microsomal incubation mixtures (29.1%). Significant decreases in arachidonic acid content of nuclear and endoplasmic reticulum lipids were also observed in animals at 6 hours of poisoning with the haloalkane. During aerobic nuclear metabolism of CCl4 or CBrCl3, cholesterol oxidation products were detected: a ketocholesterol, an epoxide like structure and 7-ketocholesterol. Nuclear protein carbonyl formation was not promoted during nuclear CCl4 biotransformation. NADPH by itself may lead to protein carbonyl formation during prolonged periods of incubation. CBrCl3 in contrast, led to decreased protein carbonyl formation. No increase in nuclear protein carbonyl formation was observed in CCl4 intoxicated animals during periods of time between 1 to 6 hours after treatment. The results indicate that during nuclear biotransformation of CCl4 or CBrCl3 reactive free radicals, PUFA degradation, reactive aldehydes and cholesterol oxidation products are formed, nearby DNA and regulatory proteins. | S. L. FANELLI G. D. CASTRO M. E. GALELLI AND J. A. CASTRO (Centro de Investigaciones Toxicologicas(CEITOX)-CITEFA/CONICET, Zufriategui 4380, 1603 Villa Martelli,Buenos Aires, Argentina)(Send correspondence to Dr. Jose Alberto Castro, Zufriategui 4380, 1 | 1998 | Biomedical and Environmental Sciences1998，11，2： | 4 |
| 2 | In vitro Effect of Dithiocarbamate Pesticides and of CaNa_2EDTA on Human Serum Dopamine-β-hydroxylase显示文摘Serum dopamine-β-hydroxylase (DBH) inhibition has been reported in lead workers treated with CaNa2EDTA and in alcoholic patients repeatedly treated with the alcohol aversive drug Disulfiram. The mechanism of inhibition involves Cu-chelation at the active site of DBH. The effect of CaNa2EDTA and Disulfiram on serum DBH has been compared to the effect of dithiocarbamate pesticides in vitro for the possible use of serum DBH determination for the biological monitoring of workers exposed to these pesticides.Most dithiocarbamates inhibit human serum DBH at micromoIar concentrations (range of I50, 0.027-1.6 μmol/L). The inhibitory potency increased from methyl- and dimethyl dithiocarbamates to diethyl dithiocarbamates up to the most potent ethylene bisdithiocarbamates. The I50 of CaNa.EDTA was 3.8 mol/L, higher than those of dithiocarbamates. Copper addition to the test system rcactivated at stoichiometric concentrations dithiocarbamaie-inhibited DBH indicating that both base line values and percent of inhibition can be calculated in a single blood sample. Results suggest that serum DBH determination couId be useful in case of acute poisoning involving high doses of dithiocarbamate | PAOLA DE PARIS AND STEFANO CAROLDI(Istituto di Medicina del Lavoro, Universita’ di Padova, Padova, Italy)(Send correspondence to: Dr. Stefano Caroldi. Istituto di Medicina del Lavoro, Via Facciolati 71,I-35127, Padova, Italy. Tel: 3949-8216652, Fax: 3949- | 1995 | Biomedical and Environmental Sciences1995，8，2： | 3 |
| 3 | Clinical efectiveness of coblationassistedinforior turbinoplasty 显示文摘 | Tani T Send S Hanamitsu M | 2008 | Arerugi2008，57，8： | 1 |
| 4 | Constitution,Choice and Change:Prob- lems with the ' Logic of Appropriateness' and its Use in Constructivist Theory 显示文摘 | Jacob Ole Sending | 2002 | European Journal of International Relations2002，，4： | 1 |
| 5 | Constitution, Choice and Change Problems with the 'Logic of Appropriateness' and its Use in Constructivist Theory显示文摘 | Sending Jacob Ole | 2002 | European Journal of International Relations2002，，4： | 1 |
| 6 | Invasive arterial blood pres- sure monitoring in an out-of-hospital setting:an observational study显示文摘 | Sende J Jabre P Leroux B | 2009 | Emerg Med J2009，26，3： | 1 |
| 7 | Alterations of Monoamine Metabolites and Neurobehavioral Function in Lead-Exposed Workers显示文摘Neurobehavioral and neurochemical effects of occupational lead exposure were invstigated by WHO Ncurobehavioral Core Test Battery (NCTB) testing and a serics of monoamine neurotransmitters and their metabolites analyzing in workers from lead smeltery and storage-battery manufacturing factory and matched controls. Indicators of lead exposure, the blood lead (PbB) and zinc protophorphyrin (ZPP) levels were found significantly higher in the expeed group compared with that of the controls (70.55μg/dL vs 3.6μg/dL; and 294.92 μg/dL vs 38.32μg/dL, respectively). Furthermore, elevated urinary homovanillic acid (HVA) and impairment of certain neurobehavioral performances were also found in the lead exposed wokers; the latter included attention/response speed, manual dexterity, perceptual-motor speed, visual perception/memory, and motor speed/steadiness. Positive or negative correlations were observed between certain parameters. Thus, homovanillic acid (HVA) is peitively correlated With PbB and ZPP; dopamine (DA) negatively correlated with Benton visual retention (BVR); and HVA negatively correlated with digit symbol (DSy), BVR, and pursuit aiming (PA). It is suggested that the alterations of dopamine and its metabolites HVA in urine associated with impairment of neurobehavioral function might be served as biomarkers of lead-induced neurotoxicity. | TANG HAI-WANG LIANG YOU-XON HU XIAO-HONG AND YANG HONG-GUANG(Department of Occupational Health, Shanghai Medical University Shanghai 200032, China Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 200031, China)(Please send req | 1995 | Biomedical and Environmental Sciences1995，8，1： | 1 |
| 8 | Chitosan films and hydrogels of chlorhexidine gluconate for oral mucosal delivery显示文摘 | Send S lkinci G Kas S | 2000 | Int J Phatrn2000，193，2： | 1 |
| 9 | Orogeny and relative plate motions: Example of the Japanese Islands显示文摘 | Maruyama S Send T | 1986 | Teetonophysies1986，127，： | 1 |
| 10 | The Ocean Takes a Deep Breath显示文摘 | Kortzinger A Schimanski J Send U | 2004 | Science2004，306，5700： | 1 |
| 11 | Orogeny and relative plate motions:Example of the Japanese Islands显示文摘 | Maruyama S Send T | | 0，，3： | 1 |
| 12 | Clinical effectiveness of coblation-assistedinferior turbinoplasty显示文摘 | Tani T Send S Hanamitsu M | 2008 | Arerugi2008，57，8： | 1 |
| 13 | Effect of detergents in the release of bisphenol A from polycarbonate baby bottles显示文摘 | Maia J Cruz J M Sendón R | 2009 | Food Research International2009，42，10： | 1 |
| 14 | Effect of amines in the release of bisphenol A from polycarbonate baby bottles显示文摘 | Maia J Cruz J M Sendón R | 2010 | Food Research International2010，43，5： | 1 |
| 15 | Orogeny and relative plate motions : example of the Japanese Islands 显示文摘 | MARUYAMA S SEND T | 1986 | Tectono- physics1986，127，3： | 1 |
| 16 | Orogeny and relative plate mo- tions: example of the Japanese Islands 显示文摘 | Maruyama S Send T | 1986 | Tectono- physics1986，127，3： | 1 |
| 17 | Constitution, Choiee and Change: Problems with the 'Logic of Appropriateness' and its Use in Construetivist Theory 显示文摘 | Jacob Ole Sending | 2002 | European Journal of International Relations2002，，4： | 1 |
| 18 | Hydrodeoxygenation of methyl esters on sulphided NiMo/γ-Al2O3 and CoMo/γAl2O3 catalysts显示文摘 | Send O I Viljava T R Krause A O I | 2005 | Catalysis Today2005，100，34： | 1 |
| 19 | Stop the Noise: A Quali- ty Improvement Proiect to Decrease Electrocardiographic Nui- sance Alarms显示文摘 | Send elbach S Wahl S Anthony A | 2015 | Crit Care Nurse2015，35，4： | 1 |
| 20 | Constitution,Choice and Change:Problems with the'Logic of Appropriateness' and its Use in Constructivist Theory显示文摘 | Jacob Ole Sending | | 0，，04： | 1 |
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