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| 1 | Endoplasmic reticulum stress-mediated pathways to both apoptosis and autophagy: Significance for melanoma treatment显示文摘Melanoma is the most aggressive form of skin cancer.Disrupted intracellular signaling pathways are responsible for melanoma's extraordinary resistance to current chemotherapeutic modalities. The pathophysiologic basis for resistance to both chemo- and radiation therapy is rooted in altered genetic and epigenetic mechanisms that, in turn, result in the impairing of cell death machinery and/or excessive activation of cell growth and survival-dependent pathways. Although most current melanoma therapies target mitochondrial dysregulation,there is increasing evidence that endoplasmic reticulum(ER) stress-associated pathways play a role in the potentiation,initiation and maintenance of cell death machinery and autophagy. This review focuses on the reliability of ER-associated pathways as therapeutic targets for melanoma treatment. | Mohamed Hassan Denis Selimovic Matthias Hannig Youssef Haikel Robert T Brodell Mossaad Megahed | 2015 | World Journal of Experimental Medicine2015，5，4： | 15 |
| 2 | 丙肝病毒相关的 hepatocellular 癌: 卓见进分子的机制和治疗学的策略显示文摘 Hepatitis C virus(HCV) infects more than 170 million people worldwide,and thereby becomes a series global health challenge.Chronic infection with HCV is considered one of the major causes of end-stage liver disease including cirrhosis and hepatocellular carcinoma.Although the multiple functions of the HCV proteins and their impacts on the modulation of the intracellular signaling transduction processes,the drive of carcinogenesis during the infection with HCV,is thought to result from the interactions of viral proteins with host cell proteins.Thus,the induction of mutator phenotype,in liver,by the expression of HCV proteins provides a key mechanism for the development of HCV-associated hepatocellular carcinoma(HCC).HCC is considered one of the most common malignancies worldwide with increasing incidence during the past decades.In many countries,the trend of HCC is attributed to several liver diseases including HCV infection.However,the development of HCC is very complicated and results mainly from the imbalance between tumor suppressor genes and oncogenes,as well as from the alteration of cellular factors leading to a genomic instability.Besides the poor prognosis of HCC patients,this type of tumor is quite resistance to the available therapies.Thus,understanding the molecular mechanisms,which are implicated in the development of HCC during the course of HCV infection,may help to design a general therapeutic protocol for the treatment and/or the prevention of this malignancy.This review summarizes the current knowledge of the molecular mechanisms,which are involved in the development of HCV-associated HCC and the possible therapeutic strategies. | Denis Selimovic Abdelouahid El-Khattouti Hanan Ghozlan Youssef Haikel Ola Abdelkader Mohamed Hassan | 2012 | World Journal of Hepatology2012，4，12： | 7 |
| 3 | Combined solid oxide fuel cell and gas turbine systems for efficient power and heat generation 显示文摘 | PALSSON J SELIMOVIC A SJUNNESSON L | 2000 | J Power Sources2000，86，： | 1 |
| 4 | Improved algorithms for the projection of points on NURBS curves and surfaces 显示文摘 | Selimovic I | 2006 | Computer Aided Geometric Design2006，23，5： | 1 |
| 5 | Bortezomib/ proteasome inhibitor triggers both apoptosis and autophagy- dependent pathways in melanoma cells显示文摘 | Selimovic D Porzig BB El-Khattouti A | 2013 | Cell Signal2013，25，： | 1 |
| 6 | Hepatitis C virus-mediated angiogenesis:Molecular mechanisms and therapeutic strategies显示文摘Angiogenesis is an essential process for organ growth and repair. Thus, an imbalance in this process can lead to several diseases including malignancy. Angiogenesis is a critical step in vascular remodeling, tissue damage and wound healing besides being required for invasive tumor growth and metastasis. Because angiogenesis sets an important point in the control of tumor progression, its inhibition is considered a valuable therapeutic approach for tumor treatment. Chronic liver disease including hepatitis C virus(HCV) infection is one of the main cause for the development of hepatic angiogenesis and thereby plays a critical role in the modulation of hepatic angiogenesis that finally leads to hepatocellular carcinoma progression and invasion. Thus, understanding of the molecular mechanisms of HCV-mediated hepatic angiogenesis will help design a therapeutic protocol for the intervention of HCV-mediated angiogenesis and subsequently its outcome. In this review, we will focus on the molecular mechanisms of HCV-mediated hepatic angiogenesis and the related signaling pathways that can be target for current and under development therapeutic approaches. | Mohamed Hassan Denis Selimovic Abdelouahid El-Khattouti Martine Soell Hanan Ghozlan Youssef Haikel Ola Abdelkader Mosaad Megahed | 2014 | World Journal of Gastroenterology2014，20，42： | 1 |
| 7 | Improved algorithms for the projection of points on NURBS curves and surfaces显示文摘 | Ilijas Selimovic | 2006 | Computer Aided Geometric Design2006，23，5： | 1 |
| 8 | Modelling evolution and the evolving mechanical environment of saccular cerebral aneurysms显示文摘 | Watton PN Selimovic A Raberger NB | 2011 | Biomech Model Mechanobiol2011，10，1： | 1 |
| 9 | Increased apoptosis the contra lateral testis of patients with testicular torsion as a factor for in-fertility显示文摘 | Hadz selimovic F Geneto R Emmons L | 1998 | J Urol1998，160，： | 1 |
| 10 | Increased apoptosis the contra lateral testis of patients with testicular torsion as a factor for in-fertility显示文摘 | Geneto R Emmons L | 1998 | J Urol1998，160，： | 1 |
| 11 | Synthesis of alkyl-substituted pyridines by liquid-phase condensation of aldehydes with amines assisted by metal complex catalysts显示文摘 | Selimov F A Akhmetov A Zh Dzhemilev U M | 1987 | Seriya Khimicheskaya1987，，9： | 1 |
| 12 | Taxol-induced mitochondrial stress in melanoma cells is mediated by activation of c-Jun N-terminal kinase (JNK) and p38 pathways via uncoupling protein 2显示文摘 | SELIMOVIC D HASSAN M HAIKEL Y | 2008 | Cell Signal2008，20，2： | 1 |
| 13 | Electrochemical model of the integrated planar solid oxide fuel cell(IP-SOFC) 显示文摘 | Costamagna P Selimovic A Borghi M D | 2004 | Journal of Chemical Engineering Journal2004，102，1： | 1 |
| 14 | Combined solid oxide fuel cell and gas turbine systems for efficient power and heat generation显示文摘 | Jens Palsson Azra Selimovic Lars Sjunnesson | 2000 | Journal of Power Sources2000，86，1： | 1 |
| 15 | Cat-scratch disease显示文摘 | Saracevic E Sabanovic S Selimovic A | 2000 | Med Arh2000，54，56： | 1 |
| 16 | Electrochemical model of the integrated planar solid oxide fuel cell (IP-SOFC) 显示文摘 | Costamagna P Selimovic A Del Borghi M Agnew G | 2004 | Chemical Engineering Journal (S1385-8947)2004，102，1： | 1 |
| 17 | Artificial neural network simulator for SOFC performance prediction显示文摘 | ARRIAGADA J OLAUSSON P SELIMOVIC A | 2002 | Power Sources2002，112，： | 1 |
| 18 | Artificial neural network simulator for SOFC performance prediction 显示文摘 | ARRIAGADA J OLAUSSON P SELIMOVIC A | 2002 | Journal of Power Sources2002，112，1： | 1 |
| 19 | Combined solid oxide fuel cell and gas turbine systems for efficient power and heat generation显示文摘 | Palsson J Selimovic A Sjunnesson L | 2000 | Journal of Power Sources2000，86，12： | 1 |
| 20 | Improved algorithm for the projection of points on NURBS curves and surfaces显示文摘 | Selimovic I | 2006 | Computer Aided Geometric Design2006，23，5： | 1 |
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