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| 1 | The characteristics of CO_2 assimilation of photosynthesis and chlorophyll fluorescence in transgenic PEPC rice显示文摘With PEPC, PPDK, NADP-ME and PEPC+ PPDK transgenic and untransformed rice (Orysa sativa L.), the activities of related C4 photosynthesis enzymes, the chlorophyll fluorescence parameters, CO2 exchange and other physiological indexes were compared, in which the physiological characteristics of PEPC transgenic rice were mainly studied. The results were as follows: (i) The activities of PEPC in PEPC transgenic rice were 20-fold higher than those in untransformed rice; the light-saturation photosynthetic rates and the carboxylation efficiency of PEPC transgenic rice were increased by 55% and 50% more than those of untransformed rice, respectively, while the CO2 compensation point decreased by 27%. (ii) The PS II photochemical efficiency (Fv/Fm) and photochemical quenching (qp) of transgenic PEPC rice decreased less in comparison with those of untransformed rice after the treatment with high light intensity (3 h) or methyl viologen (MV), a photooxidative reagent, which demonstrated that the tolerance of PEPC | JIAO Demao, LI Xia, HUANG Xueqing, CHI Wei, KUANG Tingyun & Ku SB Maurice1. Institute of Agrobiological Genetics and Physiology, Jiangsu Academy of Agricultural Sciences, Nangjing 210014, China 2. Institute of Botany, the Chinese Academy of Sciences, Beijing 100093, China 3. Botany Department, Washington State University, Pullman, WA 99164-4236, USA | 2001 | Chinese Science Bulletin2001，46，13： | 29 |
| 2 | Modulatory effect of pineapple peel extract on lipid peroxidation,catalase activity and hepatic biomarker levels in blood plasma of alcoholinduced oxidative stressed rats显示文摘Objective:To investigate the ability of the methanolic extract of pineapple peel to modulate alcohol-induced lipid peroxidation,changes in catalase activities and hepatic biochemical marker levels in blood plasma.Methods:Oxidative stress was induced by oral administration of ethanol(20%w/v) at a dosage of 5 niL/kg bw in rats.After 28 days of treatment,the rats were fasted overnight and sacrificed by cervical dislocation.Blood was collected with a 2 mL syringe by cardiac puncture and was centrifuged at 3000 rpm for 10 min.The plasma was analyzed to evaluate malondialdehyde(MDA),catalase activity,aspartate aminotransferase(AST),alkaline phosphatase(ALP) and alanine aminotransferase(ALT) concentrations.Results:Administration of alcohol caused a drastic increase(87.74%) in MDA level compared with the control.Pineapple peel extract significantly reduced the MDA level by 60.16%at 2.S mL/kg bw.Rats fed alcohol only had the highest catalase activity,treatment with pineapple peel extract at 2.5 mL/kg bw however, reduced the activity.Increased AST,ALP and ALT activities were observed in rats fed alcohol only respectively,treatment with pineapple peel extract drastically reduced their activities. Conclusions:The positive modulation of lipid peroxidation,catalase activities as well as hepatic biomarker levels of blood plasma by the methanolic extract of pineapple peels under alcoholinduced oxidative stress is an indication of its protective ability in the management of alcoholinduced toxicity. | Okafor OY Erukainure OL Ajiboye JA Adejobi RO Owolabi FO Kosoko SB | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，1： | 13 |
| 3 | 牛蒡子中血小板活化因子(PAF)受体拮抗剂的分离和结构鉴定显示文摘 | 韩桂秋 白光清 王夕红 Liesch JM Zink DL Hwang SB | 1992 | 中草药1992，23，11： | 12 |
| 4 | Luminescence Properties of the Ternary Terbium Complexes with (Ortho and Para) Aminobenzoic acids and 1,10-Phenanthroline Incorporated in Silica Matrix by a Sol-gel Method显示文摘Ternary complexes of terbium with ortho (and para) aminobenzoic acid and 1.10 phenanthroline were introduced into silica gel by the sol-gel method. The luminescence behavior of the solid-state samples was studied during the sol-gel aging process by means of emission, excitation spectra, lifetimes and quantum efficiencies. | Yan, B Zhang, HJ Wang, SB Ni, JZ | 1997 | Chinese Chemical Letters1997，8，7： | 10 |
| 5 | 樟叶胡椒中新木脂素成分的研究显示文摘自胡椒科胡椒属植物樟叶胡椒(Piper polysyphorum C. DC)中分离到六个新木脂素(neolignans)类化合物,经光谱(UV,IR,MS,~1H-NMR,^(13)C-NMR,2D-NMR,CD)分析及衍生物制备,确定Ⅱ为新化合物,即threo-△~7-7-羟基-3,4,5,3′,5′-五甲氧基-8-O-4′-新木脂素,为一对对映体,命名为樟叶素(polysyphorin),Ⅰ,Ⅲ,Ⅳ为新的对映体,分別为(+)-virolongin,(+)-grandisin及(+)-lancifolin D.化合物Ⅴ为南藤素(wallichinine),Ⅵ为山蒟素D(hancinone D)。血小板活化因子(PAF)受体结合实验及PAF引起的血小板聚集实验证明化合物Ⅰ~Ⅴ具有明显的抑制活性。 | 马迎 韩桂秋 李长龄 诚静容 BH Arison SB Hwang | 1991 | 药学学报1991，26，5： | 7 |
| 6 | 长期应用埃索美拉唑是维持已愈合糜烂性食管炎疗效及控制胃食管反流症状的有效方法显示文摘 | Johnson DA Benjamin SB Vakil NB Goldstein JL Lamet M Whipple J Damico D Hamelin B 钟捷 | 2002 | 中华消化杂志2002，22，12： | 6 |
| 7 | 电针激活迷走神经-肾上腺轴的神经解剖学基础显示文摘电针刺激 (ES) 通过躯体感觉自主神经反射来调控机体的生理功能(如抑制严重的炎症)。二十世纪七十年代有学者认为针刺反射具有身体区域特异性(穴位特异性)。例如,低强度 (0.5 mA,10 Hz) ES 小鼠后肢穴位足三里 (ST36) 可激活迷走神经-肾上腺抗炎通路,而 ES 腹部天枢穴 (ST25) 无效,这种现象的神经解剖学基础尚不清楚。最近,在一项新的研究中,来自哈佛大学医学院、中国中医科学院和复旦大学的研究人员阐明了 ES 激活迷走神经-肾上腺轴抗炎通路的神经解剖学机制,并发现了由 PROKR2^(Cre)标记的感觉神经元对激活迷走神经-肾上腺轴至关重要。特异性敲除小鼠表达 PROKR2^(Cre)标记的 DRG 神经元,低强度电针 (0.5 mA) 刺激后肢 ST36 穴位不产生任何反应,不能使肾上腺释放儿茶酚胺类神经递质,也无法抑制细菌内毒素脂多糖 (LPS) 所诱发的全身炎症;而高强度电针 (3.0 mA)刺激后肢穴位 ST36 和腹部穴位 ST25 可激活交感神经抗炎通路。该研究还发现,进一步运用交叉遗传的方法特异性诱导光敏感通道蛋白 CatCh 表达于 PROKR2^(Cre)标记的神经末梢,可以激活迷走神经-肾上腺抗炎通路,但不能激活交感神经-肾上腺抗炎通路。此外,PROKR2^(Cre)神经纤维的分布可以预测低强度 ES 产生抗炎作用的身体区域(穴位特异性)。该研究为穴位选择和特异性激活自主神经通路提供了神经解剖学基础。尽管现代解剖学没有文献支持经络的物理存在,但针灸确实可以通过躯体神经反射来达到治疗效果。这些反射始于背根神经节 (DRG) 和/或三叉神经节周围神经的激活,然后从脊髓向大脑传递感觉信息,进而激活外周自主神经通路,最终对机体进行调控。该研究解读了为什么 ES 足三里 (ST36) 可激活迷走-肾上腺轴,而刺激腹部天枢穴 (ST25) 无任何效果,ES 刺激 ST25反而激活了脊髓交感神经通路。该研究认为迷走神经-肾上腺抗炎通道是由感觉神经介导,是后肢特有的 PROKR2^(Cre)标记的 DRG 神经元(一种 Cre 介导的重组标记神经元具有 PROKR2 持续或瞬时表达的作用)激活的,这些神经纤维密集分布在后肢深层筋膜组织。 | 陈紫悦(译) 韩清见(校) Liu SB Wang ZF Su YS | 2022 | 中国疼痛医学杂志2022，28，4： | 6 |
| 8 | Crustal structure in western Tibetan Plateau显示文摘USING explosional seismic data from the profile of Coqen,Dongco,Gerze,Lugu to Sangehu inwestern Tibet,we studied the structure and tectonic of the crust of the north-west Qinghai-Xizang(Tibet)Plateau.Bangonghu-Nujiang Suture Zone(BNSZ)is a deep fault | Xiong, SB Liu, HB | 1997 | Chinese Science Bulletin1997，42，8： | 4 |
| 9 | 阵发性心房颤动患者心房复极离散度的研究显示文摘目的 通过记录阵发性心房颤动 (房颤 )患者心房单相动作电位 (MAP) ,分析心房复极离散度与房颤发生的关系。方法 特发性阵发性房颤患者与无自发房颤病史的阵发性室上性心动过速患者各 1 5例 ,均接受心内电生理检查和 /或导管射频消融治疗。两根 MAP电极于右心房共取 4~ 1 0个不同部位进行同步的窦性心律基础刺激 (S1)及期前刺激 S2 时的 MAP记录。测量、计算心房复极离散度(RTd)及动作电位时限和局部冲动时间的离散度 (APDd、ATd)。 结果 窦性心律时房颤组最大 RTd显著大于对照组 (1 2 3 .69± 54.67) ms比 (64 .2 5± 2 3 .2 9) ms,(P<0 .0 1 )。其差异主要来源于 APDd(1 1 5.0 0± 4 6.90 ) ms比 (57.56± 3 3 .57) ms,(P<0 .0 1 ) ,ATd差异无显著性。随 S1、S2 的加入 ,各组局部激动时间和离散度逐渐增大 ,而动作电位时限逐渐缩短 ,且房颤组的这种改变程度显著大于对照组。在S1时无房颤发生 ,加入期前刺激时 ,大多数房颤组患者均多次诱发出短阵房颤。其诱发率及次数均显著高于对照组。 结论 研究结果表明 ,MAP记录技术是临床观察、分析心房复极离散度及其在阵发性房颤中的作用的较佳方法。心房复极离散度的增加是阵发性房颤发生的重要因素。 | 李真 eva hertervig 袁世文 杨延宗 林治湖 olsson sb | 1999 | 中华心律失常学杂志1999，3，4： | 4 |
| 10 | Hyperinsulinemic hypoglycemia due to adult nesidioblastosis in insulin-dependent diabetes显示文摘In neonates, persistent hyperinsulinemic hypoglycemia (PHH) is associated with nesidioblastosis. In adults, PHH is usually caused by solitary benign insulinomas. We report on an adult patient who suffered from insulin-de- pendent diabetes mellitus, and subsequently developed PHH caused by diffuse nesidioblastosis. Mutations of the MEN1 and Mody 2/3 genes were ruled out. Preoperative diagnostic procedures, the histopathological criteria and the surgical treatment options of adult nesidioblastosis are discussed. So far only one similar case of adult nesidioblastosis subsequent to diabetes mellitus Ⅱ has been reported in the literature. In case of conversion of diabetes into hyperinsulinemic hypoglycemia syndrome, nesidioblastosis in addition to insulinoma should be con- sidered. | A Raffel M Anlauf SB Hosch M Krausch T Henopp J Bauersfeld R Klofat D Bach CF Eisenberger G Klppel WT Knoefel | 2006 | World Journal of Gastroenterology2006，12，44： | 3 |
| 11 | 心房颤动——当今面临的挑战显示文摘在过去数年里,临床和科撞方面对心房颤动(房颤)的关注明显增加,有关这一论题的出版物数量迅速、稳定的增长就是证明。虽然已有一些新方法治疗遮一心律失常一但大多数房颤患者仍然不得不忍受这一心律失常,包括其不良后果和症状,房颤无疑是虽迫切需要有更好治疗方法的一种心律失常。为了达到这一目的,就需要更深刻地认识房颤的机制.以便开发直接影响这一基础病理生理机制的治疗措施。 | Olsson SB Hansson A Hedin E Holm M Ingemansson M Johansson R Meurling C Pehrson S Roijer A Yuan S 方丕华 | 1997 | 中华心律失常学杂志1997，1，1： | 3 |
| 12 | 前蛋白转化酶枯草杆菌蛋白酶kexin-9在肾病综合征相关性高胆固醇血症中的作用显示文摘肾病综合征中,肾脏足细胞损害可导致严重的高胆固醇血症,迫切需要新的治疗方法。前蛋白转化酶枯草杆菌蛋白酶kexin-9(proprotein convertase subtilisin/kexin type 9,PCSK9)逐渐成为血浆总胆固醇水平和治疗目标的重要调节因子。 | 刘莉 叶鹏 Haas ME Levenson AE Sun X Liao WH Rutkowski JM de Ferranti SD Schumacher VA Scherer PE Salant DJ Biddinger SB | 2016 | 中华高血压杂志2016，24，7： | 3 |
| 13 | The multi-soliton solutions of the CH-γ equation显示文摘This paper solves the integrable CH-γequation for analytical multiple soliton solutions with the Darboux transformation method.Some properties of the soliton solutions are different from the CH equation. | CHEN ChunLi~(1+) LI YiShen~2 ZHANG JinE~3 1 Department of Mathematics,Shanghai Jiaotong University,Shanghai 200240,China 2 Department of Mathematics,University of Science and Technology of China,Hefei 230026,China 3 SB and SEF,University of Hong Kong,Pokfulam Road,Hong Kong,China | 2008 | Science China Mathematics2008，51，2： | 3 |
| 14 | 生物学疗法在亚洲炎症性肠病患者中的应用前景显示文摘在不断揭秘炎症性肠病(IBD)发病机制的过程中,发现越来越多的具有治疗干预作用的靶点。目前一般认为溃疡性结肠炎(UC)与克罗恩病(CD)均是肠道对尚未明确的环境触发因素发生过度免疫反应所致。这一概念开启了发展针对肠道微观生物医学(the intestinal microbiome)进行干预治疗的设想。 | Hanauer SB 郑家驹(译) | 2008 | 中华消化杂志2008，28，12： | 2 |
| 15 | Surgical management of persistent,symptomatic nonvenereal Sclerosing lymphangitis of the Penis显示文摘 | Broaddus SB Leadbtter GW | 1982 | J Urol1982，127，5： | 2 |
| 16 | Endovascular stent implantation in patients with stenotic aortoarteriopathies: early and medium-term results显示文摘 | Siwik ES Perry SB Lock JE | 2003 | Catheter Cardiovasc Interv2003，59，3： | 2 |
| 17 | Transcatheter closure of atrial and ventricular septal defects显示文摘 | Perry SB Van der Velde ME Brideges NO | 1993 | Herz1993，18，2： | 2 |
| 18 | Early and late results of intracoronary arterial stenting after coronary angioplasty in dogs显示文摘 | Roubin GS Robinson KA King SB | 1987 | Circulation1987，76，4： | 2 |
| 19 | Erythropoietin显示文摘 | Krantz SB | 1991 | Blood1991，77，： | 2 |
| 20 | Enhancement of neuromuscular recovery after nerve repair in primates 显示文摘 | Badala mente MA Hurst LC Paul SB | 1987 | J Hand Surg1987，12，2： | 2 |
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