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| 1 | 应用对乙酰氨基酚、布洛芬或二者交替使用对发热幼儿行解热治疗的一项随机双盲试验显示文摘Objective:To compare the antipyretic benefit of acetaminophen or ibuprofen mo notherapy with an alternating regimen of both drugs in young children aged 6 to 36 months.Design:Randomized,double-blind,parallel-group trial.Setting:Th ree primary pediatric community ambulatory centers in central Israel.Participan ts:A total of 464 children aged 6 to 36 months with fever.Intervention:Infant s were assigned to receive either acetaminophen(12.5 mg/kg per dose every 6 hou rs)(n=154)or ibuprofen(5 mg/kg per dose every 8 hours)(n=155)or to receive alternating acetaminophen and ibuprofen(every 4 hours)(n=155)for 3 days after a loading dose.Main Outcome Measures:Temperature,stress score,amount of ant ipyretic received,total days that the infant or caregiver was absent from day c are or work,respectively,at the 3-day time point,recurrence of fever,and nu mber of emergency department visits.Results:The group given the alternating re gimen was characterized by a lower mean temperature,more rapid reduction of fev er,receiving less antipyretic medication,less stress,and less absenteeism fro m day care as compared with the other groups;all of the differences were statis tically significant(P < 0.001).None of the regimens were associated with a sig nificantly higher number of emergency department visits(P=.65)or serious long-term complications(P=.66).The drug used for initial loading had no effect on outcome in any of the groups.Conclusions:An alternating treatment regimen of acetaminophen(12.5 mg/kg per dose)and ibuprofen(5 mg/kg per dose)every 4 hou rs for 3 days,regardless of the initial loading medication,is more effective t han monotherapy in lowering fever in infants and children. | Sarrell E. M. Wielunsky E. Cohen H. A. 俞晓梅(译) | 2006 | 世界核心医学期刊文摘(儿科学分册)2006，2，8： | 2 |
| 2 | 17 beta-estradiol attenuates acetylcholine-induced coronary arterial constriction in women but not men wifth coronaryheart disease显示文摘 | Rosano GM Sarrel PM | 1995 | Circulation1995，92，： | 1 |
| 3 | Nebulized 3% Hypertonic saline solution treatment in ambulatory children with viral, bronchiolitis decreases symptoms显示文摘 | Sarrell EM Tal G Witzling M | 2009 | Chest2009，122，1： | 1 |
| 4 | 17 beta-estradiol regulation of human endothelial cell basal nitric oxide release, independent of cytosolic Ca^2+ mobilization显示文摘 | Caulin-Glaser T Garcia-Cardena G Sarrel P | 1997 | Cire Res1997，81，5： | 1 |
| 5 | The effect of hysterec- tomy on the age at ovarian failure: identifications of a subgroup of review显示文摘 | SIDDLE N SARREL P WHITEHEAD H | 1987 | Fertil Skeril1987，47，2： | 1 |
| 6 | The effect of hysterectomy on the age at ovarian failure:identifications of review显示文摘 | SIDDLE N SARREL P WHITEHEAD H | 1987 | Fertil Sterl1987，47，2： | 1 |
| 7 | The effects of hysterectomy on the age at ovarian failure:identification of a subgroup of women with premature loss of ovarian function显示文摘 | Siddle N Sarrel P Whitehead M | 1987 | Fertil1987，47，1： | 1 |
| 8 | The effect of hysterectomy on the age at ovarian failure : identifications of a subgroup of review显示文摘 | SIDDLE N SARREL P WHITEHEAD M | 1987 | Fertil Steril1987，47，2： | 1 |
| 9 | 17 betaestradiol attenuates acetylcholine-lnduceel coronary arterial constriction in women but ont men with coronay arterial contriction in women but not men with coeonary heart disease 显示文摘 | Collins P Rosano G M Sarrel P | 1995 | Circulation1995，92，1： | 1 |
| 10 | Nebulized 3%hypertonic saline solution treatment in ambulatory children with viral bronchiolitis decreases symptoms显示文摘 | Sarrell EM Tal G Witzling M | 2002 | Chest2002，122，6： | 1 |
| 11 | The effect of hysterectomy on the age at ovarin failure: identification of a subgroup of women with premature loss of ovarian function and literature review显示文摘 | Siddle N Sarrel P Whitehead M | 1987 | Fertil Steril1987，47，： | 1 |
| 12 | The effect of hysterectomy on the age at ovarian failure: identification of a subgroup of women with premature loss of ovarian function and literature review显示文摘 | Siddle N Sarrel P Whitehead M | 1987 | Fertil Steril1987，47，1： | 1 |
| 13 | The effect of hysterectomy on the age at ovarian failure: identification of a subgroup of women with pre?mature loss of ovarian function and literature review显示文摘 | Siddle N Sarrel P Whitehead M | 1987 | Fertil Steril1987，47，： | 1 |
| 14 | The effect of hyste- vectomy on the age at ovarian failure:identification of a subgroup of women with premature loss of ovarian function and literature review 显示文摘 | Siddle N Sarrel P Whitehead H | 1987 | Fertil Steril1987，47，1： | 1 |
| 15 | Antipyretic treat- ment in young children with fever: acetaminophen, ibuprofen, or both alternating in a randomized, double-blind study 显示文摘 | SARRELL E lVl COHEN 14 A WIELUNSKY E | 2006 | Digest of the World Core Medical Journals2006，160，2： | 1 |
| 16 | Nebulized 3% hyper- tonic saline solution treatment in ambulatory children with viral bronchiolitis decreases symptoms显示文摘 | Sarrell EM Tal G Witzling M | 2002 | Chest2002，122，6： | 1 |
| 17 | The effect of hysterectomy on the age at ovarian failure:identifications of a subgroup of review显示文摘 | SIDDLE N SARREL P WHITEHEAD H | 1987 | Fertil Steril1987，47，2： | 1 |
| 18 | The effect of hysterectomy on the age at ovarian failure:identifications of a Subgroup of Women with premature loss of ovarian function and literature review显示文摘 | Siddle N Sarrel P Whitehead H | 1987 | Fertil Steril1987，47，1： | 1 |
| 19 | The effect of hystectomy on the age at ovarian of identification of a subgroup of review显示文摘 | SIDDLE N SARREL P WHITEHEAD H | 1987 | Fertil Steril1987，47，2： | 1 |
| 20 | Beneficial effect of oestrogen on exercise-induced myocardial ischaemia in women with coronary artery disease 显示文摘 | Sarrel PM Poole-Wilson PA | 1993 | Lancet1993，142，8864： | 1 |
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