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| 1 | Pyogenic liver abscess:An audit of 10 years’experience显示文摘AIM:To describe our own experience with pyogenic liver abscesses over the past 10 years and investigate the risk factors associated with failure of initial percutaneous therapy.METHODS:A retrospective study of records of 63 PLA patients presenting between 1998 and 2008 to Australian tertiary referral centre,were reviewed.Amoebic and hydatid abscesses were excluded.Demographic,clinical,radiological,and microbiological characteristics,as well as surgical/radiological interventions,were recorded.RESULTS:Sixty-three patients(42 males,21 females) aged 65(±14) years[mean±(SD) ]had prodromal symptoms for a median(interquartile range;IQR) of 7(5-14) d.Only 59%of patients were febrile at presentation;however,the serum C-reactive protein was elevated in all 47 in whom it was measured.Liver function tests were non-specifically abnormal.67%of patients had a solitary abscess,while 32%had>3 abscesses with a median(IQR) diameter of 6.3(4-9) cm.Causative organisms were:Streptococcus milleri 25%,Klebsiella pneumoniae 21%,and Escherichia coli 16%.A presumptive cryptogenic cause was most common (34%).Four patients died in this series:one from sepsis,two from advanced cancer,and one from acute myocardial infarction.The initial procedure was radiological aspiration±drainage in 54 and surgery in two patients.17%underwent surgical management during their hospitalization.Serum hypoalbuminaemia[mean (95%CI) :32(29-35) g/L vs 28(25-31) g/L,P=0.045] on presentation was found to be the only factor related to failure of initial percutaneous therapy on univariate analysis.CONCLUSION:PLA is a diagnostic challenge,because the presentation of this condition is non-specific.Intravenous antibiotics and radiological drainage in the first instance allows resolution of most PLAs;However,a small proportion of patients still require surgical drainage. | Tony CY Pang Thomas Fung Jaswinder Samra Thomas J Hugh Ross C Smith | 2011 | World Journal of Gastroenterology2011，17，12： | 46 |
| 2 | Diagnosis of gastrointestinal bleeding: A practical guide for clinicians显示文摘Gastrointestinal bleeding is a common problem encountered in the emergency department and in the primary care setting. Acute or overt gastrointestinal bleeding is visible in the form of hematemesis, melena or hematochezia. Chronic or occult gastrointestinal bleeding is notapparent to the patient and usually presents as positive fecal occult blood or iron deficiency anemia. Obscure gastrointestinal bleeding is recurrent bleeding when the source remains unidentified after upper endoscopy and colonoscopic evaluation and is usually from the small intestine. Accurate clinical diagnosis is crucial and guides definitive investigations and interventions. This review summarizes the overall diagnostic approach to gastrointestinal bleeding and provides a practical guide for clinicians. | Bong Sik Matthew Kim Bob T Li Alexander Engel Jaswinder S Samra Stephen Clarke Ian D Norton Angela E Li | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，4： | 13 |
| 3 | One hundred and seventy-eight consecutive pancreatoduodenectomies without mortality:role of the multidisciplinary approach显示文摘BACKGROUND:Pancreatoduodenectomy offers the only chance of cure for patients with periampullary cancers.This,however,is a major undertaking in most patients and is associated with a significant morbidity and mortality.A multidisciplinary approach to the workup and follow-up of patients undergoing pancreatoduodenectomy was initiated at our institution to improve the diagnosis,resection rate,mortality and morbidity.We undertook the study to assess the effect of this approach on diagnosis,resection rates and short-term outcomes such as morbidity and mortality.METHODS:A prospective database of patients presenting with periampullary cancers to a single surgeon between April 2004 and April 2010 was reviewed.All cases were discussed at a multidisciplinary meeting comprising surgeons,gastroenterologists,radiologists,oncologists,radiation oncologists,pathologists and nursing staff.A standardized investigation and management algorithm was followed.Complications were graded according to the Clavien-Dindo classification.RESULTS:A total of 295 patients with a periampullary lesion were discussed and 178 underwent pancreatoduodenectomy (resection rate 60%).Sixty-one patients (34%) required either a vascular or an additional organ resection.Eighty-nine patients experienced complications,of which the commonest was blood transfusion (12%).Thirty-four patients (19%) had major complications,i.e.grade 3 or above.There was no in-hospital,30-day or 60-day mortality.CONCLUSIONS:Pancreatoduodenectomy can safely be performed in high-volume centers with very low mortality.The surgeon's role should be careful patient selection,intensive preoperative investigations,use of a team approach,and an unbiased discussion at a multidisciplinary meeting to optimize the outcome in these patients. | Jaswinder S Samra Raul Alvarado Bachmann Julian Choi Anthony Gill Michael Neale Vikram Puttaswamy Cameron Bell Ian Norton Sarah Cho Steven Blome Ritchie Maher Sivakumar Gananadha Thomas J Hugh | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，4： | 8 |
| 4 | Ampullary cancer of intestinal origin and duodenal cancer-A logical clinical and therapeutic subgroup in periampullary cancer显示文摘Periampullary cancers include pancreatic, ampullary, biliary and duodenal cancers. At presentation, the majority of periampullary tumours have grown to involve the pancreas, bile duct, ampulla and duodenum. This can result in difficulty in defining the primary site of origin in all but the smallest tumors due to anatomical proximity and architectural distortion. This has led to variation in the reported proportions of resected periampullary cancers. Pancreatic cancer is the most common cancer resected with a pancreaticoduodenectomy followed by ampullary(16%-50%), bile duct(5%-39%), and duodenal cancer(3%-17%). Patients with resected duodenal and ampullary cancers have a better reported median survival(29-47 mo and 22-54 mo) compared to pancreatic cancer(13-19 mo). The poorer survival with pancreatic cancer relates to differences in tumour characteristics such as a higher incidence of nodal, neural and vascular invasion. While small ampullary cancers can present early with biliary obstruction, pancreatic cancers need to reach a certain size before biliary obstruction ensues. This larger size at presentation contributes to a higher incidence of resection margin involvement in pancreatic cancer. Ampullary cancers can be subdivided into intestinal or pancreatobiliary subtype cancers with histomolecular staining. This avoids relying on histomorphology alone, as even some poorly differentiated cancers preserve the histomolecular profile of their mucosa of origin. Histomolecular profiling is superior to anatomic location in prognosticating survival. Ampullary cancers of intestinal subtype and duodenal cancers are similar in their intestinal origin and form a logical clinical and therapeutic subgroup of periampullary cancers. They respond to 5-FU based chemotherapeutic regimens such as capecitabine-oxaliplatin. Unlike pancreatic cancers, KRAS mutation occurs in only approximately a third of ampullary and duodenal cancers. Future clinical trials should group ampullary cancers of intestinal origin and duodenal cancers together given their similarities and their response to fluoropyrimidine therapy in combination with oxaliplatin. The addition of anti-epidermal growth factor receptor therapy in this group warrants study. | Manju D Chandrasegaram Anthony J Gill Jas Samra Tim Price John Chen Jonathan Fawcett Neil D Merrett | 2017 | World Journal of Gastrointestinal Oncology2017，9，10： | 4 |
| 5 | Long-term results of Ahmed glaucoma valve implantation in Egyptian population显示文摘AIM: To evaluate the long-term results and complications of Ahmed glaucoma valve(AGV) implantation in a cohort of Egyptian patients.METHODS: A retrospective study of 124 eyes of 99 patients with refractory glaucoma who underwent AGV implantation and had a minimum follow-up of 5 y was performed. All patients underwent complete ophthalmic examination and intraocular pressure(IOP) measurement before surgery and at 1 d, weekly for the 1 st month, 3, 6 mo,and 1 y after surgery and yearly afterward for 5 y. IOP was measured by Goldmann applanation tonometry and/or Tono-Pen. Complications and the number of anti-glaucoma medications needed were recorded. Success was defined as IOP less than 21 mm Hg with or without anti-glaucoma medication and without additional glaucoma surgery. RESULTS: Mean age was 23.1±19.9 y. All eyes had at least one prior glaucoma surgery. IOP was reduced from a mean of 37.2±6.8 to 19.2±5.2 mm Hg after 5 y follow-up with a reduced number of medications from 2.64±0.59 to 1.81±0.4.Complete and qualified success rates were 31.5% and 46.0%respectively at the end of follow-up. The most common complications were encapsulated cyst formation in 51 eyes(41.1%), complicated cataract in 9 eyes(7.25%), recessed tube in 8 eyes(6.45%), tube exposure in 6 eyes(4.8%) and corneal touch in 6 eyes(4.8%). Other complications included extruded AGV, endophthalmitis and persistent hypotony.Each of them was recorded in only 2 eyes(1.6%). CONCLUSION: Although refractory glaucoma is a difficult problem to manage, AGV is effective and relatively safe procedure in treating refractory glaucoma in Egyptian patients with long-term follow-up. Encapsulated cyst formation was the most common complication, which limits successful IOP control after AGV implantation.However, effective complications management can improve the rate of success. | Eman Elhefney Tharwat Mokbel Waleed Abou Samra Hanem Kishk Tarek Mohsen Amr El-Kannishy | 2018 | International Journal of Ophthalmology(English edition)2018，11，3： | 4 |
| 6 | Functional and anatomical evaluation of the effect of nepafenac in prevention of macular edema after phacoemulsification in diabetic patients显示文摘AIM: To evaluate the effect of prophylactic administration of nepafenac in prevention of macular edema occurring in diabetic patients after phacoemulsification and to investigate the correlation between optical coherence tomography(OCT) foveal thickness and multifocal electroretinogram(MF-ERG) parameters.METHODS: The study included two groups. Group 1 included 50 diabetic patients with senile cataract(50 eyes, 30 females, 20 males, aged 55±7 y) received nepafenac 0.1% eye drop. Group 2 included another 50 diabetic patients with senile cataract(50 eyes, 22 female, 28 males, aged 53.8±8 y) did not receive nepafenac. All patients were followed up for 3 mo postoperatively. OCT and MF-ERG were done preoperative and at 1 wk, 1, 2 and 3 mo.RESULTS: The mean foveal thickness was statistically significantly lower in Group 1. Five eyes in Group 2 developed clinical cystoid macular oedema(CMO)(10%), and no patients in Group 1 developed central macular thickening more than 50 μm. There were insignificant differences in MF-ERG amplitudes and latencies between the two groups except in the five eyes that developed CMO, there statistically significant reduction of MF-ERG amplitude with increase in foveal thickness. CONCLUSION: Perioperative nepafenac reduces the incidence of CMO following uncomplicated phacoemulsification significantly. Nepafenac has no side effects. | Tharwat Mokbel Sameh Saleh Mona Abdelkader Sherief E.El-khouly Waleed Abou Samra Mohamed Mamdouh | 2019 | International Journal of Ophthalmology(English edition)2019，12，3： | 3 |
| 7 | Pharmacological basis for the use of Fumaria indica in constipation and diarrhea显示文摘 | Anwar H. Gilani Samra Bashir Khalid H. Janbaz Arifullah Khan | 2004 | Journal of Ethnopharmacology2004，，3： | 2 |
| 8 | 比较超声乳化术中林格液和乳酸盐林格液对角膜内皮细胞的影响(英文)显示文摘目的:比较林格液和乳酸林格液(RL)在超声乳化术中作为冲洗液的差异,并探讨其对角膜内皮细胞的影响。方法:这是一项前瞻性介入性双盲临床研究,包括100例(100眼)年龄在50~65岁之间的年龄相关性白内障患者。随机分为两组(每组各50眼)。组1使用林格液,组2使用乳酸盐林格液冲洗液。结果:组1患者平均年龄57.5±8岁,组2患者平均年龄58.6±9岁。3mo后,组1内皮细胞密度平均下降8.5%,组2平均下降3.6%(P=0.013)。此外,组1中央角膜厚度平均增加6.9%,组2平均增加1.5%(P=0.006)。通过将测厚仪和高光显微镜参数的变化率与灌水量相关联得出两者间无显著相关性。结论:与乳酸盐林格液相比,使用林格液作为冲洗液可减少术后内皮细胞的损失,也可减轻术后水肿。 | Eman Desoky Amir Abou Samra Hany Ahmed Helaly | 2019 | 国际眼科杂志2019，19，8： | 2 |
| 9 | Prospective evaluation of deep topical fornix nerve block versus peribulbar nerve block in patients undergoing cataract surgery using phacoemulsification 显示文摘 | Aziz E S Samra A | 2000 | Br J Anaesth2000，85，2： | 1 |
| 10 | Time-dependent deflection of reinforced concrete beam revisited显示文摘 | SAMRA R M | 1997 | Journal of Structural Engineering ASCE1997，123，6： | 1 |
| 11 | New analysis for creep behavior in concrete columns显示文摘 | SAMRA R M | 1995 | Journal of Structural Engineering ASCE1995，121，3： | 1 |
| 12 | Dexmedetomidine and neuroprotection 显示文摘 | Janke EL Samra S | 2006 | Semin Anesth Pcrioper Med Pain2006，25，2： | 1 |
| 13 | The 'thrifty' gene encoding Ahsg/Fetuin - A meets the in- sulin receptor: Insights into the mechanism of insulin resistance 显示文摘 | Goustin AS Abou - Samra AB | 2011 | Cell Signal2011，23，6： | 1 |
| 14 | Encapsulation and capsular types in isolates of Staphylococcus aureus from different sources and relationship to phage types显示文摘 | SOMPOLNSKY D SAMRA Z KARAKAWA W W | 1985 | J Clin Microbiol1985，22，： | 1 |
| 15 | Recovery of cognitive function after surgery for aneurysmal subarachnoid hemorrhage 显示文摘 | Samra SK Giordani B Caveney AF | 2007 | Stroke2007，38，6： | 1 |
| 16 | A comparisonof remifentanil and fentanyl in patients undergoing surgeryfor intracranial mass lesions, 显示文摘 | BalakrishnanG Raudzens P Samra SK | 2000 | Anesthesia Analgesia2000，91，1： | 1 |
| 17 | Cloning and characterization of two glutathione S-transferases from pyrethroid- resistant Culexpipiens显示文摘 | SAMRA A I KAMITA S G YAO H W | 2012 | Pest Manage Sci2012，68，5： | 1 |
| 18 | Understanding the neuro-ophthalmology of head trauma : a review of the current literature 显示文摘 | Samra KA | 2015 | Asia Pae J Ophthalmol ( Phila )2015，3，4： | 1 |
| 19 | Upstream tissue inhibitor of metalloproteinases-1 (T IMP-1 ) element-1, a novel and essential regulatory DNA motif in the human TIMP-1 gene promoter, directly interacts with a 30-kDa nuclear protein显示文摘 | Trim JE Samra SK Arthur MJ | 2000 | J Biol Chem2000，275，9： | 1 |
| 20 | Subcellular distribution of xanthine oxidase during cardiac ischemia and reperfusion: an immunocytochemical study 显示文摘 | Ashraf M Samra ZQ | 1993 | J Submicrosc Cytol Pathol1993，25，2： | 1 |
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