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| 1 | Phytochemical studies and anti-ulcerative colitis effect of Moringa oleifera seeds and Egyptian propolis methanol extracts in a rat model显示文摘Objective: To analyze the phytochemical constituents, and to explore potential protective effect of the methanol extract of Moringa oleifera(M. oleifera) seeds and Egyptian propolis, each alone or concurrently administered on acetic acid-induced ulcerative colitis in rats. Methods: Eight groups of 5 rats each were used: normal control group with distilled water, model group, two groups with M. oleifera seeds(100 and 200 mg/kg), two groups with propolis(50 and 100 mg/kg), one group with concurrent administration of both, and one group with prednisolone(reference drug). Macro-and microscopic picture, ulcer index and lesion scores, oxidative markers, inflammatory mediators, in vitro activity of the inflammatory enzymes and 1, 1-diphenyl-2-picrylhydrazyl free radicals scavenging activity were evaluated. The phytochemical constituents of both extracts were explored by GC-MS analysis. Results: Both treatments modulated the macro-and microscopic picture, decreased the ulcerative index, lesion score, oxidative markers and inflammatory mediators, and inhibited the COX-1 and COX-2 enzymes. Propolis appeared to be powerful free radicals scavenger. A powerful synergistic effect of both treatments in modulating the course of the disease was reported. GCMS analysis of methanol extract of M. oleifera seeds and propolis revealed the presence of 50 and 34 compounds, respectively. Conclusions: M. oleifera seeds and propolis methanol extracts have modulated the course of acetic acid-induced ulcerative colitis. Moreover, both treatments induce a good synergistic effect against the disease. Isolation of the active constituents is recommended. | Attia H.Atta Samar M.Mouneir Soad M.Nasr Doaa Sedky Amany M.Mohamed Shimaa A.Atta Hassan Mohamed Desouky | 2019 | Asian Pacific Journal of Tropical Biomedicine2019，9，3： | 4 |
| 2 | Prader-Willi syndrome and obstructive sleep apnea: co-occurrence in the pediatric population 显示文摘 | Sedky K Bennett DS Pumariega A | 2014 | J Clin Sleep Med2014，10，4： | 1 |
| 3 | Evolving neural network using real coded genetic algorithm for daily rainfall-runoff forecasting显示文摘 | Sedki A Ouazar D Ei Mazoudi E | 2009 | Expert Systems with Applications2009，36，3： | 1 |
| 4 | Culture-independent investigation of the microbiome associated with the nematode aerobeloides maximus显示文摘 | BaquiranJP Thater B Sedky S | 2013 | PLoS One2013，8，67： | 1 |
| 5 | Nonlinear I-V characteristics in doped ZnO based-ceramic varistor显示文摘 | Sedky A Abu-Abdeen M | 2007 | Physica B2007，388，： | 1 |
| 6 | Comparative study of biosorption of Zn2+ by Pseudomonas aeruginosa and Bacillus cereus 显示文摘 | Jinho J Sedky HA Hassan S | 2010 | Int Biodeterior Biodegrad2010，64，： | 1 |
| 7 | IR Bolometers Made of Polycrystalline Silicon Germanium显示文摘 | Sedky S Fiorini P Caymax M | 1998 | Sensors and Actuators A1998，66，： | 1 |
| 8 | Phytochemical, antioxidant and hepatoprotective effects of different fractions of Moringa oleifera leaves methanol extract against liver injury in animal model显示文摘Objective: To evaluate the potential antioxidant and hepatoprotective effects of n-hexane, dichloromethane(DCM), ethyl acetate(EtOAc), n-butanol and aqueous fractions of Moringa oleifera(M. oleifera) leaves methanol extract against carbon tetrachloride(CCl_4)-induced liver injury in rats. Methods: These fractions were prepared from the M. oleifera leaves methanol extract by solubilization in water and partitioning in n-hexane, EtOAc, DCM and n-butanol. Their phyto-components were identified by GC-MS analysis. The in vitro antioxidant effect of these fractions was carried out by assessment of 1,1-diphenyl-2-picrylhydrazyl scavenging activity. A total of 40 Sprague Dawley rats were allocated into 8 equal groups: group 1 given olive oil(1 m L/kg b.wt.), group 2 injected with CCl_4, group 3 to 7 administered with n-hexane, DCM, EtOAc, n-butanol and aqueous fractions, respectively after CCl_4, group 8 administered with silymarin after CCl_4. The activities of aspartate aminotransferase, alanine aminotransferase, and the levels of total cholesterol, triglycerides, glucose, total proteins and albumin in serum were determined spectrophotometrically. Glutathione reduced, lipid peroxide by-products levels, glutathione-s-transferase and catalase enzyme activities in the liver homogenate were determined by spectrophotometer. Liver specimens were also examined for histopathological alterations under light microscope. Results: The GCMS analysis of different fractions of the M. oleifera leaves methanol extract revealed that n-hexane, DCM, EtOAc, n-butanol, and aqueous fractions contained 17, 22, 23, 19 and 32 compounds, respectively. The percent and the molecular structure of each component in each fraction were identified. The n-butanol and EtOAc fractions exhibited the strongest in vitro antioxidant activity against 1,1-diphenyl-2-picrylhydrazyl. CCl_4 significantly decreased glutathione reduced and total proteins concentration and glutathione-s-transferase and catalase activities but increased lipid peroxide by-products and total cholesterol levels. The n-hexane followed by aqueous and DCM fractions were the most potent to regulate serum enzyme activities and lipid peroxide by-products levels in the liver homogenate. Conclusions: n-hexane, DCM, and aqueous fractions have the highest effectiveness against CCl_4-induced hepatotoxicity. Isolation and purification of the active constituents require further experiments. | Attia H.Atta Soad M.Nasr Abduljalil H.Almaweri Doaa Sedky Amany M.Mohamed Hassan M.Desouky Mostafa A.Shalaby | 2018 | Asian Pacific Journal of Tropical Medicine2018，11，7： | 1 |
| 9 | Enhancement of electrical conductivity by Al-doped ZnO ceramic varistors显示文摘 | Sedky A Sawalha A Yassin A M | 2009 | Physi- ca B: Condensed Matter2009，404，20： | 1 |
| 10 | Evolving neural network using real coded genetic algorithm for daily rainfall-runoff forecasting显示文摘 | SEDKI A -OUAZAR D MAZOUDI E E I | 2009 | Expert Systems with Applications2009，36，3： | 1 |
| 11 | Paliperidone palmitate: Once-monthly treatment option for schizophrenia 显示文摘 | Sedky K Nazir R Lindenmayer JP | 2010 | Curr Psychiatry2010，9，3： | 1 |
| 12 | Wide-bandmeasurement of the complex permittivity of dielectricmaterials using a wide - band cavity 显示文摘 | Mohammd A S Sedki M R Aicha E | 1989 | IEEETransactions on Instrumentation and Measurement1989，38，2： | 1 |
| 13 | Prader Willi Syndrome and Ob- structive Sleep Apnea: Co-occurrence in the Pediatric Population 显示文摘 | Sedky K Bennett DS Pumariega A | 2014 | J Clin Sleep Med2014，10，4： | 1 |
| 14 | Evolving neural network using real coded genetic algorithm for daily rainfall-runoff forecasting显示文摘 | SEDKI A OUAZAR D MAZOUDI E El | | 0，，03： | 1 |
| 15 | Body weight changes associated with psychopharmacology显示文摘 | PODOLSKAYA A SEDKY K | 2002 | Psychiatr Serv2002，53，： | 1 |
| 16 | Modeling of the HP-1430A feed-through wide-band (28-ps) sampling head显示文摘 | SEDKI M RIAD | 1982 | IEEE Transactions on Instrumentation and Measurement1982，31，2： | 1 |
| 17 | Evolving neural network using real coded genetic algorithm for daily rainfall-run- off forecasting显示文摘 | SEDKI A OUAZAR D MAZOUDI E E | 2009 | Expert Systems with Applications2009，36，3： | 1 |
| 18 | Nonlinear I-V characteristics in doped ZnO based-ceramic varistor显示文摘 | Sedky A Abu-Abdeen M Abdalaziz A A | 2007 | Physical B2007，，388： | 1 |
| 19 | Extraeranial carotid aneurysm in Behcet disease: Report of two new cases 显示文摘 | Bouarhroum A Sedki N Bouziane Z | 2006 | J Vasc Surg2006，43，3： | 1 |
| 20 | Toxic and essential trace metals in muscle, liver and kidney of bovines from a polluted area of Morocco显示文摘 | Sedki A Lekouch N Gamon S | 2003 | The Science of the Total Environment2003，317，： | 1 |
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