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| 1 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 2 | Modulation of systemic hemostatic parameters by enoxaparin during gestation in women with thrombophilia and pregnancy loss显示文摘 | Saring G Blumenfrld Z Leiba R | 2005 | Throml Haemost2005，94，5： | 1 |
| 3 | Relationship between hyperacute blood pressure and outcome after ischemic stroke: data from the VISTA collaboration显示文摘 | Sare GM Ali M Shuaib A | 2009 | Stroke2009，40，6： | 1 |
| 4 | Abrasion resistance and fracture tonghness of whit cast iron显示文摘 | Sare I R | 1979 | Metals Technology1979，，11： | 1 |
| 5 | Preoperative left ventricular systolic dysfunction correlates with the adverse postoperative consequences of annular-papilary disconnection in the course of mitral valve replacement for stenosi显示文摘 | Essop MR Kontozis Sareli P | 1998 | J Heart Valve Dis1998，7，4： | 1 |
| 6 | The effect of heat treatment on the abrasion resistance of alloy white irons显示文摘 | Tabrett C P Sare I R | 1997 | Wear1997，，： | 1 |
| 7 | Intermittent pneumatic sequential eompression of the lower extremities restores the cerebral oxygen saturation during laparoscopic eholecysteeto-my显示文摘 | Kurukahveeioglu O Sare M Karamerean A | 2008 | Surg Endosc2008，22，4： | 1 |
| 8 | Robotics of fruit harvesting: a state - of- the - air review显示文摘 | Saring Y | 1993 | Journal of Agricultural Engineering Research1993，54，： | 1 |
| 9 | Asymptomatic hemorrhagic transformation of infarction and its relationship with functional out- come and stroke subtype: assessment from the Tinzaparin in Acute Isch- aemic Stroke Trial 显示文摘 | England TJ Bath PM Sare GM | 2010 | Stroke2010，41，12： | 1 |
| 10 | Clinical results with the medennium Pha- kic refractive lens for the correction of high myopia 显示文摘 | Jong saree jit A | 2006 | Refract Surg2006，22，9： | 1 |
| 11 | Correlation of E-cadherin, VEGF, COX-2 expression to prognostic parameters in papillary thyroid carcinoma显示文摘 | Havva Erdem Cemal Gündogdu Sare ?ipal | 2010 | Experimental and Molecular Pathology2010，，3： | 1 |
| 12 | The influence of heat treatment on the high-stress abrasion resistance and fracture toughness of alloy white cast irons 显示文摘 | Sare I Arnold B | 1995 | Metallurgical and Materials Transactions A1995，26，7： | 1 |
| 13 | The effect of heat treatment on the abrasion resistance of alloy white iron显示文摘 | Tabrett C P Sare I R | 1997 | Wear1997，，： | 1 |
| 14 | Preoperative left ventricular systolic dysfunction correlates with the adverse postoperative consequences of annular papillary disconnection in the course of mitral valve replacement for stenosis显示文摘 | Essop MR Kontozis L Sareli P | 1998 | J Heart Valve Dis1998，7，4： | 1 |
| 15 | Effect of high temperature and sub-ambient treatment on the matrix structure and abrasion resistance of a high-chromium white iron显示文摘 | Tabrett C P Sare I R | 1998 | Scripta Mater1998，38，12： | 1 |
| 16 | 显示文摘 | Weber T de Wit L Sares F W | 1995 | Materials Science and Engineering A1995，199，： | 1 |
| 17 | Effect of heat treatment on the abrasion resistance of alloy white irons显示文摘 | Tabrett C P and Sare I R | 1997 | Wear1997，，： | 1 |
| 18 | Is lowering blood pressure hazardous in patients with significant ipsilateral carotid stenosis and acute ischaemic stroke Interim assessment in the 'efficacy of nitric oxide in stroke' trial显示文摘 | SARE G M GRAY L J WARDLAW J | 2009 | Blood Press Monit2009，14，1： | 1 |
| 19 | Abrasion resistance and fracture toughness of white cast irons显示文摘 | Sare R | 1979 | Metals Technology1979，，11： | 1 |
| 20 | Thrombophilia is common in women with idiopathic pregnancy loss and is associated with late pregnancy wast age显示文摘 | Saring G Younis JS Hoffman R | 2002 | Fertil Steril2002，77，： | 1 |
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