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| 1 | Participation of peribiliary glands in biliary tract pathophysiologies显示文摘AIM:To investigate the roles of peribiliary glands around the bile ducts in the pathophysiology of the biliary tract.METHODS:The expression of fetal pancreatic markers,pancreatic duodenal homeobox factor 1(PDX1)and hairy and enhancer of split 1(HES1)and endodermal stem/progenitor(S/P)cell markers[CD44s,chemokine receptor type 4(CXCR4),SOX9 and epithelial cell adhesion molecule(EpCAM)]were examined immunohistochemically in 32 normal adult livers(autopsy livers)and 22 hepatolithiatic livers(surgically resected livers).The latter was characterized by the proliferation of the peribiliary glands.Immunohistochemistry was performed using formalin-fixed,paraffin-embedded tissue sections after deparaffinization.Although PDX1and HES1 were expressed in both the nucleus and cytoplasm of epithelial cells,only nuclear staining was evaluated.SOX9 was expressed in the nucleus,while CD44s,CXCR4 and EpCAM were expressed in the cell membranes.The frequency and extent of the expression of these molecules in the lining epithelia and peribiliary glands were evaluated semi-quantitatively based on the percentage of positive cells:0,1+(focal),2+(moderate)and 3+(extensive).RESULTS:In normal livers,PDX1 was infrequently expressed in the lining epithelia,but was frequently expressed in the peribiliary glands.In contrast,HES1was frequently expressed in the lining epithelia,but its expression in the peribiliary glands was focal,suggesting that the peribiliary glands retain the potential of differentiation toward the pancreas and the lining epithelia exhibit properties to inhibit such differentiation.This unique combination was also seen in hepatolithiatic livers.The expression of endodermal S/P cell markers varied in the peribiliary glands in normal livers:SOX9 and EpCAM were frequently expressed,CD44s infrequently,and CXCR4 almost not at all.The expression of these markers,particularly CD44s and CXCR4,increased in the peribiliary glands and lining epithelia in hepatolithiatic livers.This increased expression of endodermal S/P cell markers may be related to the increased production of intestinal and gastric mucin and also to the biliary neoplasia associated with the gastric and intestinal phenotypes reported in hepatolithiasis.CONCLUSION:The unique expression pattern of PDX1and HES1 and increased expression of endodermal S/P cell markers in the peribiliary glands may be involved in biliary pathophysiologies. | Saya Igarashi Yasunori Sato Xiang Shan Ren Kenichi Harada Motoko Sasaki Yasuni Nakanuma | 2013 | World Journal of Hepatology2013，5，8： | 3 |
| 2 | Reactive Oxygen Species-Induced Autophagic Degradation of Helicobacter pylori CagA Is Specifically Suppressed in Cancer Stem-like Cells显示文摘 | Hitoshi Tsugawa Hidekazu Suzuki Hideyuki Saya Masanori Hatakeyama Toshiya Hirayama Kenro Hirata Osamu Nagano Juntaro Matsuzaki Toshifumi Hibi | 2012 | Cell Host & Microbe2012，，6： | 2 |
| 3 | Mechanism and biological significance of CD44 cleavage 显示文摘 | Nagano O Saya H | 2004 | Cancer Sci2004，95，12： | 1 |
| 4 | Aurora-A-a guardian of poles 显示文摘 | Marumoto T Zhang D Saya H | 2005 | Nat Rev Cancer2005，5，1： | 1 |
| 5 | Adenylyl cyclase type-Ⅷactivity is regulated by Gβγsubunits显示文摘 | Saya D Schallmach E | 2006 | Cell Signal2006，18，1： | 1 |
| 6 | Development of a stable isotope dilution UPLC‐MS/MS method for quantification of dexmedetomidine in a small amount of human plasma显示文摘 | Koichi Inoue Tasuku Sakamoto Yoshihito Fujita Saya Yoshizawa Maiko Tomita Jun Zhe Min Kenichiro Todoroki Kazuya Sobue Toshimasa Toyo’oka | 2013 | Biomed. Chromatogr2013，，7： | 1 |
| 7 | coronary slow flow phenomenon and risk for sudden cardiac death due to ventricular arrhythmias: a case report and review of literature 显示文摘 | Saya S Hennebry TA Lozano P | 2008 | Clin Cardiol2008，31，8： | 1 |
| 8 | Aurora - A - a guardian of poles 显示文摘 | Marumoto T Zhang D Saya H | 2005 | Nat Rev Cancer2005，5，1： | 1 |
| 9 | Mechanism and biological significanceof CD44 cleavage显示文摘 | Nagano O Saya H | 2004 | Cancer Sci2004，95，12： | 1 |
| 10 | Pyruvate kinase M2: multiple faces for conferring benefits on cancer cells显示文摘 | Tamada M Suematsu M Saya H | 2012 | Clin Cancer Res2012，18，20： | 1 |
| 11 | Reactive oxygen species-induced autophagic degradation of Helicobacter pylori CagA is specifically suppressed in cancer stem-like cells显示文摘 | Tsugawa H Suzuki H Saya H | 2012 | Cell Host Microbe2012，12，： | 1 |
| 12 | Adenylyl cyclase type-VIII activity is regulated by GPy subunits 显示文摘 | Steiner D Saya D Schallmach Ev | 2006 | Cell Signal2006，18，1： | 1 |
| 13 | Dependence of paclitaxel Sensitivity on a Functional Spindle Assembly Checkpoint 显示文摘 | Sudo T Nitta M Saya H | 2004 | Cancer Res2004，64，7： | 1 |
| 14 | Dependence of paclitaxel sensitivity on a functional spindle assembly checkpoin显示文摘 | Sudo T Nitta M Saya H | 2004 | Cancer Res2004，64，7： | 1 |
| 15 | The CD《,44》 adhesion molecule and metastasis显示文摘 | Tanabe KK Saya H | 1994 | Crit Rev Oncog1994，5，23： | 1 |
| 16 | Expression of CD44 adhesion molecule in colon carcinomas and metastases 显示文摘 | Filis LM Saya H | 1993 | Lancet1993，341，8847： | 1 |
| 17 | GSK-3 is aetiviated by the tyrosine kinase Pyk2 during LPAl-mediated neurite restraction 显示文摘 | Sayas CL Ariaens A Ponsioen B | 2006 | Mol Biol Cell2006，17，4： | 1 |
| 18 | Quality characteristics of ostrich (struthio camelus)burgers显示文摘 | FEMANDEZ L J JIMENEZ S SAYAS B E | 2006 | Meat Sci2006，73，： | 1 |
| 19 | Role of CD44 - mediated signal in cancer inva- sion and metastasis 显示文摘 | Saya H Nagano O | 2008 | Tanpakushitsu Kakusan Koso2008，53，10： | 1 |
| 20 | Basic fibroblast growth factor and fibroblast growth factor receptor 1 are implicated in the growth of human astrocytomas显示文摘 | Morrison R S Yamaguchi F Saya H | 1994 | J Neuronol1994，18，3： | 1 |
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