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| 1 | Interaction of insulin with prokinetic drugs in STZ-induced diabetic mice显示文摘AIM:To study the possible interactions of metoclopramide,domperidone and erythromycin in streptozotocin-induced diabetic mice treated with insulin by various parameters.METHODS:Effects of the individual as well as combined drugs were studied in diabetic mice via estimation of the blood glucose and serum insulin levels,small intestinal transit(SIT),gastric emptying(GE),xylose absorption and glucose tolerance tests.Groups were given insulin 2 IU/kg s.c.,metoclopramide 20 mg/kg p.o.,domperidone 20 mg/kg p.o.and erythromycin 6 mg/kg p.o.individually and in combination.There were also normal and diabetic control groups.The first set of experiments was carried out to investigate the subchronic effect on blood glucose and serum insulin levels in diabetic mice of one week of daily dose administration of the tested drugs individually as well as the combination of insulin with each prokinetic drug.The other five sets of experiments were carried out to investigate the acute effect of a single dose of each drug individually and in combination on blood glucose and serum insulin levels,SIT,GE,oral xylose absorption and glucose tolerance tests.RESULTS:The study included the prokinetic drugs metoclopramide(20 mg/kg),domperidone(20 mg/kg) and erythromycin(6 mg/kg),as well as insulin(2 IU/kg),which was individually effective in decreasing SIT,enhancing GE and increasing xylose absorption significantly in diabetic mice.Erythromycin tended to decrease blood glucose level and increase serum insulin level after 1 wk of daily administration in diabetic mice.Erythromycin potentiated the effect of insulin on blood glucose level and serum insulin level whereas other prokinetic agents failed to do so after repeated dose administration in diabetic mice.Metoclopramide or erythromycin in combination with insulin significantly decreased SIT,in diabetic mice,to lower levels than with insulin alone.Administration of prokinetic drugs along with insulin antagonized the action of insulin on xylose absorption.These combinations also increased the rate of glucose absorption from the gut.CONCLUSION:The present study suggests that prokinetic drugs could potentially improve glycemic control in diabetic gastroparesis by allowing a more predictable absorption of nutrients,matched to the action of exogenous insulin.The use of prokinetics,such as erythromycin,may be interesting in the clinic in decreasing the need for insulin in diabetic patients.The dose of insulin may be safely decreased with erythromycin in chronic treatments. | Mohamed A Fouad Shalaby Hekma A Abd El Latif Mostafa E El Sayed | 2013 | World Journal of Gastrointestinal Pharmacology and Therapeutics2013，4，2： | 3 |
| 2 | The role of fringing coral reef in beach protection of Hurghada, Gulf of Suez, Red Sea of Egypt显示文摘 | Frihy O E El Ganaini M A El Sayed W R | 2004 | Ecological Engineering2004，22，1： | 1 |
| 3 | Deep neck space Abscesses显示文摘 | Dousary A L | 1996 | J Otolaryngol1996，25，4： | 1 |
| 4 | Hepatic complications of antituberculosis therapy revisited显示文摘 | Cohen C D Sayed A R Kirsch R E | 1983 | S Afr Med J1983，63，： | 1 |
| 5 | Experimental study of turbulent flow inside a circular tube with longitudinal interrupted fins in the streamwise direction显示文摘 | SAAD A E SAYED A E MOHAMED E A | 1997 | Experimental qlaermal Fluid Science1997，15，1： | 1 |
| 6 | Stress corrosion behavior of α-aluminum bronze in saline water显示文摘 | Ateya B G Ashour E A Sayed S M | 1994 | Corrosion1994，50，1： | 1 |
| 7 | A new steel anchorage system for post-tensioning applications using carbon fibre reinforced plastic tendons 显示文摘 | SAYED A E Y SHRIVE N G | 1998 | Can J Civil Eng1998，25，1： | 1 |
| 8 | Fuzzy Controller for Inverter Fed Induction Machines 显示文摘 | Sayed A Mir Zinger Malik E Elbuluk | 1994 | IEEE Trans on Industry Application1994，30，4： | 1 |
| 9 | Domain analysis of electromagnetic transients on nonuniform lines显示文摘 | Saied M M Alfuhaid A S Elshandwily M E | 1990 | IEEE Trans on Power Delivery1990，5，4： | 1 |
| 10 | Stress corrosion behavior of α-aluminum bronze in saline water 显示文摘 | Ateya B G Ashour E A Sayed S M | 1994 | Corrosion1994，50，1： | 1 |
| 11 | Growth of hydrocarbonutilizing isolated in chemically defined media显示文摘 | Haiim A EL - Sayed M M Mahmond W M Davis E M Conghlin R W | 1996 | International Biodeterioration & Biodegradation1996，37，12： | 1 |
| 12 | The H^∞ optimality of the LMS algo- rithm显示文摘 | Hansler E Sayed A H Kailath T | 1996 | IEEE Trans Signal Process1996，44，： | 1 |
| 13 | Self -assembly of platinum nanoparticles of various size and shape显示文摘 | Petroski J M Green T C E El - Sayed M A | 2001 | J Phys Chem A2001，105，： | 1 |
| 14 | 查看详情显示文摘 | Li Y Boone E E Sayed M A | | 0，，12： | 1 |
| 15 | Stress corrosionbehavior of a-aluminum bronze in saline water 显示文摘 | ATEYA B G ASHOUR E A SAYED S M | 1994 | Corrosion1994，50，1： | 1 |
| 16 | Stress corrosion behavior of α-aluminum bronze in saline water 显示文摘 | Ateya B G Ashour E A Sayed S M | 1994 | Corrosion1994，50，1： | 1 |
| 17 | Treatment of mammary and extramammary Paget's skin disease with topical imiquimod显示文摘 | Mirer E El Sayed F Ammoury A | 2006 | J Dermatolog Treat2006，17，3： | 1 |
| 18 | Cortical comminution in distal radial fractures can predict the radio- logical outcome: a cohort muhicentre study 显示文摘 | Wadsten MA Sayed - Noor A Englund E | 2014 | Bone and Joint Journal2014，96，7： | 1 |
| 19 | Controlling chitosan molecular weight via bio-chitosanolysis显示文摘 | Abd-Elmohdy F A El Sayed Z E Essam S | 2010 | Carbohydr Polym2010，82，3： | 1 |
| 20 | Improved corneal bioavailability of ofloxacin:biodegradable microsphere-loaded ion-activated in situ gel delivery system显示文摘 | SAYED E G HUSSEIN A K KHALED K A | 2015 | Drug Design Development and Therapy2015，9，9： | 1 |
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